Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 May 1995:
Vol. 268. no. 5212, pp. 863 - 865
DOI: 10.1126/science.7538697

Articles

Science, Vol 268, Issue 5212, 863-865
Copyright © 1995 by American Association for the Advancement of Science


articles

CD1 recognition by mouse NK1+ T lymphocytes

A Bendelac, O Lantz, ME Quimby, JW Yewdell, Bennink JR, and RR Brutkiewicz

Department of Molecular Biology, Princeton University, NJ 08544, USA.

Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
NKT-cell help to B lymphocytes can occur independently of cognate interaction.
E. Tonti, G. Galli, C. Malzone, S. Abrignani, G. Casorati, and P. Dellabona (2009)
Blood 113, 370-376
   Abstract »    Full Text »    PDF »
Vesicular Stomatitis Virus Matrix Protein Impairs CD1d-Mediated Antigen Presentation through Activation of the p38 MAPK Pathway.
G. J. Renukaradhya, M. A. Khan, D. Shaji, and R. R. Brutkiewicz (2008)
J. Virol. 82, 12535-12542
   Abstract »    Full Text »    PDF »
Natural killer T-cell autoreactivity leads to a specialized activation state.
X. Wang, X. Chen, L. Rodenkirch, W. Simonson, S. Wernimont, R. M. Ndonye, N. Veerapen, D. Gibson, A. R. Howell, G. S. Besra, et al. (2008)
Blood 112, 4128-4138
   Abstract »    Full Text »    PDF »
Type I NKT cells protect (and type II NKT cells suppress) the host's innate antitumor immune response to a B-cell lymphoma.
G. J. Renukaradhya, M. A. Khan, M. Vieira, W. Du, J. Gervay-Hague, and R. R. Brutkiewicz (2008)
Blood 111, 5637-5645
   Abstract »    Full Text »    PDF »
NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis.
J. A. Berzofsky and M. Terabe (2008)
J. Immunol. 180, 3627-3635
   Abstract »    Full Text »    PDF »
A Critical Role of Costimulation during Intrathymic Development of Invariant NK T Cells.
Y. Chung, R. Nurieva, E. Esashi, Y.-H. Wang, D. Zhou, L. Gapin, and C. Dong (2008)
J. Immunol. 180, 2276-2283
   Abstract »    Full Text »    PDF »
Protective Role for CD1d-Reactive Invariant Natural Killer T Cells in Cauterization-Induced Corneal Inflammation.
T. Oshima, K.-H. Sonoda, S. Nakao, K. Hijioka, M. Taniguchi, and T. Ishibashi (2008)
Invest. Ophthalmol. Vis. Sci. 49, 105-112
   Abstract »    Full Text »    PDF »
T-Cell-Independent Humoral Immunity Is Sufficient for Protection against Fatal Intracellular Ehrlichia Infection.
C. Bitsaktsis, B. Nandi, R. Racine, K. C. MacNamara, and G. Winslow (2007)
Infect. Immun. 75, 4933-4941
   Abstract »    Full Text »    PDF »
NKT Cell-Derived Urokinase-Type Plasminogen Activator Promotes Peripheral Tolerance Associated with Eye.
K.-H. Sonoda, T. Nakamura, H. A. Young, D. Hart, P. Carmeliet, and J. Stein-Streilein (2007)
J. Immunol. 179, 2215-2222
   Abstract »    Full Text »    PDF »
A Single Early Activation of Invariant NK T Cells Confers Long-Term Protection against Collagen-Induced Arthritis in a Ligand-Specific Manner.
K. Coppieters, K. Van Beneden, P. Jacques, P. Dewint, A. Vervloet, B. Vander Cruyssen, S. Van Calenbergh, G. Chen, R. W. Franck, G. Verbruggen, et al. (2007)
J. Immunol. 179, 2300-2309
   Abstract »    Full Text »    PDF »
CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells.
A. Thedrez, C. de Lalla, S. Allain, L. Zaccagnino, S. Sidobre, C. Garavaglia, G. Borsellino, P. Dellabona, M. Bonneville, E. Scotet, et al. (2007)
Blood 110, 251-258
   Abstract »    Full Text »    PDF »
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d.
Y. Sagiv, L. Bai, D. G. Wei, R. Agami, P. B. Savage, L. Teyton, and A. Bendelac (2007)
J. Exp. Med. 204, 921-928
   Abstract »    Full Text »    PDF »
NKT cells: manipulable managers of joint inflammation.
K. Coppieters, P. Dewint, K. Van Beneden, P. Jacques, S. Seeuws, G. Verbruggen, D. Deforce, and D. Elewaut (2007)
Rheumatology 46, 565-571
   Abstract »    Full Text »    PDF »
MTP regulated by an alternate promoter is essential for NKT cell development.
S. K. Dougan, P. Rava, M. M. Hussain, and R. S. Blumberg (2007)
J. Exp. Med. 204, 533-545
   Abstract »    Full Text »    PDF »
CD1d Degradation in Chlamydia trachomatis-infected Epithelial Cells Is the Result of Both Cellular and Chlamydial Proteasomal Activity.
K. Kawana, A. J. Quayle, M. Ficarra, J. A. Ibana, L. Shen, Y. Kawana, H. Yang, L. Marrero, S. Yavagal, S. J. Greene, et al. (2007)
J. Biol. Chem. 282, 7368-7375
   Abstract »    Full Text »    PDF »
Invariant NKT cells sustain specific B cell responses and memory.
G. Galli, P. Pittoni, E. Tonti, C. Malzone, Y. Uematsu, M. Tortoli, D. Maione, G. Volpini, O. Finco, S. Nuti, et al. (2007)
PNAS 104, 3984-3989
   Abstract »    Full Text »    PDF »
Characterization of the Natural Killer T-Cell Response in an Adoptive Transfer Model of Atherosclerosis.
P. A. VanderLaan, C. A. Reardon, Y. Sagiv, L. Blachowicz, J. Lukens, M. Nissenbaum, C.-R. Wang, and G. S. Getz (2007)
Am. J. Pathol. 170, 1100-1107
   Abstract »    Full Text »    PDF »
Prevention of Type 1 Diabetes by Invariant NKT Cells Is Independent of Peripheral CD1d Expression.
J. Novak, L. Beaudoin, S. Park, T. Griseri, L. Teyton, A. Bendelac, and A. Lehuen (2007)
J. Immunol. 178, 1332-1340
   Abstract »    Full Text »    PDF »
Sensitivity of NK1.1-Negative NKT Cells to Transgenic BATF Defines a Role for Activator Protein-1 in the Expansion and Maturation of Immature NKT Cells in the Thymus.
A. J. Zullo, K. Benlagha, A. Bendelac, and E. J. Taparowsky (2007)
J. Immunol. 178, 58-66
   Abstract »    Full Text »    PDF »
Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms.
P. S. Joshi, J.-Q. Liu, Y. Wang, X. Chang, J. Richards, E. Assarsson, F.-D. Shi, H.-G. Ljunggren, and X.-F. Bai (2006)
J. Leukoc. Biol. 80, 1345-1353
   Abstract »    Full Text »    PDF »
CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo.
P. O. Ilyinskii, R. Wang, S. P. Balk, and M. A. Exley (2006)
J. Virol. 80, 7146-7158
   Abstract »    Full Text »    PDF »
Cutting Edge: Impaired Glycosphingolipid Trafficking and NKT Cell Development in Mice Lacking Niemann-Pick Type C1 Protein.
Y. Sagiv, K. Hudspeth, J. Mattner, N. Schrantz, R. K. Stern, D. Zhou, P. B. Savage, L. Teyton, and A. Bendelac (2006)
J. Immunol. 177, 26-30
   Abstract »    Full Text »    PDF »
Comparative gene expression analysis of NKT cell subpopulations.
H. Lin, M. Nieda, J. F. Hutton, V. Rozenkov, and A. J. Nicol (2006)
J. Leukoc. Biol. 80, 164-173
   Abstract »    Full Text »    PDF »
CD44 Differentially Activates Mouse NK T Cells and Conventional T Cells.
J. Larkin, G. J. Renukaradhya, V. Sriram, W. Du, J. Gervay-Hague, and R. R. Brutkiewicz (2006)
J. Immunol. 177, 268-279
   Abstract »    Full Text »    PDF »
T-cell recognition of glycolipids presented by CD1 proteins.
D. C. Young and D. B. Moody (2006)
Glycobiology 16, 103R-112R
   Abstract »    Full Text »    PDF »
Dual function for the adaptor MIST in IFN-{gamma} production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
H. Sasanuma, A. Tatsuno, S. Hidano, K. Ohshima, Y. Matsuzaki, K. Hayashi, C. A. Lowell, D. Kitamura, and R. Goitsuka (2006)
Blood 107, 3647-3655
   Abstract »    Full Text »    PDF »
DOCK2 Is Required in T Cell Precursors for Development of V{alpha}14 NK T Cells..
Y. Kunisaki, Y. Tanaka, T. Sanui, A. Inayoshi, M. Noda, T. Nakayama, M. Harada, M. Taniguchi, T. Sasazuki, and Y. Fukui (2006)
J. Immunol. 176, 4640-4645
   Abstract »    Full Text »    PDF »
Long-Term Retention of Mature NK1.1+ NKT Cells in the Thymus.
S. P. Berzins, F. W. McNab, C. M. Jones, M. J. Smyth, and D. I. Godfrey (2006)
J. Immunol. 176, 4059-4065
   Abstract »    Full Text »    PDF »
Regulation of immune responses by T cells..
H. Jiang and L. Chess (2006)
N. Engl. J. Med. 354, 1166-1176
   Full Text »    PDF »
Sexual Dimorphism in the Control of Amebic Liver Abscess in a Mouse Model of Disease.
H. Lotter, T. Jacobs, I. Gaworski, and E. Tannich (2006)
Infect. Immun. 74, 118-124
   Abstract »    Full Text »    PDF »
Natural Killer T-Cells Participate in Rejection of Islet Allografts in the Liver of Mice.
A. Toyofuku, Y. Yasunami, K. Nabeyama, M. Nakano, M. Satoh, N. Matsuoka, J. Ono, T. Nakayama, M. Taniguchi, M. Tanaka, et al. (2006)
Diabetes 55, 34-39
   Abstract »    Full Text »    PDF »
Transforming Growth Factor-{beta} and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes.
M.-A. Alyanakian, F. Grela, A. Aumeunier, C. Chiavaroli, C. Gouarin, E. Bardel, G. Normier, L. Chatenoud, N. Thieblemont, and J.-F. Bach (2006)
Diabetes 55, 179-185
   Abstract »    Full Text »    PDF »
CD1a-, b-, and c-Restricted TCRs Recognize Both Self and Foreign Antigens.
M. S. Vincent, X. Xiong, E. P. Grant, W. Peng, and M. B. Brenner (2005)
J. Immunol. 175, 6344-6351
   Abstract »    Full Text »    PDF »
Lyme Arthritis Synovial {gamma}{delta} T Cells Instruct Dendritic Cells via Fas Ligand.
C. Collins, J. Wolfe, K. Roessner, C. Shi, L. H. Sigal, and R. C. Budd (2005)
J. Immunol. 175, 5656-5665
   Abstract »    Full Text »    PDF »
Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK.
G. J. Renukaradhya, T. J. R. Webb, M. A. Khan, Y. L. Lin, W. Du, J. Gervay-Hague, and R. R. Brutkiewicz (2005)
J. Immunol. 175, 4301-4308
   Abstract »    Full Text »    PDF »
Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT Cells.
S. C. Kent, Y. Chen, S. M. Clemmings, V. Viglietta, N. S. Kenyon, C. Ricordi, B. Hering, and D. A. Hafler (2005)
J. Immunol. 175, 4458-4464
   Abstract »    Full Text »    PDF »
Protective conditioning for acute graft-versus-host disease..
R. Lowsky, T. Takahashi, Y. P. Liu, S. Dejbakhsh-Jones, F. C. Grumet, J. A. Shizuru, G. G. Laport, K. E. Stockerl-Goldstein, L. J. Johnston, R. T. Hoppe, et al. (2005)
N. Engl. J. Med. 353, 1321-1331
   Abstract »    Full Text »    PDF »
Interplay of Cytokines and Microbial Signals in Regulation of CD1d Expression and NKT Cell Activation.
M. Skold, X. Xiong, P. A. Illarionov, G. S. Besra, and S. M. Behar (2005)
J. Immunol. 175, 3584-3593
   Abstract »    Full Text »    PDF »
Induction of Regulatory Properties in Dendritic Cells by V{alpha}14 NKT Cells.
S. Kojo, K.-i. Seino, M. Harada, H. Watarai, H. Wakao, T. Uchida, T. Nakayama, and M. Taniguchi (2005)
J. Immunol. 175, 3648-3655
   Abstract »    Full Text »    PDF »
The Influence of CD1d in Postselection NKT Cell Maturation and Homeostasis.
F. W. McNab, S. P. Berzins, D. G. Pellicci, K. Kyparissoudis, K. Field, M. J. Smyth, and D. I. Godfrey (2005)
J. Immunol. 175, 3762-3768
   Abstract »    Full Text »    PDF »
NK T Cell Activation Promotes Chlamydia trachomatis Infection In Vivo.
L. Bilenki, S. Wang, J. Yang, Y. Fan, A. G. Joyee, and X. Yang (2005)
J. Immunol. 175, 3197-3206
   Abstract »    Full Text »    PDF »
Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells.
S. K. Dougan, A. Salas, P. Rava, A. Agyemang, A. Kaser, J. Morrison, A. Khurana, M. Kronenberg, C. Johnson, M. Exley, et al. (2005)
J. Exp. Med. 202, 529-539
   Abstract »    Full Text »    PDF »
Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.
D. G. Wei, H. Lee, S.-H. Park, L. Beaudoin, L. Teyton, A. Lehuen, and A. Bendelac (2005)
J. Exp. Med. 202, 239-248
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of CD1D1 by Ets Family Transcription Factors.
Y. Geng, P. Laslo, K. Barton, and C.-R. Wang (2005)
J. Immunol. 175, 1022-1029
   Abstract »    Full Text »    PDF »
{alpha}-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation.
H. Matsuda, T. Suda, J. Sato, T. Nagata, Y. Koide, K. Chida, and H. Nakamura (2005)
Am. J. Respir. Cell Mol. Biol. 33, 22-31
   Abstract »    Full Text »    PDF »
Exacerbated Susceptibility to Infection-Stimulated Immunopathology in CD1d-Deficient Mice.
S. T. Smiley, P. A. Lanthier, K. N. Couper, F. M. Szaba, J. E. Boyson, W. Chen, and L. L. Johnson (2005)
J. Immunol. 174, 7904-7911
   Abstract »    Full Text »    PDF »
Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells.
S. Huang, S. Gilfillan, M. Cella, M. J. Miley, O. Lantz, L. Lybarger, D. H. Fremont, and T. H. Hansen (2005)
J. Biol. Chem. 280, 21183-21193
   Abstract »    Full Text »    PDF »
Coevolution of TCR-MHC interactions: Conserved MHC tertiary structure is not sufficient for interactions with the TCR.
H.-J. Kim, D. Guo, and D. B. Sant'Angelo (2005)
PNAS 102, 7263-7267
   Abstract »    Full Text »    PDF »
NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection.
M. S. Duthie and S. J. Kahn (2005)
Int. Immunol. 17, 607-613
   Abstract »    Full Text »    PDF »
Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo.
J. S. Bezbradica, A. K. Stanic, N. Matsuki, H. Bour-Jordan, J. A. Bluestone, J. W. Thomas, D. Unutmaz, L. Van Kaer, and S. Joyce (2005)
J. Immunol. 174, 4696-4705
   Abstract »    Full Text »    PDF »
The Mouse CD1d Cytoplasmic Tail Mediates CD1d Trafficking and Antigen Presentation by Adaptor Protein 3-Dependent and -Independent Mechanisms.
A. P. Lawton, T. I. Prigozy, L. Brossay, B. Pei, A. Khurana, D. Martin, T. Zhu, K. Spate, M. Ozga, S. Honing, et al. (2005)
J. Immunol. 174, 3179-3186
   Abstract »    Full Text »    PDF »
The Human CD1-Restricted T Cell Repertoire Is Limited to Cross-Reactive Antigens: Implications for Host Responses against Immunologically Related Pathogens.
P. A. Sieling, J. B. Torrelles, S. Stenger, W. Chung, A. E. Burdick, T. H. Rea, P. J. Brennan, J. T. Belisle, S. A. Porcelli, and R. L. Modlin (2005)
J. Immunol. 174, 2637-2644
   Abstract »    Full Text »    PDF »
Transient Role for CD1d-Restricted Natural Killer T Cells in the Formation of Atherosclerotic Lesions.
A. M. Aslanian, H. A. Chapman, and I. F. Charo (2005)
Arterioscler. Thromb. Vasc. Biol. 25, 628-632
   Abstract »    Full Text »    PDF »
Inhibition of T Cell Differentiation into Effectors by NKT Cells Requires Cell Contacts.
J. Novak, L. Beaudoin, T. Griseri, and A. Lehuen (2005)
J. Immunol. 174, 1954-1961
   Abstract »    Full Text »    PDF »
Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection.
Y. Lin, T. J. Roberts, P. M. Spence, and R. R. Brutkiewicz (2005)
J. Leukoc. Biol. 77, 151-158
   Abstract »    Full Text »    PDF »
Critical Proinflammatory and Anti-Inflammatory Functions of Different Subsets of CD1d-Restricted Natural Killer T Cells during Trypanosoma cruzi Infection.
M. S. Duthie, M. Kahn, M. White, R. P. Kapur, and S. J. Kahn (2005)
Infect. Immun. 73, 181-192
   Abstract »    Full Text »    PDF »
Prevention of Diabetes in Nonobese Diabetic Mice Mediated by CD1d-Restricted Nonclassical NKT Cells.
N. Duarte, M. Stenstrom, S. Campino, M.-L. Bergman, M. Lundholm, D. Holmberg, and S. L. Cardell (2004)
J. Immunol. 173, 3112-3118
   Abstract »    Full Text »    PDF »
CD1d-restricted "NKT" cells and myeloid IL-12 production: an immunological crossroads leading to promotion or suppression of effective anti-tumor immune responses?.
J. E. Gumperz (2004)
J. Leukoc. Biol. 76, 307-313
   Abstract »    Full Text »    PDF »
Production of Profibrotic Cytokines by Invariant NKT Cells Characterizes Cirrhosis Progression in Chronic Viral Hepatitis.
C. de Lalla, G. Galli, L. Aldrighetti, R. Romeo, M. Mariani, A. Monno, S. Nuti, M. Colombo, F. Callea, S. A. Porcelli, et al. (2004)
J. Immunol. 173, 1417-1425
   Abstract »    Full Text »    PDF »
Up-Regulation of CD1d Expression Restores the Immunoregulatory Function of NKT Cells and Prevents Autoimmune Diabetes in Nonobese Diabetic Mice.
M. Falcone, F. Facciotti, N. Ghidoli, P. Monti, S. Olivieri, L. Zaccagnino, E. Bonifacio, G. Casorati, F. Sanvito, and N. Sarvetnick (2004)
J. Immunol. 172, 5908-5916
   Abstract »    Full Text »    PDF »
NF-{kappa}B Controls Cell Fate Specification, Survival, and Molecular Differentiation of Immunoregulatory Natural T Lymphocytes.
A. K. Stanic, J. S. Bezbradica, J.-J. Park, N. Matsuki, A. L. Mora, L. Van Kaer, M. R. Boothby, and S. Joyce (2004)
J. Immunol. 172, 2265-2273
   Abstract »    Full Text »    PDF »
Down-regulation of the invariant V{alpha}14 antigen receptor in NKT cells upon activation.
M. Harada, K.-i. Seino, H. Wakao, S. Sakata, Y. Ishizuka, T. Ito, S. Kojo, T. Nakayama, and M. Taniguchi (2004)
Int. Immunol. 16, 241-247
   Abstract »    Full Text »    PDF »
Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins.
D. Zhou, C. Cantu III, Y. Sagiv, N. Schrantz, A. B. Kulkarni, X. Qi, D. J. Mahuran, C. R. Morales, G. A. Grabowski, K. Benlagha, et al. (2004)
Science 303, 523-527
   Abstract »    Full Text »    PDF »
NK Cells Respond to Pulmonary Infection with Mycobacterium tuberculosis, but Play a Minimal Role in Protection.
A. P. Junqueira-Kipnis, A. Kipnis, A. Jamieson, M. G. Juarrero, A. Diefenbach, D. H. Raulet, J. Turner, and I. M. Orme (2003)
J. Immunol. 171, 6039-6045
   Abstract »    Full Text »    PDF »
Structural Features of the Acyl Chain Determine Self-phospholipid Antigen Recognition by a CD1d-restricted Invariant NKT (iNKT) Cell.
J. Rauch, J. Gumperz, C. Robinson, M. Skold, C. Roy, D. C. Young, M. Lafleur, D. B. Moody, M. B. Brenner, C. E. Costello, et al. (2003)
J. Biol. Chem. 278, 47508-47515
   Abstract »    Full Text »    PDF »
Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR.
A. K. Stanic, R. Shashidharamurthy, J. S. Bezbradica, N. Matsuki, Y. Yoshimura, S. Miyake, E. Y. Choi, T. D. Schell, L. Van Kaer, S. S. Tevethia, et al. (2003)
J. Immunol. 171, 4539-4551
   Abstract »    Full Text »    PDF »
The Adaptor Protein AP-3 Is Required for CD1d-Mediated Antigen Presentation of Glycosphingolipids and Development of V{alpha}14i NKT Cells.
D. Elewaut, A. P. Lawton, N. A. Nagarajan, E. Maverakis, A. Khurana, S. Honing, C. A. Benedict, E. Sercarz, O. Bakke, M. Kronenberg, et al. (2003)
J. Exp. Med. 198, 1133-1146
   Abstract »    Full Text »    PDF »
Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells.
N. Y. Crowe, A. P. Uldrich, K. Kyparissoudis, K. J. L. Hammond, Y. Hayakawa, S. Sidobre, R. Keating, M. Kronenberg, M. J. Smyth, and D. I. Godfrey (2003)
J. Immunol. 171, 4020-4027
   Abstract »    Full Text »    PDF »
T Cell Development in Mice Expressing CD1d Directed by a Classical MHC Class II Promoter.
C. Forestier, S.-H. Park, D. Wei, K. Benlagha, L. Teyton, and A. Bendelac (2003)
J. Immunol. 171, 4096-4104
   Abstract »    Full Text »    PDF »
Expression of CD1d Under the Control of a MHC Class Ia Promoter Skews the Development of NKT Cells, But Not CD8+ T Cells.
H. Xu, T. Chun, A. Colmone, H. Nguyen, and C.-R. Wang (2003)
J. Immunol. 171, 4105-4112
   Abstract »    Full Text »    PDF »
Repeated {alpha}-Galactosylceramide Administration Results in Expansion of NK T Cells and Alleviates Inflammatory Dermatitis in MRL-lpr/lpr Mice.
J.-Q. Yang, V. Saxena, H. Xu, L. Van Kaer, C.-R. Wang, and R. R. Singh (2003)
J. Immunol. 171, 4439-4446
   Abstract »    Full Text »    PDF »
Role of CD1d-Restricted NKT Cells in Microbial Immunity.
M. Skold and S. M. Behar (2003)
Infect. Immun. 71, 5447-5455
   Full Text »    PDF »
Phenotypic and Functional Characterization of Long-Term Cultured Rhesus Macaque Spleen-Derived NKT Cells.
B. Gansuvd, W. J. Hubbard, A. Hutchings, F. T. Thomas, J. Goodwin, S. B. Wilson, M. A. Exley, and J. M. Thomas (2003)
J. Immunol. 171, 2904-2911
   Abstract »    Full Text »    PDF »
CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site.
T. Nakamura, K.-H. Sonoda, D. E. Faunce, J. Gumperz, T. Yamamura, S. Miyake, and J. Stein-Streilein (2003)
J. Immunol. 171, 1266-1271
   Abstract »    Full Text »    PDF »
Cross-presentation of Disialoganglioside GD3 to Natural Killer T Cells.
D. Y. Wu, N. H. Segal, S. Sidobre, M. Kronenberg, and P. B. Chapman (2003)
J. Exp. Med. 198, 173-181
   Abstract »    Full Text »    PDF »
Differential Requirement for Rel/Nuclear Factor {kappa}B Family Members in Natural Killer T Cell Development.
V. Sivakumar, K. J.L. Hammond, N. Howells, K. Pfeffer, and F. Weih (2003)
J. Exp. Med. 197, 1613-1621
   Abstract »    Full Text »    PDF »
The Paradox of Immune Molecular Recognition of {alpha}-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for {alpha}{beta} TCRs.
C. Cantu III, K. Benlagha, P. B. Savage, A. Bendelac, and L. Teyton (2003)
J. Immunol. 170, 4673-4682
   Abstract »    Full Text »    PDF »
CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells.
T. Chun, M. J. Page, L. Gapin, J. L. Matsuda, H. Xu, H. Nguyen, H.-S. Kang, A. K. Stanic, S. Joyce, W. A. Koltun, et al. (2003)
J. Exp. Med. 197, 907-918
   Abstract »    Full Text »    PDF »
Self Glycosphingolipids: New Antigens Recognized by Autoreactive T Lymphocytes.
G. De Libero and L. Mori (2003)
Physiology 18, 71-76
   Abstract »    Full Text »    PDF »
Human Invariant V{alpha}24-J{alpha}Q TCR Supports the Development of CD1d-Dependent NK1.1+ and NK1.1- T Cells in Transgenic Mice.
M. Capone, D. Cantarella, J. Schumann, O. V. Naidenko, C. Garavaglia, F. Beermann, M. Kronenberg, P. Dellabona, H. R. MacDonald, and G. Casorati (2003)
J. Immunol. 170, 2390-2398
   Abstract »    Full Text »    PDF »
BATF Transgenic Mice Reveal a Role for Activator Protein-1 in NKT Cell Development.
K. L. Williams, A. J. Zullo, M. H. Kaplan, R. R. Brutkiewicz, C. D. Deppmann, C. Vinson, and E. J. Taparowsky (2003)
J. Immunol. 170, 2417-2426
   Abstract »    Full Text »    PDF »
Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta -D-glucosylceramide synthase deficiency.
A. K. Stanic, A. D. De Silva, J.-J. Park, V. Sriram, S. Ichikawa, Y. Hirabyashi, K. Hayakawa, L. Van Kaer, R. R. Brutkiewicz, and S. Joyce (2003)
PNAS 100, 1849-1854
   Abstract »    Full Text »    PDF »
Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant V{alpha}14-J{alpha}281 TCR.
B. Grubor-Bauk, A. Simmons, G. Mayrhofer, and P. G. Speck (2003)
J. Immunol. 170, 1430-1434
   Abstract »    Full Text »    PDF »
Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins from Trypanosoma cruzi Bind to CD1d but Do Not Elicit Dominant Innate or Adaptive Immune Responses Via the CD1d/NKT Cell Pathway.
D. O. Procopio, I. C. Almeida, A. C. T. Torrecilhas, J. E. Cardoso, L. Teyton, L. R. Travassos, A. Bendelac, and R. T. Gazzinelli (2002)
J. Immunol. 169, 3926-3933
   Abstract »    Full Text »    PDF »
NK T Cell Precursors Exhibit Differential Cytokine Regulation and Require Itk for Efficient Maturation.
P. Gadue and P. L. Stein (2002)
J. Immunol. 169, 2397-2406
   Abstract »    Full Text »    PDF »
The V{alpha}14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex.
S. Sidobre, O. V. Naidenko, B.-C. Sim, N. R. J. Gascoigne, K. C. Garcia, and M. Kronenberg (2002)
J. Immunol. 169, 1340-1348
   Abstract »    Full Text »    PDF »
The Homeostasis But Not the Differentiation of T Cells Is Regulated by p27Kip1.
R. Shen and M. H. Kaplan (2002)
J. Immunol. 169, 714-721
   Abstract »    Full Text »    PDF »
Absence of the CD1 Molecule Up-Regulates Antitumor Activity Induced by CpG Oligodeoxynucleotides in Mice.
L. Sfondrini, D. Besusso, M. T. Zoia, M. Rodolfo, A. M. Invernizzi, M. Taniguchi, T. Nakayama, M. P. Colombo, S. Menard, and A. Balsari (2002)
J. Immunol. 169, 151-158
   Abstract »    Full Text »    PDF »
Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor.
E. Aguado, S. Richelme, S. Nunez-Cruz, A. Miazek, A.-M. Mura, M. Richelme, X.-J. Guo, D. Sainty, H.-T. He, B. Malissen, et al. (2002)
Science 296, 2036-2040
   Abstract »    Full Text »    PDF »
Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells.
V. Sriram, S. Cho, P. Li, P. W. O'Donnell, C. Dunn, K. Hayakawa, J. S. Blum, and R. R. Brutkiewicz (2002)
PNAS 99, 8197-8202
   Abstract »    Full Text »    PDF »
Recycling CD1d1 Molecules Present Endogenous Antigens Processed in an Endocytic Compartment to NKT Cells.
T. J. Roberts, V. Sriram, P. M. Spence, M. Gui, K. Hayakawa, I. Bacik, J. R. Bennink, J. W. Yewdell, and R. R. Brutkiewicz (2002)
J. Immunol. 168, 5409-5414
   Abstract »    Full Text »    PDF »
NK T Cells Are a Source of Early Interleukin-4 following Infection with Third-Stage Larvae of the Filarial Nematode Brugia pahangi.
P. Balmer and E. Devaney (2002)
Infect. Immun. 70, 2215-2219
   Abstract »    Full Text »    PDF »
Phenotypic and Functional Differences Between NKT Cells Colonizing Splanchnic and Peripheral Lymph Nodes.
V. Laloux, L. Beaudoin, C. Ronet, and A. Lehuen (2002)
J. Immunol. 168, 3251-3258
   Abstract »    Full Text »    PDF »
Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining.
J. E. Gumperz, S. Miyake, T. Yamamura, and M. B. Brenner (2002)
J. Exp. Med. 195, 625-636
   Abstract »    Full Text »    PDF »
Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT Cells.
K.-H. Sonoda, M. Taniguchi, and J. Stein-Streilein (2002)
J. Immunol. 168, 2028-2034
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)