Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 May 1995:
Vol. 268. no. 5214, pp. 1177 - 1179
DOI: 10.1126/science.7539155
Prev | Table of Contents | Next

Articles

Science, Vol 268, Issue 5214, 1177-1179
Copyright © 1995 by American Association for the Advancement of Science

articles

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

WM Kavanaugh, CW Turck, and LT Williams

Department of Medicine, University of California, San Francisco 94143, USA.

Src homology 2 (SH2) domains mediate assembly of signaling complexes by binding specifically to tyrosine-phosphorylated proteins. A phosphotyrosine binding (PTB) domain has been identified which also binds specifically to tyrosine-phosphorylated targets, but is structurally different from SH2 domains. Expression cloning was used to identify targets of PTB domains. PTB domains bound to phosphotyrosine within a sequence motif, asparagine-X1-X2-phosphotyrosine (where X represents any amino acid), that is found in many signaling proteins and is not recognized by SH2 domains. Mutational studies indicated that high affinity binding of PTB domains may require a specific conformation of the motif.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
APPL1: role in adiponectin signaling and beyond.
S. S. Deepa and L. Q. Dong (2009)
Am J Physiol Endocrinol Metab 296, E22-E36
   Abstract »    Full Text »    PDF »
Combinatorial ShcA Docking Interactions Support Diversity in Tissue Morphogenesis.
W. R. Hardy, L. Li, Z. Wang, J. Sedy, J. Fawcett, E. Frank, J. Kucera, and T. Pawson (2007)
Science 317, 251-256
   Abstract »    Full Text »    PDF »
Analysis of a Shc Family Adaptor Protein, ShcD/Shc4, That Associates with Muscle-Specific Kinase.
N. Jones, W. R. Hardy, M. B. Friese, C. Jorgensen, M. J. Smith, N. M. Woody, S. J. Burden, and T. Pawson (2007)
Mol. Cell. Biol. 27, 4759-4773
   Abstract »    Full Text »    PDF »
Engineering the Recruitment of Phosphotyrosine Binding Domain-containing Adaptor Proteins Reveals Distinct Roles for RET Receptor-mediated Cell Survival.
T. K. Lundgren, R. P. Scott, M. Smith, T. Pawson, and P. Ernfors (2006)
J. Biol. Chem. 281, 29886-29896
   Abstract »    Full Text »    PDF »
C terminus of RGS-GAIP-interacting protein conveys neuropilin-1-mediated signaling during angiogenesis.
L. Wang, D. Mukhopadhyay, and X. Xu (2006)
FASEB J 20, 1513-1515
   Abstract »    Full Text »    PDF »
Muc4-ErbB2 Complex Formation and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an Unorthodox Ligand for ErbB2.
V. P. Ramsauer, V. Pino, A. Farooq, C. A. Carothers Carraway, P. J.I. Salas, and K. L. Carraway (2006)
Mol. Biol. Cell 17, 2931-2941
   Abstract »    Full Text »    PDF »
Kinase Activation through Dimerization by Human SH2-B.
M. Nishi, E. D. Werner, B.-C. Oh, J. D. Frantz, S. Dhe-Paganon, L. Hansen, J. Lee, and S. E. Shoelson (2005)
Mol. Cell. Biol. 25, 2607-2621
   Abstract »    Full Text »    PDF »
Mechanism of SHIP-Mediated Inhibition of Insulin- and Platelet-Derived Growth Factor-Stimulated Mitogen-Activated Protein Kinase Activity in 3T3-L1 Adipocytes.
P. M. Sharma, H.-S. Son, S. Ugi, W. Ricketts, and J. M. Olefsky (2005)
Mol. Endocrinol. 19, 421-430
   Abstract »    Full Text »    PDF »
Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.
R. Chan, W. R. Hardy, D. Dankort, M. A. Laing, and W. J. Muller (2004)
Development 131, 5551-5560
   Abstract »    Full Text »    PDF »
A Highly Conserved NTRK3 C-terminal Sequence in the ETV6-NTRK3 Oncoprotein Binds the Phosphotyrosine Binding Domain of Insulin Receptor Substrate-1: AN ESSENTIAL INTERACTION FOR TRANSFORMATION.
C. L. Lannon, M. J. Martin, C. E. Tognon, W. Jin, S.-J. Kim, and P. H. B. Sorensen (2004)
J. Biol. Chem. 279, 6225-6234
   Abstract »    Full Text »    PDF »
SH2 and PTB Domains in Tyrosine Kinase Signaling.
J. Schlessinger and M. A. Lemmon (2003)
Sci. STKE 2003, re12
   Abstract »    Full Text »    PDF »
A Unique Autophosphorylation Site on Tie2/Tek Mediates Dok-R Phosphotyrosine Binding Domain Binding and Function.
N. Jones, S. H. Chen, C. Sturk, Z. Master, J. Tran, R. S. Kerbel, and D. J. Dumont (2003)
Mol. Cell. Biol. 23, 2658-2668
   Abstract »    Full Text »    PDF »
Ceramide Kinase, a Novel Lipid Kinase. MOLECULAR CLONING AND FUNCTIONAL CHARACTERIZATION.
M. Sugiura, K. Kono, H. Liu, T. Shimizugawa, H. Minekura, S. Spiegel, and T. Kohama (2002)
J. Biol. Chem. 277, 23294-23300
   Abstract »    Full Text »    PDF »
FRS2 PTB Domain Conformation Regulates Interactions with Divergent Neurotrophic Receptors.
K. S. Yan, M. Kuti, S. Yan, S. Mujtaba, A. Farooq, M. P. Goldfarb, and M.-M. Zhou (2002)
J. Biol. Chem. 277, 17088-17094
   Abstract »    Full Text »    PDF »
The Kinase-null EphB6 Receptor Undergoes Transphosphorylation in a Complex with EphB1.
A. Freywald, N. Sharfe, and C. M. Roifman (2002)
J. Biol. Chem. 277, 3823-3828
   Abstract »    Full Text »    PDF »
c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK.
S. Matsuda, T. Yasukawa, Y. Homma, Y. Ito, T. Niikura, T. Hiraki, S. Hirai, S. Ohno, Y. Kita, M. Kawasumi, et al. (2001)
J. Neurosci. 21, 6597-6607
   Abstract »    Full Text »    PDF »
Selective Inhibition of Fibroblast Growth Factor (FGF)-stimulated Mitogenesis by a FGF Receptor-1-derived Phosphopeptide.
D. J. Dunican, E. J. Williams, F. V. Howell, and P. Doherty (2001)
Cell Growth Differ. 12, 255-264
   Abstract »    Full Text »    PDF »
FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors.
S. H. Ong, G. R. Guy, Y. R. Hadari, S. Laks, N. Gotoh, J. Schlessinger, and I. Lax (2000)
Mol. Cell. Biol. 20, 979-989
   Abstract »    Full Text »
The FHA domain mediates phosphoprotein interactions.
J Li, G. Lee, S. Van Doren, and J. Walker (2000)
J. Cell Sci. 113, 4143-4149
   Abstract »    PDF »
Lad, an Adapter Protein Interacting with the SH2 Domain of p56lck, Is Required for T Cell Activation ,2.
Y. B. Choi, C. K. Kim, and Y. Yun (1999)
J. Immunol. 163, 5242-5249
   Abstract »    Full Text »    PDF »
Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain.
J. Li, G. P. Smith, and J. C. Walker (1999)
PNAS 96, 7821-7826
   Abstract »    Full Text »    PDF »
The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids.
B. W. Howell, L. M. Lanier, R. Frank, F. B. Gertler, and J. A. Cooper (1999)
Mol. Cell. Biol. 19, 5179-5188
   Abstract »    Full Text »    PDF »
Phosphotyrosine Binding Domains of Shc and Insulin Receptor Substrate 1 Recognize the NPXpY Motif in a Thermodynamically Distinct Manner.
A. Farooq, O. Plotnikova, L. Zeng, and M.-M. Zhou (1999)
J. Biol. Chem. 274, 6114-6121
   Abstract »    Full Text »    PDF »
Action of Insulin Receptor Substrate-3 (IRS-3) and IRS-4 to Stimulate Translocation of GLUT4 in Rat Adipose Cells.
L. Zhou, H. Chen, P. Xu, L.-N. Cong, S. Sciacchitano, Y. Li, D. Graham, A. R. Jacobs, S. I. Taylor, and M. J. Quon (1999)
Mol. Endocrinol. 13, 505-514
   Abstract »    Full Text »
Different Tyrosine Autophosphorylation Requirements in Fibroblast Growth Factor Receptor-1 Mediate Urokinase-Type Plasminogen Activator Induction and Mitogenesis.
P. Dell'Era, M. Mohammadi, and M. Presta (1999)
Mol. Biol. Cell 10, 23-33
   Abstract »    Full Text »
Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein.
M. Trommsdorff, J.-P. Borg, B. Margolis, and J. Herz (1998)
J. Biol. Chem. 273, 33556-33560
   Abstract »    Full Text »    PDF »
Molecular Identification and Functional Characterization of a Novel Protein That Mediates the Attachment of Erythroblasts to Macrophages.
M. Hanspal, Y. Smockova, and Q. Uong (1998)
Blood 92, 2940-2950
   Abstract »    Full Text »    PDF »
Characterization of a Mobile Stat6 Activation Motif in the Human IL-4 Receptor.
J. J. Ryan, L. J. McReynolds, H. Huang, K. Nelms, and W. E. Paul (1998)
J. Immunol. 161, 1811-1821
   Abstract »    Full Text »    PDF »
Multiple Forms of the SH2-Containing Inositol Phosphatase, SHIP, Are Generated by C-Terminal Truncation.
J. E. Damen, L. Liu, M. D. Ware, M. Ermolaeva, P. W. Majerus, and G. Krystal (1998)
Blood 92, 1199-1205
   Abstract »    Full Text »    PDF »
Mutation of a Shc Binding Site Tyrosine Residue in ErbB3/HER3 Blocks Heregulin-dependent Activation of Mitogen-activated Protein Kinase.
U. Vijapurkar, K. Cheng, and J. G. Koland (1998)
J. Biol. Chem. 273, 20996-21002
   Abstract »    Full Text »    PDF »
Inhibition of Platelet-Derived Growth Factor and Epidermal Growth Factor Receptor Signaling Events after Treatment of Cells with Specific Synthetic Inhibitors of Tyrosine Kinase Phosphorylation.
K. E. Lipson, L. Pang, L. J. Huber, H. Chen, J.-M. Tsai, P. Hirth, A. Gazit, A. Levitzki, and G. Mcmahon (1998)
J. Pharmacol. Exp. Ther. 285, 844-852
   Abstract »    Full Text »
The Mammalian Numb Phosphotyrosine-binding Domain. CHARACTERIZATION OF BINDING SPECIFICITY AND IDENTIFICATION OF A NOVEL PDZ DOMAIN-CONTAINING NUMB BINDING PROTEIN, LNX.
S. E. Dho, S. Jacob, C. D. Wolting, M. B. French, L. R. Rohrschneider, and C. J. McGlade (1998)
J. Biol. Chem. 273, 9179-9187
   Abstract »    Full Text »    PDF »
Shc Phosphotyrosine-Binding Domain Dominantly Interacts with Epidermal Growth Factor Receptors and Mediates Ras Activation in Intact Cells.
K. Sakaguchi, Y. Okabayashi, Y. Kido, S. Kimura, Y. Matsumura, K. Inushima, and M. Kasuga (1998)
Mol. Endocrinol. 12, 536-543
   Abstract »    Full Text »
Numb-Associated Kinase Interacts with the Phosphotyrosine Binding Domain of Numb and Antagonizes the Function of Numb In Vivo.
C.-t. Chien, S. Wang, M. Rothenberg, L. Y. Jan, and Y. N. Jan (1998)
Mol. Cell. Biol. 18, 598-607
   Abstract »    Full Text »
The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of Drosophila Enabled.
K. S. Ermekova, N. Zambrano, H. Linn, G. Minopoli, F. Gertler, T. Russo, and M. Sudol (1997)
J. Biol. Chem. 272, 32869-32877
   Abstract »    Full Text »    PDF »
Signaling Through Scaffold, Anchoring, and Adaptor Proteins.
T. Pawson and J. D. Scott (1997)
Science 278, 2075-2080
   Abstract »    Full Text »
Mints, Munc18-interacting Proteins in Synaptic Vesicle Exocytosis.
M. Okamoto and T. C. Sudhof (1997)
J. Biol. Chem. 272, 31459-31464
   Abstract »    Full Text »    PDF »
The 66-kDa Shc Isoform Is a Negative Regulator of the Epidermal Growth Factor-stimulated Mitogen-activated Protein Kinase Pathway.
S. Okada, A. W. Kao, B. P. Ceresa, P. Blaikie, B. Margolis, and J. E. Pessin (1997)
J. Biol. Chem. 272, 28042-28049
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of Nicotinic Acetylcholine Receptor Mediates Grb2 Binding.
M. Colledge and S. C. Froehner (1997)
J. Neurosci. 17, 5038-5045
   Abstract »    Full Text »    PDF »
Binding of src-like Kinases to the beta -Subunit of the Interleukin-3 Receptor.
E. A. Burton, S. Hunter, S. C. Wu, and S. M. Anderson (1997)
J. Biol. Chem. 272, 16189-16195
   Abstract »    Full Text »    PDF »
Cyclin G2 Is Up-regulated during Growth Inhibition and B Cell Antigen Receptor-mediated Cell Cycle Arrest.
M. C. Horne, K. L. Donaldson, G. L. Goolsby, D. Tran, M. Mulheisen, J. W. Hell, and A. F. Wahl (1997)
J. Biol. Chem. 272, 12650-12661
   Abstract »    Full Text »    PDF »
Shc Interaction with Src Homology 2Domain Containing Inositol Phosphatase (SHIP) in Vivo Requires the Shc-Phosphotyrosine Binding Domain and Two Specific Phosphotyrosines on SHIP.
T. D. Lamkin, S. F. Walk, L. Liu, J. E. Damen, G. Krystal, and K. S. Ravichandran (1997)
J. Biol. Chem. 272, 10396-10401
   Abstract »    Full Text »    PDF »
HER-2/neu Signal Transduction in Human Breast and Ovarian Cancer.
D. M. Reese and D. J. Slamon (1997)
Stem Cells 15, 1-8
   Abstract »    Full Text »
Erythropoietin Activates Raf1 by an Shc-Independent Pathway in CTLL-EPO-R Cells.
D. L. Barber, C. N. Corless, K. Xia, T. M. Roberts, and A. D. D'Andrea (1997)
Blood 89, 55-64
   Abstract »    Full Text »    PDF »
The Inositol 5'-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation.
M. A. Osborne, G. Zenner, M. Lubinus, X. Zhang, Z. Songyang, L. C. Cantley, P. Majerus, P. Burn, and J. P. Kochan (1996)
J. Biol. Chem. 271, 29271-29278
   Abstract »    Full Text »    PDF »
Annexin II Is a Novel Player in Insulin Signal Transduction. POSSIBLE ASSOCIATION BETWEEN ANNEXIN II PHOSPHORYLATION AND INSULIN RECEPTOR INTERNALIZATION.
Y. Biener, R. Feinstein, M. Mayak, Y. Kaburagi, T. Kadowaki, and Y. Zick (1996)
J. Biol. Chem. 271, 29489-29496
   Abstract »    Full Text »    PDF »
Functional Roles of the Shc Phosphotyrosine Binding and Src Homology 2Domains in Insulin and Epidermal Growth Factor Signaling.
W. A. Ricketts, D. W. Rose, S. Shoelson, and J. M. Olefsky (1996)
J. Biol. Chem. 271, 26165-26169
   Abstract »    Full Text »    PDF »
Enhanced Tumorigenic Behavior of Glioblastoma Cells Expressing a Truncated Epidermal Growth Factor Receptor Is Mediated through the Ras-Shc-Grb2 Pathway.
S. A. Prigent, M. Nagane, H. Lin, I. Huvar, G. R. Boss, J. R. Feramisco, W. K. Cavenee, and H.-J. S. Huang (1996)
J. Biol. Chem. 271, 25639-25645
   Abstract »    Full Text »    PDF »
The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1.
L. Yenush, K. J. Makati, J. Smith-Hall, O. Ishibashi, M. G. Myers Jr., and M. F. White (1996)
J. Biol. Chem. 271, 24300-24306
   Abstract »    Full Text »    PDF »
Branching Tubulogenesis but Not Scatter of Madin-Darby Canine Kidney Cells Requires a Functional Grb2 Binding Site in the Met Receptor Tyrosine Kinase.
T. M. Fournier, D. Kamikura, K. Teng, and M. Park (1996)
J. Biol. Chem. 271, 22211-22217
   Abstract »    Full Text »    PDF »
Distinct Tyrosine Residues within the Interleukin-2 Receptor beta Chain Drive Signal Transduction Specificity, Redundancy, and Diversity.
S. L. Gaffen, S. Y. Lai, M. Ha, X. Liu, L. Hennighausen, W. C. Greene, and M. A. Goldsmith (1996)
J. Biol. Chem. 271, 21381-21390
   Abstract »    Full Text »    PDF »
Prolactin Inhibits Epidermal Growth Factor-induced Ras-MAPK Signaling in Mammary Epithelial Cells.
J. L. Johnson, S. Fenton, and L. G. Sheffield (1996)
J. Biol. Chem. 271, 21574-21578
   Abstract »    Full Text »    PDF »
A Mutation at Tyrosine 1062in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins.
N. Asai, H. Murakami, T. Iwashita, and M. Takahashi (1996)
J. Biol. Chem. 271, 17644-17649
   Abstract »    Full Text »    PDF »
The genomic structure of discoidin receptor tyrosine kinase..
M P Playford, R J Butler, X C Wang, R M Katso, I E Cooke, and T S Ganesan (1996)
Genome Res. 6, 620-627
   Abstract »    PDF »
Interaction with the Phosphotyrosine Binding Domain/Phosphotyrosine Interacting Domain of SHC Is Required for the Transforming Activity of the FLT4/VEGFR3 Receptor Tyrosine Kinase.
E. Fournier, O. Rosnet, S. Marchetto, C. W. Turck, R. Rottapel, P. G. Pelicci, D. Birnbaum, and J.-P. Borg (1996)
J. Biol. Chem. 271, 12956-12963
   Abstract »    Full Text »    PDF »
Pathways Downstream of Shc and Grb2 Are Required for Cell Transformation by the Tpr-Met Oncoprotein.
E. D. Fixman, T. M. Fournier, D. M. Kamikura, M. A. Naujokas, and M. Park (1996)
J. Biol. Chem. 271, 13116-13122
   Abstract »    Full Text »    PDF »
Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC.
J. P. O'Bryan, C. B. Martin, Z. Songyang, L. C. Cantley, and C. J. Der (1996)
J. Biol. Chem. 271, 11787-11791
   Abstract »    Full Text »    PDF »
Phosphotyrosine-independent Binding of SHC to the NPLH Sequence of Murine Protein-tyrosine Phosphatase-PEST.
A. Charest, J. Wagner, S. Jacob, C. J. McGlade, and M. L. Tremblay (1996)
J. Biol. Chem. 271, 8424-8429
   Abstract »    Full Text »    PDF »
Interaction between the Insulin Receptor and Its Downstream Effectors.
K. Paz, H. Voliovitch, Y. R. Hadari, C. T. Roberts Jr., D. LeRoith, and Y. Zick (1996)
J. Biol. Chem. 271, 6998-7003
   Abstract »    Full Text »    PDF »
Cyclin G1 and Cyclin G2 Comprise a New Family of Cyclins with Contrasting Tissue-specific and Cell Cycle-regulated Expression.
M. C. Horne, G. L. Goolsby, K. L. Donaldson, D. Tran, M. Neubauer, and A. F. Wahl (1996)
J. Biol. Chem. 271, 6050-6061
   Abstract »    Full Text »    PDF »
In Vivo Association of v-Abl with Shc Mediated by a Non-phosphotyrosine-dependent SH2 Interaction.
G. D. Raffel, K. Parmar, and N. Rosenberg (1996)
J. Biol. Chem. 271, 4640-4645
   Abstract »    Full Text »    PDF »
Interaction between the Phosphotyrosine Binding Domain of Shc and the Insulin Receptor Is Required for Shc Phosphorylation by Insulin in Vivo.
S. J. Isakoff, Y.-P. Yu, Y.-C. Su, P. Blaikie, V. Yajnik, E. Rose, K. M. Weidner, M. Sachs, B. Margolis, and E. Y. Skolnik (1996)
J. Biol. Chem. 271, 3959-3962
   Abstract »    Full Text »    PDF »
Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction.
V. Yajnik, P. Blaikie, P. Bork, and B. Margolis (1996)
J. Biol. Chem. 271, 1813-1816
   Abstract »    Full Text »    PDF »
Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors.
A. A. Laminet, G. Apell, L. Conroy, and W. M. Kavanaugh (1996)
J. Biol. Chem. 271, 264-269
   Abstract »    Full Text »    PDF »
Src Homologous and Collagen (Shc) Protein Binds to F-actin and Translocates to the Cytoskeleton upon Nerve Growth Factor Stimulation in PC12 Cells.
D. Thomas, S. D. Patterson, and R. A. Bradshaw (1995)
J. Biol. Chem. 270, 28924-28931
   Abstract »    Full Text »    PDF »
PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities.
G. Wolf, T. Trüb, E. Ottinger, L. Groninga, A. Lynch, M. F. White, M. Miyazaki, J. Lee, and S. E. Shoelson (1995)
J. Biol. Chem. 270, 27407-27410
   Abstract »    Full Text »    PDF »
Distinct Modes of Interaction of SHC and Insulin Receptor Substrate-1 with the Insulin Receptor NPEY Region via Non-SH2 Domains.
W. He, T. J. O'Neill, and T. A. Gustafson (1995)
J. Biol. Chem. 270, 23258-23262
   Abstract »    Full Text »    PDF »
Binding of Shc to the NPXY Motif Is Mediated by Its N-terminal Domain.
S. A. Prigent, T. S. Pillay, K. S. Ravichandran, and W. J. Gullick (1995)
J. Biol. Chem. 270, 22097-22100
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)