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Science 12 May 1995:
Vol. 268. no. 5212, pp. 836 - 844
DOI: 10.1126/science.7754368
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Articles

Science, Vol 268, Issue 5212, 836-844
Copyright © 1995 by American Association for the Advancement of Science

articles

Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein

JE Lee, SM Hollenberg, L Snider, DL Turner, N Lipnick, and H Weintraub

Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.

Basic helix-loop-helix (bHLH) proteins are instrumental in determining cell type during development. A bHLH protein, termed NeuroD, for neurogenic differentiation, has now been identified as a differentiation factor for neurogenesis because (i) it is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons and (ii) ectopic expression of neuroD in Xenopus embryos causes premature differentiation of neuronal precursors. Furthermore, neuroD can convert presumptive epidermal cells into neurons and also act as a neuronal determination gene. However, unlike another previously identified proneural gene (XASH-3), neuroD seems competent to bypass the normal inhibitory influences that usually prevent neurogenesis in ventral and lateral ectoderm and is capable of converting most of the embryonic ectoderm into neurons. The data suggest that neuroD may participate in the terminal differentiation step during vertebrate neuronal development.


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   Abstract »    PDF »
Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation.
C. F. Wu, H. Nakamura, A. P.-Y. Chan, Y.-H. Zhou, T. Cao, J. Kuang, S.-G. Gong, G. He, and L. D. Etkin (2001)
Development 128, 3381-3393
   Abstract »    Full Text »    PDF »
Xenopus cadherin-11 restrains cranial neural crest migration and influences neural crest specification.
A. Borchers, R. David, and D. Wedlich (2001)
Development 128, 3049-3060
   Abstract »    Full Text »    PDF »
NeuroD/BETA2 Gene G->A Polymorphism May Affect Onset Pattern of Type 1 Diabetes in Japanese.
S. Yamada, Y. Motohashi, T. Yanagawa, T. Maruyama, A. Kasuga, H. Hirose, K. Matsubara, A. Shimada, and T. Saruta (2001)
Diabetes Care 24, 1438-1441
   Abstract »    Full Text »    PDF »
Role of the Transcriptional Coactivator CBP/p300 in Linking Basic Helix-Loop-Helix and CREB Responses for Follicle-Stimulating Hormone-Mediated Activation of the Transferrin Promoter in Sertoli Cells.
J. Chaudhary and M. K. Skinner (2001)
Biol Reprod 65, 568-574
   Abstract »    Full Text »    PDF »
Cloning and Functional Expression of an E Box-Binding Protein from Rat Granulosa Cells.
K. Yamada, T. Mizutani, Z. Shou, T. Yazawa, T. Sekiguchi, M. Yoshino, T. Inazu, and K. Miyamoto (2001)
Biol Reprod 64, 1315-1319
   Abstract »    Full Text »
Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei.
M. Zirlinger, G. Kreiman, and D. J. Anderson (2001)
PNAS 98, 5270-5275
   Abstract »    Full Text »    PDF »
mKlf7, a potential transcriptional regulator of TrkA nerve growth factor receptor expression in sensory and sympathetic neurons.
L Lei, L Ma, S Nef, T Thai, and L. Parada (2001)
Development 128, 1147-1158
   Abstract »    PDF »
Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation.
E Lamar, C Kintner, and M Goulding (2001)
Development 128, 1335-1346
   Abstract »    PDF »
NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development.
W. Kim, B Fritzsch, A Serls, L. Bakel, E. Huang, L. Reichardt, D. Barth, and J. Lee (2001)
Development 128, 417-426
   Abstract »    PDF »
Specification of neurotransmitter receptor identity in developing retina: the chick ATH5 promoter integrates the positive and negative effects of several bHLH proteins.
L Matter-Sadzinski, J. Matter, M. Ong, J Hernandez, and M Ballivet (2001)
Development 128, 217-231
   Abstract »    PDF »


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