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Science 9 June 1995:
Vol. 268. no. 5216, pp. 1500 - 1503
DOI: 10.1126/science.7770777
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Articles

Science, Vol 268, Issue 5216, 1500-1503
Copyright © 1995 by American Association for the Advancement of Science

articles

Progesterone synthesis and myelin formation by Schwann cells

HL Koenig, M Schumacher, B Ferzaz, AN Thi, A Ressouches, R Guennoun, I Jung-Testas, P Robel, Y Akwa, and EE Baulieu

Laboratoire Neurobiologie du Developpement, Universite Bordeaux I, Talence, France.

Progesterone is shown here to be produced from pregnenolone by Schwann cells in peripheral nerves. After cryolesion of the sciatic nerve in male mice, axons regenerate and become myelinated. Blocking either the local synthesis or the receptor-mediated action of progesterone impaired remyelination. Administration of progesterone or its precursor, pregnenolone, to the lesion site increased the extent of myelin sheath formation. Myelination of axons was also increased when progesterone was added to cultures of rat dorsal root ganglia. These observations indicate a role for locally produced progesterone in myelination, demonstrate that progesterone is not simply a sex steroid, and suggest a new therapeutic approach to promote myelin repair.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)