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Science 19 May 1995:
Vol. 268. no. 5213, pp. 1039 - 1041
DOI: 10.1126/science.7754382
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Articles

Science, Vol 268, Issue 5213, 1039-1041
Copyright © 1995 by American Association for the Advancement of Science

articles

Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein

HL Monaco, M Rizzi, and A Coda

Department of Genetics, University of Pavia, Italy.

The three-dimensional structure of the complex formed by two plasma proteins, transthyretin and retinol-binding protein, was determined from x-ray diffraction data to a nominal resolution of 3.1 angstroms. One tetramer of transthyretin was bound to two molecules of retinol-binding protein. The two retinol-binding protein molecules established molecular interactions with the same transthyretin dimer, and each also made contacts with one of the other two monomers. Thus, the other two potential binding sites in a transthyretin tetramer were blocked. The amino acid residues of the retinol-binding protein that were involved in the contacts were close to the retinol-binding site.


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