Science 2 June 1995: Vol. 268. no. 5215, pp. 1336 - 1338 DOI: 10.1126/science.7761852

Prev | Table of Contents | Next

Articles

SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology.

S. M. Woerner, Y. P. Yuan, A. Benner, S. Korff, M. von Knebel Doeberitz, and P. Bork (2009)
Nucleic Acids Res.
 |  Abstract »  |  Full Text »  |  PDF »

An A13 Repeat within the 3'-Untranslated Region of Epidermal Growth Factor Receptor (EGFR) Is Frequently Mutated in Microsatellite Instability Colon Cancers and Is Associated with Increased EGFR Expression.

Z. Yuan, J. Shin, A. Wilson, S. Goel, Y.-H. Ling, N. Ahmed, H. Dopeso, M. Jhawer, S. Nasser, C. Montagna, et al. (2009)
Cancer Res. 69, 7811-7818
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGF{beta}-Stimulated Apoptosis in Adrenocortical Cells.

B. Ragazzon, L. Cazabat, M. Rizk-Rabin, G. Assie, L. Groussin, H. Fierrard, K. Perlemoine, A. Martinez, and J. Bertherat (2009)
Cancer Res. 69, 7278-7284
 |  Abstract »  |  Full Text »  |  PDF »

Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.

K. Guda, H. Moinova, J. He, O. Jamison, L. Ravi, L. Natale, J. Lutterbaugh, E. Lawrence, S. Lewis, J. K. V. Willson, et al. (2009)
PNAS 106, 12921-12925
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of Epidermal Growth Factor Receptor by Selective Expansion of a 5'-End Regulatory Dinucleotide Repeat in Colon Cancer with Microsatellite Instability.

S. Baranovskaya, Y. Martin, S. Alonso, K. L. Pisarchuk, M. Falchetti, Y. Dai, S. Khaldoyanidi, S. Krajewski, I. Novikova, Y. S. Sidorenko, et al. (2009)
Clin. Cancer Res. 15, 4531-4537
 |  Abstract »  |  Full Text »  |  PDF »

Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): A gene-dependent effect on the cell surface glycan profile.

G. Patsos, S. Andre, N. Roeckel, R. Gromes, J. Gebert, J. Kopitz, and H.-J. Gabius (2009)
Glycobiology 19, 726-734
 |  Abstract »  |  Full Text »  |  PDF »

Smad2 and Smad3 Phosphorylated at Both Linker and COOH-Terminal Regions Transmit Malignant TGF-{beta} Signal in Later Stages of Human Colorectal Cancer.

K. Matsuzaki, C. Kitano, M. Murata, G. Sekimoto, K. Yoshida, Y. Uemura, T. Seki, S. Taketani, J.-i. Fujisawa, and K. Okazaki (2009)
Cancer Res. 69, 5321-5330
 |  Abstract »  |  Full Text »  |  PDF »

Infrequent Detection of Germline Allele-Specific Expression of TGFBR1 in Lymphoblasts and Tissues of Colon Cancer Patients.

K. Guda, L. Natale, J. Lutterbaugh, G. L. Wiesner, S. Lewis, S. M. Tanner, J. Tomsic, L. Valle, A. de la Chapelle, R. C. Elston, et al. (2009)
Cancer Res. 69, 4959-4961
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} Depletion Is the Primary Determinant of Smad Signaling Kinetics.

D. C. Clarke, M. L. Brown, R. A. Erickson, Y. Shi, and X. Liu (2009)
Mol. Cell. Biol. 29, 2443-2455
 |  Abstract »  |  Full Text »  |  PDF »

Stromal TGF-{beta} Responsiveness in the Initiation and Progression of Tumorigenesis.

X. Li and N. A. Bhowmick (2009)
Am. Assoc. Cancer Res. Educ. Book 2009, 143-147
 |  Full Text »  |  PDF »

Microsatellite Instability Predicts Improved Response to Adjuvant Therapy With Irinotecan, Fluorouracil, and Leucovorin in Stage III Colon Cancer: Cancer and Leukemia Group B Protocol 89803.

M. M. Bertagnolli, D. Niedzwiecki, C. C. Compton, H. P. Hahn, M. Hall, B. Damas, S. D. Jewell, R. J. Mayer, R. M. Goldberg, L. B. Saltz, et al. (2009)
J. Clin. Oncol. 27, 1814-1821
 |  Abstract »  |  Full Text »  |  PDF »

Different Domains Regulate Homomeric and Heteromeric Complex Formation among Type I and Type II Transforming Growth Factor-{beta} Receptors.

M. M. Rechtman, A. Nakaryakov, K. E. Shapira, M. Ehrlich, and Y. I. Henis (2009)
J. Biol. Chem. 284, 7843-7852
 |  Abstract »  |  Full Text »  |  PDF »

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.

A. Greenhough, H. J.M. Smartt, A. E. Moore, H. R. Roberts, A. C. Williams, C. Paraskeva, and A. Kaidi (2009)
Carcinogenesis 30, 377-386
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B.

S.-i. Asaka, Y. Arai, Y. Nishimura, K. Yamaguchi, T. Ishikubo, T. Yatsuoka, Y. Tanaka, and K. Akagi (2009)
Carcinogenesis 30, 494-499
 |  Abstract »  |  Full Text »  |  PDF »

A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women.

S. Tchatchou, A. Jung, K. Hemminki, C. Sutter, B. Wappenschmidt, P. Bugert, B. H.F. Weber, D. Niederacher, N. Arnold, R. Varon-Mateeva, et al. (2009)
Carcinogenesis 30, 59-64
 |  Abstract »  |  Full Text »  |  PDF »

Perturbation of transforming growth factor (TGF)-ss1 association with latent TGF-{beta} binding protein yields inflammation and tumors.

K. Yoshinaga, H. Obata, V. Jurukovski, R. Mazzieri, Y. Chen, L. Zilberberg, D. Huso, J. Melamed, P. Prijatelj, V. Todorovic, et al. (2008)
PNAS 105, 18758-18763
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes.

G.-F. Richard, A. Kerrest, and B. Dujon (2008)
Microbiol. Mol. Biol. Rev. 72, 686-727
 |  Abstract »  |  Full Text »  |  PDF »

Targeted and Nontargeted Effects of Ionizing Radiation That Impact Genomic Instability.

C. A. Maxwell, M. C. Fleisch, S. V. Costes, A. C. Erickson, A. Boissiere, R. Gupta, S. A. Ravani, B. Parvin, and M. H. Barcellos-Hoff (2008)
Cancer Res. 68, 8304-8311
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab.

S. E. Wang, B. Xiang, M. Guix, M. G. Olivares, J. Parker, C. H. Chung, A. Pandiella, and C. L. Arteaga (2008)
Mol. Cell. Biol. 28, 5605-5620
 |  Abstract »  |  Full Text »  |  PDF »

Germline Allele-Specific Expression of TGFBR1 Confers an Increased Risk of Colorectal Cancer.

L. Valle, T. Serena-Acedo, S. Liyanarachchi, H. Hampel, I. Comeras, Z. Li, Q. Zeng, H.-T. Zhang, M. J. Pennison, M. Sadim, et al. (2008)
Science 321, 1361-1365
 |  Abstract »  |  Full Text »  |  PDF »

Ugene, a Newly Identified Protein That Is Commonly Overexpressed in Cancer and Binds Uracil DNA Glycosylase.

C. Guo, X. Zhang, S. P. Fink, P. Platzer, K. Wilson, J. K.V. Willson, Z. Wang, and S. D. Markowitz (2008)
Cancer Res. 68, 6118-6126
 |  Abstract »  |  Full Text »  |  PDF »

Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors.

A.H.S. Gylling, T.T. Nieminen, W.M. Abdel-Rahman, K. Nuorva, M. Juhola, E.I. Joensuu, H.J. Jarvinen, J.-P. Mecklin, M. Aarnio, and P.T. Peltomaki (2008)
Carcinogenesis 29, 1351-1359
 |  Abstract »  |  Full Text »  |  PDF »

RHAMM, p21 Combined Phenotype Identifies Microsatellite Instability-High Colorectal Cancers with a Highly Adverse Prognosis.

I. Zlobec, K. Baker, L. M. Terracciano, and A. Lugli (2008)
Clin. Cancer Res. 14, 3798-3806
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli (APC)-Driven Tumorigenesis.

C. Gaspar, J. Cardoso, P. Franken, L. Molenaar, H. Morreau, G. Moslein, J. Sampson, J. M. Boer, R. X. de Menezes, and R. Fodde (2008)
Am. J. Pathol. 172, 1363-1380
 |  Abstract »  |  Full Text »  |  PDF »

Smad4-dependent TGF-{beta} Signaling Suppresses RON Receptor Tyrosine Kinase-dependent Motility and Invasion of Pancreatic Cancer Cells.

S. Zhao, S. Ammanamanchi, M. Brattain, L. Cao, A. Thangasamy, J. Wang, and J. W. Freeman (2008)
J. Biol. Chem. 283, 11293-11301
 |  Abstract »  |  Full Text »  |  PDF »

Unregulated smooth-muscle myosin in human intestinal neoplasia.

P. Alhopuro, D. Phichith, S. Tuupanen, H. Sammalkorpi, M. Nybondas, J. Saharinen, J. P. Robinson, Z. Yang, L.-Q. Chen, T. Orntoft, et al. (2008)
PNAS 105, 5513-5518
 |  Abstract »  |  Full Text »  |  PDF »

Methylation Silencing of Transforming Growth Factor-{beta} Receptor Type II in Rat Prostate Cancers.

S. Yamashita, S. Takahashi, N. McDonell, N. Watanabe, T. Niwa, K. Hosoya, Y. Tsujino, T. Shirai, and T. Ushijima (2008)
Cancer Res. 68, 2112-2121
 |  Abstract »  |  Full Text »  |  PDF »

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.

K. Imai and H. Yamamoto (2008)
Carcinogenesis 29, 673-680
 |  Abstract »  |  Full Text »  |  PDF »

A Mutant Allele of MRE11 Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner.

Q. Wen, J. Scorah, G. Phear, G. Rodgers, S. Rodgers, and M. Meuth (2008)
Mol. Biol. Cell 19, 1693-1705
 |  Abstract »  |  Full Text »  |  PDF »

Comparative lesion sequencing provides insights into tumor evolution.

S. Jones, W.-d. Chen, G. Parmigiani, F. Diehl, N. Beerenwinkel, T. Antal, A. Traulsen, M. A. Nowak, C. Siegel, V. E. Velculescu, et al. (2008)
PNAS 105, 4283-4288
 |  Abstract »  |  Full Text »  |  PDF »

Transforming growth factor-{beta} signaling and ubiquitinators in cancer.

E. Glasgow and L. Mishra (2008)
Endocr. Relat. Cancer 15, 59-72
 |  Abstract »  |  Full Text »  |  PDF »

UgMicroSatdb: database for mining microsatellites from unigenes.

V. Aishwarya and P. C. Sharma (2008)
Nucleic Acids Res. 36, D53-D56
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Classification and Correlates in Colorectal Cancer.

S. Ogino and A. Goel (2008)
J. Mol. Diagn. 10, 13-27
 |  Abstract »  |  Full Text »  |  PDF »

Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development.

Y. Bian, T. J. Knobloch, M. Sadim, V. Kaklamani, A. Raji, G.-Y. Yang, C. M. Weghorst, and B. Pasche (2007)
Hum. Mol. Genet. 16, 3128-3135
 |  Abstract »  |  Full Text »  |  PDF »

Common and Distinct Genomic Events in Sporadic Colorectal Cancer and Diverse Cancer Types.

E. S. Martin, G. Tonon, R. Sinha, Y. Xiao, B. Feng, A. C. Kimmelman, A. Protopopov, E. Ivanova, C. Brennan, K. Montgomery, et al. (2007)
Cancer Res. 67, 10736-10743
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-{beta} Blocks Inhibin Binding to Different Target Cell Types in a Context-Dependent Manner through Dual Mechanisms Involving Betaglycan.

P. G. Farnworth, Y. Wang, R. Escalona, P. Leembruggen, G. T. Ooi, and J. K. Findlay (2007)
Endocrinology 148, 5355-5368
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-{beta} Promotes Survival of Mammary Carcinoma Cells through Induction of Antiapoptotic Transcription Factor DEC1.

S. Ehata, A. Hanyu, M. Hayashi, H. Aburatani, Y. Kato, M. Fujime, M. Saitoh, K. Miyazawa, T. Imamura, and K. Miyazono (2007)
Cancer Res. 67, 9694-9703
 |  Abstract »  |  Full Text »  |  PDF »

Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis.

C.-L. Chen, I-H. Liu, S. J. Fliesler, X. Han, S. S. Huang, and J. S. Huang (2007)
J. Cell Sci. 120, 3509-3521
 |  Abstract »  |  Full Text »  |  PDF »

Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma.

S. I. Berndt, W.-Y. Huang, N. Chatterjee, M. Yeager, R. Welch, S. J. Chanock, J. L. Weissfeld, R. E. Schoen, and R. B. Hayes (2007)
Carcinogenesis 28, 1965-1970
 |  Abstract »  |  Full Text »  |  PDF »

Background Mutation Frequency in Microsatellite-Unstable Colorectal Cancer.

H. Sammalkorpi, P. Alhopuro, R. Lehtonen, J. Tuimala, J.-P. Mecklin, H. J. Jarvinen, J. Jiricny, A. Karhu, and L. A. Aaltonen (2007)
Cancer Res. 67, 5691-5698
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to TGF-{beta}1 correlates with aberrant expression of TGF-{beta} receptor II in human B-cell lymphoma cell lines.

G. Chen, P. Ghosh, H. Osawa, C. Y. Sasaki, L. Rezanka, J. Yang, T. J. O'Farrell, and D. L. Longo (2007)
Blood 109, 5301-5307
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta} and atherosclerosis in man.

D. J. Grainger (2007)
Cardiovasc Res 74, 213-222
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Human cancers express a mutator phenotype.

J. H. Bielas, K. R. Loeb, B. P. Rubin, L. D. True, and L. A. Loeb (2006)
PNAS 103, 18238-18242
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} Receptor Type II Inactivation Induces the Malignant Transformation of Intestinal Neoplasms Initiated by Apc Mutation..

N. M. Munoz, M. Upton, A. Rojas, M. K. Washington, L. Lin, A. Chytil, E. G. Sozmen, B. B. Madison, A. Pozzi, R. T. Moon, et al. (2006)
Cancer Res. 66, 9837-9844
 |  Abstract »  |  Full Text »  |  PDF »

Coordinated Functions of E-Cadherin and Transforming Growth Factor {beta} Receptor II In vitro and In vivo..

C. D. Andl, B. B. Fargnoli, T. Okawa, M. Bowser, M. Takaoka, H. Nakagawa, A. Klein-Szanto, X. Hua, M. Herlyn, and A. K. Rustgi (2006)
Cancer Res. 66, 9878-9885
 |  Abstract »  |  Full Text »  |  PDF »

The Consensus Coding Sequences of Human Breast and Colorectal Cancers.

T. Sjoblom, S. Jones, L. D. Wood, D. W. Parsons, J. Lin, T. D. Barber, D. Mandelker, R. J. Leary, J. Ptak, N. Silliman, et al. (2006)
Science 314, 268-274
 |  Abstract »  |  Full Text »  |  PDF »

The molecular genetics of Marfan syndrome and related disorders.

P N Robinson, E Arteaga-Solis, C Baldock, G Collod-Beroud, P Booms, A De Paepe, H C Dietz, G Guo, P A Handford, D P Judge, et al. (2006)
J. Med. Genet. 43, 769-787
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Transforming Growth Factor-{beta} Signaling in Human Cancer: Targeting a Tumor Suppressor Network as a Therapeutic Strategy..

S. Biswas, T. L. Criswell, S. E. Wang, and C. L. Arteaga (2006)
Clin. Cancer Res. 12, 4142-4146
 |  Full Text »  |  PDF »

Imaging and Oncologic Drug Development.

W. S. El-Deiry, C. C. Sigman, and G. J. Kelloff (2006)
J. Clin. Oncol. 24, 3261-3273
 |  Abstract »  |  Full Text »  |  PDF »

Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.

E. C. Chao and S. M. Lipkin (2006)
Nucleic Acids Res. 34, 840-852
 |  Abstract »  |  Full Text »  |  PDF »

Int7G24A Variant of Transforming Growth Factor-{beta} Receptor Type I Is Associated with Invasive Breast Cancer.

T. Chen, C. R. Jackson, A. Link, M. P. Markey, B. M. Colligan, L. E. Douglass, J. O. Pemberton, J. A. Deddens, J. R. Graff, and J. H. Carter (2006)
Clin. Cancer Res. 12, 392-397
 |  Abstract »  |  Full Text »  |  PDF »

Detection of Mononucleotide Repeat Sequence Alterations in a Large Background of Normal DNA for Screening High-Frequency Microsatellite Instability Cancers.

X. Sun, Y. Liu, J. Lutterbaugh, W.-D. Chen, S. D. Markowitz, and B. Guo (2006)
Clin. Cancer Res. 12, 454-459
 |  Abstract »  |  Full Text »  |  PDF »

Mouse models of transforming growth factor {beta} impact in breast development and cancer.

R Serra and M R Crowley (2005)
Endocr. Relat. Cancer 12, 749-760
 |  Abstract »  |  Full Text »  |  PDF »

A Gene Expression Signature of Genetic Instability in Colon Cancer.

C. P. Giacomini, S. Y. Leung, X. Chen, S. T. Yuen, Y. H. Kim, E. Bair, and J. R. Pollack (2005)
Cancer Res. 65, 9200-9205
 |  Abstract »  |  Full Text »  |  PDF »

Somatic Acquisition and Signaling of TGFBR1*6A in Cancer.

B. Pasche, T. J. Knobloch, Y. Bian, J. Liu, S. Phukan, D. Rosman, V. Kaklamani, L. Baddi, F. S. Siddiqui, W. Frankel, et al. (2005)
JAMA 294, 1634-1646
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.

V Johnson, L R Lipton, C Cummings, A T Eftekhar Sadat, L Izatt, S V Hodgson, I C Talbot, H J W Thomas, A J R Silver, and I P M Tomlinson (2005)
J. Med. Genet. 42, 756-762
 |  Abstract »  |  Full Text »  |  PDF »

Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling.

S. Kfir, M. Ehrlich, A. Goldshmid, X. Liu, Y. Kloog, and Y. I. Henis (2005)
Mol. Cell. Biol. 25, 8239-8250
 |  Abstract »  |  Full Text »  |  PDF »

Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers.

J. El-Bchiri, O. Buhard, V. Penard-Lacronique, G. Thomas, R. Hamelin, and A. Duval (2005)
Hum. Mol. Genet. 14, 2435-2442
 |  Abstract »  |  Full Text »  |  PDF »

Detection in Fecal DNA of Colon Cancer-Specific Methylation of the Nonexpressed Vimentin Gene.

W.-D. Chen, Z. J. Han, J. Skoletsky, J. Olson, J. Sah, L. Myeroff, P. Platzer, S. Lu, D. Dawson, J. Willis, et al. (2005)
J Natl Cancer Inst 97, 1124-1132
 |  Abstract »  |  Full Text »  |  PDF »

Change of Plasma Transforming Growth Factor-{beta}1 Levels in Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemo-radiotherapy.

H.-W. Chen, Y.-C. Chang, Y.-L. Lai, Y.-J. Chen, M.-J. Huang, Y.-S. Leu, Y.-K. Fu, L.-W. Wang, and J.-J. Hwang (2005)
Jpn. J. Clin. Oncol. 35, 427-432
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} (TGF-{beta})-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-{beta} Function.

S. E. Wang, F. Y. Wu, I. Shin, S. Qu, and C. L. Arteaga (2005)
Mol. Cell. Biol. 25, 4703-4715
 |  Abstract »  |  Full Text »  |  PDF »

Mutations in Two Short Noncoding Mononucleotide Repeats in Most Microsatellite-Unstable Colorectal Cancers.

T. Hienonen, H. Sammalkorpi, S. Enholm, P. Alhopuro, T. D. Barber, R. Lehtonen, N. N. Nupponen, H. Lehtonen, R. Salovaara, J.-P. Mecklin, et al. (2005)
Cancer Res. 65, 4607-4613
 |  Abstract »  |  Full Text »  |  PDF »

Inability of Transforming Growth Factor-{beta} to Cause SnoN Degradation Leads to Resistance to Transforming Growth Factor-{beta}-Induced Growth Arrest in Esophageal Cancer Cells.

J. S. Edmiston, W. A. Yeudall, T. D. Chung, and D. A. Lebman (2005)
Cancer Res. 65, 4782-4788
 |  Abstract »  |  Full Text »  |  PDF »

Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are Targets for Mutation in Microsatellite-Unstable Acute Leukemia/Myelodysplastic Syndrome.

J. Offman, K. Gascoigne, F. Bristow, P. Macpherson, M. Bignami, I. Casorelli, G. Leone, L. Pagano, S. Sica, O. Halil, et al. (2005)
Mol. Cancer Res. 3, 251-260
 |  Abstract »  |  Full Text »  |  PDF »

Wnt signaling in the intestinal epithelium: from endoderm to cancer.

A. Gregorieff and H. Clevers (2005)
Genes & Dev. 19, 877-890
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic K-RAS Is Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells.

C. B. Pollock, S. Shirasawa, T. Sasazuki, W. Kolch, and A. S. Dhillon (2005)
Cancer Res. 65, 1244-1250
 |  Abstract »  |  Full Text »  |  PDF »

Modeling variation in tumors in vivo.

J. R. Stringer, J. S. Larson, J. M. Fischer, M. Medvedovic, M. N. Hersh, G. P. Boivin, and S. L. Stringer (2005)
PNAS 102, 2408-2413
 |  Abstract »  |  Full Text »  |  PDF »

Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial Hypertension.

R. D. Machado, V. James, M. Southwood, R. E. Harrison, C. Atkinson, S. Stewart, N. W. Morrell, R. C. Trembath, and M. A. Aldred (2005)
Circulation 111, 607-613
 |  Abstract »  |  Full Text »  |  PDF »

Aberrantly Methylated CDKN2A, MGMT, and MLH1 in Colon Polyps and in Fecal DNA from Patients with Colorectal Polyps.

Z. Petko, M. Ghiassi, A. Shuber, J. Gorham, W. Smalley, M. K. Washington, S. Schultenover, S. Gautam, S. D. Markowitz, and W. M. Grady (2005)
Clin. Cancer Res. 11, 1203-1209
 |  Abstract »  |  Full Text »  |  PDF »

Dual Role of Transforming Growth Factor ss in Mammary Tumorigenesis and Metastatic Progression.

R. S. Muraoka-Cook, N. Dumont, and C. L. Arteaga (2005)
Clin. Cancer Res. 11, 937s-943s
 |  Abstract »  |  Full Text »  |  PDF »

Acceleration of Smad2 and Smad3 Phosphorylation via c-Jun NH2-Terminal Kinase during Human Colorectal Carcinogenesis.

H. Yamagata, K. Matsuzaki, S. Mori, K. Yoshida, Y. Tahashi, F. Furukawa, G. Sekimoto, T. Watanabe, Y. Uemura, N. Sakaida, et al. (2005)
Cancer Res. 65, 157-165
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Overexpression of Active Transforming Growth Factor {beta}1 In vivo Accelerates Metastases of Transgenic Mammary Tumors.

R. S. Muraoka-Cook, H. Kurokawa, Y. Koh, J. T. Forbes, L. R. Roebuck, M. H. Barcellos-Hoff, S. E. Moody, L. A. Chodosh, and C. L. Arteaga (2004)
Cancer Res. 64, 9002-9011
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-{beta}-induced suppressor of human gastrointestinal cancers.

M. Yan, R. M. Rerko, P. Platzer, D. Dawson, J. Willis, M. Tong, E. Lawrence, J. Lutterbaugh, S. Lu, J. K. V. Willson, et al. (2004)
PNAS 101, 17468-17473
 |  Abstract »  |  Full Text »  |  PDF »

Lower Incidence of Colorectal Cancer and Later Age of Disease Onset in 27 Families With Pathogenic MSH6 Germline Mutations Compared With Families With MLH1 or MSH2 Mutations: The German Hereditary Nonpolyposis Colorectal Cancer Consortium.

J. Plaschke, C. Engel, S. Kruger, E. Holinski-Feder, C. Pagenstecher, E. Mangold, G. Moeslein, K. Schulmann, J. Gebert, M. von Knebel Doeberitz, et al. (2004)
J. Clin. Oncol. 22, 4486-4494
 |  Abstract »  |  Full Text »  |  PDF »

THE ROLE OF TGF-{beta} IN EPITHELIAL MALIGNANCY AND ITS RELEVANCE TO THE PATHOGENESIS OF ORAL CANCER (PART II).

S.S. Prime, M. Davies, M. Pring, and I.C. Paterson (2004)
Critical Reviews in Oral Biology & Medicine 15, 337-347
 |  Abstract »  |  Full Text »  |  PDF »

Activin Type II Receptor Restoration in ACVR2-Deficient Colon Cancer Cells Induces Transforming Growth Factor-{beta} Response Pathway Genes.

E. Deacu, Y. Mori, F. Sato, J. Yin, A. Olaru, A. Sterian, Y. Xu, S. Wang, K. Schulmann, A. Berki, et al. (2004)
Cancer Res. 64, 7690-7696
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis and colorectal cancer.

A J M Watson (2004)
Gut 53, 1701-1709
 |  Full Text »  |  PDF »

Autocrine and Exogenous Transforming Growth Factor {beta} Control Cell Cycle Inhibition through Pathways with Different Sensitivity.

J. Wang, N. Sergina, T. C. Ko, J. Gong, and M. G. Brattain (2004)
J. Biol. Chem. 279, 40237-40244
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-{beta} Pathway Serves as a Primary Tumor Suppressor in CD8+ T Cell Tumorigenesis.

P. J. Lucas, N. McNeil, E. Hilgenfeld, B. Choudhury, S.-J. Kim, M. A. Eckhaus, T. Ried, and R. E. Gress (2004)
Cancer Res. 64, 6524-6529
 |  Abstract »  |  Full Text »  |  PDF »

Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells.

D. E. Spaner (2004)
J. Leukoc. Biol. 76, 338-351
 |  Abstract »  |  Full Text »  |  PDF »

The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.

J R Howe, M G Sayed, A F Ahmed, J Ringold, J Larsen-Haidle, A Merg, F A Mitros, C A Vaccaro, G M Petersen, F M Giardiello, et al. (2004)
J. Med. Genet. 41, 484-491
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression in the Urinary Bladder: A Common Carcinoma in Situ Gene Expression Signature Exists Disregarding Histopathological Classification.

L. Dyrskjot, M. Kruhoffer, T. Thykjaer, N. Marcussen, J. L. Jensen, K. Moller, and T. F. Orntoft (2004)
Cancer Res. 64, 4040-4048
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellites Within Genes: Structure, Function, and Evolution.

Y.-C. Li, A. B. Korol, T. Fahima, and E. Nevo (2004)
Mol. Biol. Evol. 21, 991-1007
 |  Abstract »  |  Full Text »  |  PDF »

Unique and Selective Effects of Five Ets Family Members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the Promoter of the Type II Transforming Growth Factor-{beta} Receptor Gene.

J. L. Kopp, P. J. Wilder, M. Desler, J.-H. Kim, J. Hou, T. Nowling, and A. Rizzino (2004)
J. Biol. Chem. 279, 19407-19420
 |  Abstract »  |  Full Text »  |  PDF »

Colorectal Pretumor Progression Before and After Loss of DNA Mismatch Repair.

P. Calabrese, J.-L. Tsao, Y. Yatabe, R. Salovaara, J.-P. Mecklin, H. J. Jarvinen, L. A. Aaltonen, S. Tavare, and D. Shibata (2004)
Am. J. Pathol. 164, 1447-1453
 |  Abstract »  |  Full Text »  |  PDF »

Defective Expression of Transforming Growth Factor {beta} Receptor Type II Is Associated with CpG Methylated Promoter in Primary Non-Small Cell Lung Cancer.

H.-T. Zhang, X.-F. Chen, M.-H. Wang, J.-C. Wang, Q.-Y. Qi, R.-M. Zhang, W.-Q. Xu, Q.-Y. Fei, F. Wang, Q.-Q. Cheng, et al. (2004)
Clin. Cancer Res. 10, 2359-2367
 |  Abstract »  |  Full Text »  |  PDF »

PKC{alpha} mediates TGF{beta}-induced growth inhibition of human keratinocytes via phosphorylation of S100C/A11.

M. Sakaguchi, M. Miyazaki, H. Sonegawa, M. Kashiwagi, M. Ohba, T. Kuroki, M. Namba, and N.-h. Huh (2004)
J. Cell Biol. 164, 979-984
 |  Abstract »  |  Full Text »  |  PDF »

Elucidation of Epigenetic Inactivation of SMAD8 in Cancer Using Targeted Expressed Gene Display.

K.-h. Cheng, J. F. Ponte, and S. Thiagalingam (2004)
Cancer Res. 64, 1639-1646
 |  Abstract »  |  Full Text »  |  PDF »

A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability.

Y. Ionov, S.-I. Matsui, and J. K. Cowell (2004)
PNAS 101, 1273-1278
 |  Abstract »  |  Full Text »  |  PDF »

Loss of MSH3 Protein Expression Is Frequent in MLH1-Deficient Colorectal Cancer and Is Associated with Disease Progression1.

J. Plaschke, S. Kruger, B. Jeske, F. Theissig, F. R. Kreuz, S. Pistorius, H. D. Saeger, I. Iaccarino, G. Marra, and H. K. Schackert (2004)
Cancer Res. 64, 864-870
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.

M. Morkel, J. Huelsken, M. Wakamiya, J. Ding, M. van de Wetering, H. Clevers, M. M. Taketo, R. R. Behringer, M. M. Shen, and W. Birchmeier (2003)
Development 130, 6283-6294
 |  Abstract »  |  Full Text »  |  PDF »

Smad7 but not Smad6 Cooperates with Oncogenic ras to Cause Malignant Conversion in a Mouse Model for Squamous Cell Carcinoma.

X. Liu, J. Lee, M. Cooley, E. Bhogte, S. Hartley, and A. Glick (2003)
Cancer Res. 63, 7760-7768
 |  Abstract »  |  Full Text »  |  PDF »

BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) Mutations in Distinct Subsets of Pancreatic Cancer: Potential Therapeutic Targets.

E. S. Calhoun, J. B. Jones, R. Ashfaq, V. Adsay, S. J. Baker, V. Valentine, P. M. Hempen, W. Hilgers, C. J. Yeo, R. H. Hruban, et al. (2003)
Am. J. Pathol. 163, 1255-1260
 |  Abstract »  |  Full Text »  |  PDF »

Microsatellite Instability Is a Predictive Factor of the Tumor Response to Irinotecan in Patients with Advanced Colorectal Cancer.

D. Fallik, F. Borrini, V. Boige, J. Viguier, S. Jacob, C. Miquel, J.-C. Sabourin, M. Ducreux, and F. Praz (2003)
Cancer Res. 63, 5738-5744
 |  Abstract »  |  Full Text »  |  PDF »

Acetylated Sp3 Is a Transcriptional Activator.

S. Ammanamanchi, J. W. Freeman, and M. G. Brattain (2003)
J. Biol. Chem. 278, 35775-35780
 |  Abstract »  |  Full Text »  |  PDF »

TGFBR1*6A and Cancer Risk: A Meta-Analysis of Seven Case-Control Studies.

V. G. Kaklamani, N. Hou, Y. Bian, J. Reich, K. Offit, L. S. Michel, W.S. Rubinstein, A. Rademaker, and B. Pasche (2003)
J. Clin. Oncol. 21, 3236-3243
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Transforming Growth Factor {alpha} in Determining Growth Factor Independence.

R. A. Awwad, N. Sergina, H. Yang, B. Ziober, J. K. V. Willson, E. Zborowska, L. E. Humphrey, R. Fan, T. C. Ko, M. G. Brattain, et al. (2003)
Cancer Res. 63, 4731-4738
 |  Abstract »  |  Full Text »  |  PDF »

Smad3 Regulates Senescence and Malignant Conversion in a Mouse Multistage Skin Carcinogenesis Model.

K. Vijayachandra, J. Lee, and A. B. Glick (2003)
Cancer Res. 63, 3447-3452
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products