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Science 21 April 1995: Vol. 268. no. 5209, pp. 405 - 408 DOI: 10.1126/science.7716543
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Articles
Science, Vol 268, Issue 5209, 405-408
Copyright © 1995 by American Association for the Advancement of Science
Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells
M Colonna
and
J Samaridis
Basel Institute for Immunology, Switzerland.
Cytotoxicity by natural killer (NK) cells is inhibited by major histocompatibility complex (MHC) class I molecules on target cells. This inhibition may be mediated by NK receptors with different MHC specificities. A family of four NK-specific complementary DNAs (cDNAs), designated NKATs (NK-associated transcripts), was identified that encoded related transmembrane proteins, characterized by an extracellular region with two or three immunoglobulin-superfamily domains and by a cytoplasmic domain with an unusual antigen receptor activation motif (ARAM). The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells.
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- Killer Cell Inhibitory Receptors for MHC Class I Molecules Regulate Lysis of Melanoma Cells Mediated by NK cells, {gamma}{delta} T Cells, and Antigen-Specific CTL.
- A. B. H. Bakker, J. H. Phillips, C. G. Figdor, and L. L. Lanier (1998)
J. Immunol.
160, 5239-5245
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- HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.
- N. Lee, M. Llano, M. Carretero, A. Ishitani, F. Navarro, M. Lopez-Botet, and D. E. Geraghty (1998)
PNAS
95, 5199-5204
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- Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells.
- O. Mandelboim, S. Kent, D. M. Davis, S. B. Wilson, T. Okazaki, R. Jackson, D. Hafler, and J. L. Strominger (1998)
PNAS
95, 3798-3803
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- HLA class I-specific inhibitory receptors in human T lymphocytes: Interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells.
- M. C. Mingari, M. Ponte, S. Bertone, F. Schiavetti, C. Vitale, R. Bellomo, A. Moretta, and L. Moretta (1998)
PNAS
95, 1172-1177
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- Association of Tyrosine Phosphatases SHP-1 and SHP-2, Inositol 5-Phosphatase SHIP with gp49B1, and Chromosomal Assignment of the Gene.
- A. Kuroiwa, Y. Yamashita, M. Inui, T. Yuasa, M. Ono, A. Nagabukuro, Y. Matsuda, and T. Takai (1998)
J. Biol. Chem.
273, 1070-1074
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- Interleukin-12-Activated Natural Killer Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells.
- A. B. Geldhof, M. Moser, L. Lespagnard, K. Thielemans, and P. De Baetselier (1998)
Blood
91, 196-206
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- Association with FcRgamma Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells.
- N. Arase, H. Arase, S. Y. Park, H. Ohno, C. Ra, and T. Saito (1997)
J. Exp. Med.
186, 1957-1963
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- A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells.
- M. Colonna, F. Navarro, T. Bellon, M. Llano, P. Garcia, J. Samaridis, L. Angman, M. Cella, and M. Lopez-Botet (1997)
J. Exp. Med.
186, 1809-1818
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- p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation.
- S. Sivori, M. Vitale, L. Morelli, L. Sanseverino, R. Augugliaro, C. Bottino, L. Moretta, and A. Moretta (1997)
J. Exp. Med.
186, 1129-1136
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- Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene.
- M. H. Johansson, C. Bieberich, G. Jay, K. Karre, and P. Hoglund (1997)
J. Exp. Med.
186, 353-364
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- Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex-dependent Education Process in Natural Killer Cell Development.
- W. Held and D. H. Raulet (1997)
J. Exp. Med.
185, 2079-2088
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- Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis.
- F. Zappacosta, F. Borrego, A. G. Brooks, K. C. Parker, and J. E. Coligan (1997)
PNAS
94, 6313-6318
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- Platelet Endothelial Cell Adhesion Molecule-1 Is Phosphorylatable by c-Src, Binds Src-Src homology 2 Domain, and Exhibits Immunoreceptor Tyrosine-based Activation Motif-like Properties.
- T. T. Lu, M. Barreuther, S. Davis, and J. A. Madri (1997)
J. Biol. Chem.
272, 14442-14446
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- Preferential Interaction of a Novel Tumor Surface Protein (p38.5) with Naive Natural Killer Cells.
- B. Das, M. O. Mondragon, S.-Z. Tao, and A. J. Norin (1997)
J. Exp. Med.
185, 1735-1742
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- A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing.
- M. Cella, C. Dohring, J. Samaridis, M. Dessing, M. Brockhaus, A. Lanzavecchia, and M. Colonna (1997)
J. Exp. Med.
185, 1743-1751
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- The alpha 1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: Is HLA-G the public ligand for natural killer cell inhibitory receptors?.
- N. Rouas-Freiss, R. E. Marchal, M. Kirszenbaum, J. Dausset, and E. D. Carosella (1997)
PNAS
94, 5249-5254
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- A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.
- H. Kubagawa, P. D. Burrows, and M. D. Cooper (1997)
PNAS
94, 5261-5266
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- Self and viral peptides can initiate lysis by autologous natural killer cells.
- O. Mandelboim, S. B. Wilson, M. Vales-Gomez, H. T. Reyburn, and J. L. Strominger (1997)
PNAS
94, 4604-4609
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- The Direct Binding of a p58 Killer Cell Inhibitory Receptor to Human Histocompatibility Leukocyte Antigen (HLA)-Cw4 Exhibits Peptide Selectivity.
- S. Rajagopalan and E. O. Long (1997)
J. Exp. Med.
185, 1523-1528
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- Reconstituted Killer Cell Inhibitory Receptors for Major Histocompatibility Complex Class I Molecules Control Mast Cell Activation Induced via Immunoreceptor Tyrosine-based Activation Motifs.
- M. Blery, J. Delon, A. Trautmann, A. Cambiaggi, L. Olcese, R. Biassoni, L. Moretta, P. Chavrier, A. Moretta, M. Daeron, et al. (1997)
J. Biol. Chem.
272, 8989-8996
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- Molecular Cloning of a Novel Murine Cell-surface Glycoprotein Homologous to Killer Cell Inhibitory Receptors.
- K. Hayami, D. Fukuta, Y. Nishikawa, Y. Yamashita, M. Inui, Y. Ohyama, M. Hikida, H. Ohmori, and T. Takai (1997)
J. Biol. Chem.
272, 7320-7327
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- Mouse Ly-49A Interrupts Early Signaling Events in Natural Killer Cell Cytotoxicity and Functionally Associates with the SHP-1 Tyrosine Phosphatase.
- M. C. Nakamura, E. C. Niemi, M. J. Fisher, L. D. Shultz, W. E. Seaman, and J. C. Ryan (1997)
J. Exp. Med.
185, 673-684
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- NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor.
- A. G. Brooks, P. E. Posch, C. J. Scorzelli, F. Borrego, and J. E. Coligan (1997)
J. Exp. Med.
185, 795-800
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- Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells.
- C. Munz, N. Holmes, A. King, Y. W. Loke, M. Colonna, H. Schild, and H.-G. Rammensee (1997)
J. Exp. Med.
185, 385-392
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