Science 28 April 1995: Vol. 268. no. 5210, pp. 579 - 582 DOI: 10.1126/science.7725107

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Articles

HslVU ATP-dependent Protease Utilizes Maximally Six among Twelve Threonine Active Sites during Proteolysis.

J. W. Lee, E. Park, M. S. Jeong, Y. J. Jeon, S. H. Eom, J. H. Seol, and C. H. Chung (2009)
J. Biol. Chem. 284, 33475-33484
 |  Abstract »  |  Full Text »  |  PDF »

Curcumin Inhibits the Proteasome Activity in Human Colon Cancer Cells In vitro and In vivo.

V. Milacic, S. Banerjee, K. R. Landis-Piwowar, F. H. Sarkar, A. P.N. Majumdar, and Q. P. Dou (2008)
Cancer Res. 68, 7283-7292
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutation of the Proteasome {beta}5 Subunit Gene Is an Important Mechanism of Bortezomib Resistance in Bortezomib-Selected Variants of Jurkat T Cell Lymphoblastic Lymphoma/Leukemia Line.

S. Lu, J. Yang, X. Song, S. Gong, H. Zhou, L. Guo, N. Song, X. Bao, P. Chen, and J. Wang (2008)
J. Pharmacol. Exp. Ther. 326, 423-431
 |  Abstract »  |  Full Text »  |  PDF »

Autoimmune reactivity against the 20S-proteasome includes immunosubunits LMP2 ({beta}1i), MECL1 ({beta}2i) and LMP7 ({beta}5i).

S. Scheffler, U. Kuckelkorn, K. Egerer, T. Dorner, K. Reiter, A. Soza, G.-R. Burmester, and E. Feist (2008)
Rheumatology 47, 622-626
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Proteasome Subpopulations with Distinct Molecular Compositions and Proteolytic Activities.

O. Drews, R. Wildgruber, C. Zong, U. Sukop, M. Nissum, G. Weber, A. V. Gomes, and P. Ping (2007)
Mol. Cell. Proteomics 6, 2021-2031
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of CD8+ T Cell Development by Thymus-Specific Proteasomes.

S. Murata, K. Sasaki, T. Kishimoto, S.-i. Niwa, H. Hayashi, Y. Takahama, and K. Tanaka (2007)
Science 316, 1349-1353
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular proteasome in the human alveolar space: a new housekeeping enzyme?.

S. U. Sixt, M. Beiderlinden, H. P. Jennissen, and J. Peters (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1280-L1288
 |  Abstract »  |  Full Text »  |  PDF »

Anti-proteasome autoantibodies contribute to anti-nuclear antibody patterns on human larynx carcinoma cells.

E Feist, M Brychcy, G Hausdorf, B Hoyer, K Egerer, T Dorner, U Kuckelkorn, and G-R Burmester (2007)
Ann Rheum Dis 66, 5-11
 |  Abstract »  |  Full Text »  |  PDF »

Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity.

D. Chen, Q. C. Cui, H. Yang, and Q. P. Dou (2006)
Cancer Res. 66, 10425-10433
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Anticancer Gold(III) Dithiocarbamate Compound Inhibits the Activity of a Purified 20S Proteasome and 26S Proteasome in Human Breast Cancer Cell Cultures and Xenografts.

V. Milacic, D. Chen, L. Ronconi, K. R. Landis-Piwowar, D. Fregona, and Q. P. Dou (2006)
Cancer Res. 66, 10478-10486
 |  Abstract »  |  Full Text »  |  PDF »

Archaeal Proteasomes Effectively Degrade Aggregation-prone Proteins and Reduce Cellular Toxicities in Mammalian Cells.

S.-i. Yamada, J.-i. Niwa, S. Ishigaki, M. Takahashi, T. Ito, J. Sone, M. Doyu, and G. Sobue (2006)
J. Biol. Chem. 281, 23842-23851
 |  Abstract »  |  Full Text »  |  PDF »

20S Proteasomes Have the Potential to Keep Substrates in Store for Continual Degradation.

M. Sharon, S. Witt, K. Felderer, B. Rockel, W. Baumeister, and C. V. Robinson (2006)
J. Biol. Chem. 281, 9569-9575
 |  Abstract »  |  Full Text »  |  PDF »

VAT, the Thermoplasma Homolog of Mammalian p97/VCP, Is an N Domain-regulated Protein Unfoldase.

A. Gerega, B. Rockel, J. Peters, T. Tamura, W. Baumeister, and P. Zwickl (2005)
J. Biol. Chem. 280, 42856-42862
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome Inhibition As a Novel Therapeutic Target in Human Cancer.

S. V. Rajkumar, P. G. Richardson, T. Hideshima, and K. C. Anderson (2005)
J. Clin. Oncol. 23, 630-639
 |  Abstract »  |  Full Text »  |  PDF »

Myogenin Protein Stability Is Decreased by BMP-2 through a Mechanism Implicating Id1.

F. Vinals and F. Ventura (2004)
J. Biol. Chem. 279, 45766-45772
 |  Abstract »  |  Full Text »  |  PDF »

Role of C-terminal Extensions of Subunits {beta}2 and {beta}7 in Assembly and Activity of Eukaryotic Proteasomes.

P. C. Ramos, A. J. Marques, M. K. London, and R. J. Dohmen (2004)
J. Biol. Chem. 279, 14323-14330
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of RcsA by the ClpYQ (HslUV) protease in Escherichia coli.

M.-S. Kuo, K.-P. Chen, and W. F. Wu (2004)
Microbiology 150, 437-446
 |  Abstract »  |  Full Text »  |  PDF »

The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites.

A. F. Kisselev, M. Garcia-Calvo, H. S. Overkleeft, E. Peterson, M. W. Pennington, H. L. Ploegh, N. A. Thornberry, and A. L. Goldberg (2003)
J. Biol. Chem. 278, 35869-35877
 |  Abstract »  |  Full Text »  |  PDF »

Participation of the sperm proteasome in human fertilization.

P. Morales, M. Kong, E. Pizarro, and C. Pasten (2003)
Hum. Reprod. 18, 1010-1017
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei.

C. C. Wang, Z. Bozdech, C.-l. Liu, A. Shipway, B. J. Backes, J. L. Harris, and M. Bogyo (2003)
J. Biol. Chem. 278, 15800-15808
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Oligomerization and Substrate Recognition of the Escherichia coli ClpYQ (HslUV) Protease Implicated by In Vivo Protein-Protein Interactions in the Yeast Two-Hybrid System.

Y.-Y. Lee, C.-F. Chang, C.-L. Kuo, M.-C. Chen, C. H. Yu, P.-I Lin, and W. F. Wu (2003)
J. Bacteriol. 185, 2393-2401
 |  Abstract »  |  Full Text »  |  PDF »

beta 2 Subunit Propeptides Influence Cooperative Proteasome Assembly.

M. De, K. Jayarapu, L. Elenich, J. J. Monaco, R. A. Colbert, and T. A. Griffin (2003)
J. Biol. Chem. 278, 6153-6159
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Topology of Two 20S Proteasomes from Haloferax volcanii.

S. J. Kaczowka and J. A. Maupin-Furlow (2003)
J. Bacteriol. 185, 165-174
 |  Abstract »  |  Full Text »  |  PDF »

Specific Orientation and Two-dimensional Crystallization of the Proteasome at Metal-chelating Lipid Interfaces.

A. Thess, S. Hutschenreiter, M. Hofmann, R. Tampe, W. Baumeister, and R. Guckenberger (2002)
J. Biol. Chem. 277, 36321-36328
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Immunoproteasome Subunit Expression In Vivo Following Pathogenic Fungal Infection.

L. F. Barton, M. Cruz, R. Rangwala, G. S. Deepe Jr., and J. J. Monaco (2002)
J. Immunol. 169, 3046-3052
 |  Abstract »  |  Full Text »  |  PDF »

Clastosome: A Subtype of Nuclear Body Enriched in 19S and 20S Proteasomes, Ubiquitin, and Protein Substrates of Proteasome.

M. Lafarga, M. T. Berciano, E. Pena, I. Mayo, J. G. Castano, D. Bohmann, J. P. Rodrigues, J. P. Tavanez, and M. Carmo-Fonseca (2002)
Mol. Biol. Cell 13, 2771-2782
 |  Abstract »  |  Full Text »  |  PDF »

The C-terminal Tails of HslU ATPase Act as a Molecular Switch for Activation of HslV Peptidase.

I. S. Seong, M. S. Kang, M. K. Choi, J. W. Lee, O. J. Koh, J. Wang, S. H. Eom, and C. H. Chung (2002)
J. Biol. Chem. 277, 25976-25982
 |  Abstract »  |  Full Text »  |  PDF »

A Membrane-Bound Archaeal Lon Protease Displays ATP-Independent Proteolytic Activity towards Unfolded Proteins and ATP-Dependent Activity for Folded Proteins.

T. Fukui, T. Eguchi, H. Atomi, and T. Imanaka (2002)
J. Bacteriol. 184, 3689-3698
 |  Abstract »  |  Full Text »  |  PDF »

Presentation of a major histocompatibility complex class 1-binding peptide by monocyte-derived dendritic cells incorporating hydrophobized polysaccharide-truncated HER2 protein complex: implications for a polyvalent immuno-cell therapy.

Y. Ikuta, N. Katayama, L. Wang, T. Okugawa, Y. Takahashi, M. Schmitt, X. Gu, M. Watanabe, K. Akiyoshi, H. Nakamura, et al. (2002)
Blood 99, 3717-3724
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Drosophila 26 S Proteasome Using RNA Interference.

C. Wojcik and G. N. DeMartino (2002)
J. Biol. Chem. 277, 6188-6197
 |  Abstract »  |  Full Text »  |  PDF »

TSP50, A Possible Protease in Human Testes, Is Activated in Breast Cancer Epithelial Cells.

J. Shan, L. Yuan, Q. Xiao, N. Chiorazzi, D. Budman, S. Teichberg, and H.-p. Xu (2002)
Cancer Res. 62, 290-294
 |  Abstract »  |  Full Text »  |  PDF »

The Transporter Associated With Antigen Processing: Function and Implications in Human Diseases.

B. Lankat-Buttgereit and R. Tampe (2002)
Physiol Rev 82, 187-204
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Specific Nuclear Transport of Adriamycin: The Mode of Nuclear Translocation of Adriamycin-Proteasome Complex.

K.-i. Kiyomiya, S. Matsuo, and M. Kurebe (2001)
Cancer Res. 61, 2467-2471
 |  Abstract »  |  Full Text »

Why Does Threonine, and Not Serine, Function as the Active Site Nucleophile in Proteasomes?.

A. F. Kisselev, Z. Songyang, and A. L. Goldberg (2000)
J. Biol. Chem. 275, 14831-14837
 |  Abstract »  |  Full Text »  |  PDF »

Localization of proteasomes in human oocytes and preimplantation embryos.

C. Wojcik, M. Benchaib, J. Lornage, J.C. Czyba, and J.F. Guerin (2000)
Mol. Hum. Reprod. 6, 331-336
 |  Abstract »  |  Full Text »  |  PDF »

Nalpha -Acetylation and Proteolytic Activity of the Yeast 20 S Proteasome.

Y. Kimura, M. Takaoka, S. Tanaka, H. Sassa, K. Tanaka, B. Polevoda, F. Sherman, and H. Hirano (2000)
J. Biol. Chem. 275, 4635-4639
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role of Human Leukocyte Antigen-encoded Proteasome Subunits in NF-kappa B Activation and Prevention of Tumor Necrosis Factor-alpha -induced Apoptosis.

T. Hayashi and D. Faustman (2000)
J. Biol. Chem. 275, 5238-5247
 |  Abstract »  |  Full Text »  |  PDF »

Mapping Subunit Contacts in the Regulatory Complex of the 26 S Proteasome. S2 AND S5b FORM A TETRAMER WITH ATPase SUBUNITS S4 and S7.

C. Gorbea, D. Taillandier, and M. Rechsteiner (2000)
J. Biol. Chem. 275, 875-882
 |  Abstract »  |  Full Text »  |  PDF »

Generation of an Immunodominant CTL Epitope Is Affected by Proteasome Subunit Composition and Stability of the Antigenic Protein.

U. Gileadi, H. T. Moins-Teisserenc, I. Correa, B. L. Booth Jr., P. R. Dunbar, A. K. Sewell, J. Trowsdale, R. E. Phillips, and V. Cerundolo (1999)
J. Immunol. 163, 6045-6052
 |  Abstract »  |  Full Text »  |  PDF »

Intrinsic Nucleoside Diphosphate Kinase-like Activity Is a Novel Function of the 20 S Proteasome.

M. Yano, S. Mori, and H. Kido (1999)
J. Biol. Chem. 274, 34375-34382
 |  Abstract »  |  Full Text »  |  PDF »

The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study.

M. Groll, W. Heinemeyer, S. Jager, T. Ullrich, M. Bochtler, D. H. Wolf, and R. Huber (1999)
PNAS 96, 10976-10983
 |  Abstract »  |  Full Text »  |  PDF »

Halophilic 20S Proteasomes of the Archaeon Haloferax volcanii: Purification, Characterization, and Gene Sequence Analysis.

H. L. Wilson, H. C. Aldrich, and J. Maupin-Furlow (1999)
J. Bacteriol. 181, 5814-5824
 |  Abstract »  |  Full Text »

An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes.

P. Zwickl, D. Ng, K. M. Woo, H.-P. Klenk, and A. L. Goldberg (1999)
J. Biol. Chem. 274, 26008-26014
 |  Abstract »  |  Full Text »  |  PDF »

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms.

G. N. DeMartino and C. A. Slaughter (1999)
J. Biol. Chem. 274, 22123-22126
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Proteases in Cellular Regulation Minireview Series.

T. C. Vanaman and R. A. Bradshaw (1999)
J. Biol. Chem. 274, 20047
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Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival.

Y. Fujio, K. Guo, T. Mano, Y. Mitsuuchi, J. R. Testa, and K. Walsh (1999)
Mol. Cell. Biol. 19, 5073-5082
 |  Abstract »  |  Full Text »  |  PDF »

Redundant In Vivo Proteolytic Activities of Escherichia coli Lon and the ClpYQ (HslUV) Protease.

W.-F. Wu, Y. Zhou, and S. Gottesman (1999)
J. Bacteriol. 181, 3681-3687
 |  Abstract »  |  Full Text »

Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents.

J. Adams, V. J. Palombella, E. A. Sausville, J. Johnson, A. Destree, D. D. Lazarus, J. Maas, C. S. Pien, S. Prakash, and P. J. Elliott (1999)
Cancer Res. 59, 2615-2622
 |  Abstract »  |  Full Text »  |  PDF »

Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States.

S. H. Lecker, V. Solomon, W. E. Mitch, and A. L. Goldberg (1999)
J. Nutr. 129, 227S
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The Proteasome Activator 11 S Regulator or PA28. CONTRIBUTION BY BOTH alpha  AND beta  SUBUNITS TO PROTEASOME ACTIVATION.

Z. Zhang, A. Clawson, and M. Rechsteiner (1998)
J. Biol. Chem. 273, 30660-30668
 |  Abstract »  |  Full Text »  |  PDF »

The 20S Proteasome of Streptomyces coelicolor.

I. Nagy, T. Tamura, J. Vanderleyden, W. Baumeister, and R. De Mot (1998)
J. Bacteriol. 180, 5448-5453
 |  Abstract »  |  Full Text »

Contribution of Proteasomal beta -Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants.

T. P. Dick, A. K. Nussbaum, M. Deeg, W. Heinemeyer, M. Groll, M. Schirle, W. Keilholz, D. H. Wolf, R. Huber, H.-G. Rammensee, et al. (1998)
J. Biol. Chem. 273, 25637-25646
 |  Abstract »  |  Full Text »  |  PDF »

Structure and Mechanism of Action of the Protease That Degrades Small, Acid-Soluble Spore Proteins during Germination of Spores of Bacillus Species.

C. Nessi, M. J. Jedrzejas, and P. Setlow (1998)
J. Bacteriol. 180, 5077-5084
 |  Abstract »  |  Full Text »

Proteasome Inhibitors Prevent Tracheary Element Differentiation in Zinnia Mesophyll Cell Cultures.

B. J. Woffenden, T. B. Freeman, and E. P. Beers (1998)
Plant Physiology 118, 419-430
 |  Abstract »  |  Full Text »

Effects of the Cys Mutations on Structure and Function of the ATP-dependent HslVU Protease in Escherichia coli. THE CYS287 TO VAL MUTATION IN HslU UNCOUPLES THE ATP-DEPENDENT PROTEOLYSIS BY HslVU FROM ATP HYDROLYSIS.

S. J. Yoo, H. H. Kim, D. H. Shin, C. S. Lee, I. S. Seong, J. H. Seol, N. Shimbara, K. Tanaka, and C. H. Chung (1998)
J. Biol. Chem. 273, 22929-22935
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation.

A. Song, Q. Wang, M. G. Goebl, and M. A. Harrington (1998)
Mol. Cell. Biol. 18, 4994-4999
 |  Abstract »  |  Full Text »

Mutations in the Yeast Proteasome beta -Type Subunit Pre3 Uncover Position-dependent Effects on Proteasomal Peptidase Activity and in Vivo Function.

R. Gueckel, C. Enenkel, D. H. Wolf, and W. Hilt (1998)
J. Biol. Chem. 273, 19443-19452
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Organization of the 20S Proteasome Gene Family from Arabidopsis thaliana.

H. Fu, J. H. Doelling, C. S. Arendt, M. Hochstrasser, and R. D. Vierstra (1998)
Genetics 149, 677-692
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein.

G. Schmidtke, M. Eggers, T. Ruppert, M. Groettrup, U. H. Koszinowski, and P.-M. Kloetzel (1998)
J. Exp. Med. 187, 1641-1646
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome Activation by REG Molecules Lacking Homolog-specific Inserts.

Z. Zhang, C. Realini, A. Clawson, S. Endicott, and M. Rechsteiner (1998)
J. Biol. Chem. 273, 9501-9509
 |  Abstract »  |  Full Text »  |  PDF »

Phenotype-Dependent Differences in Proteasome Subunit Composition and Cleavage Specificity in B Cell Lines.

T. Frisan, V. Levitsky, A. Polack, and M. G. Masucci (1998)
J. Immunol. 160, 3281-3289
 |  Abstract »  |  Full Text »  |  PDF »

Identification of an activation region in the proteasome activator REGalpha.

Z. Zhang, A. Clawson, C. Realini, C. C. Jensen, J. R. Knowlton, C. P. Hill, and M. Rechsteiner (1998)
PNAS 95, 2807-2811
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Characterization of the 20S Proteasome from the Methanoarchaeon Methanosarcina thermophila.

J. A. Maupin-Furlow, H. C. Aldrich, and J. G. Ferry (1998)
J. Bacteriol. 180, 1480-1487
 |  Abstract »  |  Full Text »

Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes.

A. F. Kisselev, T. N. Akopian, and A. L. Goldberg (1998)
J. Biol. Chem. 273, 1982-1989
 |  Abstract »  |  Full Text »  |  PDF »

Immunoproteasome Assembly: Cooperative Incorporation of Interferon {gamma} (IFN-{gamma})-inducible Subunits.

T. A. Griffin, D. Nandi, M. Cruz, H. J. Fehling, L. V. Kaer, J. J. Monaco, and R. A. Colbert (1998)
J. Exp. Med. 187, 97-104
 |  Abstract »  |  Full Text »  |  PDF »

Relative Functions of the alpha  and beta  Subunits of the Proteasome Activator, PA28.

X. Song, J. von Kampen, C. A. Slaughter, and G. N. DeMartino (1997)
J. Biol. Chem. 272, 27994-28000
 |  Abstract »  |  Full Text »  |  PDF »

Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome. KINETICS AND MECHANISM.

T. Mc Cormack, W. Baumeister, L. Grenier, C. Moomaw, L. Plamondon, B. Pramanik, C. Slaughter, F. Soucy, R. Stein, F. Zuhl, et al. (1997)
J. Biol. Chem. 272, 26103-26109
 |  Abstract »  |  Full Text »  |  PDF »

Catalytic Properties of 26 S and 20 S Proteasomes and Radiolabeling of MB1, LMP7, and C7 Subunits Associated with Trypsin-like and Chymotrypsin-like Activities.

J. Reidlinger, A. M. Pike, P. J. Savory, R. Z. Murray, and A. J. Rivett (1997)
J. Biol. Chem. 272, 24899-24905
 |  Abstract »  |  Full Text »  |  PDF »

The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing.

W. Heinemeyer, M. Fischer, T. Krimmer, U. Stachon, and D. H. Wolf (1997)
J. Biol. Chem. 272, 25200-25209
 |  Abstract »  |  Full Text »  |  PDF »

The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome.

M. Groettrup, S. Standera, R. Stohwasser, and P. M. Kloetzel (1997)
PNAS 94, 8970-8975
 |  Abstract »  |  Full Text »  |  PDF »

Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System.

G. Niedermann, R. Grimm, E. Geier, M. Maurer, C. Realini, C. Gartmann, J. Soll, S. Omura, M. C. Rechsteiner, W. Baumeister, et al. (1997)
J. Exp. Med. 186, 209-220
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation.

C. S. Arendt and M. Hochstrasser (1997)
PNAS 94, 7156-7161
 |  Abstract »  |  Full Text »  |  PDF »

Covalent modification of the active site threonine of proteasomal beta  subunits and the Escherichia coli homolog HslV by a new class of inhibitors.

M. Bogyo, J. S. McMaster, M. Gaczynska, D. Tortorella, A. L. Goldberg, and H. Ploegh (1997)
PNAS 94, 6629-6634
 |  Abstract »  |  Full Text »  |  PDF »

Lactacystin and clasto-Lactacystin beta -Lactone Modify Multiple Proteasome beta -Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation.

A. Craiu, M. Gaczynska, T. Akopian, C. F. Gramm, G. Fenteany, A. L. Goldberg, and K. L. Rock (1997)
J. Biol. Chem. 272, 13437-13445
 |  Abstract »  |  Full Text »  |  PDF »

Bovine Spleen Multicatalytic Proteinase Complex (Proteasome). REPLACEMENT OF X, Y, AND Z SUBUNITS BY LMP7, LMP2, AND MECL1 AND CHANGES IN PROPERTIES AND SPECIFICITY.

A. M. Eleuteri, R. A. Kohanski, C. Cardozo, and M. Orlowski (1997)
J. Biol. Chem. 272, 11824-11831
 |  Abstract »  |  Full Text »  |  PDF »

The Human alpha -Type Proteasomal Subunit HsC8 Forms a Double Ringlike Structure, but Does Not Assemble into Proteasome-like Particles with the beta -Type Subunits HsDelta or HsBPROS26.

W. L.H. Gerards, J. Enzlin, M. Haner, I. L.A.M. Hendriks, U. Aebi, H. Bloemendal, and W. Boelens (1997)
J. Biol. Chem. 272, 10080-10086
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance.

K. T. Bush, A. L. Goldberg, and S. K. Nigam (1997)
J. Biol. Chem. 272, 9086-9092
 |  Abstract »  |  Full Text »  |  PDF »

Subunit arrangement in the human 20S proteasome.

F. Kopp, K. B. Hendil, B. Dahlmann, P. Kristensen, A. Sobek, and W. Uerkvitz (1997)
PNAS 94, 2939-2944
 |  Abstract »  |  Full Text »  |  PDF »

Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum.

T. N. Akopian, A. F. Kisselev, and A. L. Goldberg (1997)
J. Biol. Chem. 272, 1791-1798
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Muscle Wasting -- The Role of the Ubiquitin-Proteasome Pathway.

W. E. Mitch and A. L. Goldberg (1996)
N. Engl. J. Med. 335, 1897-1905
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Proteasome Subunits X and Y Alter Peptidase Activities in Opposite Ways to the Interferon-gamma -induced Subunits LMP2 and LMP7.

M. Gaczynska, A. L. Goldberg, K. Tanaka, K. B. Hendil, and K. L. Rock (1996)
J. Biol. Chem. 271, 17275-17280
 |  Abstract »  |  Full Text »  |  PDF »

The Antitumor Drug Aclacinomycin A, Which Inhibits the Degradation of Ubiquitinated Proteins, Shows Selectivity for the Chymotrypsin-like Activity of the Bovine Pituitary 20S Proteasome.

M. E. Figueiredo-Pereira, W. E. Chen, J. Li, and O. Johdo (1996)
J. Biol. Chem. 271, 16455-16459
 |  Abstract »  |  Full Text »  |  PDF »

Purification and Characterization of the Heat Shock Proteins HslV and HslU That Form a New ATP-dependent Protease in Escherichia coli.

S. J. Yoo, J. H. Seol, D. H. Shin, M. Rohrwild, M.-S. Kang, K. Tanaka, A. L. Goldberg, and C. H. Chung (1996)
J. Biol. Chem. 271, 14035-14040
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for the Existence of both Proteasomes and a Novel High Molecular Weight Peptidase in Entamoeba histolytica.

H. Scholze, S. Frey, Z. Cejka, and T. Bakker-Grunwald (1996)
J. Biol. Chem. 271, 6212-6216
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Glycosylasparaginase.

C. Guan, T. Cui, V. Rao, W. Liao, J. Benner, C.-L. Lin, and D. Comb (1996)
J. Biol. Chem. 271, 1732-1737
 |  Abstract »  |  Full Text »  |  PDF »

A Proteasome Activator Subunit Binds Calcium.

C. Realini and M. Rechsteiner (1995)
J. Biol. Chem. 270, 29664-29667
 |  Abstract »  |  Full Text »  |  PDF »

A Proteasome from the Methanogenic Archaeon Methanosarcina thermophila.

J. A. Maupin-Furlow and J. G. Ferry (1995)
J. Biol. Chem. 270, 28617-28622
 |  Abstract »  |  Full Text »  |  PDF »

Puromycin-sensitive Aminopeptidase.

D. B. Constam, A. R. Tobler, A. Rensing-Ehl, I. Kemler, L. B. Hersh, and A. Fontana (1995)
J. Biol. Chem. 270, 26931-26939
 |  Abstract »  |  Full Text »  |  PDF »

Differences in Catalytic Activities and Subunit Pattern of Multicatalytic Proteinase Complexes (Proteasomes) Isolated from Bovine Pituitary, Lung, and Liver.

C. Cardozo, A. M. Eleuteri, and M. Orlowski (1995)
J. Biol. Chem. 270, 22645-22651
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin.

G Fenteany, R. Standaert, W. Lane, S Choi, E. Corey, and S. Schreiber (1995)
Science 268, 726-731
 |  Abstract »  |  PDF »

Functions of the proteasome: the lysis at the end of the tunnel.

A. Goldberg (1995)
Science 268, 522-523
 |  PDF »

From the cradle to the grave: ring complexes in the life of a protein.

J. Weissman, P. Sigler, and A. Horwich (1995)
Science 268, 523-524
 |  PDF »

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution.

J Lowe, D Stock, B Jap, P Zwickl, W Baumeister, and R Huber (1995)
Science 268, 533-539
 |  Abstract »  |  PDF »

Functions of the Proteasome in Antigen Presentation.

A.L. Goldberg, M. Gaczynska, E. Grant, M. Michalek, and K.L. Rock (1995)
Cold Spring Harb Symp Quant Biol 60, 479-490
 |  Abstract »  |  PDF »

The DOA Pathway: Studies on the Functions and Mechanisms of Ubiquitin-dependent Protein Degradation in the Yeast Saccharomyces cerevisiae.

M. Hochstrasser, F.R. Papa, P. Chen, S. Swaminathan, P. Johnson, L. Stillman, A.Y. Amerik, and S.-J. Li (1995)
Cold Spring Harb Symp Quant Biol 60, 503-513
 |  Abstract »  |  PDF »

Structure and Function of the 20S Proteasome and of Its Regulatory Complexes.

A. Lupas, P. Zwickl, T. Wenzel, E. Seemuller, and W. Baumeister (1995)
Cold Spring Harb Symp Quant Biol 60, 515-524
 |  Abstract »  |  PDF »

Catalytic Mechanism of the 20S Proteasome of Thermoplasma acidophilum Revealed by X-ray Crystallography.

D. Stock, L. Ditzel, W. Baumeister, R. Huber, and J. Lowe (1995)
Cold Spring Harb Symp Quant Biol 60, 525-532
 |  Abstract »  |  PDF »

cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome.

S. L. McCutchen-Maloney, K. Matsuda, N. Shimbara, D. D. Binns, K. Tanaka, C. A. Slaughter, and G. N. DeMartino (2000)
J. Biol. Chem. 275, 18557-18565
 |  Abstract »  |  Full Text »  |  PDF »

Novel Propeptide Function in 20 S Proteasome Assembly Influences beta Subunit Composition.

D. J. Kingsbury, T. A. Griffin, and R. A. Colbert (2000)
J. Biol. Chem. 275, 24156-24162
 |  Abstract »  |  Full Text »  |  PDF »

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