Science 21 April 1995: Vol. 268. no. 5209, pp. 423 - 426 DOI: 10.1126/science.7716547

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Articles

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

M. Lamkanfi, J. L. Mueller, A. C. Vitari, S. Misaghi, A. Fedorova, K. Deshayes, W. P. Lee, H. M. Hoffman, and V. M. Dixit (2009)
J. Cell Biol. 187, 61-70
 |  Abstract »  |  Full Text »  |  PDF »

Epac2: A Molecular Target for Sulfonylurea-Induced Insulin Release.

S. A. Hinke (2009)
Science Signaling 2, pe54
 |  Abstract »  |  Full Text »  |  PDF »

A selective small molecule glucagon-like peptide-1 secretagogue acting via depolarization-coupled Ca2+ influx.

J.-i. Eiki, K. Saeki, N. Nagano, T. Iino, M. Yonemoto, Y. Takayenoki-Iino, S. Ito, T. Nishimura, Y. Sato, M. Bamba, et al. (2009)
J. Endocrinol. 201, 361-367
 |  Abstract »  |  Full Text »  |  PDF »

The genetic basis of congenital hyperinsulinism.

C James, R R Kapoor, D Ismail, and K Hussain (2009)
J. Med. Genet. 46, 289-299
 |  Abstract »  |  Full Text »  |  PDF »

A cytosolic factor that inhibits KATP channels expressed in Xenopus oocytes by impairing Mg-nucleotide activation by SUR1.

P. Tammaro and F. M. Ashcroft (2009)
J. Physiol. 587, 1649-1656
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Two KCNJ11 Neonatal Diabetes Mutations, V59G and V59A, and the Analogous KCNJ8 I60G Substitution: DIFFERENCES BETWEEN THE CHANNEL SUBTYPES FORMED WITH SUR1.

M. Winkler, R. Lutz, U. Russ, U. Quast, and J. Bryan (2009)
J. Biol. Chem. 284, 6752-6762
 |  Abstract »  |  Full Text »  |  PDF »

KCNJ11 knockout morula re-engineered by stem cell diploid aggregation.

T. J Nelson, A. Martinez-Fernandez, and A. Terzic (2009)
Phil Trans R Soc B 364, 269-276
 |  Abstract »  |  Full Text »  |  PDF »

Metabolic cycling in control of glucose-stimulated insulin secretion.

M. V. Jensen, J. W. Joseph, S. M. Ronnebaum, S. C. Burgess, A. D. Sherry, and C. B. Newgard (2008)
Am J Physiol Endocrinol Metab 295, E1287-E1297
 |  Abstract »  |  Full Text »  |  PDF »

Channel regulation of glucose sensing in the pancreatic {beta}-cell.

M. Hiriart and L. Aguilar-Bryan (2008)
Am J Physiol Endocrinol Metab 295, E1298-E1306
 |  Abstract »  |  Full Text »  |  PDF »

Functional Clustering of Mutations in the Dimer Interface of the Nucleotide Binding Folds of the Sulfonylurea Receptor.

R. Masia and C. G. Nichols (2008)
J. Biol. Chem. 283, 30322-30329
 |  Abstract »  |  Full Text »  |  PDF »

Type 2 Diabetes Mellitus in Childhood: Obesity and Insulin Resistance.

M. S. Schwartz and A. Chadha (2008)
J Am Osteopath Assoc 108, 518-524
 |  Abstract »  |  Full Text »  |  PDF »

Novel De Novo Mutation in Sulfonylurea Receptor 1 Presenting as Hyperinsulinism in Infancy Followed by Overt Diabetes in Early Adolescence.

M. Abdulhadi-Atwan, J. D. Bushman, S. Tornovsky-Babaey, A. Perry, A. Abu-Libdeh, B. Glaser, S.-L. Shyng, and D. H. Zangen (2008)
Diabetes 57, 1935-1940
 |  Abstract »  |  Full Text »  |  PDF »

Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the KATP channel subunits SUR2A and Kir6.2.

J. P. Dupuis, J. Revilloud, C. J. Moreau, and M. Vivaudou (2008)
J. Physiol. 586, 3075-3085
 |  Abstract »  |  Full Text »  |  PDF »

Neonatal Diabetes Mellitus.

L. Aguilar-Bryan and J. Bryan (2008)
Endocr. Rev. 29, 265-291
 |  Abstract »  |  Full Text »  |  PDF »

A Novel ABCC8 (SUR1)-dependent Mechanism of Metabolism-Excitation Uncoupling.

A. P. Babenko (2008)
J. Biol. Chem. 283, 8778-8782
 |  Abstract »  |  Full Text »  |  PDF »

Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury.

J. W. Elrod, M. Harrell, T. P. Flagg, S. Gundewar, M. A. Magnuson, C. G. Nichols, W. A. Coetzee, and D. J. Lefer (2008)
Circulation 117, 1405-1413
 |  Abstract »  |  Full Text »  |  PDF »

The Sulfonylurea Receptor, an Atypical ATP-Binding Cassette Protein, and Its Regulation of the KATP Channel.

M. A. Burke, R. K. Mutharasan, and H. Ardehali (2008)
Circ. Res. 102, 164-176
 |  Abstract »  |  Full Text »  |  PDF »

Pathological Features of Aberrant Pancreatic Development in Congenital Hyperinsulinism Due to ABCC8 Mutations.

N. Brunetti-Pierri, O. O. Olutoye, R. Heptulla, and N. Tatevian (2008)
Ann. Clin. Lab. Sci. 38, 386-389
 |  Abstract »  |  Full Text »  |  PDF »

A Role for ATP-Citrate Lyase, Malic Enzyme, and Pyruvate/Citrate Cycling in Glucose-induced Insulin Secretion.

C. Guay, S. R. M. Madiraju, A. Aumais, E. Joly, and M. Prentki (2007)
J. Biol. Chem. 282, 35657-35665
 |  Abstract »  |  Full Text »  |  PDF »

ATP-sensitive potassium channels: metabolic sensing and cardioprotection.

L. V. Zingman, A. E. Alekseev, D. M. Hodgson-Zingman, and A. Terzic (2007)
J Appl Physiol 103, 1888-1893
 |  Abstract »  |  Full Text »  |  PDF »

Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study.

Y. Doi, M. Kubo, T. Ninomiya, K. Yonemoto, M. Iwase, H. Arima, J. Hata, Y. Tanizaki, M. Iida, and Y. Kiyohara (2007)
Diabetes 56, 2829-2833
 |  Abstract »  |  Full Text »  |  PDF »

Diabetes Treatment, Part 2: Oral Agents for Glycemic Management.

M. J. Fowler (2007)
Clin. Diabetes 25, 131-134
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ATP-sensitive K+ channels and disease: from molecule to malady.

F. M. Ashcroft (2007)
Am J Physiol Endocrinol Metab 293, E880-E889
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Sulfonylurea Receptor Subunits, SUR2A and SUR2B, in Rat Heart.

M. Zhou, H.-J. He, R. Suzuki, K.-X. Liu, O. Tanaka, M. Sekiguchi, H. Itoh, K. Kawahara, and H. Abe (2007)
J. Histochem. Cytochem. 55, 795-804
 |  Abstract »  |  Full Text »  |  PDF »

Iptakalim, a Vascular ATP-Sensitive Potassium (KATP) Channel Opener, Closes Rat Pancreatic beta-Cell KATP Channels and Increases Insulin Release.

N. Misaki, X. Mao, Y.-F. Lin, S. Suga, G.-H. Li, Q. Liu, Y. Chang, H. Wang, M. Wakui, and J. Wu (2007)
J. Pharmacol. Exp. Ther. 322, 871-878
 |  Abstract »  |  Full Text »  |  PDF »

Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels.

X. Geng, L. Li, R. Bottino, A. N. Balamurugan, S. Bertera, E. Densmore, A. Su, Y. Chang, M. Trucco, and P. Drain (2007)
Am J Physiol Endocrinol Metab 293, E293-E301
 |  Abstract »  |  Full Text »  |  PDF »

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.

P. Tammaro and F. Ashcroft (2007)
J. Physiol. 581, 1259-1269
 |  Abstract »  |  Full Text »  |  PDF »

New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features.

M. Vaxillaire, A. Dechaume, K. Busiah, H. Cave, S. Pereira, R. Scharfmann, G. P. de Nanclares, L. Castano, P. Froguel, M. Polak, et al. (2007)
Diabetes 56, 1737-1741
 |  Abstract »  |  Full Text »  |  PDF »

Dual regulation of the ATP-sensitive potassium channel by caffeine.

X. Mao, Y. Chai, and Y.-F. Lin (2007)
Am J Physiol Cell Physiol 292, C2239-C2258
 |  Abstract »  |  Full Text »  |  PDF »

A Mutation in the TMD0-L0 Region of Sulfonylurea Receptor-1 (L225P) Causes Permanent Neonatal Diabetes Mellitus (PNDM).

R. Masia, D. D. De Leon, C. MacMullen, H. McKnight, C. A. Stanley, and C. G. Nichols (2007)
Diabetes 56, 1357-1362
 |  Abstract »  |  Full Text »  |  PDF »

Role of KATP channels in repetitive induction of ventricular fibrillation.

A. Bauer, R. Becker, J. Dreyhaupt, F. Voss, P. Kraft, K. Kelemen, J. C. Senges-Becker, H. A. Katus, and W. Schoels (2007)
Europace 9, 154-161
 |  Abstract »  |  Full Text »  |  PDF »

A Systematic Review and Meta-Analysis of Hypoglycemia and Cardiovascular Events: A comparison of glyburide with other secretagogues and with insulin.

A. S. Gangji, T. Cukierman, H. C. Gerstein, C. H. Goldsmith, and C. M. Clase (2007)
Diabetes Care 30, 389-394
 |  Abstract »  |  Full Text »  |  PDF »

An ATP-Binding Mutation (G334D) in KCNJ11 Is Associated With a Sulfonylurea-Insensitive Form of Developmental Delay, Epilepsy, and Neonatal Diabetes.

R. Masia, J. C. Koster, S. Tumini, F. Chiarelli, C. Colombo, C. G. Nichols, and F. Barbetti (2007)
Diabetes 56, 328-336
 |  Abstract »  |  Full Text »  |  PDF »

Sulfonylurea Compounds Uncouple the Glucose Dependence of the Insulinotropic Effect of Glucagon-Like Peptide 1.

J. de Heer and J. J. Holst (2007)
Diabetes 56, 438-443
 |  Abstract »  |  Full Text »  |  PDF »

Effects of the Combination of a Dipeptidyl Peptidase IV Inhibitor and an Insulin Secretagogue on Glucose and Insulin Levels in Mice and Rats.

K. Yamazaki, N. Yasuda, T. Inoue, E. Yamamoto, Y. Sugaya, T. Nagakura, M. Shinoda, R. Clark, T. Saeki, and I. Tanaka (2007)
J. Pharmacol. Exp. Ther. 320, 738-746
 |  Abstract »  |  Full Text »  |  PDF »

Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels.

W. H. Vila-Carriles, G. Zhao, and J. Bryan (2007)
FASEB J 21, 18-25
 |  Abstract »  |  Full Text »  |  PDF »

Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant.

S. Yamada, G. C. Kane, A. Behfar, X.-K. Liu, R. B. Dyer, R. S. Faustino, T. Miki, S. Seino, and A. Terzic (2006)
J. Physiol. 577, 1053-1065
 |  Abstract »  |  Full Text »  |  PDF »

Targeted expression of Kir6.2 in mitochondria confers protection against hypoxic stress.

M. Ljubkovic, J. Marinovic, A. Fuchs, Z. J. Bosnjak, and M. Bienengraeber (2006)
J. Physiol. 577, 17-29
 |  Abstract »  |  Full Text »  |  PDF »

Sulfonylureas Correct Trafficking Defects of Disease-causing ATP-sensitive Potassium Channels by Binding to the Channel Complex.

F.-F. Yan, J. Casey, and S.-L. Shyng (2006)
J. Biol. Chem. 281, 33403-33413
 |  Abstract »  |  Full Text »  |  PDF »

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus..

A. P. Babenko, M. Polak, H. Cave, K. Busiah, P. Czernichow, R. Scharfmann, J. Bryan, L. Aguilar-Bryan, M. Vaxillaire, and P. Froguel (2006)
N. Engl. J. Med. 355, 456-466
 |  Abstract »  |  Full Text »  |  PDF »

ATP-sensitive potassium channels--neonatal diabetes mellitus and beyond..

M. A. Sperling (2006)
N. Engl. J. Med. 355, 507-510
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Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins..

R. G. Deeley, C. Westlake, and S. P. C. Cole (2006)
Physiol Rev 86, 849-899
 |  Abstract »  |  Full Text »  |  PDF »

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic {beta} cells and rat INS-1 cells.

G. Kang, O. G. Chepurny, B. Malester, M. J. Rindler, H. Rehmann, J. L. Bos, F. Schwede, W. A. Coetzee, and G. G. Holz (2006)
J. Physiol. 573, 595-609
 |  Abstract »  |  Full Text »  |  PDF »

The E23K Variant of KCNJ11 Encoding the Pancreatic {beta}-Cell Adenosine 5'-Triphosphate-Sensitive Potassium Channel Subunit Kir6.2 Is Associated with an Increased Risk of Secondary Failure to Sulfonylurea in Patients with Type 2 Diabetes.

G. Sesti, E. Laratta, M. Cardellini, F. Andreozzi, S. Del Guerra, C. Irace, A. Gnasso, M. Grupillo, R. Lauro, M. L. Hribal, et al. (2006)
J. Clin. Endocrinol. Metab. 91, 2334-2339
 |  Abstract »  |  Full Text »  |  PDF »

Mutations at the Same Residue (R50) of Kir6.2 (KCNJ11) That Cause Neonatal Diabetes Produce Different Functional Effects.

K. Shimomura, C. A.J. Girard, P. Proks, J. Nazim, J. D. Lippiat, F. Cerutti, R. Lorini, S. Ellard, A. T. Hattersley, F. Barbetti, et al. (2006)
Diabetes 55, 1705-1712
 |  Abstract »  |  Full Text »  |  PDF »

Functional Effects of Mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), Causing Neonatal Diabetes, and Response to Sulfonylurea Therapy.

P. Proks, C. Girard, H. Baevre, P. R. Njolstad, and F. M. Ashcroft (2006)
Diabetes 55, 1731-1737
 |  Abstract »  |  Full Text »  |  PDF »

L-Cysteine Inhibits Insulin Release From the Pancreatic {beta}-Cell: Possible Involvement of Metabolic Production of Hydrogen Sulfide, a Novel Gasotransmitter..

Y. Kaneko, Y. Kimura, H. Kimura, and I. Niki (2006)
Diabetes 55, 1391-1397
 |  Abstract »  |  Full Text »  |  PDF »

Functional effects of naturally occurring KCNJ11 mutations causing neonatal diabetes on cloned cardiac KATP channels.

P. Tammaro, P. Proks, and F. M. Ashcroft (2006)
J. Physiol. 571, 3-14
 |  Abstract »  |  Full Text »  |  PDF »

Functional Importance of Three Basic Residues Clustered at the Cytosolic Interface of Transmembrane Helix 15 in the Multidrug and Organic Anion Transporter MRP1 (ABCC1).

G. Conseil, R. G. Deeley, and S. P. C. Cole (2006)
J. Biol. Chem. 281, 43-50
 |  Abstract »  |  Full Text »  |  PDF »

Glucose-sensing mechanisms in pancreatic {beta}-cells.

P. E MacDonald, J. W Joseph, and P. Rorsman (2005)
Phil Trans R Soc B 360, 2211-2225
 |  Abstract »  |  Full Text »  |  PDF »

Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily.

F. H. Yu, V. Yarov-Yarovoy, G. A. Gutman, and W. A. Catterall (2005)
Pharmacol. Rev. 57, 387-395
 |  Full Text »  |  PDF »

Diabetes and Insulin Secretion: The ATP-Sensitive K+ Channel (KATP) Connection.

J. C. Koster, M. A. Permutt, and C. G. Nichols (2005)
Diabetes 54, 3065-3072
 |  Abstract »  |  Full Text »  |  PDF »

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels.

F.-F. Yan, C.-W. Lin, E. A. Cartier, and S.-L. Shyng (2005)
Am J Physiol Cell Physiol 289, C1351-C1359
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacological Properties and Functional Role of Kslow Current in Mouse Pancreatic {beta}-Cells: SK Channels Contribute to Kslow Tail Current and Modulate Insulin Secretion.

M. Zhang, K. Houamed, S. Kupershmidt, D. Roden, and L. S. Satin (2005)
J. Gen. Physiol. 126, 353-363
 |  Abstract »  |  Full Text »  |  PDF »

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

P. Proks, C. Girard, and F. M. Ashcroft (2005)
Hum. Mol. Genet. 14, 2717-2726
 |  Abstract »  |  Full Text »  |  PDF »

ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K+ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy.

J. C. Koster, M. S. Remedi, C. Dao, and C. G. Nichols (2005)
Diabetes 54, 2645-2654
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the KATP Channel.

L. Li, X. Geng, M. Yonkunas, A. Su, E. Densmore, P. Tang, and P. Drain (2005)
J. Gen. Physiol. 126, 285-299
 |  Abstract »  |  Full Text »  |  PDF »

Review: Sulphonylureas and the rise and fall of beta-cell function.

D. R Matthews and T. M Wallace (2005)
The British Journal of Diabetes & Vascular Disease 5, 192-196
 |  Abstract »  |  PDF »

The E23K variant in the Kir6.2 subunit of the ATP-sensitive K+ channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes.

C. Ezenwaka, R. Kalloo, M. Uhlig, R. Schwenk, and J. Eckel (2005)
J. Endocrinol. 185, 439-444
 |  Abstract »  |  Full Text »  |  PDF »

The Size of a Single Residue of the Sulfonylurea Receptor Dictates the Effectiveness of KATP Channel Openers.

C. Moreau, F. Gally, H. Jacquet-Bouix, and M. Vivaudou (2005)
Mol. Pharmacol. 67, 1026-1033
 |  Abstract »  |  Full Text »  |  PDF »

Two SUR1-specific Histidine Residues Mandatory for Zinc-induced Activation of the Rat KATP Channel.

V. Bancila, T. Cens, D. Monnier, F. Chanson, C. Faure, Y. Dunant, and A. Bloc (2005)
J. Biol. Chem. 280, 8793-8799
 |  Abstract »  |  Full Text »  |  PDF »

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion.

M. J. MacDonald, L. A. Fahien, L. J. Brown, N. M. Hasan, J. D. Buss, and M. A. Kendrick (2005)
Am J Physiol Endocrinol Metab 288, E1-E15
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Diversity and Regulation of Renal Potassium Channels.

S. C. Hebert, G. Desir, G. Giebisch, and W. Wang (2005)
Physiol Rev 85, 319-371
 |  Abstract »  |  Full Text »  |  PDF »

Hyperinsulinism of Infancy: Novel ABCC8 and KCNJ11 Mutations and Evidence for Additional Locus Heterogeneity.

S. Tornovsky, A. Crane, K. E. Cosgrove, K. Hussain, J. Lavie, M. Heyman, Y. Nesher, N. Kuchinski, E. Ben-Shushan, O. Shatz, et al. (2004)
J. Clin. Endocrinol. Metab. 89, 6224-6234
 |  Abstract »  |  Full Text »  |  PDF »

Impact of Treatment on Islet Function in Type 2 Diabetes.

J.-C. Henquin, C. Boitard, E. Cerasi, E. Ferrannini, D. F. Steiner, and S. Efendic (2004)
Diabetes 53, S1-S5
 |  Full Text »  |  PDF »

Toward Linking Structure With Function in ATP-Sensitive K+ Channels.

J. Bryan, W. H. Vila-Carriles, G. Zhao, A. P. Babenko, and L. Aguilar-Bryan (2004)
Diabetes 53, S104-S112
 |  Abstract »  |  Full Text »  |  PDF »

Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K+ Channel: A Pas de Deux.

A. Tarasov, J. Dusonchet, and F. Ashcroft (2004)
Diabetes 53, S113-S122
 |  Abstract »  |  Full Text »  |  PDF »

ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits.

G. C. Kane, A. Behfar, S. Yamada, C. Perez-Terzic, F. O'Cochlain, S. Reyes, P. P. Dzeja, T. Miki, S. Seino, and A. Terzic (2004)
Diabetes 53, S169-S175
 |  Abstract »  |  Full Text »  |  PDF »

Syntaxin-1A Inhibits Cardiac KATP Channels by Its Actions on Nucleotide Binding Folds 1 and 2 of Sulfonylurea Receptor 2A.

Y. Kang, Y.-M. Leung, J. E. Manning-Fox, F. Xia, H. Xie, L. Sheu, R. G. Tsushima, P. E. Light, and H. Y. Gaisano (2004)
J. Biol. Chem. 279, 47125-47131
 |  Abstract »  |  Full Text »  |  PDF »

The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.

F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
 |  Abstract »  |  Full Text »  |  PDF »

Mutation in Nucleotide-Binding Domains of Sulfonylurea Receptor 2 Evokes Na-ATP-Dependent Activation of ATP-Sensitive K+ Channels: Implication for Dimerization of Nucleotide-Binding Domains to Induce Channel Opening.

M. Yamada, M. Ishii, H. Hibino, and Y. Kurachi (2004)
Mol. Pharmacol. 66, 807-816
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of Glucose Sensing and Insulin Secretion by Ribozyme Kir6.2-Gene Targeting in Insulin-Secreting Cells.

L. Li, A. Rojas, J. Wu, and C. Jiang (2004)
Endocrinology 145, 4408-4414
 |  Abstract »  |  Full Text »  |  PDF »

Both Triggering and Amplifying Pathways Contribute to Fuel-induced Insulin Secretion in the Absence of Sulfonylurea Receptor-1 in Pancreatic {beta}-Cells.

M. Nenquin, A. Szollosi, L. Aguilar-Bryan, J. Bryan, and J.-C. Henquin (2004)
J. Biol. Chem. 279, 32316-32324
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Mouse Glutamine-Fructose-6-phosphate Amidotransferase 2 (GFAT2) by cAMP-dependent Protein Kinase Increases the Enzyme Activity.

Y. Hu, L. Riesland, A. J. Paterson, and J. E. Kudlow (2004)
J. Biol. Chem. 279, 29988-29993
 |  Abstract »  |  Full Text »  |  PDF »

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.

M. Dabrowski, A. Tarasov, and F. M. Ashcroft (2004)
J. Physiol. 557, 347-354
 |  Abstract »  |  Full Text »  |  PDF »

Multisite Phosphorylation Mechanism for Protein Kinase A Activation of the Smooth Muscle ATP-Sensitive K+ Channel.

K. V. Quinn, J. P. Giblin, and A. Tinker (2004)
Circ. Res. 94, 1359-1366
 |  Abstract »  |  Full Text »  |  PDF »

The Nucleotide-Binding Domains of Sulfonylurea Receptor 2A and 2B Play Different Functional Roles in Nicorandil-Induced Activation of ATP-Sensitive K+ Channels.

M. Yamada and Y. Kurachi (2004)
Mol. Pharmacol. 65, 1198-1207
 |  Abstract »  |  Full Text »

Role of Neuronal KATP Channels and Extraneuronal Monoamine Transporter on Norepinephrine Overflow in a Model of Myocardial Low Flow Ischemia.

C. Burgdorf, A. Dendorfer, T. Kurz, E. Schomig, I. Stolting, F. Schutte, and G. Richardt (2004)
J. Pharmacol. Exp. Ther. 309, 42-48
 |  Abstract »  |  Full Text »

Type 2 diabetes mellitus: not quite exciting enough?.

F. Ashcroft and P. Rorsman (2004)
Hum. Mol. Genet. 13, R21-R31
 |  Abstract »  |  Full Text »  |  PDF »

Sulfonylureas Correct Trafficking Defects of ATP-sensitive Potassium Channels Caused by Mutations in the Sulfonylurea Receptor.

F. Yan, C.-W. Lin, E. Weisiger, E. A. Cartier, G. Taschenberger, and S.-L. Shyng (2004)
J. Biol. Chem. 279, 11096-11105
 |  Abstract »  |  Full Text »  |  PDF »

Assembly, Maturation, and Turnover of KATP Channel Subunits.

A. Crane and L. Aguilar-Bryan (2004)
J. Biol. Chem. 279, 9080-9090
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Mitochondrial K+ Channels and Their Role in Cardioprotection.

B. O'Rourke (2004)
Circ. Res. 94, 420-432
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Adenosine Triphosphate-Sensitive Potassium Channels by Acyl Coenzyme A Esters Involves Multiple Phosphatidylinositol 4,5-Bisphosphate-Interacting Residues.

J. E. Manning Fox, C. G. Nichols, and P. E. Light (2004)
Mol. Endocrinol. 18, 679-686
 |  Abstract »  |  Full Text »  |  PDF »

Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons.

L. Kang, V. H. Routh, E. V. Kuzhikandathil, L. D. Gaspers, and B. E. Levin (2004)
Diabetes 53, 549-559
 |  Abstract »  |  Full Text »  |  PDF »

Epinephrine-induced hyperpolarization of islet cells without KATP channels.

A. Sieg, J. Su, A. Munoz, M. Buchenau, M. Nakazaki, L. Aguilar-Bryan, J. Bryan, and S. Ullrich (2004)
Am J Physiol Endocrinol Metab 286, E463-E471
 |  Abstract »  |  Full Text »

Assembly and Trafficking of a Multiprotein ROMK (Kir 1.1) Channel Complex by PDZ Interactions.

D. Yoo, T. P. Flagg, O. Olsen, V. Raghuram, J. K. Foskett, and P. A. Welling (2004)
J. Biol. Chem. 279, 6863-6873
 |  Abstract »  |  Full Text »  |  PDF »

Syntaxin-1A Binds the Nucleotide-binding Folds of Sulphonylurea Receptor 1 to Regulate the KATP Channel.

E. A. Pasyk, Y. Kang, X. Huang, N. Cui, L. Sheu, and H. Y. Gaisano (2004)
J. Biol. Chem. 279, 4234-4240
 |  Abstract »  |  Full Text »  |  PDF »

Hyperinsulinism in Infancy: From Basic Science to Clinical Disease.

M. J. DUNNE, K. E. COSGROVE, R. M. SHEPHERD, A. AYNSLEY-GREEN, and K. J. LINDLEY (2004)
Physiol Rev 84, 239-275
 |  Abstract »  |  Full Text »  |  PDF »

SUR Domains That Associate with and Gate KATP Pores Define a Novel Gatekeeper.

A. P. Babenko and J. Bryan (2003)
J. Biol. Chem. 278, 41577-41580
 |  Abstract »  |  Full Text »  |  PDF »

Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism.

F. Kamp, N. Kizilbash, B. E. Corkey, P.-O. Berggren, and J. A. Hamilton (2003)
Diabetes 52, 2526-2531
 |  Abstract »  |  Full Text »  |  PDF »

Kir6.2 Polymorphisms Sensitize {beta}-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs: A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?.

M. J. Riedel, P. Boora, D. Steckley, G. de Vries, and P. E. Light (2003)
Diabetes 52, 2630-2635
 |  Abstract »  |  Full Text »  |  PDF »

Functional Coupling between Sulfonylurea Receptor Type 1 and a Nonselective Cation Channel in Reactive Astrocytes from Adult Rat Brain.

M. Chen, Y. Dong, and J. M. Simard (2003)
J. Neurosci. 23, 8568-8577
 |  Abstract »  |  Full Text »  |  PDF »

Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea Receptor.

P. S. Thornton, C. MacMullen, A. Ganguly, E. Ruchelli, L. Steinkrauss, A. Crane, L. Aguilar-Bryan, and C. A. Stanley (2003)
Diabetes 52, 2403-2410
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH.

Y.-J. Liu, H. Cheng, H. Drought, M. J. MacDonald, G. W. G. Sharp, and S. G. Straub (2003)
Am J Physiol Endocrinol Metab 285, E380-E389
 |  Abstract »  |  Full Text »  |  PDF »

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.

M. Dabrowski, S. Trapp, and F. M Ashcroft (2003)
J. Physiol. 550, 357-363
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Functional Bacterial Homologue of Sodium-dependent Neurotransmitter Transporters.

A. Androutsellis-Theotokis, N. R. Goldberg, K. Ueda, T. Beppu, M. L. Beckman, S. Das, J. A. Javitch, and G. Rudnick (2003)
J. Biol. Chem. 278, 12703-12709
 |  Abstract »  |  Full Text »  |  PDF »

The Insulin Secretory Granule Is the Major Site of KATP Channels of the Endocrine Pancreas.

X. Geng, L. Li, S. Watkins, P. D. Robbins, and P. Drain (2003)
Diabetes 52, 767-776
 |  Abstract »  |  Full Text »  |  PDF »

The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma.

C. Sempoux, Y. Guiot, K. Dahan, P. Moulin, M. Stevens, V. Lambot, P. d. Lonlay, J.-C. Fournet, C. Junien, F. Jaubert, et al. (2003)
Diabetes 52, 784-794
 |  Abstract »  |  Full Text »  |  PDF »

Nateglinide, a D-Phenylalanine Derivative Lacking Either a Sulfonylurea or Benzamido Moiety, Specifically Inhibits Pancreatic beta -Cell-Type KATP Channels.

M. Chachin, M. Yamada, A. Fujita, T. Matsuoka, K. Matsushita, and Y. Kurachi (2003)
J. Pharmacol. Exp. Ther. 304, 1025-1032
 |  Abstract »  |  Full Text »  |  PDF »

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