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Science 30 June 1995:
Vol. 268. no. 5219, pp. 1899 - 1902
DOI: 10.1126/science.7604262
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Articles

Science, Vol 268, Issue 5219, 1899-1902
Copyright © 1995 by American Association for the Advancement of Science

articles

Common virulence factors for bacterial pathogenicity in plants and animals

LG Rahme, EJ Stevens, SF Wolfort, J Shao, RG Tompkins, and FM Ausubel

Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.

A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for Arabidopsis, causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied P. aeruginosa strains. Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals.


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Infect. Immun. 71, 2404-2413
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Alginate gene expression by Pseudomonas syringae pv. tomato DC3000 in host and non-host plants.
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P. J. Wilderman, A. I. Vasil, Z. Johnson, M. J. Wilson, H. E. Cunliffe, I. L. Lamont, and M. L. Vasil (2001)
Infect. Immun. 69, 5385-5394
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Identification of one insertion site of IS6110 in Mycobacterium tuberculosis H37Ra and analysis of the RvD2 deletion in M. tuberculosis clinical isolates.
N. LARI, L. RINDI, and C. GARZELLI (2001)
J. Med. Microbiol. 50, 805-811
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SirA Orthologs Affect both Motility and Virulence.
R. I. Goodier and B. M. M. Ahmer (2001)
J. Bacteriol. 183, 2249-2258
   Abstract »