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Science 19 May 1995: Vol. 268. no. 5213, pp. 1045 - 1049 DOI: 10.1126/science.7754384
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Articles
Science, Vol 268, Issue 5213, 1045-1049
Copyright © 1995 by American Association for the Advancement of Science
The control of calcium release in heart muscle
MB Cannell,
H Cheng,
and
WJ Lederer
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.
The control of calcium release from intracellular stores (the sarcoplasmic reticulum) in cardiac muscle was examined with the use of a confocal microscope and voltage clamp techniques. Depolarization evoked graded calcium release by altering the extent of spatial and temporal summation of elementary calcium release events called "calcium sparks." These evoked sparks were triggered by local L-type calcium channel currents in a stochastic manner, were similar at different potentials, and resembled spontaneous calcium sparks. Once triggered, the calcium release from the sarcoplasmic reticulum during a calcium spark was independent of the duration of the triggering calcium influx. These results were used to develop a unifying model for cardiac excitation-contraction coupling that explains the large (but paradoxically stable) amplification of the trigger calcium influx by a combination of digital and analog behavior.
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J. Biol. Chem.
275, 4407-4416
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- Calcium sparks in smooth muscle.
- J. H. Jaggar, V. A. Porter, W. J. Lederer, and M. T. Nelson (2000)
Am J Physiol Cell Physiol
278, C235-C256
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- Neuronal calcium sparks and intracellular calcium "noise".
- N. Melamed-Book, S. G. Kachalsky, I. Kaiserman, and R. Rahamimoff (1999)
PNAS
96, 15217-15221
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- Rapid Activation of the Cardiac Ryanodine Receptor by Submillisecond Calcium Stimuli.
- A. Zahradnikova, I. Zahradnik, I. Gyorke, and S. Gyorke (1999)
J. Gen. Physiol.
114, 787-798
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- Constitutive {beta}2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart.
- Y.-Y. Zhou, L.-S. Song, E. G Lakatta, R.-P. Xiao, and H. Cheng (1999)
J. Physiol.
521, 351-361
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- Ca2+ Release Mechanisms, Ca2+ Sparks, and Local Control of Excitation-Contraction Coupling in Normal Heart Muscle.
- W. G. Wier and C. W. Balke (1999)
Circ. Res.
85, 770-776
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- Excitation-contraction coupling in rat ventricular myocytes after formamide-induced detubulation.
- M. Kawai, M. Hussain, and C. H. Orchard (1999)
Am J Physiol Heart Circ Physiol
277, H603-H609
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- Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes.
- J. H B Bridge, P. R Ershler, and M. B Cannell (1999)
J. Physiol.
518, 469-478
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- Sodium/Calcium Exchange: Its Physiological Implications.
- M. P. Blaustein and W. J. Lederer (1999)
Physiol Rev
79, 763-854
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- Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias.
- E. Carmeliet (1999)
Physiol Rev
79, 917-1017
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- Calcium-Induced Calcium Release Contributes to Action Potential-Evoked Calcium Transients in Hippocampal CA1 Pyramidal Neurons.
- V. M. Sandler and J.-G. Barbara (1999)
J. Neurosci.
19, 4325-4336
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- Effects of IKr and IKs Heterogeneity on Action Potential Duration and Its Rate Dependence : A Simulation Study.
- P. C. Viswanathan, R. M. Shaw, and Y. Rudy (1999)
Circulation
99, 2466-2474
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- Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release.
- D. M Bers and E. Perez-Reyes (1999)
Cardiovasc Res
42, 339-360
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- Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes.
- M. L. Collier, A. P Thomas, and J. R Berlin (1999)
J. Physiol.
516, 117-128
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- Cellular Mechanisms of Altered Contractility in the Hypertrophied Heart : Big Hearts, Big Sparks.
- S. R. Shorofsky, R. Aggarwal, M. Corretti, J. M. Baffa, J. M. Strum, B. A. Al-Seikhan, Y. M. Kobayashi, L. R. Jones, W. G. Wier, and C. W. Balke (1999)
Circ. Res.
84, 424-434
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- Local Control Models of Cardiac Excitation-Contraction Coupling: A Possible Role for Allosteric Interactions between Ryanodine Receptors.
- M. D. Stern, L.-S. Song, H. Cheng, J. S.K. Sham, H. T. Yang, K. R. Boheler, and E. Rios (1999)
J. Gen. Physiol.
113, 469-489
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