Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 June 1995:
Vol. 268. no. 5217, pp. 1629 - 1632
DOI: 10.1126/science.7539937
Prev | Table of Contents | Next

Articles

Science, Vol 268, Issue 5217, 1629-1632
Copyright © 1995 by American Association for the Advancement of Science

articles

Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation

PW Mantyh, E DeMaster, A Malhotra, Ghilardi JR, SD Rogers, CR Mantyh, H Liu, AI Basbaum, Vigna SR, JE Maggio, and al. et

Molecular Neurobiology Laboratory, Veterans Administration Medical Center, Minneapolis, MN 55417, USA.

In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in the spinal cord and stimulated endocytosis of substance P receptors in rat spinal cord neurons. The distal dendrites that showed substance P receptor internalization underwent morphological reorganization, changing from a tubular structure to one characterized by swollen varicosities connected by thin segments. This internalization and dendritic structural reorganization provided a specific image of neurons activated by substance P. Thus receptor internalization can drive reversible structural changes in central nervous system neurons in vivo. Both of these processes may be involved in neuronal plasticity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa.
L. Cheng, S. de la Monte, J. Ma, J. Hong, M. Tong, W. Cao, J. Behar, P. Biancani, and K. M. Harnett (2009)
Am J Physiol Gastrointest Liver Physiol 297, G135-G143
   Abstract »    Full Text »    PDF »
Glycine Inhibitory Dysfunction Induces a Selectively Dynamic, Morphine-Resistant, and Neurokinin 1 Receptor- Independent Mechanical Allodynia.
L. S. Miraucourt, X. Moisset, R. Dallel, and D. L. Voisin (2009)
J. Neurosci. 29, 2519-2527
   Abstract »    Full Text »    PDF »
Large Projection Neurons in Lamina I of the Rat Spinal Cord That Lack the Neurokinin 1 Receptor Are Densely Innervated by VGLUT2-Containing Axons and Possess GluR4-Containing AMPA Receptors.
E. Polgar, K. M. Al-Khater, S. Shehab, M. Watanabe, and A. J. Todd (2008)
J. Neurosci. 28, 13150-13160
   Abstract »    Full Text »    PDF »
Applying Osteopathic Principles to Formulate Treatment for Patients With Chronic Pain.
M. L. Kuchera (2007)
J Am Osteopath Assoc 107, ES28-ES38
   Abstract »    Full Text »    PDF »
Upregulation of Substance P in Low-Threshold Myelinated Afferents Is Not Required for Tactile Allodynia in the Chronic Constriction Injury and Spinal Nerve Ligation Models.
D. I. Hughes, D. T. Scott, J. S. Riddell, and A. J. Todd (2007)
J. Neurosci. 27, 2035-2044
   Abstract »    Full Text »    PDF »
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
A. D. Grant, G. S. Cottrell, S. Amadesi, M. Trevisani, P. Nicoletti, S. Materazzi, C. Altier, N. Cenac, G. W. Zamponi, F. Bautista-Cruz, et al. (2007)
J. Physiol. 578, 715-733
   Abstract »    Full Text »    PDF »
Biology of bone cancer pain..
M. J. Goblirsch, P. P. Zwolak, and D. R. Clohisy (2006)
Clin. Cancer Res. 12, 6231s-6235s
   Abstract »    Full Text »    PDF »
Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats..
M. D. Noble, J. Romac, Y. Wang, J. Hsu, J. E. Humphrey, and R. A. Liddle (2006)
Am J Physiol Gastrointest Liver Physiol 291, G128-G134
   Abstract »    Full Text »    PDF »
Safety Evaluation of Intrathecal Substance P-Saporin, a Targeted Neurotoxin, in Dogs.
J. W. Allen, P. W. Mantyh, K. Horais, N. Tozier, S. D. Rogers, J. R. Ghilardi, D. Cizkova, M. R. Grafe, P. Richter, D. A. Lappi, et al. (2006)
Toxicol. Sci. 91, 286-298
   Abstract »    Full Text »    PDF »
Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis.
E. C. Wick, S. G. Hoge, S. W. Grahn, E. Kim, L. A. Divino, E. F. Grady, N. W. Bunnett, and K. S. Kirkwood (2006)
Am J Physiol Gastrointest Liver Physiol 290, G959-G969
   Abstract »    Full Text »    PDF »
Basic Science of Pain.
J. A. DeLeo (2006)
J. Bone Joint Surg. Am. 88, 58-62
   Abstract »    Full Text »    PDF »
Disinhibition Opens the Gate to Pathological Pain Signaling in Superficial Neurokinin 1 Receptor-Expressing Neurons in Rat Spinal Cord.
C. Torsney and A. B. MacDermott (2006)
J. Neurosci. 26, 1833-1843
   Abstract »    Full Text »    PDF »
Osteopathic Manipulative Medicine Considerations in Patients With Chronic Pain.
M. L. Kuchera (2005)
J Am Osteopath Assoc 105, S29-S36
   Abstract »    Full Text »    PDF »
Inhibition by Spinal {micro}- and {delta}-Opioid Agonists of Afferent-Evoked Substance P Release.
I. Kondo, J. C. G. Marvizon, B. Song, F. Salgado, S. Codeluppi, X.-Y. Hua, and T. L. Yaksh (2005)
J. Neurosci. 25, 3651-3660
   Abstract »    Full Text »    PDF »
Somatostatin Receptor 2 Is Activated in Cortical Neurons and Contributes to Neurodegeneration after Focal Ischemia.
R. K. Stumm, C. Zhou, S. Schulz, M. Endres, G. Kronenberg, J. P. Allen, G. Tulipano, and V. Hollt (2004)
J. Neurosci. 24, 11404-11415
   Abstract »    Full Text »    PDF »
Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization.
Y. Kawasaki, T. Kohno, Z.-Y. Zhuang, G. J. Brenner, H. Wang, C. Van Der Meer, K. Befort, C. J. Woolf, and R.-R. Ji (2004)
J. Neurosci. 24, 8310-8321
   Abstract »    Full Text »    PDF »
Characterization of Wide Dynamic Range Neurons in the Deep Dorsal Horn of the Spinal Cord in Preprotachykinin-A Null Mice In Vivo.
W. J. Martin, Y. Cao, and A. I. Basbaum (2004)
J Neurophysiol 91, 1945-1954
   Abstract »    Full Text »    PDF »
Constitutive Spinal Cyclooxygenase-2 Participates in the Initiation of Tissue Injury-Induced Hyperalgesia.
J. R. Ghilardi, C. I. Svensson, S. D. Rogers, T. L. Yaksh, and P. W. Mantyh (2004)
J. Neurosci. 24, 2727-2732
   Abstract »    Full Text »    PDF »
Dorsal Horn Neurons Firing at High Frequency, But Not Primary Afferents, Release Opioid Peptides that Produce {micro}-Opioid Receptor Internalization in the Rat Spinal Cord.
B. Song and J. C. G. Marvizon (2003)
J. Neurosci. 23, 9171-9184
   Abstract »    Full Text »    PDF »
Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy.
J. C. Reubi (2003)
Endocr. Rev. 24, 389-427
   Abstract »    Full Text »    PDF »
In Vivo Pain-Inhibitory Role of Nociceptin/Orphanin FQ in Spinal Cord.
M. Inoue, T. Kawashima, H. Takeshima, G. Calo, A. Inoue, Y. Nakata, and H. Ueda (2003)
J. Pharmacol. Exp. Ther. 305, 495-501
   Abstract »    Full Text »    PDF »
Peptidases Prevent {micro}-Opioid Receptor Internalization in Dorsal Horn Neurons by Endogenously Released Opioids.
B. Song and J. C. G. Marvizon (2003)
J. Neurosci. 23, 1847-1858
   Abstract »    Full Text »    PDF »
Endocannabinoids Induce Ileitis in Rats via the Capsaicin Receptor (VR1).
D. C. McVey, P. C. Schmid, H. H. O. Schmid, and S. R. Vigna (2003)
J. Pharmacol. Exp. Ther. 304, 713-722
   Abstract »    Full Text »    PDF »
Simultaneous Reduction in Cancer Pain, Bone Destruction, and Tumor Growth by Selective Inhibition of Cyclooxygenase-2.
M. A. C. Sabino, J. R. Ghilardi, J. L. M. Jongen, C. P. Keyser, N. M. Luger, D. B. Mach, C. M. Peters, S. D. Rogers, M. J. Schwei, C. de Felipe, et al. (2002)
Cancer Res. 62, 7343-7349
   Abstract »    Full Text »    PDF »
Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct.
M.-C. Ma, H.-S. Huang, C.-T. Chien, M.-S. Wu, and C.-F. Chen (2002)
Am J Physiol Renal Physiol 283, F164-F172
   Abstract »    Full Text »    PDF »
Projection Neurons in Lamina I of Rat Spinal Cord with the Neurokinin 1 Receptor Are Selectively Innervated by Substance P-Containing Afferents and Respond to Noxious Stimulation.
A. J. Todd, Z. Puskar, R. C. Spike, C. Hughes, C. Watt, and L. Forrest (2002)
J. Neurosci. 22, 4103-4113
   Abstract »    Full Text »    PDF »
Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis.
J. D. Nathan, A. A. Patel, D. C. McVey, J. E. Thomas, V. Prpic, S. R. Vigna, and R. A. Liddle (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1322-G1328
   Abstract »    Full Text »    PDF »
Dendrites.
Y.-N. Jan and L. Y. Jan (2001)
Genes & Dev. 15, 2627-2641
   Full Text »    PDF »
Progesterone Blockade of Estrogen Activation of {micro}-Opioid Receptors Regulates Reproductive Behavior.
K. Sinchak and P. E Micevych (2001)
J. Neurosci. 21, 5723-5729
   Abstract »    Full Text »    PDF »
Osteoprotegerin Diminishes Advanced Bone Cancer Pain.
N. M. Luger, P. Honore, M. A. C. Sabino, M. J. Schwei, S. D. Rogers, D. B. Mach, D. R. Clohisy, and P. W. Mantyh (2001)
Cancer Res. 61, 4038-4047
   Abstract »    Full Text »
Postsynaptic Signaling via the {micro}-Opioid Receptor: Responses of Dorsal Horn Neurons to Exogenous Opioids and Noxious Stimulation.
J. A. Trafton, C. Abbadie, K. Marek, and A. I. Basbaum (2000)
J. Neurosci. 20, 8578-8584
   Abstract »    Full Text »    PDF »
Abnormal Phrenic Motoneuron Activity and Morphology in Neonatal Monoamine Oxidase A-Deficient Transgenic Mice: Possible Role of a Serotonin Excess.
C. Bou-Flores, A.-M. Lajard, R. Monteau, E. De Maeyer, I. Seif, J. Lanoir, and G. Hilaire (2000)
J. Neurosci. 20, 4646-4656
   Abstract »    Full Text »    PDF »
Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.
B. Dumartin, M. Jaber, F. Gonon, M. G. Caron, B. Giros, and B. Bloch (2000)
PNAS 97, 1879-1884
   Abstract »    Full Text »    PDF »
Neurochemical and Cellular Reorganization of the Spinal Cord in a Murine Model of Bone Cancer Pain.
M. J. Schwei, P. Honore, S. D. Rogers, J. L. Salak-Johnson, M. P. Finke, M. L. Ramnaraine, D. R. Clohisy, and P. W. Mantyh (1999)
J. Neurosci. 19, 10886-10897
   Abstract »    Full Text »    PDF »
Spinal Opioid Analgesia: How Critical Is the Regulation of Substance P Signaling?.
J. A. Trafton, C. Abbadie, S. Marchand, P. W. Mantyh, and A. I. Basbaum (1999)
J. Neurosci. 19, 9642-9653
   Abstract »    Full Text »    PDF »
Vanilloid (Capsaicin) Receptors and Mechanisms.
A. Szallasi and P. M. Blumberg (1999)
Pharmacol. Rev. 51, 159-212
   Abstract »    Full Text »    PDF »
Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus.
H. Liu, A. M. Mazarati, H. Katsumori, R. Sankar, and C. G. Wasterlain (1999)
PNAS 96, 5286-5291
   Abstract »    Full Text »    PDF »
Primary Afferent Fibers That Contribute to Increased Substance P Receptor Internalization in the Spinal Cord After Injury.
B. J. Allen, J. Li, P. M. Menning, S. D. Rogers, J. Ghilardi, P. W. Mantyh, and D. A. Simone (1999)
J Neurophysiol 81, 1379-1390
   Abstract »    Full Text »    PDF »
The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versus Recycling.
J. Trejo and S. R. Coughlin (1999)
J. Biol. Chem. 274, 2216-2224
   Abstract »    Full Text »    PDF »
Neurons in the dorsal column white matter of the spinal cord: Complex neuropil in an unexpected location.
C. Abbadie, K. Skinner, I. Mitrovic, and A. I. Basbaum (1999)
PNAS 96, 260-265
   Abstract »    Full Text »    PDF »
Subcellular Redistribution of m2 Muscarinic Acetylcholine Receptors in Striatal Interneurons In Vivo after Acute Cholinergic Stimulation.
V. Bernard, O. Laribi, A. I. Levey, and B. Bloch (1998)
J. Neurosci. 18, 10207-10218
   Abstract »    Full Text »    PDF »
Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting.
J. Trejo, S. R. Hammes, and S. R. Coughlin (1998)
PNAS 95, 13698-13702
   Abstract »    Full Text »    PDF »
Spine Loss and Other Persistent Alterations of Hippocampal Pyramidal Cell Dendrites in a Model of Early-Onset Epilepsy.
M. Jiang, C. L. Lee, K. L. Smith, and J. W. Swann (1998)
J. Neurosci. 18, 8356-8368
   Abstract »    Full Text »    PDF »
Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part I: Trans-Golgi Network-Derived Organelles Undergo Regulated Exocytosis.
M. Maletic-Savatic and R. Malinow (1998)
J. Neurosci. 18, 6803-6813
   Abstract »    Full Text »    PDF »
Desensitization of the Neurokinin-1 Receptor (NK1-R) in Neurons: Effects of Substance P on the Distribution of NK1-R, Galpha q/11, G-Protein Receptor Kinase-2/3, and beta -Arrestin-1/2.
K. McConalogue, C. U. Corvera, P. D. Gamp, E. F. Grady, and N. W. Bunnett (1998)
Mol. Biol. Cell 9, 2305-2324
   Abstract »    Full Text »
Substance P Enhances NMDA Channel Function in Hippocampal Dentate Gyrus Granule Cells.
D. N. Lieberman and I. Mody (1998)
J Neurophysiol 80, 113-119
   Abstract »    Full Text »    PDF »
Estrogen-Induced Alteration of µ-Opioid Receptor Immunoreactivity in the Medial Preoptic Nucleus and Medial Amygdala.
C. B. Eckersell, P. Popper, and P. E Micevych (1998)
J. Neurosci. 18, 3967-3976
   Abstract »    Full Text »    PDF »
II. Regulation of neuropeptide receptors in enteric neurons.
K. McConalogue and N. W. Bunnett (1998)
Am J Physiol Gastrointest Liver Physiol 274, G792-G796
   Abstract »    Full Text »    PDF »
Internalization of D1 Dopamine Receptor in Striatal Neurons In Vivo as Evidence of Activation by Dopamine Agonists.
B. Dumartin, I. Caille, F. Gonon, and B. Bloch (1998)
J. Neurosci. 18, 1650-1661
   Abstract »    Full Text »    PDF »
µ-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic Mechanism In Vitro and in the Mammalian Brain.
D. E. Keith, B. Anton, S. R. Murray, P. A. Zaki, P. C. Chu, D. V. Lissin, G. Monteillet-Agius, P. L. Stewart, C. J. Evans, and M. v. Zastrow (1998)
Mol. Pharmacol. 53, 377-384
   Abstract »    Full Text »
Interrelationships between Somatostatin sst2A Receptors and Somatostatin-Containing Axons in Rat Brain: Evidence for Regulation of Cell Surface Receptors by Endogenous Somatostatin.
P. Dournaud, H. Boudin, A. Schonbrunn, G. S. Tannenbaum, and A. Beaudet (1998)
J. Neurosci. 18, 1056-1071
   Abstract »    Full Text »    PDF »
Activity-Dependent Dendritic Targeting of BDNF and TrkB mRNAs in Hippocampal Neurons.
E. Tongiorgi, M. Righi, and A. Cattaneo (1997)
J. Neurosci. 17, 9492-9505
   Abstract »    Full Text »    PDF »
Neurokinin 1 Receptor Internalization in Spinal Cord Slices Induced by Dorsal Root Stimulation Is Mediated by NMDA Receptors.
J. C. G. Marvizon, V. Martinez, E. F. Grady, N. W. Bunnett, and E. A. Mayer (1997)
J. Neurosci. 17, 8129-8136
   Abstract »    Full Text »    PDF »
Inflammation Increases the Distribution of Dorsal Horn Neurons That Internalize the Neurokinin-1 Receptor in Response to Noxious and Non-Noxious Stimulation.
C. Abbadie, J. Trafton, H. Liu, P. W. Mantyh, and A. I. Basbaum (1997)
J. Neurosci. 17, 8049-8060
   Abstract »    Full Text »    PDF »
Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor.
P. W. Mantyh, S. D. Rogers, P. Honore, B. J. Allen, J. R. Ghilardi, J. Li, R. S. Daughters, D. A. Lappi, R. G. Wiley, and D. A. Simone (1997)
Science 278, 275-279
   Abstract »    Full Text »
Substance P Receptors in Brain Stem Respiratory Centers of the Rat: Regulation of NK1 Receptors by Hypoxia.
S. B. Mazzone, C. F. Hinrichsen, and D. P. Geraghty (1997)
J. Pharmacol. Exp. Ther. 282, 1547-1556
   Abstract »    Full Text »
Noxious Cutaneous Thermal Stimuli Induce a Graded Release of Endogenous Substance P in the Spinal Cord: Imaging Peptide Action In Vivo.
B. J. Allen, S. D. Rogers, J. R. Ghilardi, P. M. Menning, M. A. Kuskowski, A. I. Basbaum, D. A. Simone, and P. W. Mantyh (1997)
J. Neurosci. 17, 5921-5927
   Abstract »    Full Text »    PDF »
Cells in Laminae III and IV of the Rat Spinal Cord that Possess the Neurokinin-1 Receptor and Have Dorsally Directed Dendrites Receive a Major Synaptic Input from Tachykinin-Containing Primary Afferents.
M. Naim, R. C. Spike, C. Watt, S. A. S. Shehab, and A. J. Todd (1997)
J. Neurosci. 17, 5536-5548
   Abstract »    Full Text »    PDF »
Recordings From Brain Stem Neurons Responding to Chemical Stimulation of the Subarachnoid Space.
A. Ebersberger, M. Ringkamp, P. W. Reeh, and H. O. Handwerker (1997)
J Neurophysiol 77, 3122-3133
   Abstract »    Full Text »    PDF »
.
R. A. Velázquez, K. F. Kitto, and A. A. Larson (1997)
J. Pharmacol. Exp. Ther. 281, 1231-1237
   Abstract »    Full Text »
LY303870, a Centrally Active Neurokinin-1 Antagonist with a Long Duration of Action.
S. Iyengar, P. A. Hipskind, D. R. Gehlert, D. Schober, K. L. Lobb, J. A. Nixon, D. R. Helton, M. J. Kallman, S. Boucher, R. Couture, et al. (1997)
J. Pharmacol. Exp. Ther. 280, 774-785
   Abstract »    Full Text »
Actions of Substance P on Rat Neostriatal Neurons In Vitro.
T. Aosaki and Y. Kawaguchi (1996)
J. Neurosci. 16, 5141-5153
   Abstract »    Full Text »    PDF »
Dynamin and Rab5a-dependent Trafficking and Signaling of the Neurokinin 1 Receptor.
F. Schmidlin, O. Dery, K. O. DeFea, L. Slice, S. Patierno, C. Sternini, E. F. Grady, and N. W. Bunnett (2001)
J. Biol. Chem. 276, 25427-25437
   Abstract »    Full Text »    PDF »
The Neurokinin A Receptor Activates Calcium and cAMP Responses through Distinct Conformational States.
T. Palanche, B. Ilien, S. Zoffmann, M.-P. Reck, B. Bucher, S. J. Edelstein, and J.-L. Galzi (2001)
J. Biol. Chem. 276, 34853-34861
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)