Science 28 April 1995: Vol. 268. no. 5210, pp. 563 - 566 DOI: 10.1126/science.7725103

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Articles

Comparative Evaluation of Two Vaccine Candidates against Experimental Leishmaniasis Due to Leishmania major Infection in Four Inbred Mouse Strains.

F. Benhnini, M. Chenik, D. Laouini, H. Louzir, P. A. Cazenave, and K. Dellagi (2009)
Clin. Vaccine Immunol. 16, 1529-1537
 |  Abstract »  |  Full Text »  |  PDF »

Thymic OX40 Expression Discriminates Cells Undergoing Strong Responses to Selection Ligands.

M. Klinger, J. K. Kim, S. A. Chmura, A. Barczak, D. J. Erle, and N. Killeen (2009)
J. Immunol. 182, 4581-4589
 |  Abstract »  |  Full Text »  |  PDF »

Protective Response to Leishmania major in BALB/c Mice Requires Antigen Processing in the Absence of DM.

T. Kamala and N. K. Nanda (2009)
J. Immunol. 182, 4882-4890
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Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection.

K. Suzue, S. Kobayashi, T. Takeuchi, M. Suzuki, and S. Koyasu (2008)
Int. Immunol. 20, 337-343
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An MHC Class II Restriction Bias in CD4 T Cell Responses toward I-A Is Altered to I-E in DM-Deficient Mice.

P. R. Menges, S. A. Jenks, E. K. Bikoff, D. R. Friedmann, Z. A. G. Knowlden, and A. J. Sant (2008)
J. Immunol. 180, 1619-1633
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Testing of Four Leishmania Vaccine Candidates in a Mouse Model of Infection with Leishmania (Viannia) braziliensis, the Main Causative Agent of Cutaneous Leishmaniasis in the New World.

G. Salay, M. L. Dorta, N. M. Santos, R. A. Mortara, C. Brodskyn, C. I. Oliveira, C. L. Barbieri, and M. M. Rodrigues (2007)
Clin. Vaccine Immunol. 14, 1173-1181
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A subset of dendritic cells induces CD4+ T cells to produce IFN-{gamma} by an IL-12-independent but CD70-dependent mechanism in vivo.

H. Soares, H. Waechter, N. Glaichenhaus, E. Mougneau, H. Yagita, O. Mizenina, D. Dudziak, M. C. Nussenzweig, and R. M. Steinman (2007)
J. Exp. Med. 204, 1095-1106
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Antigen-Experienced T Cells Limit the Priming of Naive T Cells during Infection with Leishmania major.

P. M. Gray, S. L. Reiner, D. F. Smith, P. M. Kaye, and P. Scott (2006)
J. Immunol. 177, 925-933
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T-Cell Expression Cloning of Porphyromonas gingivalis Genes Coding for T Helper-Biased Immune Responses during Infection.

R. B. Goncalves, O. Leshem, K. Bernards, J. R. Webb, P. P. Stashenko, and A. Campos-Neto (2006)
Infect. Immun. 74, 3958-3966
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The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability.

C. A. Lazarski, F. A. Chaves, and A. J. Sant (2006)
J. Exp. Med. 203, 1319-1328
 |  Abstract »  |  Full Text »  |  PDF »

The RACK1 Homologue from Trypanosoma brucei Is Required for the Onset and Progression of Cytokinesis.

K. G. Rothberg, D. L. Burdette, J. Pfannstiel, N. Jetton, R. Singh, and L. Ruben (2006)
J. Biol. Chem. 281, 9781-9790
 |  Abstract »  |  Full Text »  |  PDF »

Protective and Destructive Immunity in the Periodontium: Part 2--T-cell-mediated Immunity in the Periodontium.

Y.-T.A. Teng (2006)
Journal of Dental Research 85, 209-219
 |  Abstract »  |  Full Text »  |  PDF »

A Soluble Pyrophosphatase, a Key Enzyme for Polyphosphate Metabolism in Leishmania.

B. Espiau, G. Lemercier, A. Ambit, F. Bringaud, G. Merlin, T. Baltz, and N. Bakalara (2006)
J. Biol. Chem. 281, 1516-1523
 |  Abstract »  |  Full Text »  |  PDF »

DM Peptide-Editing Function Leads to Immunodominance in CD4 T Cell Responses In Vivo.

N. K. Nanda and E. K. Bikoff (2005)
J. Immunol. 175, 6473-6480
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 (IL-4) and IL-10 Collude in Vaccine Failure for Novel Exacerbatory Antigens in Murine Leishmania major Infection.

M. T. M. Roberts, C. B. Stober, A. N McKenzie, and J. M. Blackwell (2005)
Infect. Immun. 73, 7620-7628
 |  Abstract »  |  Full Text »  |  PDF »

Live Nonpathogenic Parasitic Vector as a Candidate Vaccine against Visceral Leishmaniasis.

M. Breton, M. J Tremblay, M. Ouellette, and B. Papadopoulou (2005)
Infect. Immun. 73, 6372-6382
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Antigen Requirements for Efficient Priming of CD8+ T Cells by Leishmania major-Infected Dendritic Cells.

S. Bertholet, A. Debrabant, F. Afrin, E. Caler, S. Mendez, K. S. Tabbara, Y. Belkaid, and D. L. Sacks (2005)
Infect. Immun. 73, 6620-6628
 |  Abstract »  |  Full Text »  |  PDF »

IL-10 from Regulatory T Cells Determines Vaccine Efficacy in Murine Leishmania major Infection.

C. B. Stober, U. G. Lange, M. T. M. Roberts, A. Alcami, and J. M. Blackwell (2005)
J. Immunol. 175, 2517-2524
 |  Abstract »  |  Full Text »  |  PDF »

Heterologous Prime-Boost Vaccination with the LACK Antigen Protects against Murine Visceral Leishmaniasis.

B. Dondji, E. Perez-Jimenez, K. Goldsmith-Pestana, M. Esteban, and D. McMahon-Pratt (2005)
Infect. Immun. 73, 5286-5289
 |  Abstract »  |  Full Text »  |  PDF »

Phenotype and Homing of CD4 Tumor-Specific T Cells Is Modulated by Tumor Bulk.

F. Benigni, V. S. Zimmermann, S. Hugues, S. Caserta, V. Basso, L. Rivino, E. Ingulli, L. Malherbe, N. Glaichenhaus, and A. Mondino (2005)
J. Immunol. 175, 739-748
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Proteomic Approach for Characterization of Immunodominant Membrane-Associated 30- to 36-Kilodalton Fraction Antigens of Leishmania infantum Promastigotes, Reacting with Sera from Mediterranean Visceral Leishmaniasis Patients.

S. Kamoun-Essghaier, I. Guizani, J. M. Strub, A. Van Dorsselaer, K. Mabrouk, L. Ouelhazi, and K. Dellagi (2005)
Clin. Vaccine Immunol. 12, 310-320
 |  Abstract »  |  Full Text »  |  PDF »

The Leishmania major LACK Antigen with an Immunodominant Epitope at Amino Acids 156 to 173 Is Not Required for Early Th2 Development in BALB/c Mice.

B. L. Kelly and R. M. Locksley (2004)
Infect. Immun. 72, 6924-6931
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of an I-E-Restricted, gp63-Specific, CD4-T-Cell Clone from Leishmania major-Resistant C3H Mice That Secretes Type 2 Cytokines and Exacerbates Infection with L. major.

C. M. Theodos, R. V. Morris, J. V. Bishop, J. D. Jones, W. R. McMaster, and R. G. Titus (2004)
Infect. Immun. 72, 4486-4493
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Inbred Strains Derived from Feral Mice Reveal New Pathogenic Mechanisms of Experimental Leishmaniasis Due to Leishmania major.

B. E. C. Babay, H. Louzir, C. Kebaier, S. Boubaker, K. Dellagi, and P.-A. Cazenave (2004)
Infect. Immun. 72, 4603-4611
 |  Abstract »  |  Full Text »  |  PDF »

DNA-Salmonella enterica Serovar Typhimurium Primer-Booster Vaccination Biases towards T Helper 1 Responses and Enhances Protection against Leishmania major Infection in Mice.

U. G. Lange, P. Mastroeni, J. M. Blackwell, and C. B. Stober (2004)
Infect. Immun. 72, 4924-4928
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Molecular Characterization of a Gene Encoding a Protective Leishmania amazonensis Trp-Asp (WD) Protein.

K. Campbell, V. Popov, and L. Soong (2004)
Infect. Immun. 72, 2194-2202
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Leishmania major LACK Antigen Is Required for Efficient Vertebrate Parasitization.

B. L. Kelly, D. B. Stetson, and R. M. Locksley (2003)
J. Exp. Med. 198, 1689-1698
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Coinjection with CpG-Containing Immunostimulatory Oligodeoxynucleotides Reduces the Pathogenicity of a Live Vaccine against Cutaneous Leishmaniasis but Maintains Its Potency and Durability.

S. Mendez, K. Tabbara, Y. Belkaid, S. Bertholet, D. Verthelyi, D. Klinman, R. A. Seder, and D. L. Sacks (2003)
Infect. Immun. 71, 5121-5129
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CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex-independent Differences within Dendritic Cells.

C. Filippi, S. Hugues, J. Cazareth, V. Julia, N. Glaichenhaus, and S. Ugolini (2003)
J. Exp. Med. 198, 201-209
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Dendritic Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides to Act as an Adjuvant for Protective Vaccine Immunity Against Leishmania major in Mice.

J. A. Shah, P. A. Darrah, D. R. Ambrozak, T. N. Turon, S. Mendez, J. Kirman, C.-Y. Wu, N. Glaichenhaus, and R. A. Seder (2003)
J. Exp. Med. 198, 281-291
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Immune Responses Induced by the Leishmania (Leishmania) donovani A2 Antigen, but Not by the LACK Antigen, Are Protective against Experimental Leishmania (Leishmania) amazonensis Infection.

E. A. F. Coelho, C. A. P. Tavares, F. A. A. Carvalho, K. F. Chaves, K. N. Teixeira, R. C. Rodrigues, H. Charest, G. Matlashewski, R. T. Gazzinelli, and A. P. Fernandes (2003)
Infect. Immun. 71, 3988-3994
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The Levels and Patterns of Cytokines Produced by CD4 T Lymphocytes of BALB/c Mice Infected with Leishmania major by Inoculation into the Ear Dermis Depend on the Infectiousness and Size of the Inoculum.

T. Lang, N. Courret, J.-H. Colle, G. Milon, and J.-C. Antoine (2003)
Infect. Immun. 71, 2674-2683
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Dendritic Cell (DC)-Based Protection Against an Intracellular Pathogen Is Dependent Upon DC-Derived IL-12 and Can Be Induced by Molecularly Defined Antigens.

C. Berberich, J. R. Ramirez-Pineda, C. Hambrecht, G. Alber, Y. A. W. Skeiky, and H. Moll (2003)
J. Immunol. 170, 3171-3179
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Enteral Immunization with Attenuated Recombinant Listeria monocytogenes as a Live Vaccine Vector: Organ-Dependent Dynamics of CD4 T Lymphocytes Reactive to a Leishmania major Tracer Epitope.

H. Saklani-Jusforgues, E. Fontan, N. Soussi, G. Milon, and P. L. Goossens (2003)
Infect. Immun. 71, 1083-1090
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COMPARATIVE EVALUATION OF ELISAS BASED ON TEN RECOMBINANT OR PURIFIED LEISHMANIA ANTIGENS FOR THE SERODIAGNOSIS OF MEDITERRANEAN VISCERAL LEISHMANIASIS.

I. A. MAALEJ, M. CHENIK, H. LOUZIR, A. BEN SALAH, C. BAHLOUL, F. AMRI, and K. DELLAGI (2003)
Am J Trop Med Hyg 68, 312-320
 |  Abstract »  |  Full Text »  |  PDF »

Transcutaneous Immunization with Cholera Toxin B Subunit Adjuvant Suppresses IgE Antibody Responses Via Selective Induction of Th1 Immune Responses.

F. Anjuere, A. George-Chandy, F. Audant, D. Rousseau, J. Holmgren, and C. Czerkinsky (2003)
J. Immunol. 170, 1586-1592
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Characterization of Leishmania donovani Antigens Encapsulated in Liposomes That Induce Protective Immunity in BALB/c Mice.

F. Afrin, R. Rajesh, K. Anam, M. Gopinath, S. Pal, and N. Ali (2002)
Infect. Immun. 70, 6697-6706
 |  Abstract »  |  Full Text »  |  PDF »

T Cells Primed by Leishmania major Infection Cross-React with Alloantigens and Alter the Course of Allograft Rejection.

B. Pantenburg, F. Heinzel, L. Das, P. S. Heeger, and A. Valujskikh (2002)
J. Immunol. 169, 3686-3693
 |  Abstract »  |  Full Text »  |  PDF »

The Early IL-4 Response to Leishmania major and the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells.

A. Aseffa, A. Gumy, P. Launois, H. R. MacDonald, J. A. Louis, and F. Tacchini-Cottier (2002)
J. Immunol. 169, 3232-3241
 |  Abstract »  |  Full Text »  |  PDF »

Immunization with a Polyprotein Vaccine Consisting of the T-Cell Antigens Thiol-Specific Antioxidant, Leishmania major Stress-Inducible Protein 1, and Leishmania Elongation Initiation Factor Protects against Leishmaniasis.

R. N. Coler, Y. A. W. Skeiky, K. Bernards, K. Greeson, D. Carter, C. D. Cornellison, F. Modabber, A. Campos-Neto, and S. G. Reed (2002)
Infect. Immun. 70, 4215-4225
 |  Abstract »  |  Full Text »  |  PDF »

LACK-Specific CD4+ T Cells That Induce Gamma Interferon Production in Patients with Localized Cutaneous Leishmaniasis during an Early Stage of Infection.

E. Bourreau, G. Prevot, J. Gardon, R. Pradinaud, H. Hasagewa, G. Milon, and P. Launois (2002)
Infect. Immun. 70, 3122-3129
 |  Abstract »  |  Full Text »  |  PDF »

Rapid IL-4 Production by Leishmania Homolog of Mammalian RACK1-Reactive CD4+ T Cells in Resistant Mice Treated Once with Anti-IL-12 or -IFN-{gamma} Antibodies at the Onset of Infection with Leishmania major Instructs Th2 Cell Development, Resulting in Nonhealing Lesions.

P. Launois, A. Gumy, H. Himmelrich, R. M. Locksley, M. Rocken, and J. A. Louis (2002)
J. Immunol. 168, 4628-4635
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Homeostatic Competition Among T Cells Revealed by Conditional Inactivation of the Mouse Cd4 Gene.

Q. Wang, J. Strong, and N. Killeen (2001)
J. Exp. Med. 194, 1721-1730
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CD4 Promotes Breadth in the TCR Repertoire.

Q. Wang, L. Malherbe, D. Zhang, K. Zingler, N. Glaichenhaus, and N. Killeen (2001)
J. Immunol. 167, 4311-4320
 |  Abstract »  |  Full Text »  |  PDF »

Leishmania donovani p36(LACK) DNA Vaccine Is Highly Immunogenic but Not Protective against Experimental Visceral Leishmaniasis.

P. C. Melby, J. Yang, W. Zhao, L. E. Perez, and J. Cheng (2001)
Infect. Immun. 69, 4719-4725
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Cutaneous Leishmaniasis Induced by Recombinant Antigens in Murine and Nonhuman Primate Models of the Human Disease.

A. Campos-Neto, R. Porrozzi, K. Greeson, R. N. Coler, J. R. Webb, Y. A. W. Seiky, S. G. Reed, and G. Grimaldi Jr. (2001)
Infect. Immun. 69, 4103-4108
 |  Abstract »  |  Full Text »  |  PDF »

Flow Cytometric Determination of Cellular Sources and Frequencies of Key Cytokine-Producing Lymphocytes Directed against Recombinant LACK and Soluble Leishmania Antigen in Human Cutaneous Leishmaniasis.

R. L. A. Bottrel, W. O. Dutra, F. A. Martins, B. Gontijo, E. Carvalho, M. Barral-Netto, A. Barral, R. P. Almeida, W. Mayrink, R. Locksley, et al. (2001)
Infect. Immun. 69, 3232-3239
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination against the Intracellular Pathogens Leishmania major and L. amazonensis by Directing CD40 Ligand to Macrophages.

G. Chen, P. A. Darrah, and D. M. Mosser (2001)
Infect. Immun. 69, 3255-3263
 |  Abstract »  |  Full Text »  |  PDF »

The Potency and Durability of DNA- and Protein-Based Vaccines Against Leishmania major Evaluated Using Low-Dose, Intradermal Challenge.

S. Mendez, S. Gurunathan, S. Kamhawi, Y. Belkaid, M. A. Moga, Y. A. W. Skeiky, A. Campos-Neto, S. Reed, R. A. Seder, and D. Sacks (2001)
J. Immunol. 166, 5122-5128
 |  Abstract »  |  Full Text »  |  PDF »

Leishmaniasis: Current Status of Vaccine Development.

E. Handman (2001)
Clin. Microbiol. Rev. 14, 229-243
 |  Abstract »  |  Full Text »  |  PDF »

T Cells That React to the Immunodominant Leishmania major LACK Antigen Prevent Early Dissemination of the Parasite in Susceptible BALB/c Mice.

S. Schilling and N. Glaichenhaus (2001)
Infect. Immun. 69, 1212-1214
 |  Abstract »  |  Full Text »  |  PDF »

Protective Immunity Against the Protozoan Leishmania chagasi Is Induced by Subclinical Cutaneous Infection with Virulent But Not Avirulent Organisms.

J. A. Streit, T. J. Recker, F. G. Filho, S. M. Beverley, and M. E. Wilson (2001)
J. Immunol. 166, 1921-1929
 |  Abstract »  |  Full Text »  |  PDF »

Vervet Monkeys Vaccinated with Killed Leishmania major Parasites and Interleukin-12 Develop a Type 1 Immune Response but Are Not Protected against Challenge Infection.

M. M. Gicheru, J. O. Olobo, C. O. Anjili, A. S. Orago, F. Modabber, and P. Scott (2001)
Infect. Immun. 69, 245-251
 |  Abstract »  |  Full Text »  |  PDF »

T-Cell Responses to Immunodominant LACK Antigen Do Not Play a Critical Role in Determining Susceptibility of BALB/c Mice to Leishmania mexicana.

F. A. Torrentera, N. Glaichenhaus, J. D. Laman, and Y. Carlier (2001)
Infect. Immun. 69, 617-621
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of T Cell-Stimulating Antigens from Leishmania by CD4 T Cell Expression Cloning.

P. Probst, E. Stromberg, H. W. Ghalib, M. Mozel, R. Badaro, S. G. Reed, and J. R. Webb (2001)
J. Immunol. 166, 498-505
 |  Abstract »  |  Full Text »  |  PDF »

Immunization with a Recombinant Stage-Regulated Surface Protein from Leishmania donovani Induces Protection Against Visceral Leishmaniasis.

S. Stager, D. F. Smith, and P. M. Kaye (2000)
J. Immunol. 165, 7064-7071
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Expression Cloning of a Mycobacterium tuberculosis Gene Encoding a Protective Antigen Associated with the Early Control of Infection.

Y. A. W. Skeiky, P. J. Ovendale, S. Jen, M. R. Alderson, D. C. Dillon, S. Smith, C. B. Wilson, I. M. Orme, S. G. Reed, and A. Campos-Neto (2000)
J. Immunol. 165, 7140-7149
 |  Abstract »  |  Full Text »  |  PDF »

Priming by Microbial Antigens from the Intestinal Flora Determines the Ability of CD4+ T Cells to Rapidly Secrete IL-4 in BALB/c Mice Infected with Leishmania major.

V. Julia, S. S. McSorley, L. Malherbe, J.-P. Breittmayer, F. Girard-Pipau, A. Beck, and N. Glaichenhaus (2000)
J. Immunol. 165, 5637-5645
 |  Abstract »  |  Full Text »  |  PDF »

The Serpin Secreted by Brugia malayi Microfilariae, Bm-SPN-2, Elicits Strong, but Short-Lived, Immune Responses in Mice and Humans.

X. Zang, A. K. Atmadja, P. Gray, J. E. Allen, C. A. Gray, R. A. Lawrence, M. Yazdanbakhsh, and R. M. Maizels (2000)
J. Immunol. 165, 5161-5169
 |  Abstract »  |  Full Text »  |  PDF »

Identification of T Cell Ligands in a Library of Peptides Covalently Attached to HLA-DR4.

E. Boen, A. R. Crownover, M. McIlhaney, A. J. Korman, and J. Bill (2000)
J. Immunol. 165, 2040-2047
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Requirements for the Maintenance of Th1 Immunity In Vivo Following DNA Vaccination: A Potential Immunoregulatory Role for CD8+ T Cells.

S. Gurunathan, L. Stobie, C. Prussin, D. L. Sacks, N. Glaichenhaus, D. J. Fowell, R. M. Locksley, J. T. Chang, C.-Y. Wu, and R. A. Seder (2000)
J. Immunol. 165, 915-924
 |  Abstract »  |  Full Text »  |  PDF »

Potentiality of Interleukin-18 as a Useful Reagent for Treatment and Prevention of Leishmania major Infection.

K. Ohkusu, T. Yoshimoto, K. Takeda, T. Ogura, S.-i. Kashiwamura, Y. Iwakura, S. Akira, H. Okamura, and K. Nakanishi (2000)
Infect. Immun. 68, 2449-2456
 |  Abstract »  |  Full Text »  |  PDF »

In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with Leishmania major Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive Disease.

H. Himmelrich, P. Launois, I. Maillard, T. Biedermann, F. Tacchini-Cottier, R. M. Locksley, M. Rocken, and J. A. Louis (2000)
J. Immunol. 164, 4819-4825
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Vaccination of Mice against New World Cutaneous Leishmaniasis: Comparison of Three Proteins Expressed in Amastigotes and Six Adjuvants.

T. Aebischer, M. Wolfram, S. I. Patzer, T. Ilg, M. Wiese, and P. Overath (2000)
Infect. Immun. 68, 1328-1336
 |  Abstract »  |  Full Text »  |  PDF »

Listeria monocytogenes as a Short-Lived Delivery System for the Induction of Type 1 Cell-Mediated Immunity against the p36/LACK Antigen of Leishmania major.

N. Soussi, G. Milon, J.-H. Colle, E. Mougneau, N. Glaichenhaus, and P. L. Goossens (2000)
Infect. Immun. 68, 1498-1506
 |  Abstract »  |  Full Text »  |  PDF »

LdARL-3A, a Leishmania promastigote-specific ADP-ribosylation factor-like protein, is essential for flagellum integrity.

A Cuvillier, F Redon, J. Antoine, P Chardin, T DeVos, and G Merlin (2000)
J. Cell Sci. 113, 2065-2074
 |  Abstract »  |  PDF »

Protective Immunity Using Recombinant Human IL-12 and Alum as Adjuvants in a Primate Model of Cutaneous Leishmaniasis.

R. T. Kenney, D. L. Sacks, J. P. Sypek, L. Vilela, A. A. Gam, and K. Evans-Davis (1999)
J. Immunol. 163, 4481-4488
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory DNA as an Adjuvant in Vaccination against Leishmania major.

K. J. Stacey and J. M. Blackwell (1999)
Infect. Immun. 67, 3719-3726
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of T-Cell Antigens by Using a Recombinant Protein Library and Its Application to the Identification of Novel Vaccine Candidates against Schistosomiasis.

M. Eberl, A. P. Mountford, D. Jankovic, and E. Beck (1999)
Infect. Immun. 67, 3383-3389
 |  Abstract »  |  Full Text »  |  PDF »

Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma -dependent mechanisms.

P. S. Walker, T. Scharton-Kersten, A. M. Krieg, L. Love-Homan, E. D. Rowton, M. C. Udey, and J. C. Vogel (1999)
PNAS 96, 6970-6975
 |  Abstract »  |  Full Text »  |  PDF »

Different Doses of Adenoviral Vector Expressing IL-12 Enhance or Depress the Immune Response to a Coadministered Antigen: the Role of Nitric Oxide.

J. J. Lasarte, F. J. Corrales, N. Casares, A. Lopez-Diaz de Cerio, C. Qian, X. Xie, F. Borras-Cuesta, and J. Prieto (1999)
J. Immunol. 162, 5270-5277
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Leishmania mexicana Cysteine Proteinase-Deficient Mutants Have Attenuated Virulence for Mice and Potentiate a Th1 Response.

J. Alexander, G. H. Coombs, and J. C. Mottram (1998)
J. Immunol. 161, 6794-6801
 |  Abstract »  |  Full Text »  |  PDF »

CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge.

S. Gurunathan, K. R. Irvine, C.-Y. Wu, J. I. Cohen, E. Thomas, C. Prussin, N. P. Restifo, and R. A. Seder (1998)
J. Immunol. 161, 4563-4571
 |  Abstract »  |  Full Text »  |  PDF »

Bacterial Surface Proteins Recognized by CD4+ T Cells During Murine Infection with Listeria monocytogenes.

D. J. Campbell and N. Shastri (1998)
J. Immunol. 161, 2339-2347
 |  Abstract »  |  Full Text »  |  PDF »

The Role of the Bacterial Membrane Protein ActA in Immunity and Protection Against Listeria monocytogenes.

A. Darji, D. Bruder, S. zur Lage, B. Gerstel, T. Chakraborty, J. Wehland, and S. Weiss (1998)
J. Immunol. 161, 2414-2420
 |  Abstract »  |  Full Text »  |  PDF »

Human and Murine Immune Responses to a Novel Leishmania major Recombinant Protein Encoded by Members of a Multicopy Gene Family.

J. R. Webb, A. Campos-Neto, P. J. Ovendale, T. I. Martin, E. J. Stromberg, R. Badaro, and S. G. Reed (1998)
Infect. Immun. 66, 3279-3289
 |  Abstract »  |  Full Text »  |  PDF »

The Transcriptional Regulator Hap1p (Cyp1p) Is Essential for Anaerobic or Heme-Deficient Growth of Saccharomyces cerevisiae: Genetic and Molecular Characterization of an Extragenic Suppressor that Encodes a WD Repeat Protein.

Y. Chantrel, M. Gaisne, C. Lions, and J. Verdiere (1998)
Genetics 148, 559-570
 |  Abstract »  |  Full Text »  |  PDF »

Control of Leishmania major by a Monoclonal {alpha}{beta} T Cell Repertoire.

S. L. Reiner, D. J. Fowell, N. H. Moskowitz, K. Swier, D. R. Brown, C. R. Brown, C. W. Turck, P. A. Scott2, N. Killeen, and R. M. Locksley3 (1998)
J. Immunol. 160, 884-889
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major.

S. Gurunathan, D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder (1997)
J. Exp. Med. 186, 1137-1147
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Pathways for the Initiation of T Helper 2 (Th2) Responses.

R. L. Coffman and T. Weid (1997)
J. Exp. Med. 185, 373-376
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T Helper Subset Differentiation in the Absence of Invariant Chain.

D. R. Brown, K. Swier, N. H. Moskowitz, M. F. Naujokas, R. M. Locksley, and S. L. Reiner (1997)
J. Exp. Med. 185, 31-42
 |  Abstract »  |  Full Text »  |  PDF »

The Immunologically Protective P-4 Antigen of Leishmania Amastigotes. A DEVELOPMENTALLY REGULATED SINGLE STRAND-SPECIFIC NUCLEASE ASSOCIATED WITH THE ENDOPLASMIC RETICULUM.

S. Kar, L. Soong, M. Colmenares, K. Goldsmith-Pestana, and D. McMahon-Pratt (2000)
J. Biol. Chem. 275, 37789-37797
 |  Abstract »  |  Full Text »  |  PDF »

The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge.

L. Stobie, S. Gurunathan, C. Prussin, D. L. Sacks, N. Glaichenhaus, C.-Y. Wu, and R. A. Seder (2000)
PNAS 97, 8427-8432
 |  Abstract »  |  Full Text »  |  PDF »

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