Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 12 May 1995:
Vol. 268. no. 5212, pp. 877 - 880
DOI: 10.1126/science.7754372

Articles

Science, Vol 268, Issue 5212, 877-880
Copyright © 1995 by American Association for the Advancement of Science


articles

Gene trap tagging of PROLIFERA, an essential MCM2-3-5-like gene in Arabidopsis

PS Springer, WR McCombie, V Sundaresan, and RA Martienssen

Cold Spring Harbor Laboratory, NY 11724, USA.

Gene trap transposon mutagenesis can identify essential genes whose functions in later development are obscured by an early lethal phenotype. In higher plants, many genes are required for haploid gametophyte viability, so that the phenotypic effects of their disruption cannot be readily observed in the diploid plant body. The PROLIFERA (PRL) gene, identified by gene trap transposon mutagenesis in Arabidopsis, is required for megaga-metophyte and embryo development. Reporter gene expression patterns revealed that PRL was expressed in dividing cells throughout the plant. PRL is related to the MCM2-3-5 family of yeast genes that are required for the initiation of DNA replication.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
SLOW WALKER2, a NOC1/MAK21 Homologue, Is Essential for Coordinated Cell Cycle Progression during Female Gametophyte Development in Arabidopsis.
N. Li, L. Yuan, N. Liu, D. Shi, X. Li, Z. Tang, J. Liu, V. Sundaresan, and W.-C. Yang (2009)
Plant Physiology 151, 1486-1497
   Abstract »    Full Text »    PDF »
Dynamic Localization of the DNA Replication Proteins MCM5 and MCM7 in Plants.
R. W. Shultz, T.-J. Lee, G. C. Allen, W. F. Thompson, and L. Hanley-Bowdoin (2009)
Plant Physiology 150, 658-669
   Abstract »    Full Text »    PDF »
Positive regulation of minichromosome maintenance gene expression, DNA replication, and cell transformation by a plant retinoblastoma gene.
P. A. Sabelli, G. Hoerster, L. E. Lizarraga, S. W. Brown, W. J. Gordon-Kamm, and B. A. Larkins (2009)
PNAS 106, 4042-4047
   Abstract »    Full Text »    PDF »
The Maternal to Zygotic Transition in Animals and Plants.
C. Baroux, D. Autran, C.S. Gillmor, D. Grimanelli, and U. Grossniklaus (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Meiotic and Mitotic Cell Cycle Mutants Involved in Gametophyte Development in Arabidopsis.
J. Liu and L.-J. Qu (2008)
Mol Plant 1, 564-574
   Abstract »    Full Text »    PDF »
A Strong Nucleotypic Effect on the Cell Cycle Regardless of Ploidy Level.
D. Francis, M. S. Davies, and P. W. Barlow (2008)
Ann. Bot. 101, 747-757
   Abstract »    Full Text »    PDF »
A GUS/Luciferase Fusion Reporter for Plant Gene Trapping and for Assay of Promoter Activity with Luciferin-Dependent Control of the Reporter Protein Stability.
J. Koo, Y. Kim, J. Kim, M. Yeom, I. C. Lee, and H. G. Nam (2007)
Plant Cell Physiol. 48, 1121-1131
   Abstract »    Full Text »    PDF »
Genome-Wide Analysis of the Core DNA Replication Machinery in the Higher Plants Arabidopsis and Rice.
R. W. Shultz, V. M. Tatineni, L. Hanley-Bowdoin, and W. F. Thompson (2007)
Plant Physiology 144, 1697-1714
   Abstract »    Full Text »    PDF »
Genetic and Epigenetic Regulation of Embryogenesis.
N. A. Eckardt (2006)
PLANT CELL 18, 781-784
   Full Text »    PDF »
Arabidopsis GLUTAMINE-RICH PROTEIN23 Is Essential for Early Embryogenesis and Encodes a Novel Nuclear PPR Motif Protein That Interacts with RNA Polymerase II Subunit III.
Y.-H. Ding, N.-Y. Liu, Z.-S. Tang, J. Liu, and W.-C. Yang (2006)
PLANT CELL 18, 815-830
   Abstract »    Full Text »    PDF »
The Fertilization-Induced DNA Replication Factor MCM6 of Maize Shuttles between Cytoplasm and Nucleus, and Is Essential for Plant Growth and Development.
T. Dresselhaus, K.-o. Srilunchang, D. Leljak-Levanic, D. N. Schreiber, and P. Garg (2006)
Plant Physiology 140, 512-527
   Abstract »    Full Text »    PDF »
Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis.
S. Ryu, J. Holzschuh, S. Erhardt, A.-K. Ettl, and W. Driever (2005)
PNAS 102, 18467-18472
   Abstract »    Full Text »    PDF »
Analysis of the Female Gametophyte Transcriptome of Arabidopsis by Comparative Expression Profiling.
H.-J. Yu, P. Hogan, and V. Sundaresan (2005)
Plant Physiology 139, 1853-1869
   Abstract »    Full Text »    PDF »
SLOW WALKER1, Essential for Gametogenesis in Arabidopsis, Encodes a WD40 Protein Involved in 18S Ribosomal RNA Biogenesis.
D.-Q. Shi, J. Liu, Y.-H. Xiang, D. Ye, V. Sundaresan, and W.-C. Yang (2005)
PLANT CELL 17, 2340-2354
   Abstract »    Full Text »    PDF »
Transcriptional Profile of the Arabidopsis Root Quiescent Center.
T. Nawy, J.-Y. Lee, J. Colinas, J. Y. Wang, S. C. Thongrod, J. E. Malamy, K. Birnbaum, and P. N. Benfey (2005)
PLANT CELL 17, 1908-1925
   Abstract »    Full Text »    PDF »
Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis.
G. C. Pagnussat, H.-J. Yu, Q. A. Ngo, S. Rajani, S. Mayalagu, C. S. Johnson, A. Capron, L.-F. Xie, D. Ye, and V. Sundaresan (2005)
Development 132, 603-614
   Abstract »    Full Text »    PDF »
Large-Scale Mutagenesis of the Yeast Genome Using a Tn7-Derived Multipurpose Transposon.
A. Kumar, M. Seringhaus, M. C. Biery, R. J. Sarnovsky, L. Umansky, S. Piccirillo, M. Heidtman, K.-H. Cheung, C. J. Dobry, M. B. Gerstein, et al. (2004)
Genome Res. 14, 1975-1986
   Abstract »    Full Text »    PDF »
A Classical Arabinogalactan Protein Is Essential for the Initiation of Female Gametogenesis in Arabidopsis.
G. Acosta-Garcia and J.-P. Vielle-Calzada (2004)
PLANT CELL 16, 2614-2628
   Abstract »    Full Text »    PDF »
mRNA deadenylation by PARN is essential for embryogenesis in higher plants.
S. V. REVERDATTO, J. A. DUTKO, J. A. CHEKANOVA, D. A. HAMILTON, and D. A. BELOSTOTSKY (2004)
RNA 10, 1200-1214
   Abstract »    Full Text »    PDF »
The ABNORMAL GAMETOPHYTES (AGM) Gene Product of Arabidopsis Demonstrates a Role in Mitosis During Gamete Development.
A.-M. Sorensen, S. Kroeber, and H. Saedler (2004)
Plant Cell Physiol. 45, 905-913
   Abstract »    Full Text »    PDF »
Female Gametophyte Development.
R. Yadegari and G. N. Drews (2004)
PLANT CELL 16, S133-S141
   Full Text »    PDF »
Genetic Regulation of Embryonic Pattern Formation.
T. Laux, T. Wurschum, and H. Breuninger (2004)
PLANT CELL 16, S190-S202
   Full Text »    PDF »
Gene and Enhancer Trap Tagging of Vascular-Expressed Genes in Poplar Trees.
A. Groover, J. R. Fontana, G. Dupper, C. Ma, R. Martienssen, S. Strauss, and R. Meilan (2004)
Plant Physiology 134, 1742-1751
   Abstract »    Full Text »    PDF »
Eukaryotic MCM Proteins: Beyond Replication Initiation.
S. L. Forsburg (2004)
Microbiol. Mol. Biol. Rev. 68, 109-131
   Abstract »    Full Text »    PDF »
Plant DNA helicases: the long unwinding road.
N. Tuteja (2003)
J. Exp. Bot. 54, 2201-2214
   Abstract »    Full Text »    PDF »
The Arabidopsis LATERAL ORGAN BOUNDARIES-Domain Gene ASYMMETRIC LEAVES2 Functions in the Repression of KNOX Gene Expression and in Adaxial-Abaxial Patterning.
W.-c. Lin, B. Shuai, and P. S. Springer (2003)
PLANT CELL 15, 2241-2252
   Abstract »    Full Text »    PDF »
Phyllotactic pattern and stem cell fate are determined by the Arabidopsis homeobox gene BELLRINGER.
M. E. Byrne, A. T. Groover, J. R. Fontana, and R. A. Martienssen (2003)
Development 130, 3941-3950
   Abstract »    Full Text »    PDF »
Secretion Trap Tagging of Secreted and Membrane-Spanning Proteins Using Arabidopsis Gene Traps.
A. T. Groover, J. R. Fontana, J. M. Arroyo, C. Yordan, W. R. McCombie, and R. A. Martienssen (2003)
Plant Physiology 132, 698-708
   Abstract »    Full Text »    PDF »
AtSig5 Is an Essential Nucleus-Encoded Arabidopsis {sigma}-Like Factor.
J. Yao, S. Roy-Chowdhury, and L. A. Allison (2003)
Plant Physiology 132, 739-747
   Abstract »    Full Text »    PDF »
ASYMMETRIC LEAVES1 reveals knox gene redundancy in Arabidopsis.
M. E. Byrne, J. Simorowski, and R. A. Martienssen (2003)
Development 129, 1957-1965
   Abstract »    Full Text »    PDF »
Agrobacterium-Mediated Plant Transformation: the Biology behind the "Gene-Jockeying" Tool.
S. B. Gelvin (2003)
Microbiol. Mol. Biol. Rev. 67, 16-37
   Abstract »    Full Text »    PDF »
Comparative Transcriptional Profiling of Placenta and Endosperm in Developing Maize Kernels in Response to Water Deficit.
L.-X. Yu and T. L. Setter (2003)
Plant Physiology 131, 568-582
   Abstract »    Full Text »    PDF »
Isolation of GUS marker lines for genes expressed in Arabidopsis endosperm, embryo and maternal tissues.
B. Stangeland, Z. Salehian, R. Aalen, A. Mandal, and O.-A. Olsen (2003)
J. Exp. Bot. 54, 279-290
   Abstract »    Full Text »    PDF »
Embryo and Endosperm Development Is Disrupted in the Female Gametophytic capulet Mutants of Arabidopsis.
P. E. Grini, G. Jurgens, and M. Hulskamp (2002)
Genetics 162, 1911-1925
   Abstract »    Full Text »    PDF »
The Lateral Organ Boundaries Gene Defines a Novel, Plant-Specific Gene Family.
B. Shuai, C. G. Reynaga-Pena, and P. S. Springer (2002)
Plant Physiology 129, 747-761
   Abstract »    Full Text »    PDF »
Insertional Mutagenesis of Genes Required for Seed Development in Arabidopsis thaliana.
J. McElver, I. Tzafrir, G. Aux, R. Rogers, C. Ashby, K. Smith, C. Thomas, A. Schetter, Q. Zhou, M. A. Cushman, et al. (2001)
Genetics 159, 1751-1763
   Abstract »    Full Text »    PDF »
High-Resolution Metabolic Phenotyping of Genetically and Environmentally Diverse Potato Tuber Systems. Identification of Phenocopies.
U. Roessner, L. Willmitzer, and A. R. Fernie (2001)
Plant Physiology 127, 749-764
   Abstract »    Full Text »    PDF »
The Arabidopsis Dual-Affinity Nitrate Transporter Gene AtNRT1.1 (CHL1) Is Activated and Functions in Nascent Organ Development during Vegetative and Reproductive Growth.
F.-Q. Guo, R. Wang, M. Chen, and N. M. Crawford (2001)
PLANT CELL 13, 1761-1777
   Abstract »    Full Text »    PDF »
Networking Senescence-Regulating Pathways by Using Arabidopsis Enhancer Trap Lines.
Y. He, W. Tang, J. D. Swain, A. L. Green, T. P. Jack, and S. Gan (2001)
Plant Physiology 126, 707-716
   Abstract »    Full Text »    PDF »
Origins and complexes: the initiation of DNA replication.
J. A. Bryant, K. Moore, and S. J. Aves (2001)
J. Exp. Bot. 52, 193-202
   Abstract »    Full Text »    PDF »
Gene Traps: Tools for Plant Development and Genomics.
P. S. Springer (2000)
PLANT CELL 12, 1007-1020
   Abstract »    Full Text »
From the Cover: Insights into DNA replication from the third domain of life.
B. K. Tye (2000)
PNAS 97, 2399-2401
   Full Text »    PDF »
The essential Mcm7 protein PROLIFERA is localized to the nucleus of dividing cells during the G(1) phase and is required maternally for early Arabidopsis development.
P. Springer, D. Holding, A Groover, C Yordan, and R. Martienssen (2000)
Development 127, 1815-1822
   Abstract »    PDF »
The dyad gene is required for progression through female meiosis in Arabidopsis.
I Siddiqi, G Ganesh, U Grossniklaus, and V Subbiah (2000)
Development 127, 197-207
   Abstract »    PDF »
Transposon Tagging of the Sulfur Gene of Tobacco Using Engineered Maize Ac/Ds Elements.
W. P. Fitzmaurice, L. V. Nguyen, E. A. Wernsman, W. F. Thompson, and M. A. Conkling (1999)
Genetics 153, 1919-1928
   Abstract »    Full Text »
Cyclin-Dependent Kinases and Cell Division in Plants— The Nexus.
V. Mironov, L. De Veylder, M. Van Montagu, and D. Inzé (1999)
PLANT CELL 11, 509-522
   Full Text »
Isolation of Ethyl Methanesulfonate-Induced Gametophytic Mutants in Arabidopsis thaliana by a Segregation Distortion Assay Using the Multimarker Chromosome 1.
P. E. Grini, A. Schnittger, H. Schwarz, I. Zimmermann, B. Schwab, G. Jürgens, and M. Hülskamp (1999)
Genetics 151, 849-863
   Abstract »    Full Text »
A Chloroplast DNA Helicase II from Pea That Prefers Fork-Like Replication Structures.
N. Tuteja and T.-N. Phan (1998)
Plant Physiology 118, 1029-1038
   Abstract »    Full Text »
Axonal Injury Alters Alternative Splicing of the Retinal NR1 Receptor: the Preferential Expression of the NR1b Isoforms Is Crucial for Retinal Ganglion Cell Survival.
M. R. Kreutz, T. M. Bockers, J. Bockmann, C. I. Seidenbecher, B. Kracht, C. K. Vorwerk, J. Weise, and B. A. Sabel (1998)
J. Neurosci. 18, 8278-8291
   Abstract »    Full Text »    PDF »
Selection of T-DNA-Tagged Male and Female Gametophytic Mutants by Segregation Distortion in Arabidopsis.
R. Howden, S. K. Park, J. M. Moore, J. Orme, U. Grossniklaus, and D. Twell (1998)
Genetics 149, 621-631
   Abstract »    Full Text »    PDF »
Maternal Control of Embryogenesis by MEDEA, a Polycomb Group Gene in Arabidopsis.
U. Grossniklaus, J. Vielle-Calzada, M. A. Hoeppner, and W. B. Gagliano (1998)
Science 280, 446-450
   Abstract »    Full Text »
Functional genomics: Probing plant gene function and expression with transposons.
R. A. Martienssen (1998)
PNAS 95, 2021-2026
   Abstract »    Full Text »    PDF »
An Embryo-Defective Mutant of Arabidopsis Disrupted in the Final Step of Biotin Synthesis.
D. A. Patton, A. L. Schetter, L. H. Franzmann, K. Nelson, E. R. Ward, and D. W. Meinke (1998)
Plant Physiology 116, 935-946
   Abstract »    Full Text »
Capturing novel mouse genes encoding chromosomal and other nuclear proteins.
P Tate, M Lee, S Tweedie, W. Skarnes, and W. Bickmore (1998)
J. Cell Sci. 111, 2575-2585
   Abstract »    PDF »
The FRUITFULL MADS-box gene mediates cell differentiation during Arabidopsis fruit development.
Q Gu, C Ferrandiz, M. Yanofsky, and R Martienssen (1998)
Development 125, 1509-1517
   Abstract »    PDF »
Genetic Analysis of Female Gametophyte Development and Function.
G. N. Drews, D. Lee, and C. A. Christensen (1998)
PLANT CELL 10, 5-18
   Abstract »    Full Text »
Efficient gene tagging in Arabidopsis thaliana using a gene trap approach.
E. Babiychuk, M. Fuangthong, M. Van Montagu, D. Inze, and S. Kushnir (1997)
PNAS 94, 12722-12727
   Abstract »    Full Text »    PDF »
Characterization of the transposition pattern of the Ac element in Arabidopsis thaliana using endonuclease I-SceI.
C. Machida, H. Onouchi, J. Koizumi, S. Hamada, E. Semiarti, S. Torikai, and Y. Machida (1997)
PNAS 94, 8675-8680
   Abstract »    Full Text »    PDF »
In Vivo Interaction of Human MCM Heterohexameric Complexes with Chromatin. POSSIBLE INVOLVEMENT OF ATP.
M. Fujita, T. Kiyono, Y. Hayashi, and M. Ishibashi (1997)
J. Biol. Chem. 272, 10928-10935
   Abstract »    Full Text »    PDF »
A leucine-rich repeat containing receptor-like kinase marks somatic plant cells competent to form embryos.
E. Schmidt, F Guzzo, M. Toonen, and S. de Vries (1997)
Development 124, 2049-2062
   Abstract »    PDF »
Genetic Characterization of hadad, a Mutant Disrupting Female Gametogenesis in Arabidopsis thaliana.
J.M. Moore, J.-P. Vielle Calzada, W. Gagliano, and U. Grossniklaus (1997)
Cold Spring Harb Symp Quant Biol 62, 35-47
   Abstract »    PDF »
hCDC47, a Human Member of the MCM Family.
M. Fujita, T. Kiyono, Y. Hayashi, and M. Ishibashi (1996)
J. Biol. Chem. 271, 4349-4354
   Abstract »    Full Text »    PDF »
sidecar pollen, an Arabidopsis thaliana male gametophytic mutant with aberrant cell divisions during pollen development.
Y. Chen and S McCormick (1996)
Development 122, 3243-3253
   Abstract »    PDF »
Physical Map and Organization of Arabidopsis thaliana Chromosome 4.
R. Schmidt, J. West, K. Love, Z. Lenehan, C. Lister, H. Thompson, D. Bouchez, and C. Dean (1995)
Science 270, 480-483
   Abstract »    PDF »
Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements..
V Sundaresan, P Springer, T Volpe, S Haward, J D Jones, C Dean, H Ma, and R Martienssen (1995)
Genes & Dev. 9, 1797-1810
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)