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Science 26 May 1995:
Vol. 268. no. 5214, pp. 1188 - 1190
DOI: 10.1126/science.7761838
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Articles

Science, Vol 268, Issue 5214, 1188-1190
Copyright © 1995 by American Association for the Advancement of Science

articles

Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling

A Kauffmann-Zeh, GM Thomas, A Ball, S Prosser, E Cunningham, S Cockcroft, and JJ Hsuan

Protein Biochemistry Group, Ludwig Institute for Cancer Research, University College London School of Medicine, UK.

Stimulation of phosphatidylinositol-4,5-bisphosphate (PIP2) hydrolysis is a widespread mechanism for receptor-mediated signaling in eukaryotes. Cytosolic phosphatidylinositol transfer protein (PITP) is necessary for guanosine triphosphate (GTP)-dependent hydrolysis of PIP2 by phospholipase C-beta (PLC-beta), but the role of PITP is unclear. Stimulation of phospholipase C-gamma (PLC-gamma) in A431 human epidermoid carcinoma cells treated with epidermal growth factor (EGF) required PITP. Stimulation of PI-4 kinase in cells treated with EGF also required PITP. Coprecipitation studies revealed an EGF-dependent association of PITP with the EGF receptor, with PI-4 kinase, and with PLC-gamma.


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