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Science 9 June 1995:
Vol. 268. no. 5216, pp. 1495 - 1499
DOI: 10.1126/science.7770776
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Articles

Science, Vol 268, Issue 5216, 1495-1499
Copyright © 1995 by American Association for the Advancement of Science

articles

Muscle-derived neurotrophin-4 as an activity-dependent trophic signal for adult motor neurons

H Funakoshi, N Belluardo, E Arenas, Y Yamamoto, A Casabona, H Persson, and CF Ibanez

Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

The production of neurotrophin-4 (NT-4) in rat skeletal muscle was found to depend on muscle activity. The amounts of NT-4 messenger RNA present decreased after blockade of neuromuscular transmission with alpha-bungarotoxin and increased during postnatal development and after electrical stimulation in a dose-dependent manner. NT-4 immunoreactivity was detected in slow, type I muscle fibers. Intramuscular administration of NT-4 induced sprouting of intact adult motor nerves. Thus, muscle-derived NT-4 acted as an activity-dependent neurotrophic signal for growth and remodeling of adult motor neuron innervation. NT-4 may thus be partly responsible for the effects of exercise and electrical stimulation on neuromuscular performance.


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