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Science 12 May 1995: Vol. 268. no. 5212, pp. 863 - 865 DOI: 10.1126/science.7538697
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Articles
Science, Vol 268, Issue 5212, 863-865
Copyright © 1995 by American Association for the Advancement of Science
CD1 recognition by mouse NK1+ T lymphocytes
A Bendelac,
O Lantz,
ME Quimby,
JW Yewdell,
Bennink JR,
and
RR Brutkiewicz
Department of Molecular Biology, Princeton University, NJ 08544, USA.
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.
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- CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site.
- T. Nakamura, K.-H. Sonoda, D. E. Faunce, J. Gumperz, T. Yamamura, S. Miyake, and J. Stein-Streilein (2003)
J. Immunol.
171, 1266-1271
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- Cross-presentation of Disialoganglioside GD3 to Natural Killer T Cells.
- D. Y. Wu, N. H. Segal, S. Sidobre, M. Kronenberg, and P. B. Chapman (2003)
J. Exp. Med.
198, 173-181
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- Differential Requirement for Rel/Nuclear Factor {kappa}B Family Members in Natural Killer T Cell Development.
- V. Sivakumar, K. J.L. Hammond, N. Howells, K. Pfeffer, and F. Weih (2003)
J. Exp. Med.
197, 1613-1621
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- The Paradox of Immune Molecular Recognition of {alpha}-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for {alpha}{beta} TCRs.
- C. Cantu III, K. Benlagha, P. B. Savage, A. Bendelac, and L. Teyton (2003)
J. Immunol.
170, 4673-4682
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- CD1d-expressing Dendritic Cells but Not Thymic Epithelial Cells Can Mediate Negative Selection of NKT Cells.
- T. Chun, M. J. Page, L. Gapin, J. L. Matsuda, H. Xu, H. Nguyen, H.-S. Kang, A. K. Stanic, S. Joyce, W. A. Koltun, et al. (2003)
J. Exp. Med.
197, 907-918
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- Self Glycosphingolipids: New Antigens Recognized by Autoreactive T Lymphocytes.
- G. De Libero and L. Mori (2003)
Physiology
18, 71-76
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- Human Invariant V{alpha}24-J{alpha}Q TCR Supports the Development of CD1d-Dependent NK1.1+ and NK1.1- T Cells in Transgenic Mice.
- M. Capone, D. Cantarella, J. Schumann, O. V. Naidenko, C. Garavaglia, F. Beermann, M. Kronenberg, P. Dellabona, H. R. MacDonald, and G. Casorati (2003)
J. Immunol.
170, 2390-2398
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- BATF Transgenic Mice Reveal a Role for Activator Protein-1 in NKT Cell Development.
- K. L. Williams, A. J. Zullo, M. H. Kaplan, R. R. Brutkiewicz, C. D. Deppmann, C. Vinson, and E. J. Taparowsky (2003)
J. Immunol.
170, 2417-2426
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- Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta -D-glucosylceramide synthase deficiency.
- A. K. Stanic, A. D. De Silva, J.-J. Park, V. Sriram, S. Ichikawa, Y. Hirabyashi, K. Hayakawa, L. Van Kaer, R. R. Brutkiewicz, and S. Joyce (2003)
PNAS
100, 1849-1854
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- Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant V{alpha}14-J{alpha}281 TCR.
- B. Grubor-Bauk, A. Simmons, G. Mayrhofer, and P. G. Speck (2003)
J. Immunol.
170, 1430-1434
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- Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins from Trypanosoma cruzi Bind to CD1d but Do Not Elicit Dominant Innate or Adaptive Immune Responses Via the CD1d/NKT Cell Pathway.
- D. O. Procopio, I. C. Almeida, A. C. T. Torrecilhas, J. E. Cardoso, L. Teyton, L. R. Travassos, A. Bendelac, and R. T. Gazzinelli (2002)
J. Immunol.
169, 3926-3933
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- NK T Cell Precursors Exhibit Differential Cytokine Regulation and Require Itk for Efficient Maturation.
- P. Gadue and P. L. Stein (2002)
J. Immunol.
169, 2397-2406
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- The V{alpha}14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex.
- S. Sidobre, O. V. Naidenko, B.-C. Sim, N. R. J. Gascoigne, K. C. Garcia, and M. Kronenberg (2002)
J. Immunol.
169, 1340-1348
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- The Homeostasis But Not the Differentiation of T Cells Is Regulated by p27Kip1.
- R. Shen and M. H. Kaplan (2002)
J. Immunol.
169, 714-721
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- Absence of the CD1 Molecule Up-Regulates Antitumor Activity Induced by CpG Oligodeoxynucleotides in Mice.
- L. Sfondrini, D. Besusso, M. T. Zoia, M. Rodolfo, A. M. Invernizzi, M. Taniguchi, T. Nakayama, M. P. Colombo, S. Menard, and A. Balsari (2002)
J. Immunol.
169, 151-158
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- Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor.
- E. Aguado, S. Richelme, S. Nunez-Cruz, A. Miazek, A.-M. Mura, M. Richelme, X.-J. Guo, D. Sainty, H.-T. He, B. Malissen, et al. (2002)
Science
296, 2036-2040
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- Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells.
- V. Sriram, S. Cho, P. Li, P. W. O'Donnell, C. Dunn, K. Hayakawa, J. S. Blum, and R. R. Brutkiewicz (2002)
PNAS
99, 8197-8202
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- Recycling CD1d1 Molecules Present Endogenous Antigens Processed in an Endocytic Compartment to NKT Cells.
- T. J. Roberts, V. Sriram, P. M. Spence, M. Gui, K. Hayakawa, I. Bacik, J. R. Bennink, J. W. Yewdell, and R. R. Brutkiewicz (2002)
J. Immunol.
168, 5409-5414
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- NK T Cells Are a Source of Early Interleukin-4 following Infection with Third-Stage Larvae of the Filarial Nematode Brugia pahangi.
- P. Balmer and E. Devaney (2002)
Infect. Immun.
70, 2215-2219
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- Phenotypic and Functional Differences Between NKT Cells Colonizing Splanchnic and Peripheral Lymph Nodes.
- V. Laloux, L. Beaudoin, C. Ronet, and A. Lehuen (2002)
J. Immunol.
168, 3251-3258
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- Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining.
- J. E. Gumperz, S. Miyake, T. Yamamura, and M. B. Brenner (2002)
J. Exp. Med.
195, 625-636
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- Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT Cells.
- K.-H. Sonoda, M. Taniguchi, and J. Stein-Streilein (2002)
J. Immunol.
168, 2028-2034
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