Science 9 June 1995: Vol. 268. no. 5216, pp. 1472 - 1476 DOI: 10.1126/science.7770771

Prev | Table of Contents | Next

Articles

CD4+ CD25+ Foxp3+ T Regulatory Cells with Limited TCR Diversity in Control of Autoimmunity.

D. Adeegbe, T. Matsutani, J. Yang, N. H. Altman, and T. R. Malek (2010)
J. Immunol. 184, 56-66
 |  Abstract »  |  Full Text »  |  PDF »

FoxP3+ Regulatory T Cells Restrain Splenic Extramedullary Myelopoiesis via Suppression of Hemopoietic Cytokine-Producing T Cells.

J. H. Lee, C. Wang, and C. H. Kim (2009)
J. Immunol. 183, 6377-6386
 |  Abstract »  |  Full Text »  |  PDF »

How Diverse--CD4 Effector T Cells and their Functions.

Y. Y. Wan and R. A. Flavell (2009)
J Mol Cell Biol 1, 20-36
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory T cells: how do they suppress immune responses?.

S. Sakaguchi, K. Wing, Y. Onishi, P. Prieto-Martin, and T. Yamaguchi (2009)
Int. Immunol. 21, 1105-1111
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Progression following Naive T Cell Activation Is Independent of Jak3/Common {gamma}-Chain Cytokine Signals.

M. Shi, T. H. Lin, K. C. Appell, and L. J. Berg (2009)
J. Immunol. 183, 4493-4501
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.

S. Saint Fleur, A. Hoshino, K. Kondo, T. Egawa, and H. Fujii (2009)
Blood 114, 1355-1365
 |  Abstract »  |  Full Text »  |  PDF »

Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT.

A. L. Bayer, M. Jones, J. Chirinos, L. de Armas, T. H. Schreiber, T. R. Malek, and R. B. Levy (2009)
Blood 113, 733-743
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or -9 Receptor Subunits and the {gamma} Chain.

Y. Malka, T. Hornakova, Y. Royer, L. Knoops, J.-C. Renauld, S. N. Constantinescu, and Y. I. Henis (2008)
J. Biol. Chem. 283, 33569-33577
 |  Abstract »  |  Full Text »  |  PDF »

Development of regulatory T cells requires IL-7R{alpha} stimulation by IL-7 or TSLP.

R. Mazzucchelli, J. A. Hixon, R. Spolski, X. Chen, W. Q. Li, V. L. Hall, J. Willette-Brown, A. A. Hurwitz, W. J. Leonard, and S. K. Durum (2008)
Blood 112, 3283-3292
 |  Abstract »  |  Full Text »  |  PDF »

IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development.

K. B. Vang, J. Yang, S. A. Mahmud, M. A. Burchill, A. L. Vegoe, and M. A. Farrar (2008)
J. Immunol. 181, 3285-3290
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells.

F. Guo, C. Iclozan, W.-K. Suh, C. Anasetti, and X.-Z. Yu (2008)
J. Immunol. 181, 2285-2291
 |  Abstract »  |  Full Text »  |  PDF »

Biphasic Regulation of Il2 Transcription in CD4+ T Cells: Roles for TNF-{alpha} Receptor Signaling and Chromatin Structure.

S. C. McKarns and R. H. Schwartz (2008)
J. Immunol. 181, 1272-1281
 |  Abstract »  |  Full Text »  |  PDF »

CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-{alpha}{beta}TCR interaction and become IL-10-producing active regulatory cells.

M. Rifa'i, Z. Shi, S.-Y. Zhang, Y. H. Lee, H. Shiku, K.-i. Isobe, and H. Suzuki (2008)
Int. Immunol. 20, 937-947
 |  Abstract »  |  Full Text »  |  PDF »

Preferential Development of CD4 and CD8 T Regulatory Cells in RasGRP1-Deficient Mice.

X. Chen, J. J. Priatel, M. T. Chow, and H.-S. Teh (2008)
J. Immunol. 180, 5973-5982
 |  Abstract »  |  Full Text »  |  PDF »

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.

L. Hennighausen and G. W. Robinson (2008)
Genes & Dev. 22, 711-721
 |  Abstract »  |  Full Text »  |  PDF »

CD8+CD122+ T Cells, a Newly Identified Regulatory T Subset, Negatively Regulate Graves' Hyperthyroidism in a Murine Model.

O. Saitoh, N. Abiru, M. Nakahara, and Y. Nagayama (2007)
Endocrinology 148, 6040-6046
 |  Abstract »  |  Full Text »  |  PDF »

Ex Vivo Expansion of CD4+CD25+FoxP3+ T Regulatory Cells Based on Synergy between IL-2 and 4-1BB Signaling.

K. G. Elpek, E. S. Yolcu, D. D. H. Franke, C. Lacelle, R.-H. Schabowsky, and H. Shirwan (2007)
J. Immunol. 179, 7295-7304
 |  Abstract »  |  Full Text »  |  PDF »

CD8+ T Cells Induce Complete Regression of Advanced Ovarian Cancers by an Interleukin (IL)-2/IL-15 Dependent Mechanism.

T. Yang, E. M. Wall, K. Milne, P. Theiss, P. Watson, and B. H. Nelson (2007)
Clin. Cancer Res. 13, 7172-7180
 |  Abstract »  |  Full Text »  |  PDF »

CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.

C. A.J. Vosshenrich, S. Lesjean-Pottier, M. Hasan, O. Richard-Le Goff, E. Corcuff, O. Mandelboim, and J. P. Di Santo (2007)
J. Exp. Med. 204, 2569-2578
 |  Abstract »  |  Full Text »  |  PDF »

Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo.

D. J. Powell Jr., A. Felipe-Silva, M. J. Merino, M. Ahmadzadeh, T. Allen, C. Levy, D. E. White, S. Mavroukakis, R. J. Kreitman, S. A. Rosenberg, et al. (2007)
J. Immunol. 179, 4919-4928
 |  Abstract »  |  Full Text »  |  PDF »

An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.

J.-H. Cho, O. Boyman, H.-O. Kim, B. Hahm, M. P. Rubinstein, C. Ramsey, D. M. Kim, C. D. Surh, and J. Sprent (2007)
J. Exp. Med. 204, 1787-1801
 |  Abstract »  |  Full Text »  |  PDF »

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease.

B. D. Sather, P. Treuting, N. Perdue, M. Miazgowicz, J. D. Fontenot, A. Y. Rudensky, and D. J. Campbell (2007)
J. Exp. Med. 204, 1335-1347
 |  Abstract »  |  Full Text »  |  PDF »

The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro.

J. Yates, F. Rovis, P. Mitchell, B. Afzali, J.-S Tsang, M. Garin, R. Lechler, G. Lombardi, and O. Garden (2007)
Int. Immunol. 19, 785-799
 |  Abstract »  |  Full Text »  |  PDF »

Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells.

A. L. Bayer, A. Yu, and T. R. Malek (2007)
J. Immunol. 178, 4062-4071
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R{alpha}-expressing cells.

H. Dooms, K. Wolslegel, P. Lin, and A. K. Abbas (2007)
J. Exp. Med. 204, 547-557
 |  Abstract »  |  Full Text »  |  PDF »

IL-2/Neuroantigen Fusion Proteins as Antigen-Specific Tolerogens in Experimental Autoimmune Encephalomyelitis (EAE): Correlation of T Cell-Mediated Antigen Presentation and Tolerance Induction.

M. D. Mannie, B. A. Clayson, E. J. Buskirk, J. L. DeVine, J. J. Hernandez, and D. J. Abbott (2007)
J. Immunol. 178, 2835-2843
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory T Cells and T Cell Depletion: Role of Immunosuppressive Drugs.

M. Noris, F. Casiraghi, M. Todeschini, P. Cravedi, D. Cugini, G. Monteferrante, S. Aiello, L. Cassis, E. Gotti, F. Gaspari, et al. (2007)
J. Am. Soc. Nephrol. 18, 1007-1018
 |  Abstract »  |  Full Text »  |  PDF »

Th3 Cells in Peripheral Tolerance. II. TGF-beta-Transgenic Th3 Cells Rescue IL-2-Deficient Mice from Autoimmunity.

Y. Carrier, J. Yuan, V. K. Kuchroo, and H. L. Weiner (2007)
J. Immunol. 178, 172-178
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Receptor beta-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells.

M. A. Burchill, J. Yang, C. Vogtenhuber, B. R. Blazar, and M. A. Farrar (2007)
J. Immunol. 178, 280-290
 |  Abstract »  |  Full Text »  |  PDF »

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells.

A. R. M. Almeida, B. Zaragoza, and A. A. Freitas (2006)
Int. Immunol. 18, 1607-1613
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation.

A. Bernasconi, R. Marino, A. Ribas, J. Rossi, M. Ciaccio, M. Oleastro, A. Ornani, R. Paz, M. A. Rivarola, M. Zelazko, et al. (2006)
Pediatrics 118, e1584-e1592
 |  Abstract »  |  Full Text »  |  PDF »

Indexation as a Novel Mechanism of Lymphocyte Homeostasis: The Number of CD4+CD25+ Regulatory T Cells Is Indexed to the Number of IL-2-Producing Cells.

A. R. M. Almeida, B. Zaragoza, and A. A. Freitas (2006)
J. Immunol. 177, 192-200
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 In Vivo Activities and Antitumor Efficacy Enhanced by an Anti-IL-2 mAb.

D. Kamimura, Y. Sawa, M. Sato, E. Agung, T. Hirano, and M. Murakami (2006)
J. Immunol. 177, 306-314
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Allogeneic CD4+CD25+Foxp3+ T Regulatory Cells Suppress Autoimmunity while Establishing Transplantation Tolerance..

D. Adeegbe, A. L. Bayer, R. B. Levy, and T. R. Malek (2006)
J. Immunol. 176, 7149-7153
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Drak2 Overexpression in Mice Leads to Increased T Cell Apoptosis and Compromised Memory T Cell Development.

J. Mao, X. Qiao, H. Luo, and J. Wu (2006)
J. Biol. Chem. 281, 12587-12595
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of high-affinity IL-2-IL-2R interaction for T cell anergy induction.

R. J Hayashi and O. Kanagawa (2006)
Int. Immunol. 18, 645-651
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo.

P. A. Antony, C. M. Paulos, M. Ahmadzadeh, A. Akpinarli, D. C. Palmer, N. Sato, A. Kaiser, C. Heinrichs, C. A. Klebanoff, Y. Tagaya, et al. (2006)
J. Immunol. 176, 5255-5266
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative assessment concerning the contribution of IL-2R{beta} for superantigen-mediated T cell responses in vivo.

H. Jin, D. Gong, D. Adeegbe, A. L. Bayer, C. Rolle, A. Yu, and T. R. Malek (2006)
Int. Immunol. 18, 565-572
 |  Abstract »  |  Full Text »  |  PDF »

IL-7 Is a Critical Factor in Modulating Lesion Development in Skn-Directed Autoimmunity.

P. J. Staton, A. B. Carpenter, and S. H. Jackman (2006)
J. Immunol. 176, 3978-3986
 |  Abstract »  |  Full Text »  |  PDF »

Experimental Models to Study Development and Function of the Human Immune System In Vivo.

N. Legrand, K. Weijer, and H. Spits (2006)
J. Immunol. 176, 2053-2058
 |  Abstract »  |  Full Text »  |  PDF »

CD25+ Regulatory T Cell Depletion Augments Immunotherapy of Micrometastases by an IL-21-Secreting Cellular Vaccine.

A. Comes, O. Rosso, A. M. Orengo, E. Di Carlo, C. Sorrentino, R. Meazza, T. Piazza, B. Valzasina, P. Nanni, M. P. Colombo, et al. (2006)
J. Immunol. 176, 1750-1758
 |  Abstract »  |  Full Text »  |  PDF »

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.

B. Knoechel, J. Lohr, E. Kahn, J. A. Bluestone, and A. K. Abbas (2005)
J. Exp. Med. 202, 1375-1386
 |  Abstract »  |  Full Text »  |  PDF »

Phenotypic, Functional, and Kinetic Parameters Associated with Apparent T-Cell Control of Human Immunodeficiency Virus Replication in Individuals with and without Antiretroviral Treatment.

B. Emu, E. Sinclair, D. Favre, W. J. Moretto, P. Hsue, R. Hoh, J. N. Martin, D. F. Nixon, J. M. McCune, and S. G. Deeks (2005)
J. Virol. 79, 14169-14178
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Fas in the Immune System Biology of IL-2R{alpha} Knockout Mice: Interplay among Regulatory T Cells, Inflammation, Hemopoiesis, and Apoptosis.

R. Sharma, H. Bagavant, W. N. Jarjour, S.-S. J. Sung, and S.-T. Ju (2005)
J. Immunol. 175, 1965-1973
 |  Abstract »  |  Full Text »  |  PDF »

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes.

P. E. Kovanen, L. Young, A. Al-Shami, V. Rovella, C. A. Pise-Masison, M. F. Radonovich, J. Powell, J. Fu, J. N. Brady, P. J. Munson, et al. (2005)
Int. Immunol. 17, 1009-1021
 |  Abstract »  |  Full Text »  |  PDF »

BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25- responder T cells than C57BL/6 mice.

X. Chen, J. J. Oppenheim, and O. M. Z. Howard (2005)
J. Leukoc. Biol. 78, 114-121
 |  Abstract »  |  Full Text »  |  PDF »

Emergent autoimmunity in graft-versus-host disease.

E. Tivol, R. Komorowski, and W. R. Drobyski (2005)
Blood 105, 4885-4891
 |  Abstract »  |  Full Text »  |  PDF »

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.

R. Setoguchi, S. Hori, T. Takahashi, and S. Sakaguchi (2005)
J. Exp. Med. 201, 723-735
 |  Abstract »  |  Full Text »  |  PDF »

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period.

A. L. Bayer, A. Yu, D. Adeegbe, and T. R. Malek (2005)
J. Exp. Med. 201, 769-777
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation.

O. Alpdogan, J. M. Eng, S. J. Muriglan, L. M. Willis, V. M. Hubbard, K. H. Tjoe, T. H. Terwey, A. Kochman, and M. R. M. van den Brink (2005)
Blood 105, 865-873
 |  Abstract »  |  Full Text »  |  PDF »

Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis.

M. Rifa'i, Y. Kawamoto, I. Nakashima, and H. Suzuki (2004)
J. Exp. Med. 200, 1123-1134
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Expression of CTLA-4 Controls Lymphoproliferation in IL-2-Deficient Mice.

K. W. Hwang, W. B. Sweatt, M. Mashayekhi, D. A. Palucki, H. Sattar, E. Chuang, and M.-L. Alegre (2004)
J. Immunol. 173, 5415-5424
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Expression and Trans Presentation of Interleukin (IL)-15R{alpha} and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis.

P. R. Burkett, R. Koka, M. Chien, S. Chai, D. L. Boone, and A. Ma (2004)
J. Exp. Med. 200, 825-834
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation and Differentiation of CD8+ T Cells in the Absence of IL-2/15 Receptor {beta}-Chain Expression or STAT5 Activation.

R. M. Teague, R. M. Tempero, S. Thomas, K. Murali-Krishna, and B. H. Nelson (2004)
J. Immunol. 173, 3131-3139
 |  Abstract »  |  Full Text »  |  PDF »

Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection.

T. L. Sumpter and D. S. Wilkes (2004)
Am J Physiol Lung Cell Mol Physiol 286, L1129-L1139
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function.

A. M. Thornton, E. E. Donovan, C. A. Piccirillo, and E. M. Shevach (2004)
J. Immunol. 172, 6519-6523
 |  Abstract »  |  Full Text »  |  PDF »

Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor {alpha} expression.

K. S. Schluns, E. C. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, and H. L. Aguila (2004)
PNAS 101, 5616-5621
 |  Abstract »  |  Full Text »  |  PDF »

IL-2, Regulatory T Cells, and Tolerance.

B. H. Nelson (2004)
J. Immunol. 172, 3983-3988
 |  Abstract »  |  Full Text »  |  PDF »

Smad3 Is Essential for TGF-{beta}1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation.

S. C. McKarns, R. H. Schwartz, and N. E. Kaminski (2004)
J. Immunol. 172, 4275-4284
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 2 plays a central role in Th2 differentiation.

J. Cote-Sierra, G. Foucras, L. Guo, L. Chiodetti, H. A. Young, J. Hu-Li, J. Zhu, and W. E. Paul (2004)
PNAS 101, 3880-3885
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells.

I. Takeda, S. Ine, N. Killeen, L. C. Ndhlovu, K. Murata, S. Satomi, K. Sugamura, and N. Ishii (2004)
J. Immunol. 172, 3580-3589
 |  Abstract »  |  Full Text »  |  PDF »

Zwitterionic Polysaccharides Stimulate T Cells with No Preferential V{beta} Usage and Promote Anergy, Resulting in Protection against Experimental Abscess Formation.

F. Stingele, B. Corthesy, N. Kusy, S. A. Porcelli, D. L. Kasper, and A. O. Tzianabos (2004)
J. Immunol. 172, 1483-1490
 |  Abstract »  |  Full Text »  |  PDF »

The main function of IL-2 is to promote the development of T regulatory cells.

T. R. Malek (2003)
J. Leukoc. Biol. 74, 961-965
 |  Abstract »  |  Full Text »

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion.

W. N. D'Souza and L. Lefrancois (2003)
J. Immunol. 171, 5727-5735
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells.

M. A. Burchill, C. A. Goetz, M. Prlic, J. J. O'Neil, I. R. Harmon, S. J. Bensinger, L. A. Turka, P. Brennan, S. C. Jameson, and M. A. Farrar (2003)
J. Immunol. 171, 5853-5864
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Tolerance and Autoimmunity Affecting Multiple Organs in STAT5A/5B-Deficient Mice.

J. W. Snow, N. Abraham, M. C. Ma, B. G. Herndier, A. W. Pastuszak, and M. A. Goldsmith (2003)
J. Immunol. 171, 5042-5050
 |  Abstract »  |  Full Text »  |  PDF »

The role of the combination of IL-2 and TGF-{beta} or IL-10 in the generation and function of CD4+ CD25+ and CD8+regulatory T cell subsets.

D. A. Horwitz, S. G. Zheng, and J. D. Gray (2003)
J. Leukoc. Biol. 74, 471-478
 |  Abstract »  |  Full Text »  |  PDF »

An IL-2-Dependent Switch Between CD95 Signaling Pathways Sensitizes Primary Human T Cells Toward CD95-Mediated Activation-Induced Cell Death.

I. Schmitz, A. Krueger, S. Baumann, H. Schulze-Bergkamen, P. H. Krammer, and S. Kirchhoff (2003)
J. Immunol. 171, 2930-2936
 |  Abstract »  |  Full Text »  |  PDF »

Impaired T Cell Death and Lupus-like Autoimmunity in T Cell-specific Adapter Protein-deficient Mice.

J. Drappa, L. A. Kamen, E. Chan, M. Georgiev, D. Ashany, F. Marti, and P. D. King (2003)
J. Exp. Med. 198, 809-821
 |  Abstract »  |  Full Text »  |  PDF »

Suppressor of Cytokine Signaling 1 Regulates IL-15 Receptor Signaling in CD8+CD44high Memory T Lymphocytes.

S. Ilangumaran, S. Ramanathan, J. La Rose, P. Poussier, and R. Rottapel (2003)
J. Immunol. 171, 2435-2445
 |  Abstract »  |  Full Text »  |  PDF »

Characterization and Analysis of the Proximal Janus Kinase 3 Promoter.

M. Aringer, S. R. Hofmann, D. M. Frucht, M. Chen, M. Centola, A. Morinobu, R. Visconti, D. L. Kastner, J. S. Smolen, and J. J. O'Shea (2003)
J. Immunol. 170, 6057-6064
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Antitumor Immunity in Mice Deficient in CD69.

E. Esplugues, D. Sancho, J. Vega-Ramos, C. Martinez-A, U. Syrbe, A. Hamann, P. Engel, F. Sanchez-Madrid, and P. Lauzurica (2003)
J. Exp. Med. 197, 1093-1106
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Potentiates Activated T Cell Apoptosis Via an IL-2-Dependent Mechanism.

J. Zhang, T. Bardos, Q. Shao, J. Tschopp, K. Mikecz, T. T. Glant, and A. Finnegan (2003)
J. Immunol. 170, 3495-3503
 |  Abstract »  |  Full Text »  |  PDF »

Anti-apoptotic Signaling by the Interleukin-2 Receptor Reveals a Function for Cytoplasmic Tyrosine Residues within the Common gamma (gamma c) Receptor Subunit.

M. J. Lindemann, M. Benczik, and S. L. Gaffen (2003)
J. Biol. Chem. 278, 10239-10249
 |  Abstract »  |  Full Text »  |  PDF »

Efficient Induction of Primary and Secondary T Cell-Dependent Immune Responses In Vivo in the Absence of Functional IL-2 and IL-15 Receptors.

A. Yu, J. Zhou, N. Marten, C. C. Bergmann, M. Mammolenti, R. B. Levy, and T. R. Malek (2003)
J. Immunol. 170, 236-242
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Receptor Ligation Triggers Novel Nonapoptotic Cell Death Pathways That Are Fas-Independent or Fas-Dependent.

W. F. Davidson, C. Haudenschild, J. Kwon, and M. S. Williams (2002)
J. Immunol. 169, 6218-6230
 |  Abstract »  |  Full Text »  |  PDF »

Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function.

D. A. Ingram, L. Zhang, J. McCarthy, M. J. Wenning, L. Fisher, F.-C. Yang, D. W. Clapp, and R. Kapur (2002)
Blood 100, 3656-3662
 |  Abstract »  |  Full Text »  |  PDF »

Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.

H.-H. Xue, P. E. Kovanen, C. A. Pise-Masison, M. Berg, M. F. Radovich, J. N. Brady, and W. J. Leonard (2002)
PNAS 99, 13759-13764
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 15 Controls both Proliferation and Survival of a Subset of Memory-Phenotype CD8+ T Cells.

A. D. Judge, X. Zhang, H. Fujii, C. D. Surh, and J. Sprent (2002)
J. Exp. Med. 196, 935-946
 |  Abstract »  |  Full Text »  |  PDF »

Physiological Mechanisms of Regulating Alloimmunity: Cytokines, CTLA-4, CD25+ Cells, and the Alloreactive T Cell Clone Size.

M. Sho, A. Yamada, N. Najafian, A. D. Salama, H. Harada, S. E. Sandner, A. Sanchez-Fueyo, X. X. Zheng, T. B. Strom, and M. H. Sayegh (2002)
J. Immunol. 169, 3744-3751
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function.

G. C. Furtado, M. A. C. de Lafaille, N. Kutchukhidze, and J. J. Lafaille (2002)
J. Exp. Med. 196, 851-857
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses.

W. N. D'Souza, K. S. Schluns, D. Masopust, and L. Lefrancois (2002)
J. Immunol. 168, 5566-5572
 |  Abstract »  |  Full Text »  |  PDF »

IFN Regulatory Factor 4 Participates in the Human T Cell Lymphotropic Virus Type I-Mediated Activation of the IL-15 Receptor {alpha} Promoter.

J. M. Mariner, Y. Mamane, J. Hiscott, T. A. Waldmann, and N. Azimi (2002)
J. Immunol. 168, 5667-5674
 |  Abstract »  |  Full Text »  |  PDF »

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells.

L. Yang, X.-F. Qin, D. Baltimore, and L. Van Parijs (2002)
PNAS 99, 6204-6209
 |  Abstract »  |  Full Text »  |  PDF »

Natural CD4 CD25+ regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10.

C. Pontoux, A. Banz, and M. Papiernik (2002)
Int. Immunol. 14, 233-239
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT.

E. Kelly, A. Won, Y. Refaeli, and L. V. Parijs (2002)
J. Immunol. 168, 597-603
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products