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Science 12 May 1995:
Vol. 268. no. 5212, pp. 866 - 869
DOI: 10.1126/science.7754369
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Articles

Science, Vol 268, Issue 5212, 866-869
Copyright © 1995 by American Association for the Advancement of Science

articles

Identification and characterization of a prostaglandin transporter

N Kanai, R Lu, JA Satriano, Y Bao, AW Wolkoff, and VL Schuster

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.


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R. J. Coffey, C. J. Hawkey, L. Damstrup, R. Graves-Deal, V. C. Daniel, P. J. Dempsey, R. Chinery, S. C. Kirkland, R. N. DuBois, T. L. Jetton, et al. (1997)
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