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Science 9 June 1995:
Vol. 268. no. 5216, pp. 1476 - 1480
DOI: 10.1126/science.7539551
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Articles

Science, Vol 268, Issue 5216, 1476-1480
Copyright © 1995 by American Association for the Advancement of Science

articles

Identification of a graft versus host disease-associated human minor histocompatibility antigen

JM den Haan, NE Sherman, E Blokland, E Huczko, F Koning, JW Drijfhout, J Skipper, J Shabanowitz, DF Hunt, VH Engelhard, and al. et

Department of Immunohaematology, University Hospital, Leiden, Netherlands.

Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.


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