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Science 30 June 1995:
Vol. 268. no. 5219, pp. 1912 - 1914
DOI: 10.1126/science.7604265
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Articles

Science, Vol 268, Issue 5219, 1912-1914
Copyright © 1995 by American Association for the Advancement of Science

articles

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

F Palombo, P Gallinari, I Iaccarino, T Lettieri, M Hughes, A D'Arrigo, O Truong, JJ Hsuan, and J Jiricny

Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Italy.

DNA mismatch recognition and binding in human cells has been thought to be mediated by the hMSH2 protein. Here it is shown that the mismatch-binding factor consists of two distinct proteins, the 100-kilodalton hMSH2 and a 160-kilodalton polypeptide, GTBP (for G/T binding protein). Sequence analysis identified GTBP as a new member of the MutS homolog family. Both proteins are required for mismatch-specific binding, a result consistent with the finding that tumor-derived cell lines devoid of either protein are also devoid of mismatch-binding activity.


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G. Aquilina, M. Crescenzi, and M. Bignami (1999)
Carcinogenesis 20, 2317-2326
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Separation-of-Function Mutations in Saccharomyces cerevisiae MSH2 That Confer Mismatch Repair Defects but Do Not Affect Nonhomologous-Tail Removal during Recombination.
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Biochemical Characterization of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 Complex and Mispaired Bases in DNA.
G. T. Marsischky and R. D. Kolodner (1999)
J. Biol. Chem. 274, 26668-26682
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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.
M. J. Hickman and L. D. Samson (1999)
PNAS 96, 10764-10769
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Oligomerization of a MutS Mismatch Repair Protein from Thermus aquaticus.
I. Biswas, C. Ban, K. G. Fleming, J. Qin, J. W. Lary, D. A. Yphantis, W. Yang, and P. Hsieh (1999)
J. Biol. Chem. 274, 23673-23678
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Inefficient in vivo repair of mismatches at an oncogenic hotspot correlated with lack of binding by mismatch repair proteins and with phase of the cell cycle.
N. Matton, J. Simonetti, and K. Williams (1999)
Carcinogenesis 20, 1417-1424
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Sequence-dependent mutations in a shuttle vector plasmid replicated in a mismatch repair deficient human cell line.
S. E. Tobi, D. D. Levy, M. M. Seidman1, and K. H. Kraemer1 (1999)
Carcinogenesis 20, 1293-1301
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Apoptosis Induced by Overexpression of hMSH2 or hMLH1.
H. Zhang, B. Richards, T. Wilson, M. Lloyd, A. Cranston, A. Thorburn, R. Fishel, and M. Meuth (1999)
Cancer Res. 59, 3021-3027
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Novel hMLH1 and hMSH2 Germline Mutations in African Americans With Colorectal Cancer.
T. K. Weber, H.-M. Chin, M. Rodriguez-Bigas, B. Keitz, R. Gilligan, L. O'Malley, E. Urf, N. Diba, J. Pazik, and N. J. Petrelli (1999)
JAMA 281, 2316-2320
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Y. CANITROT, M. FRÉCHET, L. SERVANT, C. CAZAUX, and J.-S. HOFFMANN (1999)
FASEB J 13, 1107-1111
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S. W. Vernon, E. R. Gritz, S. K. Peterson, C. A. Perz, S. Marani, C. I. Amos, and W. F. Baile (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 353-360
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Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.
K. Drotschmann, A. B. Clark, H. T. Tran, M. A. Resnick, D. A. Gordenin, and T. A. Kunkel (1999)
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G. T. Marsischky, S. Lee, J. Griffith, and R. D. Kolodner (1999)
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T. Lettieri, G. Marra, G. Aquilina, M. Bignami, N. E.A. Crompton, F. Palombo, and J. Jiricny (1999)
Carcinogenesis 20, 373-382
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S. S. de Vries, E. B. Baart, M. Dekker, A. Siezen, D. G. de Rooij, P. de Boer, and H. te Riele (1999)
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K. Park, J. Kim, H.-S. Kim, and H. S. Shin (1998)
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DNA-dependent Activation of the hMutSalpha ATPase.
L. J. Blackwell, K. P. Bjornson, and P. Modrich (1998)
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O. Fleck, C. Kunz, C. Rudolph, and J. Kohli (1998)
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H. Flores-Rozas and R. D. Kolodner (1998)
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T. Fujiwara, J. M. Stolker, T. Watanabe, A. Rashid, P. Longo, J. R. Eshleman, S. Booker, H. T. Lynch, J. R. Jass, J. S. Green, et al. (1998)
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Microsatellite Instability and Mutation of DNA Mismatch Repair Genes in Gliomas.
S. Y. Leung, T. L. Chan, L. P. Chung, A. S. Y. Chan, Y. W. Fan, K. N. Hung, W. K. Kwong, J. W. C. Ho, and S. T. Yuen (1998)
Am. J. Pathol. 153, 1181-1188
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Hereditary Factors in Gynecologic Cancer.
H. T. Lynch, M. J. Casey, T. G. Shaw, and J. F. Lynch (1998)
Oncologist 3, 319-338
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Isolation of MutSbeta from Human Cells and Comparison of the Mismatch Repair Specificities of MutSbeta and MutSalpha.
J. Genschel, S. J. Littman, J. T. Drummond, and P. Modrich (1998)
J. Biol. Chem. 273, 19895-19901
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Mismatch repair deficiency associated with overexpression of the MSH3 gene.
G. Marra, I. Iaccarino, T. Lettieri, G. Roscilli, P. Delmastro, and J. Jiricny (1998)
PNAS 95, 8568-8573
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Mismatch repair, molecular switches, and signal transduction.
R. Fishel (1998)
Genes & Dev. 12, 2096-2101
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Prediction-based threading of the hMSH2 DNA mismatch repair protein.
M. De las Alas, R. A. M. de bruin, L. T. Eyck, G. Los, and S. B. Howell (1998)
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Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein.
Q. H. Phung, D. B. Winter, A. Cranston, R. E. Tarone, V. A. Bohr, R. Fishel, and P. J. Gearhart (1998)
J. Exp. Med. 187, 1745-1751
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Mismatch-, MutS-, MutL-, and Helicase II-dependent Unwinding from the Single-strand Break of an Incised Heteroduplex.
V. Dao and P. Modrich (1998)
J. Biol. Chem. 273, 9202-9207
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Functional Overlap in Mismatch Repair by Human MSH3 and MSH6.
A. Umar, J. I. Risinger, W. E. Glaab, K. R. Tindall, J. C. Barrett, and T. A. Kunkel (1998)
Genetics 148, 1637-1646
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A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype.
N. C. Nicolaides, S. J. Littman, P. Modrich, K. W. Kinzler, and B. Vogelstein (1998)
Mol. Cell. Biol. 18, 1635-1641
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Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.
S. E. Andrew, M. McKinnon, B. S. Cheng, A. Francis, J. Penney, A. H. Reitmair, T. W. Mak, and F. R. Jirik (1998)
PNAS 95, 1126-1130
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Conserved Properties between Functionally Distinct MutS Homologs in Yeast.
P. Pochart, D. Woltering, and N. M. Hollingsworth (1997)
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Mismatch Repair Defects and O6-Methylguanine-DNA Methyltransferase Expression in Acquired Resistance to Methylating Agents in Human Cells.
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DNA Polymerase delta Is Required for Human Mismatch Repair in Vitro.
M. J. Longley, A. J. Pierce, and P. Modrich (1997)
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Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2.
L. Narayanan, J. A. Fritzell, S. M. Baker, R. M. Liskay, and P. M. Glazer (1997)
PNAS 94, 3122-3127
   Abstract »    Full Text »    PDF »
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
S. Acharya, T. Wilson, S. Gradia, M. F. Kane, S. Guerrette, G. T. Marsischky, R. Kolodner, and R. Fishel (1996)
PNAS 93, 13629-13634
   Abstract »    Full Text »    PDF »
Replication across O6-Methylguanine by Human DNA Polymerase beta in Vitro. INSIGHTS INTO THE FUTILE CYTOTOXIC REPAIR AND MUTAGENESIS OF O6-METHYLGUANINE.
J. Singh, L. Su, and E. T. Snow (1996)
J. Biol. Chem. 271, 28391-28398
   Abstract »    Full Text »    PDF »
Human MutSalpha Specifically Binds to DNA Containing Aminofluorene and Acetylaminofluorene Adducts.
G.-M. Li, H. Wang, and L. J. Romano (1996)
J. Biol. Chem. 271, 24084-24088
   Abstract »    Full Text »    PDF »
Cisplatin and Adriamycin Resistance Are Associated with MutLalpha and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line.
J. T. Drummond, A. Anthoney, R. Brown, and P. Modrich (1996)
J. Biol. Chem. 271, 19645-19648
   Abstract »    Full Text »    PDF »
Biochemistry and genetics of eukaryotic mismatch repair..
R Kolodner (1996)
Genes & Dev. 10, 1433-1442
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Requirement of the Yeast MSH3 and MSH6 Genes for MSH2-dependent Genomic Stability.
R. E. Johnson, G. K. Kovvali, L. Prakash, and S. Prakash (1996)
J. Biol. Chem. 271, 7285-7288
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Thermostable MutS Homolog from Thermus aquaticus.
I. Biswas and P. Hsieh (1996)
J. Biol. Chem. 271, 5040-5048
   Abstract »    Full Text »    PDF »
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair..
G T Marsischky, N Filosi, M F Kane, and R Kolodner (1996)
Genes & Dev. 10, 407-420
   Abstract »    PDF »
hMSH2-independent DNA Mismatch Recognition by Human Proteins.
N. E. O'Regan, P. Branch, P. Macpherson, and P. Karran (1996)
J. Biol. Chem. 271, 1789-1796
   Abstract »    Full Text »    PDF »
Appropriate partners make good matches.
P Karran (1995)
Science 268, 1857-1858
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