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Science 14 April 1995:
Vol. 268. no. 5208, pp. 301 - 304
DOI: 10.1126/science.7716525
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Articles

Science, Vol 268, Issue 5208, 301-304
Copyright © 1995 by American Association for the Advancement of Science

articles

Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons

JC Magee and D Johnston

Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

Activation of dendritic voltage-gated ion channels by local synaptic input was tested by simultaneous dendrite-attached patch-clamp recordings and whole-cell somatic voltage recordings made from CA1 pyramidal neurons in hippocampal slices. Schaffer collateral stimulation elicited subthreshold excitatory postsynaptic potentials (EPSPs) that opened voltage-gated sodium and calcium channels in the apical dendrites. The EPSP-activated sodium channels opened near the peak of the EPSP, whereas low voltage-activated calcium channels opened near the EPSP peak and during the decay phase. Dendritic high voltage-activated channels required somatic action potential generation or suprathreshold synaptic trains for activation. Dendritic voltage-gated channels are, therefore, likely to participate in dendritic integration of synaptic events.


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Local and Propagated Dendritic Action Potentials Evoked by Glutamate Iontophoresis on Rat Neocortical Pyramidal Neurons.
P. C. Schwindt and W. E. Crill (1997)
J Neurophysiol 77, 2466-2483
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Science. ISSN 0036-8075 (print), 1095-9203 (online)