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Science 19 May 1995:
Vol. 268. no. 5213, pp. 1036 - 1039
DOI: 10.1126/science.7754381
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Articles

Science, Vol 268, Issue 5213, 1036-1039
Copyright © 1995 by American Association for the Advancement of Science

articles

Requirement of a small cytoplasmic RNA for the establishment of thermotolerance

PA Fung, J Gaertig, MA Gorovsky, and RL Hallberg

Department of Biology, Syracuse University, NY 13244, USA.

Thermotolerance is an inducible state that endows cells with an enhanced resistance to thermal killing. Heat shock proteins are believed, and in a few instances have been shown, to be the agents conferring this resistance. The role of a small cytoplasmic RNA (G8 RNA) in developing thermotolerance in Tetrahymena thermophila was investigated by creating a strain devoid of all functional G8 genes. These G8 null cells mounted an apparently normal heat shock response, but they were unable to establish thermotolerance.


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