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Science 21 April 1995:
Vol. 268. no. 5209, pp. 405 - 408
DOI: 10.1126/science.7716543

Articles

Science, Vol 268, Issue 5209, 405-408
Copyright © 1995 by American Association for the Advancement of Science


articles

Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells

M Colonna and J Samaridis

Basel Institute for Immunology, Switzerland.

Cytotoxicity by natural killer (NK) cells is inhibited by major histocompatibility complex (MHC) class I molecules on target cells. This inhibition may be mediated by NK receptors with different MHC specificities. A family of four NK-specific complementary DNAs (cDNAs), designated NKATs (NK-associated transcripts), was identified that encoded related transmembrane proteins, characterized by an extracellular region with two or three immunoglobulin-superfamily domains and by a cytoplasmic domain with an unusual antigen receptor activation motif (ARAM). The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells.


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P. Bruhns, P. Marchetti, W. H. Fridman, E. Vivier, and M. Daeron (1999)
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Alloreactivity and Association of Human Natural Killer Cells with the Major Histocompatibility Complex.
E. Mavoungou, A. Sall, V. Poaty-Mavoungou, F. S. Toure, P. Yaba, A. Delicat, and J. Lansoud-Soukate (1999)
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H. Kubagawa, C.-C. Chen, Le Hong Ho, T. Shimada, L. Gartland, C. Mashburn, T. Uehara, J. V. Ravetch, and M. D. Cooper (1999)
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D. W. McVicar, L. S. Taylor, P. Gosselin, J. Willette-Brown, A. I. Mikhael, R. L. Geahlen, M. C. Nakamura, P. Linnemeyer, W. E. Seaman, S. K. Anderson, et al. (1998)
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M. Vales-Gomez, H. T. Reyburn, R. A. Erskine, and J. Strominger (1998)
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J. Immunol. 160, 5971-5978
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J. Biol. Chem. 273, 1070-1074
   Abstract »    Full Text »    PDF »
Interleukin-12-Activated Natural Killer Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells.
A. B. Geldhof, M. Moser, L. Lespagnard, K. Thielemans, and P. De Baetselier (1998)
Blood 91, 196-206
   Abstract »    Full Text »    PDF »
Association with FcRgamma Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells.
N. Arase, H. Arase, S. Y. Park, H. Ohno, C. Ra, and T. Saito (1997)
J. Exp. Med. 186, 1957-1963
   Abstract »    Full Text »    PDF »
A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells.
M. Colonna, F. Navarro, T. Bellon, M. Llano, P. Garcia, J. Samaridis, L. Angman, M. Cella, and M. Lopez-Botet (1997)
J. Exp. Med. 186, 1809-1818
   Abstract »    Full Text »    PDF »
p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation.
S. Sivori, M. Vitale, L. Morelli, L. Sanseverino, R. Augugliaro, C. Bottino, L. Moretta, and A. Moretta (1997)
J. Exp. Med. 186, 1129-1136
   Abstract »    Full Text »    PDF »
Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene.
M. H. Johansson, C. Bieberich, G. Jay, K. Karre, and P. Hoglund (1997)
J. Exp. Med. 186, 353-364
   Abstract »    Full Text »    PDF »
Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex-dependent Education Process in Natural Killer Cell Development.
W. Held and D. H. Raulet (1997)
J. Exp. Med. 185, 2079-2088
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Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis.
F. Zappacosta, F. Borrego, A. G. Brooks, K. C. Parker, and J. E. Coligan (1997)
PNAS 94, 6313-6318
   Abstract »    Full Text »    PDF »
Platelet Endothelial Cell Adhesion Molecule-1 Is Phosphorylatable by c-Src, Binds Src-Src homology 2 Domain, and Exhibits Immunoreceptor Tyrosine-based Activation Motif-like Properties.
T. T. Lu, M. Barreuther, S. Davis, and J. A. Madri (1997)
J. Biol. Chem. 272, 14442-14446
   Abstract »    Full Text »    PDF »
Preferential Interaction of a Novel Tumor Surface Protein (p38.5) with Naive Natural Killer Cells.
B. Das, M. O. Mondragon, S.-Z. Tao, and A. J. Norin (1997)
J. Exp. Med. 185, 1735-1742
   Abstract »    Full Text »    PDF »
A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing.
M. Cella, C. Dohring, J. Samaridis, M. Dessing, M. Brockhaus, A. Lanzavecchia, and M. Colonna (1997)
J. Exp. Med. 185, 1743-1751
   Abstract »    Full Text »    PDF »
The alpha 1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: Is HLA-G the public ligand for natural killer cell inhibitory receptors?.
N. Rouas-Freiss, R. E. Marchal, M. Kirszenbaum, J. Dausset, and E. D. Carosella (1997)
PNAS 94, 5249-5254
   Abstract »    Full Text »    PDF »
A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells.
H. Kubagawa, P. D. Burrows, and M. D. Cooper (1997)
PNAS 94, 5261-5266
   Abstract »    Full Text »    PDF »
Self and viral peptides can initiate lysis by autologous natural killer cells.
O. Mandelboim, S. B. Wilson, M. Vales-Gomez, H. T. Reyburn, and J. L. Strominger (1997)
PNAS 94, 4604-4609
   Abstract »    Full Text »    PDF »
The Direct Binding of a p58 Killer Cell Inhibitory Receptor to Human Histocompatibility Leukocyte Antigen (HLA)-Cw4 Exhibits Peptide Selectivity.
S. Rajagopalan and E. O. Long (1997)
J. Exp. Med. 185, 1523-1528
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Reconstituted Killer Cell Inhibitory Receptors for Major Histocompatibility Complex Class I Molecules Control Mast Cell Activation Induced via Immunoreceptor Tyrosine-based Activation Motifs.
M. Blery, J. Delon, A. Trautmann, A. Cambiaggi, L. Olcese, R. Biassoni, L. Moretta, P. Chavrier, A. Moretta, M. Daeron, et al. (1997)
J. Biol. Chem. 272, 8989-8996
   Abstract »    Full Text »    PDF »
Molecular Cloning of a Novel Murine Cell-surface Glycoprotein Homologous to Killer Cell Inhibitory Receptors.
K. Hayami, D. Fukuta, Y. Nishikawa, Y. Yamashita, M. Inui, Y. Ohyama, M. Hikida, H. Ohmori, and T. Takai (1997)
J. Biol. Chem. 272, 7320-7327
   Abstract »    Full Text »    PDF »
Mouse Ly-49A Interrupts Early Signaling Events in Natural Killer Cell Cytotoxicity and Functionally Associates with the SHP-1 Tyrosine Phosphatase.
M. C. Nakamura, E. C. Niemi, M. J. Fisher, L. D. Shultz, W. E. Seaman, and J. C. Ryan (1997)
J. Exp. Med. 185, 673-684
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NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor.
A. G. Brooks, P. E. Posch, C. J. Scorzelli, F. Borrego, and J. E. Coligan (1997)
J. Exp. Med. 185, 795-800
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Human Histocompatibility Leukocyte Antigen (HLA)-G Molecules Inhibit NKAT3 Expressing Natural Killer Cells.
C. Munz, N. Holmes, A. King, Y. W. Loke, M. Colonna, H. Schild, and H.-G. Rammensee (1997)
J. Exp. Med. 185, 385-392
   Abstract »    Full Text »    PDF »



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