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Science 28 April 1995:
Vol. 268. no. 5210, pp. 573 - 575
DOI: 10.1126/science.7725105
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Articles

Science, Vol 268, Issue 5210, 573-575
Copyright © 1995 by American Association for the Advancement of Science

articles

Potentiated necrosis of cultured cortical neurons by neurotrophins

JY Koh, BJ Gwag, D Lobner, and DW Choi

Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, MO 63110, USA.

The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure to the calcium channel antagonist nimodipine. Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.


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