Science 26 May 1995: Vol. 268. no. 5214, pp. 1185 - 1188 DOI: 10.1126/science.7761837

Prev | Table of Contents | Next

Articles

Unlike Th1, Th17 Cells Mediate Sustained Autoimmune Inflammation and Are Highly Resistant to Restimulation-Induced Cell Death.

G. Shi, M. Ramaswamy, B. P. Vistica, C. A. Cox, C. Tan, E. F. Wawrousek, R. M. Siegel, and I. Gery (2009)
J. Immunol. 183, 7547-7556
 |  Abstract »  |  Full Text »  |  PDF »

SLAT/Def6 Plays a Critical Role in the Development of Th17 Cell-Mediated Experimental Autoimmune Encephalomyelitis.

A. J. Canonigo-Balancio, C. Fos, T. Prod'homme, S. Becart, and A. Altman (2009)
J. Immunol. 183, 7259-7267
 |  Abstract »  |  Full Text »  |  PDF »

SUMO Conjugation Contributes to Immune Deviation in Nonobese Diabetic Mice by Suppressing c-Maf Transactivation of IL-4.

J. W. Leavenworth, X. Ma, Y.-y. Mo, and M. E. Pauza (2009)
J. Immunol. 183, 1110-1119
 |  Abstract »  |  Full Text »  |  PDF »

Amplification of Autoimmune Response through Induction of Dendritic Cell Maturation in Inflamed Tissues.

K. Melli, R. S. Friedman, A. E. Martin, E. B. Finger, G. Miao, G. L. Szot, M. F. Krummel, and Q. Tang (2009)
J. Immunol. 182, 2590-2600
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Cell Mass and Type 1 Diabetes: Going, Going, Gone?.

E. Akirav, J. A. Kushner, and K. C. Herold (2008)
Diabetes 57, 2883-2888
 |  Abstract »  |  Full Text »  |  PDF »

Autoregulation of Th1-mediated inflammation by twist1.

U. Niesner, I. Albrecht, M. Janke, C. Doebis, C. Loddenkemper, M. H. Lexberg, K. Eulenburg, S. Kreher, J. Koeck, R. Baumgrass, et al. (2008)
J. Exp. Med. 205, 1889-1901
 |  Abstract »  |  Full Text »  |  PDF »

Both Th1 and Th17 Are Immunopathogenic but Differ in Other Key Biological Activities.

C. A. Cox, G. Shi, H. Yin, B. P. Vistica, E. F. Wawrousek, C.-C. Chan, and I. Gery (2008)
J. Immunol. 180, 7414-7422
 |  Abstract »  |  Full Text »  |  PDF »

Genome-Wide Microarray Expression Analysis of CD4+ T Cells from Nonobese Diabetic Congenic Mice Identifies Cd55 (Daf1) and Acadl as Candidate Genes for Type 1 Diabetes.

J. Irie, B. Reck, Y. Wu, L. S. Wicker, S. Howlett, D. Rainbow, E. Feingold, and W. M. Ridgway (2008)
J. Immunol. 180, 1071-1079
 |  Abstract »  |  Full Text »  |  PDF »

A Th1-Recognized Peptide P277, When Tandemly Repeated, Enhances a Th2 Immune Response toward Effective Vaccines against Autoimmune Diabetes in Nonobese Diabetic Mice.

L. Jin, A. Zhu, Y. Wang, Q. Chen, Q. Xiong, J. Li, Y. Sun, T. Li, R. Cao, J. Wu, et al. (2008)
J. Immunol. 180, 58-63
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role for Signal Transducer and Activator of Transcription-1 in Pancreatic {beta}-Cell Death and Autoimmune Type 1 Diabetes of Nonobese Diabetic Mice.

S. Kim, H. S. Kim, K. W. Chung, S. H. Oh, J. W. Yun, S.-H. Im, M.-K. Lee, K.-W. Kim, and M.-S. Lee (2007)
Diabetes 56, 2561-2568
 |  Abstract »  |  Full Text »  |  PDF »

Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Nonobese Diabetic Mice.

C. L.-T. Chang, S.-L. Chang, Y.-M. Lee, Y.-M. Chiang, D.-Y. Chuang, H.-K. Kuo, and W.-C. Yang (2007)
J. Immunol. 178, 6984-6993
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cells Expressing Transgenic Galectin-1 Delay Onset of Autoimmune Diabetes in Mice.

M. J. Perone, S. Bertera, Z. S. Tawadrous, W. J. Shufesky, J. D. Piganelli, L. G. Baum, M. Trucco, and A. E. Morelli (2006)
J. Immunol. 177, 5278-5289
 |  Abstract »  |  Full Text »  |  PDF »

Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo..

S. E. Weber, J. Harbertson, E. Godebu, G. A. Mros, R. C. Padrick, B. D. Carson, S. F. Ziegler, and L. M. Bradley (2006)
J. Immunol. 176, 4730-4739
 |  Abstract »  |  Full Text »  |  PDF »

Prophylactic fenbendazole therapy does not affect the incidence and onset of type 1 diabetes in non-obese diabetic mice.

D. D. H. Franke and H. Shirwan (2006)
Int. Immunol. 18, 453-458
 |  Abstract »  |  Full Text »  |  PDF »

Imaging {beta}-Cell Death With a Near-Infrared Probe.

Z. Medarova, S. Bonner-Weir, M. Lipes, and A. Moore (2005)
Diabetes 54, 1780-1788
 |  Abstract »  |  Full Text »  |  PDF »

Dynamic interaction between T cell-mediated {beta}-cell damage and {beta}-cell repair in the run up to autoimmune diabetes of the NOD mouse.

S. S. Vukkadapu, J. M. Belli, K. Ishii, A. G. Jegga, J. J. Hutton, B. J. Aronow, and J. D. Katz (2005)
Physiol Genomics 21, 201-211
 |  Abstract »  |  Full Text »  |  PDF »

Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with IFN-{gamma}-Inducible Protein 10 (CXC Chemokine Ligand 10) Production but Not Cytokine Expression, Cytolytic Activity, or Homing Characteristics.

M. Ejrnaes, N. Videbaek, U. Christen, A. Cooke, B. K. Michelsen, and M. von Herrath (2005)
J. Immunol. 174, 2746-2755
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of T Cell Differentiation into Effectors by NKT Cells Requires Cell Contacts.

J. Novak, L. Beaudoin, T. Griseri, and A. Lehuen (2005)
J. Immunol. 174, 1954-1961
 |  Abstract »  |  Full Text »  |  PDF »

Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice.

S. You, G. Slehoffer, S. Barriot, J.-F. Bach, and L. Chatenoud (2004)
PNAS 101, 14580-14585
 |  Abstract »  |  Full Text »  |  PDF »

Diabetes Incidence Is Unaltered in Glutamate Decarboxylase 65-Specific TCR Retrogenic Nonobese Diabetic Mice: Generation by Retroviral-Mediated Stem Cell Gene Transfer.

P. Y. Arnold, A. R. Burton, and D. A. A. Vignali (2004)
J. Immunol. 173, 3103-3111
 |  Abstract »  |  Full Text »  |  PDF »

Inducing Experimental Arthritis and Breaking Self-Tolerance to Joint-Specific Antigens with Trackable, Ovalbumin-Specific T Cells.

P. Maffia, J. M. Brewer, J. A. Gracie, A. Ianaro, B. P. Leung, P. J. Mitchell, K. M. Smith, I. B. McInnes, and P. Garside (2004)
J. Immunol. 173, 151-156
 |  Abstract »  |  Full Text »  |  PDF »

Up-Regulation of CD1d Expression Restores the Immunoregulatory Function of NKT Cells and Prevents Autoimmune Diabetes in Nonobese Diabetic Mice.

M. Falcone, F. Facciotti, N. Ghidoli, P. Monti, S. Olivieri, L. Zaccagnino, E. Bonifacio, G. Casorati, F. Sanvito, and N. Sarvetnick (2004)
J. Immunol. 172, 5908-5916
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 but not Interleukin-10 Protects Against Spontaneous and Recurrent Type 1 Diabetes by Activated CD1d-Restricted Invariant Natural Killer T-Cells.

Q.-S. Mi, D. Ly, P. Zucker, M. McGarry, and T. L. Delovitch (2004)
Diabetes 53, 1303-1310
 |  Abstract »  |  Full Text »  |  PDF »

Recruitment of IFN-{gamma}-Producing (Th1-Like) Cells into the Inflamed Retina In Vivo Is Preferentially Regulated by P-Selectin Glycoprotein Ligand 1:P/E-Selectin Interactions.

H. Xu, A. Manivannan, H.-R. Jiang, J. Liversidge, P. F. Sharp, J. V. Forrester, and I. J. Crane (2004)
J. Immunol. 172, 3215-3224
 |  Abstract »  |  Full Text »  |  PDF »

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand.

N. Martin-Orozco, Z. Chen, L. Poirot, E. Hyatt, A. Chen, O. Kanagawa, A. Sharpe, D. Mathis, and C. Benoist (2003)
J. Immunol. 171, 6954-6960
 |  Abstract »  |  Full Text »  |  PDF »

Physiological {beta} Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model.

S. Turley, L. Poirot, M. Hattori, C. Benoist, and D. Mathis (2003)
J. Exp. Med. 198, 1527-1537
 |  Abstract »  |  Full Text »  |  PDF »

Peptide-MHC Class II Dimers as Therapeutics to Modulate Antigen-Specific T Cell Responses in Autoimmune Diabetes.

E. L. Masteller, M. R. Warner, W. Ferlin, V. Judkowski, D. Wilson, N. Glaichenhaus, and J. A. Bluestone (2003)
J. Immunol. 171, 5587-5595
 |  Abstract »  |  Full Text »  |  PDF »

Effective Destruction of Fas-deficient Insulin-producing {beta} Cells in Type 1 Diabetes.

I. Apostolou, Z. Hao, K. Rajewsky, and H. von Boehmer (2003)
J. Exp. Med. 198, 1103-1106
 |  Abstract »  |  Full Text »  |  PDF »

HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection.

D. Loirat, M. Mancini-Bourgine, J.-P. Abastado, and M.-L. Michel (2003)
Int. Immunol. 15, 1125-1136
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines Regulate the Pattern of Rejection and Susceptibility to Cyclosporine Therapy in Different Mouse Recipient Strains After Cardiac Allografting.

H. Wang, K. A. Hosiawa, W. Min, J. Yang, X. Zhang, B. Garcia, T. E. Ichim, D. Zhou, D. Lian, D. J. Kelvin, et al. (2003)
J. Immunol. 171, 3823-3836
 |  Abstract »  |  Full Text »  |  PDF »

Th1 and Th2 Pancreatic Inflammation Differentially Affects Homing of Islet-Reactive CD4 Cells in Nonobese Diabetic Mice.

N. J. Hill, K. Van Gunst, and N. Sarvetnick (2003)
J. Immunol. 170, 1649-1658
 |  Abstract »  |  Full Text »  |  PDF »

Increased Nonobese Diabetic Th1:Th2 (IFN-{gamma}:IL-4) Ratio Is CD4+ T Cell Intrinsic and Independent of APC Genetic Background.

S. Koarada, Y. Wu, G. Olshansky, and W. M. Ridgway (2002)
J. Immunol. 169, 6580-6587
 |  Abstract »  |  Full Text »  |  PDF »

Functional plasticity of an antigen-specific memory CD4 T cell population.

M. Ahmadzadeh and D. L. Farber (2002)
PNAS 99, 11802-11807
 |  Abstract »  |  Full Text »  |  PDF »

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor {beta}1 Production and Responsiveness.

C. A. Piccirillo, J. J. Letterio, A. M. Thornton, R. S. McHugh, M. Mamura, H. Mizuhara, and E. M. Shevach (2002)
J. Exp. Med. 196, 237-246
 |  Abstract »  |  Full Text »  |  PDF »

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus.

K. C. Herold, W. Hagopian, J. A. Auger, E. Poumian-Ruiz, L. Taylor, D. Donaldson, S. E. Gitelman, D. M. Harlan, D. Xu, R. A. Zivin, et al. (2002)
N. Engl. J. Med. 346, 1692-1698
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms for Gender Differences in Susceptibility to T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice.

M. Bao, Y. Yang, H.-S. Jun, and J.-W. Yoon (2002)
J. Immunol. 168, 5369-5375
 |  Abstract »  |  Full Text »  |  PDF »

Long-Term Reversal of Established Autoimmunity upon Transient Blockade of the LFA-1/Intercellular Adhesion Molecule-1 Pathway.

L. Bertry-Coussot, B. Lucas, C. Danel, L. Halbwachs-Mecarelli, J.-F. Bach, L. Chatenoud, and P. Lemarchand (2002)
J. Immunol. 168, 3641-3648
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Ocular Inflammation by T-Helper Lymphocytes Type 2.

S. J. Kim, M. Zhang, B. P. Vistica, C.-C. Chan, D.-F. Shen, E. F. Wawrousek, and I. Gery (2002)
Invest. Ophthalmol. Vis. Sci. 43, 758-765
 |  Abstract »  |  Full Text »  |  PDF »

CD4 T Cells Selected by Antigen Under Th2 Polarizing Conditions Favor an Elongated TCR{alpha} Chain Complementarity-Determining Region 3.

R. J. Boyton, N. Zaccai, E. Y. Jones, and D. M. Altmann (2002)
J. Immunol. 168, 1018-1027
 |  Abstract »  |  Full Text »  |  PDF »

A central role for IL-2 in fate determination of mature T cells--I: role in determining the Th1/Th2 profile in primary T cell cultures.

K. Raju, B. A. Rabinovich, L. G. Radvanyi, D. Spaner, and R. G. Miller (2001)
Int. Immunol. 13, 1453-1459
 |  Abstract »  |  Full Text »  |  PDF »

Cd1-Restricted Nk T Cells Protect Nonobese Diabetic Mice from Developing Diabetes.

B. Wang, Y.-B. Geng, and C.-R. Wang (2001)
J. Exp. Med. 194, 313-320
 |  Abstract »  |  Full Text »  |  PDF »

Increased Entry into the IFN-{gamma} Effector Pathway by CD4+ T Cells Selected by I-Ag7 on a Nonobese Diabetic Versus C57BL/6 Genetic Background.

S. Koarada, Y. Wu, and W. M. Ridgway (2001)
J. Immunol. 167, 1693-1702
 |  Abstract »  |  Full Text »  |  PDF »

Experimental Autoimmune Myocarditis in A/J mice Is an Interleukin-4-Dependent Disease with a Th2 Phenotype.

M. Afanasyeva, Y. Wang, Z. Kaya, S. Park, M. J. Zilliox, B. H. Schofield, S. L. Hill, and N. R. Rose (2001)
Am. J. Pathol. 159, 193-203
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-specific Th1 cells as direct effectors of Propionibacterium acnes-primed lipopolysaccharide-induced hepatic injury.

T. Okazaki, S. Ozaki, T. Nagaoka, M. Kozuki, S. Sumita, M. Tanaka, F. Osakada, M. Kishimura, T. Kakutani, and K. Nakao (2001)
Int. Immunol. 13, 607-613
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Th1 cell activation and prevention of autoimmune diabetes in NOD mice by local expression of viral IL-10.

S. Kawamoto, Y. Nitta, F. Tashiro, A. Nakano, E. Yamato, H. Tahara, K. Tabayashi, and J.-i. Miyazaki (2001)
Int. Immunol. 13, 685-694
 |  Abstract »  |  Full Text »  |  PDF »

The Activity of Immunoregulatory T Cells Mediating Active Tolerance Is Potentiated in Nonobese Diabetic Mice by an IL-4-Based Retroviral Gene Therapy.

A. M. Yamamoto, Y. Chernajovsky, F. Lepault, O. Podhajcer, M. Feldmann, J.-F. Bach, and L. Chatenoud (2001)
J. Immunol. 166, 4973-4980
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{{gamma}}/TNF-{{alpha}} Synergism as the Final Effector in Autoimmune Diabetes: A Key Role for STAT1/IFN Regulatory Factor-1 Pathway in Pancreatic {{beta}} Cell Death.

K. Suk, S. Kim, Y.-H. Kim, K.-A. Kim, I. Chang, H. Yagita, M. Shong, and M.-S. Lee (2001)
J. Immunol. 166, 4481-4489
 |  Abstract »  |  Full Text »  |  PDF »

Variable Effects of Transgenic c-Maf on Autoimmune Diabetes.

M. E. Pauza, A. Nguyen, T. Wolfe, I-C. Ho, L. H. Glimcher, M. von Herrath, and D. Lo (2001)
Diabetes 50, 39-46
 |  Abstract »  |  Full Text »

Relative Diabetogenic Properties of Islet-Specific Tc1 and Tc2 Cells in Immunocompetent Hosts.

C. Vizler, N. Bercovici, A. Heurtier, N. Pardigon, K. Goude, K. Bailly, C. Combadiere, and R. S. Liblau (2000)
J. Immunol. 165, 6314-6321
 |  Abstract »  |  Full Text »  |  PDF »

Peptide Dose, MHC Affinity, and Target Self-Antigen Expression Are Critical for Effective Immunotherapy of Nonobese Diabetic Mouse Prediabetes.

S. Winer, L. Gunaratnam, I. Astsatourov, R. K. Cheung, V. Kubiak, W. Karges, D. Hammond-McKibben, R. Gaedigk, D. Graziano, M. Trucco, et al. (2000)
J. Immunol. 165, 4086-4094
 |  Abstract »  |  Full Text »  |  PDF »

Indirect Recognition of Porcine Swine Leukocyte Ag Class I Molecules Expressed on Islets by Human CD4+ T Lymphocytes.

B. Olack, P. Manna, A. Jaramillo, N. Steward, C. Swanson, D. Kaesberg, N. Poindexter, T. Howard, and T. Mohanakumar (2000)
J. Immunol. 165, 1294-1299
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Soluble and Cell Surface Factors Regulating Anti-DNA Topoisomerase I Autoantibody Production Demonstrates Synergy Between Th1 and Th2 Autoreactive T Cells.

M. Kuwana, T. A. Medsger Jr., and T. M. Wright (2000)
J. Immunol. 164, 6138-6146
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of TCR-induced IFN-{gamma} release from islet-reactive non-obese diabetic CD8+ T cells by prostaglandin E2 receptor signaling.

V. Ganapathy, T. Gurlo, H. O. Jarstadmarken, and H. von Grafenstein (2000)
Int. Immunol. 12, 851-860
 |  Abstract »  |  Full Text »  |  PDF »

Retargeting T Cell-Mediated Inflammation: A New Perspective on Autoantibody Action.

Y.-H. Lou, K.-K. Park, S. Agersborg, P. Alard, and K. S. K. Tung (2000)
J. Immunol. 164, 5251-5257
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Nonobese Diabetic Mice from Diabetes by Gene(s) Closely Linked to IFN-{gamma} Receptor Loci.

O. Kanagawa, G. Xu, A. Tevaarwerk, and B. A. Vaupel (2000)
J. Immunol. 164, 3919-3923
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Diabetes in Nonobese Diabetic Mice by Th2 T Cell Clones from a TCR Transgenic Mouse.

M. Poulin and K. Haskins (2000)
J. Immunol. 164, 3072-3078
 |  Abstract »  |  Full Text »  |  PDF »

Low CD86 Expression in the Nonobese Diabetic Mouse Results in the Impairment of Both T Cell Activation and CTLA-4 Up-Regulation.

E. Dahlen, G. Hedlund, and K. Dawe (2000)
J. Immunol. 164, 2444-2456
 |  Abstract »  |  Full Text »  |  PDF »

Anti-CD43 Monoclonal Antibody L11 Blocks Migration of T Cells to Inflamed Pancreatic Islets and Prevents Development of Diabetes in Nonobese Diabetic Mice.

G. G. Johnson, A. Mikulowska, E. C. Butcher, L. M. McEvoy, and S. A. Michie (1999)
J. Immunol. 163, 5678-5685
 |  Abstract »  |  Full Text »  |  PDF »

Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice.

S. Trembleau, G. Penna, S. Gregori, H. D. Chapman, D. V. Serreze, J. Magram, and L. Adorini (1999)
J. Immunol. 163, 2960-2968
 |  Abstract »  |  Full Text »  |  PDF »

The role of MHC class II molecules in susceptibility to type I diabetes: Identification of peptide epitopes and characterization of the T cell repertoire.

C.-C. Chao, H.-K. Sytwu, E. L. Chen, J. Toma, and H. O. McDevitt (1999)
PNAS 96, 9299-9304
 |  Abstract »  |  Full Text »  |  PDF »

Prevalent CD8+ T cell response against one peptide/MHC complex in autoimmune diabetes.

B. Anderson, B.-J. Park, J. Verdaguer, A. Amrani, and P. Santamaria (1999)
PNAS 96, 9311-9316
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Glutamic Acid Decarboxylase 65-Specific Th2 Cells and Suppression of Autoimmune Diabetes at Late Stages of Disease Is Epitope Dependent.

R. Tisch, B. Wang, and D. V. Serreze (1999)
J. Immunol. 163, 1178-1187
 |  Abstract »  |  Full Text »  |  PDF »

IL-18 Inhibits Diabetes Development in Nonobese Diabetic Mice by Counterregulation of Th1-Dependent Destructive Insulitis.

H. Rothe, A. Hausmann, K. Casteels, H. Okamura, M. Kurimoto, V. Burkart, C. Mathieu, and H. Kolb (1999)
J. Immunol. 163, 1230-1236
 |  Abstract »  |  Full Text »  |  PDF »

Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse.

W. S. Gallichan, B. Balasa, J. D. Davies, and N. Sarvetnick (1999)
J. Immunol. 163, 1696-1703
 |  Abstract »  |  Full Text »  |  PDF »

Isolating the molecular suspect: HLA transgenic mice in the study of human autoimmune disease.

F. C. Hall, A. P. Cope, S. D. Patel, and G. Sonderstrup (1999)
Rheumatology 38, 697-704
 |  Full Text »  |  PDF »

Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-Specific Regulation.

E. Bonifacio, M. Scirpoli, K. Kredel, M. Fuchtenbusch, and A.-G. Ziegler (1999)
J. Immunol. 163, 525-532
 |  Abstract »  |  Full Text »  |  PDF »

Expansion of neonatal tolerance to self in adult life: I. The role of a bacterial adjuvant in tolerance spread.

N. Grabie, I. Wohl, S. Youssef, G. Wildbaum, and N. Karin (1999)
Int. Immunol. 11, 899-906
 |  Abstract »  |  Full Text »  |  PDF »

Cloning Genes Encoding MHC Class II-Restricted Antigens: Mutated CDC27 as a Tumor Antigen.

R. Wang, X. Wang, A. C. Atwood, S. L. Topalian, and S. A. Rosenberg (1999)
Science 284, 1351-1354
 |  Abstract »  |  Full Text »

Type I (Insulin-Dependent) Diabetes Is a Th1- and Th2-Mediated Autoimmune Disease.

S. T. Azar, H. Tamim, H. N. Beyhum, M. Z. Habbal, and W. Y. Almawi (1999)
Clin. Vaccine Immunol. 6, 306-310
 |  Full Text »  |  PDF »

T Helper Type 1 and 2 Cytokines Mediate the Onset and Progression of Type I (Insulin-Dependent) Diabetes.

W. Y. Almawi, H. Tamim, and S. T. Azar (1999)
J. Clin. Endocrinol. Metab. 84, 1497-1502
 |  Abstract »  |  Full Text »

TNF Receptor 1-Dependent {beta} Cell Toxicity as an Effector Pathway in Autoimmune Diabetes.

D. Kagi, A. Ho, B. Odermatt, A. Zakarian, P. S. Ohashi, and T. W. Mak (1999)
J. Immunol. 162, 4598-4605
 |  Abstract »  |  Full Text »  |  PDF »

Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes.

L. M. Bradley, V. C. Asensio, L.-K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick (1999)
J. Immunol. 162, 2511-2520
 |  Abstract »  |  Full Text »  |  PDF »

Tpm1, a Locus Controlling IL-12 Responsiveness, Acts by a Cell-Autonomous Mechanism.

M. L. Guler, J. D. Gorham, W. F. Dietrich, T. L. Murphy, R. G. Steen, C. A. Parvin, D. Fenoglio, A. Grupe, G. Peltz, and K. M. Murphy (1999)
J. Immunol. 162, 1339-1347
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Macrophages in T Cell-mediated Autoimmune Diabetes in Nonobese Diabetic Mice.

H.-S. Jun, C.-S. Yoon, L. Zbytnuik, N. van Rooijen, and J.-W. Yoon (1999)
J. Exp. Med. 189, 347-358
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor {beta} and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC- Cells and CD4+CD8- Thymocytes.

B. Seddon and D. Mason (1999)
J. Exp. Med. 189, 279-288
 |  Abstract »  |  Full Text »  |  PDF »

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes.

P. Hoglund, J. Mintern, C. Waltzinger, W. Heath, C. Benoist, and D. Mathis (1999)
J. Exp. Med. 189, 331-339
 |  Abstract »  |  Full Text »  |  PDF »

Neutralizing Antibodies to IFN-{gamma}-Inducing Factor Prevent Experimental Autoimmune Encephalomyelitis.

G. Wildbaum, S. Youssef, N. Grabie, and N. Karin (1998)
J. Immunol. 161, 6368-6374
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Natural Killer T Cells Protects V{alpha}14-J{alpha}281 Transgenic Nonobese Diabetic Mice against Diabetes.

A. Lehuen, O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J.-F. Bach, and R. C. Monteiro (1998)
J. Exp. Med. 188, 1831-1839
 |  Abstract »  |  Full Text »  |  PDF »

Immune system activation follows inflammation in unstable angina: pathogenetic implications.

G. Caligiuri, G. Liuzzo, L. M. Biasucci, and A. Maseri (1998)
J. Am. Coll. Cardiol. 32, 1295-1304
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Treatment with a MHC Class I-Restricted Blocking Peptide Can Prevent Virus-Induced Autoimmune Diabetes.

M. G. von Herrath, B. Coon, H. Lewicki, H. Mazarguil, J. E. Gairin, and M. B. A. Oldstone (1998)
J. Immunol. 161, 5087-5096
 |  Abstract »  |  Full Text »  |  PDF »

Mature Mainstream TCR{alpha}{beta}+CD4+ Thymocytes Expressing L-Selectin Mediate ""Active Tolerance"" in the Nonobese Diabetic Mouse.

A. Herbelin, J.-M. Gombert, F. Lepault, J.-F. Bach, and L. Chatenoud (1998)
J. Immunol. 161, 2620-2628
 |  Abstract »  |  Full Text »  |  PDF »

B Lymphocytes Are Crucial Antigen-Presenting Cells in the Pathogenic Autoimmune Response to GAD65 Antigen in Nonobese Diabetic Mice.

M. Falcone, J. Lee, G. Patstone, B. Yeung, and N. Sarvetnick (1998)
J. Immunol. 161, 1163-1168
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain.

S Matsumoto, Y Okabe, H Setoyama, K Takayama, J Ohtsuka, H Funahashi, A Imaoka, Y Okada, and Y Umesaki (1998)
Gut 43, 71-78
 |  Abstract »  |  Full Text »  |  PDF »

A Synthetic CD4-CDR3 Peptide Analog Enhances Skin Allograft Survival Across a MHC Class II Barrier.

U. Koch, S. Choksi, L. Marcucci, and R. Korngold (1998)
J. Immunol. 161, 421-429
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}/{beta}-T Cell Receptor (TCR)+CD4-CD8- (NKT) Thymocytes Prevent Insulin-dependent Diabetes Mellitus in Nonobese Diabetic (NOD)/Lt Mice by the Influence of Interleukin (IL)-4 and/or IL-10.

K. J.L. Hammond, L. D. Poulton, L. J. Palmisano, P. A. Silveira, D. I. Godfrey, and A. G. Baxter (1998)
J. Exp. Med. 187, 1047-1056
 |  Abstract »  |  Full Text »  |  PDF »

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease.

B. M. Segal, B. K. Dwyer, and E. M. Shevach (1998)
J. Exp. Med. 187, 537-546
 |  Abstract »  |  Full Text »  |  PDF »

Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes.

F. Luhder, P. Hoglund, J. P. Allison, C. Benoist, and D. Mathis (1998)
J. Exp. Med. 187, 427-432
 |  Abstract »  |  Full Text »  |  PDF »

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens.

J. Tian, P. V. Lehmann, and D. L. Kaufman (1997)
J. Exp. Med. 186, 2039-2043
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

B. Wang, I. Andre, A. Gonzalez, J. D. Katz, M. Aguet, C. Benoist, and D. Mathis (1997)
PNAS 94, 13844-13849
 |  Abstract »  |  Full Text »  |  PDF »

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice.

J. Verdaguer, D. Schmidt, A. Amrani, B. Anderson, N. Averill, and P. Santamaria (1997)
J. Exp. Med. 186, 1663-1676
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice.

D. Kagi, B. Odermatt, P. Seiler, R. M. Zinkernagel, T. W. Mak, and H. Hengartner (1997)
J. Exp. Med. 186, 989-997
 |  Abstract »  |  Full Text »  |  PDF »

Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses.

Z. Shi, A. E. Wakil, and D. C. Rockey (1997)
PNAS 94, 10663-10668
 |  Abstract »  |  Full Text »  |  PDF »

Autopathogenic T Helper Cell Type 1 (Th1) and Protective Th2 Clones Differ in Their Recognition of the Autoantigenic Peptide of Myelin Proteolipid Protein.

M. P. Das, L. B. Nicholson, J. M. Greer, and V. K. Kuchroo (1997)
J. Exp. Med. 186, 867-876
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene.

D.-H. Zhang, L. Cohn, P. Ray, K. Bottomly, and A. Ray (1997)
J. Biol. Chem. 272, 21597-21603
 |  Abstract »  |  Full Text »  |  PDF »

Tolerance Induction and Autoimmune Encephalomyelitis Amelioration After Administration of Myelin Basic Protein-derived Peptide.

S. Marusic and S. Tonegawa (1997)
J. Exp. Med. 186, 507-515
 |  Abstract »  |  Full Text »  |  PDF »

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha 1*0101,beta 1*0401) transgenic mice.

S. D. Patel, A. P. Cope, M. Congia, T. T. Chen, E. Kim, L. Fugger, D. Wherrett, and G. Sonderstrup-McDevitt (1997)
PNAS 94, 8082-8087
 |  Abstract »  |  Full Text »  |  PDF »

T Helper 2 (Th2) T Cells Induce Acute Pancreatitis and Diabetes in Immune-compromised Nonobese Diabetic (NOD) Mice.

S. V. Pakala, M. O. Kurrer, and J. D. Katz (1997)
J. Exp. Med. 186, 299-306
 |  Abstract »  |  Full Text »  |  PDF »

Myelin Basic Protein-specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease.

J. J. Lafaille, F. V. d. Keere, A. L. Hsu, J. L. Baron, W. Haas, C. S. Raine, and S. Tonegawa (1997)
J. Exp. Med. 186, 307-312
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice.

V. Thomas-Vaslin, D. Damotte, M. Coltey, N. M. Le Douarin, A. Coutinho, and J. Salaun (1997)
PNAS 94, 4598-4603
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products