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Science 28 April 1995: Vol. 268. no. 5210, pp. 560 - 563 DOI: 10.1126/science.7725102
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Articles
Science, Vol 268, Issue 5210, 560-563
Copyright © 1995 by American Association for the Advancement of Science
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2
JJ Hsieh
and
SD Hayward
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) is a transcriptional activator that is essential for EBV-driven B cell immortalization. EBNA2 is targeted to responsive promoters through interaction with a cellular DNA binding protein, C promoter binding factor 1 (CBF1). A transcriptional repression domain has been identified within CBF1. This domain also interacts with EBNA2, and repression is masked by EBNA2 binding. Thus, EBNA2 acts by countering transcriptional repression. Mutation at amino acid 233 of CBF1 abolishes repression and correlates with a loss-of-function mutation in the Drosophila homolog Su(H).
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- J. C. Aster, E. S. Robertson, R. P. Hasserjian, J. R. Turner, E. Kieff, and J. Sklar (1997)
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- The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis.
- D. Wettstein, D. Turner, and C Kintner (1997)
Development
124, 693-702
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- Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis..
- L Girard, Z Hanna, N Beaulieu, C D Hoemann, C Simard, C A Kozak, and P Jolicoeur (1996)
Genes & Dev.
10, 1930-1944
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- lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).
- S Christensen, V Kodoyianni, M Bosenberg, L Friedman, and J Kimble (1996)
Development
122, 1373-1383
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- The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling..
- M Lecourtois and F Schweisguth (1995)
Genes & Dev.
9, 2598-2608
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- Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity..
- A M Bailey and J W Posakony (1995)
Genes & Dev.
9, 2609-2622
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- Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K562 Erythroleukemic Cells by Notch-1.
- L. T. Lam, C. Ronchini, J. Norton, A. J. Capobianco, and E. H. Bresnick (2000)
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275, 19676-19684
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