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Science 30 June 1995:
Vol. 268. no. 5219, pp. 1906 - 1909
DOI: 10.1126/science.7541554
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Articles

Science, Vol 268, Issue 5219, 1906-1909
Copyright © 1995 by American Association for the Advancement of Science

articles

Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation

JC Zuniga-Pflucker, J Di, and MJ Lenardo

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-alpha or IL-1 alpha was necessary for further thymocyte maturation and CD4+CD8+ differentiation. In irradiated mice reconstituted with CD117+CD25+ thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency.


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