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Science 28 April 1995:
Vol. 268. no. 5210, pp. 560 - 563
DOI: 10.1126/science.7725102

Articles

Science, Vol 268, Issue 5210, 560-563
Copyright © 1995 by American Association for the Advancement of Science


articles

Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2

JJ Hsieh and SD Hayward

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2 binding. Thus, EBNA2 acts by countering transcriptional repression. Mutation at amino acid 233 of CBF1 abolishes repression and correlates with a loss-of-function mutation in the Drosophila homolog Su(H).


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J. Virol. 79, 4651-4663
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The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.
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Genes & Dev. 16, 1977-1989
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Repression of Activator Protein-1-mediated Transcriptional Activation by the Notch-1 Intracellular Domain.
J. Chu, S. Jeffries, J. E. Norton, A. J. Capobianco, and E. H. Bresnick (2002)
J. Biol. Chem. 277, 7587-7597
   Abstract »    Full Text »    PDF »
Epstein-Barr Virus Nuclear Antigen 3C Putative Repression Domain Mediates Coactivation of the LMP1 Promoter with EBNA-2.
J. Lin, E. Johannsen, E. Robertson, and E. Kieff (2002)
J. Virol. 76, 232-242
   Abstract »    Full Text »    PDF »
Proteasome-Independent Disruption of PML Oncogenic Domains (PODs), but Not Covalent Modification by SUMO-1, Is Required for Human Cytomegalovirus Immediate-Early Protein IE1 To Inhibit PML-Mediated Transcriptional Repression.
Y. Xu, J.-H. Ahn, M. Cheng, C. M. apRhys, C.-J. Chiou, J. Zong, M. J. Matunis, and G. S. Hayward (2001)
J. Virol. 75, 10683-10695
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Nuclear Localization of CBF1 Is Regulated by Interactions with the SMRT Corepressor Complex.
S. Zhou and S. D. Hayward (2001)
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Identification of a novel activation domain in the Notch-responsive transcription factor CSL.
Z. Tang and T. Kadesch (2001)
Nucleic Acids Res. 29, 2284-2291
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Protein-DNA Binding and CpG Methylation at Nucleotide Resolution of Latency-Associated Promoters Qp, Cp, and LMP1p of Epstein-Barr Virus.
D. Salamon, M. Takacs, D. Ujvari, J. Uhlig, H. Wolf, J. Minarovits, and H. H. Niller (2001)
J. Virol. 75, 2584-2596
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Epstein-Barr Virus BamHI-A Rightward Transcript-Encoded RPMS Protein Interacts with the CBF1-Associated Corepressor CIR To Negatively Regulate the Activity of EBNA2 and NotchIC.
J. Zhang, H. Chen, G. Weinmaster, and S. D. Hayward (2001)
J. Virol. 75, 2946-2956
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The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription.
S. Tani, H. Kurooka, T. Aoki, N. Hashimoto, and T. Honjo (2001)
Nucleic Acids Res. 29, 1373-1380
   Abstract »    Full Text »    PDF »
Activated Notch1 Can Transiently Substitute for EBNA2 in the Maintenance of Proliferation of LMP1-Expressing Immortalized B Cells.
H. Höfelmayr, L. J. Strobl, G. Marschall, G. W. Bornkamm, and U. Zimber-Strobl (2001)
J. Virol. 75, 2033-2040
   Abstract »    Full Text »
Activation of the Notch-regulated transcription factor CBF1/RBP-J{kappa} through the 13SE1A oncoprotein.
S. Ansieau, L. J. Strobl, and A. Leutz (2001)
Genes & Dev. 15, 380-385
   Abstract »    Full Text »
Amino Acids of Epstein-Barr Virus Nuclear Antigen 3A Essential for Repression of J{kappa}-Mediated Transcription and Their Evolutionary Conservation.
R. Dalbiès-Tran, E. Stigger-Rosser, T. Dotson, and C. E. Sample (2001)
J. Virol. 75, 90-99
   Abstract »    Full Text »
An Epstein-Barr Virus Protein Interacts with Notch.
S. Kusano and N. Raab-Traub (2001)
J. Virol. 75, 384-395
   Abstract »    Full Text »
Conserved Regions in the Epstein-Barr Virus Leader Protein Define Distinct Domains Required for Nuclear Localization and Transcriptional Cooperation with EBNA2.
R. Peng, J. Tan, and P. D. Ling (2000)
J. Virol. 74, 9953-9963
   Abstract »    Full Text »
Evolutionary aspects of oncogenic herpesviruses.
J Nicholas (2000)
Mol. Pathol. 53, 222-237
   Abstract »    Full Text »
The expression and function of Epstein-Barr virus encoded latent genes.
L S Young, C W Dawson, and A G Eliopoulos (2000)
Mol. Pathol. 53, 238-247
   Abstract »    Full Text »
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.
T. G. Doyle, C. Wen, and I. Greenwald (2000)
PNAS 97, 7877-7881
   Abstract »    Full Text »    PDF »
Functional interactions between an atypical NF-{kappa}B site from the rat CYP2B1 promoter and the transcriptional repressor RBP-J{kappa}/CBF1.
S. H. Lee, X.-l. Wang, and J. DeJong (2000)
Nucleic Acids Res. 28, 2091-2098
   Abstract »    Full Text »    PDF »
SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function.
S. Zhou, M. Fujimuro, J. J.-D. Hsieh, L. Chen, A. Miyamoto, G. Weinmaster, and S. D. Hayward (2000)
Mol. Cell. Biol. 20, 2400-2410
   Abstract »    Full Text »
A Role for SKIP in EBNA2 Activation of CBF1-Repressed Promoters.
S. Zhou, M. Fujimuro, J. J.-D. Hsieh, L. Chen, and S. D. Hayward (2000)
J. Virol. 74, 1939-1947
   Abstract »    Full Text »
Intracellular Forms of Human NOTCH1 Functionally Activate Essential Epstein-Barr Virus Major Latent Promoters in the Burkitt's Lymphoma BJAB Cell Line but Repress These Promoters in Jurkat Cells.
M. Cotter, J. Callahan, J. Aster, and E. Robertson (2000)
J. Virol. 74, 1486-1494
   Abstract »    Full Text »
Genetic Dissection of Cell Growth Arrest Functions Mediated by the Epstein-Barr Virus Lytic Gene Product, Zta.
A. Rodriguez, M. Armstrong, D. Dwyer, and E. Flemington (1999)
J. Virol. 73, 9029-9038
   Abstract »    Full Text »    PDF »
Methylation Status of the Epstein-Barr Virus Major Latent Promoter C in Iatrogenic B Cell Lymphoproliferative Disease : Application of PCR-Based Analysis.
Q. Tao, L. J. Swinnen, J. Yang, G. Srivastava, K. D. Robertson, and R. F. Ambinder (1999)
Am. J. Pathol. 155, 619-625
   Abstract »    Full Text »    PDF »
Epstein-Barr Virus (EBV) Nuclear Protein 2-Induced Disruption of EBV Latency in the Burkitt's Lymphoma Cell Line Akata: Analysis by Tetracycline-Regulated Expression.
S. Fujiwara, Y. Nitadori, H. Nakamura, T. Nagaishi, and Y. Ono (1999)
J. Virol. 73, 5214-5219
   Abstract »    Full Text »
Activated Mouse Notch1 Transactivates Epstein-Barr Virus Nuclear Antigen 2-Regulated Viral Promoters.
H. Höfelmayr, L. J. Strobl, C. Stein, G. Laux, G. Marschall, G. W. Bornkamm, and U. Zimber-Strobl (1999)
J. Virol. 73, 2770-2780
   Abstract »    Full Text »
Silencing of the Epstein-Barr Virus Latent Membrane Protein 1 Gene by the Max-Mad1-mSin3A Modulator of Chromatin Structure.
A. Sjöblom-Hallén, W. Yang, A. Jansson, and L. Rymo (1999)
J. Virol. 73, 2983-2993
   Abstract »    Full Text »
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis.
K. Kuroda, S. Tani, K. Tamura, S. Minoguchi, H. Kurooka, and T. Honjo (1999)
J. Biol. Chem. 274, 7238-7244
   Abstract »    Full Text »    PDF »
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
J. J.-D. Hsieh, S. Zhou, L. Chen, D. B. Young, and S. D. Hayward (1999)
PNAS 96, 23-28
   Abstract »    Full Text »    PDF »
Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts.
D Nofziger, A Miyamoto, K. Lyons, and G Weinmaster (1999)
Development 126, 1689-1702
   Abstract »    PDF »
Residues 231 to 280 of the Epstein-Barr Virus Nuclear Protein 2 Are Not Essential for Primary B-Lymphocyte Growth Transformation.
S. Harada, R. Yalamanchili, and E. Kieff (1998)
J. Virol. 72, 9948-9954
   Abstract »    Full Text »    PDF »
Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice.
W. Kulwichit, R. H. Edwards, E. M. Davenport, J. F. Baskar, V. Godfrey, and N. Raab-Traub (1998)
PNAS 95, 11963-11968
   Abstract »    Full Text »    PDF »
Identity of the beta -Globin Locus Control Region Binding Protein HS2NF5 as the Mammalian Homolog of the Notch-regulated Transcription Factor Suppressor of Hairless.
L. T. Lam and E. H. Bresnick (1998)
J. Biol. Chem. 273, 24223-24231
   Abstract »    Full Text »    PDF »
A Genetic Screen for Novel Components of the Notch Signaling Pathway During Drosophila Bristle Development.
M. J. Go and S. Artavanis-Tsakonas (1998)
Genetics 150, 211-220
   Abstract »    Full Text »
Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PML.
J.-H. Ahn, E. J. Brignole III, and G. S. Hayward (1998)
Mol. Cell. Biol. 18, 4899-4913
   Abstract »    Full Text »
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.
H.-Y. Kao, P. Ordentlich, N. Koyano-Nakagawa, Z. Tang, M. Downes, C. R. Kintner, R. M. Evans, and T. Kadesch (1998)
Genes & Dev. 12, 2269-2277
   Abstract »    Full Text »
Functional Replacement of the Intracellular Region of the Notch1 Receptor by Epstein-Barr Virus Nuclear Antigen 2.
T. Sakai, Y. Taniguchi, K. Tamura, S. Minoguchi, T. Fukuhara, L. J. Strobl, U. Zimber-Strobl, G. W. Bornkamm, and T. Honjo (1998)
J. Virol. 72, 6034-6039
   Abstract »    Full Text »    PDF »
The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription.
I. Olave, D. Reinberg, and L. D. Vales (1998)
Genes & Dev. 12, 1621-1637
   Abstract »    Full Text »
NF-kappa B2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jkappa.
F. Oswald, S. Liptay, G. Adler, and R. M. Schmid (1998)
Mol. Cell. Biol. 18, 2077-2088
   Abstract »    Full Text »
An ATF/CRE Element Mediates both EBNA2-Dependent and EBNA2-Independent Activation of the Epstein-Barr Virus LMP1 Gene Promoter.
A. Sjoblom, W. Yang, L. Palmqvist, A. Jansson, and L. Rymo (1998)
J. Virol. 72, 1365-1376
   Abstract »    Full Text »    PDF »
An Intronic Silencer Regulates B Lymphocyte Cell- and Stage-Specific Expression of the Human Complement Receptor Type 2 (CR2, CD21) Gene.
K. W. Makar, C. T. N. Pham, M. H. Dehoff, S. M. O'Connor, S. M. Jacobi, and V. M. Holers (1998)
J. Immunol. 160, 1268-1278
   Abstract »    Full Text »    PDF »
LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein.
Y. Taniguchi, T. Furukawa, T. Tun, H. Han, and T. Honjo (1998)
Mol. Cell. Biol. 18, 644-654
   Abstract »    Full Text »
Selection of peptides that functionally replace a zinc finger in the Sp1 transcription factor by using a yeast combinatorial library.
X. Cheng, J. L. Boyer, and R. L. Juliano (1997)
PNAS 94, 14120-14125
   Abstract »    Full Text »    PDF »
Methylation of the Epstein-Barr Virus Genome in Normal Lymphocytes.
K. D. Robertson and R. F. Ambinder (1997)
Blood 90, 4480-4484
   Abstract »    Full Text »    PDF »
Regulation of the ERBB-2 Promoter by RBPJkappa and NOTCH.
Y. Chen, W. H. Fischer, and G. N. Gill (1997)
J. Biol. Chem. 272, 14110-14114
   Abstract »    Full Text »    PDF »
Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jkappa or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jkappa and Activate Transcription.
J. C. Aster, E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar (1997)
J. Biol. Chem. 272, 11336-11343
   Abstract »    Full Text »    PDF »
The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis.
D. Wettstein, D. Turner, and C Kintner (1997)
Development 124, 693-702
   Abstract »    PDF »
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis..
L Girard, Z Hanna, N Beaulieu, C D Hoemann, C Simard, C A Kozak, and P Jolicoeur (1996)
Genes & Dev. 10, 1930-1944
   Abstract »    PDF »
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).
S Christensen, V Kodoyianni, M Bosenberg, L Friedman, and J Kimble (1996)
Development 122, 1373-1383
   Abstract »    PDF »
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling..
M Lecourtois and F Schweisguth (1995)
Genes & Dev. 9, 2598-2608
   Abstract »    PDF »
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity..
A M Bailey and J W Posakony (1995)
Genes & Dev. 9, 2609-2622
   Abstract »    PDF »
Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1.
L. T. Lam, C. Ronchini, J. Norton, A. J. Capobianco, and E. H. Bresnick (2000)
J. Biol. Chem. 275, 19676-19684
   Abstract »    Full Text »    PDF »



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