Science 14 April 1995: Vol. 268. no. 5208, pp. 293 - 297 DOI: 10.1126/science.7716523

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Articles

Pivotal Advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner.

E. O. Lobo, Z. Zhang, and J. E. Shively (2009)
J. Leukoc. Biol. 86, 205-218
 |  Abstract »  |  Full Text »  |  PDF »

AID constrains germinal center size by rendering B cells susceptible to apoptosis.

A. Zaheen, B. Boulianne, J.-Y. Parsa, S. Ramachandran, J. L. Gommerman, and A. Martin (2009)
Blood 114, 547-554
 |  Abstract »  |  Full Text »  |  PDF »

Fc{gamma}RIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.

J. E. Crowley, J. E. Stadanlick, J. C. Cambier, and M. P. Cancro (2009)
Blood 113, 1464-1473
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Human Peripheral IgM+ B Cells Is Transiently Inhibited by BCR-Independent Aggregation of Fc{gamma}RIIB.

E. M. Fournier, S. Siberil, A. Costes, A. Varin, W.-H. Fridman, J.-L. Teillaud, and C. Sautes-Fridman (2008)
J. Immunol. 181, 5350-5359
 |  Abstract »  |  Full Text »  |  PDF »

Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines.

N. I. Pathan, P. Chu, K. Hariharan, C. Cheney, A. Molina, and J. Byrd (2008)
Blood 111, 1594-1602
 |  Abstract »  |  Full Text »  |  PDF »

Rapid T cell receptor-mediated SHP-1 S591 phosphorylation regulates SHP-1 cellular localization and phosphatase activity.

Y. Liu, M. J. Kruhlak, J.-J. Hao, and S. Shaw (2007)
J. Leukoc. Biol. 82, 742-751
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Lipid Raft-Targeting Motif in Src Homology 2-Containing Phosphatase 1.

M. Sankarshanan, Z. Ma, T. Iype, and U. Lorenz (2007)
J. Immunol. 179, 483-490
 |  Abstract »  |  Full Text »  |  PDF »

Sequence Specificity of SHP-1 and SHP-2 Src Homology 2 Domains: CRITICAL ROLES OF RESIDUES BEYOND THE pY+3 POSITION.

D. Imhof, A.-S. Wavreille, A. May, M. Zacharias, S. Tridandapani, and D. Pei (2006)
J. Biol. Chem. 281, 20271-20282
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Tyrosine-based Motifs Enable the Inhibitory Receptor Fc{gamma}RIIB to Cooperatively Recruit the Inositol Phosphatases SHIP1/2 and the Adapters Grb2/Grap.

I. Isnardi, R. Lesourne, P. Bruhns, W. H. Fridman, J. C. Cambier, and M. Daeron (2004)
J. Biol. Chem. 279, 51931-51938
 |  Abstract »  |  Full Text »  |  PDF »

Co-aggregation of Fc{gamma}RII with Fc{epsilon}RI on Human Mast Cells Inhibits Antigen-induced Secretion and Involves SHIP-Grb2-Dok Complexes.

C. L. Kepley, S. Taghavi, G. Mackay, D. Zhu, P. A. Morel, K. Zhang, J. J. Ryan, L. S. Satin, M. Zhang, P. P. Pandolfi, et al. (2004)
J. Biol. Chem. 279, 35139-35149
 |  Abstract »  |  Full Text »  |  PDF »

Effective Dephosphorylation of Src Substrates by SHP-1.

C. Frank, C. Burkhardt, D. Imhof, J. Ringel, O. Zschornig, K. Wieligmann, M. Zacharias, and F.-D. Bohmer (2004)
J. Biol. Chem. 279, 11375-11383
 |  Abstract »  |  Full Text »  |  PDF »

Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.

N. Toyama-Sorimachi, Y. Tsujimura, M. Maruya, A. Onoda, T. Kubota, S. Koyasu, K. Inaba, and H. Karasuyama (2004)
PNAS 101, 1016-1021
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Activator of NF-{kappa}B Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis.

Z. Zhang, E. Jimi, and A. L. M. Bothwell (2003)
J. Immunol. 171, 3620-3626
 |  Abstract »  |  Full Text »  |  PDF »

The Protein-tyrosine Phosphatase SHP-1 Associates with the Phosphorylated Immunoreceptor Tyrosine-based Activation Motif of Fc{gamma}RIIa to Modulate Signaling Events in Myeloid Cells.

L. P. Ganesan, H. Fang, C. B. Marsh, and S. Tridandapani (2003)
J. Biol. Chem. 278, 35710-35717
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of Src and SHP-2 in sst2 Somatostatin Receptor-mediated Activation of SHP-1 and Inhibition of Cell Proliferation.

G. Ferjoux, F. Lopez, J.-P. Esteve, A. Ferrand, E. Vivier, F. Vely, N. Saint-Laurent, L. Pradayrol, L. Buscail, and C. Susini (2003)
Mol. Biol. Cell 14, 3911-3928
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Interleukin-4-induced Class Switch Recombination by a Human Immunoglobulin Fc{gamma}-Fc{epsilon} Chimeric Protein.

T. Yamada, D. Zhu, K. Zhang, and A. Saxon (2003)
J. Biol. Chem. 278, 32818-32824
 |  Abstract »  |  Full Text »  |  PDF »

IVIg-mediated amelioration of murine ITP via Fc{gamma}RIIB is independent of SHIP1, SHP-1, and Btk activity.

A. R. Crow, S. Song, J. Freedman, C. D. Helgason, R. K. Humphries, K. A. Siminovitch, and A. H. Lazarus (2003)
Blood 102, 558-560
 |  Abstract »  |  Full Text »  |  PDF »

Development of an Efficient "Substrate-trapping" Mutant of Src Homology Phosphotyrosine Phosphatase 2 and Identification of the Epidermal Growth Factor Receptor, Gab1, and Three Other Proteins as Target Substrates.

Y. M. Agazie and M. J. Hayman (2003)
J. Biol. Chem. 278, 13952-13958
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Dephosphorylation of Stat6. PARTICIPATION OF TYR-713 IN THE INTERLEUKIN-4 RECEPTOR alpha , THE TYROSINE PHOSPHATASE SHP-1, AND THE PROTEASOME.

E. M. Hanson, H. Dickensheets, C.-K. Qu, R. P. Donnelly, and A. D. Keegan (2003)
J. Biol. Chem. 278, 3903-3911
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation.

J. Duchene, J. P. Schanstra, C. Pecher, A. Pizard, C. Susini, J.-P. Esteve, J.-L. Bascands, and J.-P. Girolami (2002)
J. Biol. Chem. 277, 40375-40383
 |  Abstract »  |  Full Text »  |  PDF »

SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.

A. M. Kant, P. De, X. Peng, T. Yi, D. J. Rawlings, J. S. Kim, and D. L. Durden (2002)
Blood 100, 1852-1859
 |  Abstract »  |  Full Text »  |  PDF »

Complement's participation in acquired immunity.

C. H. Nielsen and R. G. Q. Leslie (2002)
J. Leukoc. Biol. 72, 249-261
 |  Abstract »  |  Full Text »  |  PDF »

SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells.

S.-i. Yusa, T. L. Catina, and K. S. Campbell (2002)
J. Immunol. 168, 5047-5057
 |  Abstract »  |  Full Text »  |  PDF »

Regulated Expression and Inhibitory Function of Fcgamma RIIb in Human Monocytic Cells.

S. Tridandapani, K. Siefker, J.-L. Teillaud, J. E. Carter, M. D. Wewers, and C. L. Anderson (2002)
J. Biol. Chem. 277, 5082-5089
 |  Abstract »  |  Full Text »  |  PDF »

Autocrine Regulation of Human Prostate Carcinoma Cell Proliferation by Somatostatin through the Modulation of the SH2 Domain Containing Protein Tyrosine Phosphatase (SHP)-1.

P. D. Zapata, R. M. Ropero, A. M. Valencia, L. Buscail, J. I. Lopez, R. M. Martin-Orozco, J. C. Prieto, J. Angulo, C. Susini, P. Lopez-Ruiz, et al. (2002)
J. Clin. Endocrinol. Metab. 87, 915-926
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor-{alpha} Inhibits Growth Factor-Mediated Cell Proliferation Through SHP-1 Activation in Endothelial Cells.

H. Nakagami, T.-X. Cui, M. Iwai, T. Shiuchi, Y. Takeda-Matsubara, L. Wu, and M. Horiuchi (2002)
Arterioscler Thromb Vasc Biol 22, 238-242
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of Negative Signaling in B Cells by Quantitative Confocal Microscopy.

H. Phee, W. Rodgers, and K. M. Coggeshall (2001)
Mol. Cell. Biol. 21, 8615-8625
 |  Abstract »  |  Full Text »  |  PDF »

Immunoreceptor Tyrosine-Based Inhibitory Motif of the IL-4 Receptor Associates with SH2-Containing Phosphatases and Regulates IL-4-Induced Proliferation.

M. Kashiwada, C. C. Giallourakis, P.-Y. Pan, and P. B. Rothman (2001)
J. Immunol. 167, 6382-6387
 |  Abstract »  |  Full Text »  |  PDF »

Passively Acquired Antibodies Suppress Humoral But Not Cell-Mediated Immunity in Mice Immunized with Live Attenuated Respiratory Syncytial Virus Vaccines.

J. E. Crowe Jr., C.-Y. Firestone, and B. R. Murphy (2001)
J. Immunol. 167, 3910-3918
 |  Abstract »  |  Full Text »  |  PDF »

Partially Distinct Molecular Mechanisms Mediate Inhibitory Fc{{gamma}}RIIB Signaling in Resting and Activated B Cells.

A. Brauweiler, I. Tamir, S. Marschner, C. D. Helgason, and J. C. Cambier (2001)
J. Immunol. 167, 204-211
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56lck.

D. K. Newman, C. Hamilton, and P. J. Newman (2001)
Blood 97, 2351-2357
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat-driven transcription and a possible implication of SHP-1.

J.-F. Fortin, B. Barbeau, G. A. Robichaud, M.-E. Pare, A.-M. Lemieux, and M. J. Tremblay (2001)
Blood 97, 2390-2400
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4+ T cells.

T. O. Nashar, Z. E. Betteridge, and R. N. Mitchell (2001)
Int. Immunol. 13, 541-551
 |  Abstract »  |  Full Text »  |  PDF »

CD5 Is Dissociated from the B-Cell Receptor in B Cells from Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle: Consequences to B-Cell Receptor-Mediated Apoptosis.

G. H. Cantor, S. M. Pritchard, F. Dequiedt, L. Willems, R. Kettmann, and W. C. Davis (2001)
J. Virol. 75, 1689-1696
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of Src Homology 2-Containing Phosphatase 1 Results in Abnormalities in Murine Neutrophil Function: Studies in Motheaten Mice.

J. Kruger, J. R. Butler, V. Cherapanov, Q. Dong, H. Ginzberg, A. Govindarajan, S. Grinstein, K. A. Siminovitch, and G. P. Downey (2000)
J. Immunol. 165, 5847-5859
 |  Abstract »  |  Full Text »  |  PDF »

Mutational Analysis Reveals Multiple Distinct Sites Within Fc{gamma} Receptor IIB That Function in Inhibitory Signaling.

D. C. Fong, A. Brauweiler, S. A. Minskoff, P. Bruhns, I. Tamir, I. Mellman, M. Daeron, and J. C. Cambier (2000)
J. Immunol. 165, 4453-4462
 |  Abstract »  |  Full Text »  |  PDF »

Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

S. P. Paul, L. S. Taylor, E. K. Stansbury, and D. W. McVicar (2000)
Blood 96, 483-490
 |  Abstract »  |  Full Text »  |  PDF »

Fc{gamma} Receptor IIB on Follicular Dendritic Cells Regulates the B Cell Recall Response.

D. Qin, J. Wu, K. A. Vora, J. V. Ravetch, A. K. Szakal, T. Manser, and J. G. Tew (2000)
J. Immunol. 164, 6268-6275
 |  Abstract »  |  Full Text »  |  PDF »

A Dual Role for Src Homology 2 Domain-Containing Inositol-5-Phosphatase (Ship) in Immunity: Aberrant Development and Enhanced Function of B Lymphocytes in Ship-/- Mice.

C. D. Helgason, C. P. Kalberer, J. E. Damen, S. M. Chappel, N. Pineault, G. Krystal, and R. K. Humphries (2000)
J. Exp. Med. 191, 781-794
 |  Abstract »  |  Full Text »  |  PDF »

Cd5 Maintains Tolerance in Anergic B Cells.

K. L. Hippen, L. E. Tze, and T. W. Behrens (2000)
J. Exp. Med. 191, 883-890
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD.

S. Zupo, R. Massara, M. Dono, E. Rossi, F. Malavasi, M. E. Cosulich, and M. Ferrarini (2000)
Blood 95, 1199-1206
 |  Abstract »  |  Full Text »  |  PDF »

PILRalpha , a Novel Immunoreceptor Tyrosine-based Inhibitory Motif-bearing Protein, Recruits SHP-1 upon Tyrosine Phosphorylation and Is Paired with the Truncated Counterpart PILRbeta.

D. D. Mousseau, D. Banville, D. L'Abbe, P. Bouchard, and S.-H. Shen (2000)
J. Biol. Chem. 275, 4467-4474
 |  Abstract »  |  Full Text »  |  PDF »

C-Reactive Protein Binding to Murine Leukocytes Requires Fc{gamma} Receptors.

M.-P. Stein, C. Mold, and T. W. Du Clos (2000)
J. Immunol. 164, 1514-1520
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Src Homology Domain 2 (SH2)-Containing Inositol Phosphatase (SHIP), SH2-Containing Phosphotyrosine Phosphatase (SHP)-1, and SHP-2 SH2 Decoy Proteins on Fc{gamma}RIIB1-Effector Interactions and Inhibitory Functions.

K. Nakamura, A. Brauweiler, and J. C. Cambier (2000)
J. Immunol. 164, 631-638
 |  Abstract »  |  Full Text »  |  PDF »

Antitumor Immune Effector Mechanisms Recruited by Phage Display-derived Fully Human IgG1 and IgA1 Monoclonal Antibodies.

G. Huls, I. A. F. M. Heijnen, E. Cuomo, J. van der Linden, E. Boel, J. G. J. van de Winkel, and T. Logtenberg (1999)
Cancer Res. 59, 5778-5784
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2.

M. Thangaraju, K. Sharma, B. Leber, D. W. Andrews, S.-H. Shen, and C. B. Srikant (1999)
J. Biol. Chem. 274, 29549-29557
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the SHP-1 Tyrosine Phosphatase in Regulation of T Cell Selection.

J. Zhang, A.-K. Somani, D. Yuen, Y. Yang, P. E. Love, and K. A. Siminovitch (1999)
J. Immunol. 163, 3012-3021
 |  Abstract »  |  Full Text »  |  PDF »

Tolerance and Alloreactivity of the Ly49D Subset of Murine NK Cells.

T. C. George, J. R. Ortaldo, S. Lemieux, V. Kumar, and M. Bennett (1999)
J. Immunol. 163, 1859-1867
 |  Abstract »  |  Full Text »  |  PDF »

The Src-Homology Domain 2-Bearing Protein Tyrosine Phosphatase-1 Inhibits Antigen Receptor-Induced Apoptosis of Activated Peripheral T Cells.

J. Zhang, A.-K. Somani, S. Watt, G. B. Mills, and K. A. Siminovitch (1999)
J. Immunol. 162, 6359-6367
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of T Cell Signaling by Mitogen-activated Protein Kinase-targeted Hematopoietic Tyrosine Phosphatase (HePTP).

M. Saxena, S. Williams, J. Brockdorff, J. Gilman, and T. Mustelin (1999)
J. Biol. Chem. 274, 11693-11700
 |  Abstract »  |  Full Text »  |  PDF »

SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation.

A. Marie-Cardine, H. Kirchgessner, E. Bruyns, A. Shevchenko, M. Mann, F. Autschbach, S. Ratnofsky, S. Meuer, and B. Schraven (1999)
J. Exp. Med. 189, 1181-1194
 |  Abstract »  |  Full Text »  |  PDF »

CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1.

J. J. Perez-Villar, G. S. Whitney, M. A. Bowen, D. H. Hewgill, A. A. Aruffo, and S. B. Kanner (1999)
Mol. Cell. Biol. 19, 2903-2912
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4.

J. D. Schatzle, S. Sheu, S. E. Stepp, P. A. Mathew, M. Bennett, and V. Kumar (1999)
PNAS 96, 3870-3875
 |  Abstract »  |  Full Text »  |  PDF »

Negative Regulation of Myeloid Cell Proliferation and Function by the SH2 Domain-Containing Tyrosine Phosphatase-1.

Q. Dong, K. A. Siminovitch, L. Fialkow, T. Fukushima, and G. P. Downey (1999)
J. Immunol. 162, 3220-3230
 |  Abstract »  |  Full Text »  |  PDF »

Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors.

K. Nishida, Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, et al. (1999)
Blood 93, 1809-1816
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of a Lymphoid-Specific, Inducible Human Protein Tyrosine Phosphatase, Lyp.

S. Cohen, H. Dadi, E. Shaoul, N. Sharfe, and C. M. Roifman (1999)
Blood 93, 2013-2024
 |  Abstract »  |  Full Text »  |  PDF »

Alloreactivity and Association of Human Natural Killer Cells with the Major Histocompatibility Complex.

E. Mavoungou, A. Sall, V. Poaty-Mavoungou, F. S. Toure, P. Yaba, A. Delicat, and J. Lansoud-Soukate (1999)
Clin. Vaccine Immunol. 6, 254-259
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Dominant-Negative Src-Homology Domain 2-Containing Protein Tyrosine Phosphatase-1 Results in Increased Syk Tyrosine Kinase Activity and B Cell Activation.

L. B. Dustin, D. R. Plas, J. Wong, Y. T. Hu, C. Soto, A. C. Chan, and M. L. Thomas (1999)
J. Immunol. 162, 2717-2724
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of B Cell Receptor-Mediated MHC Class II Antigen Processing by Fc{gamma}RIIB1.

N. M. Wagle, A. E. Faassen, J. H. Kim, and S. K. Pierce (1999)
J. Immunol. 162, 2732-2740
 |  Abstract »  |  Full Text »  |  PDF »

Positive Recognition of MHC Class I Molecules by the Ly49D Receptor of Murine NK Cells.

T. C. George, L. H. Mason, J. R. Ortaldo, V. Kumar, and M. Bennett (1999)
J. Immunol. 162, 2035-2043
 |  Abstract »  |  Full Text »  |  PDF »

Specificity of the SH2 Domains of SHP-1 in the Interaction with the Immunoreceptor Tyrosine-Based Inhibitory Motif-Bearing Receptor gp49B.

L. L. Wang, J. Blasioli, D. R. Plas, M. L. Thomas, and W. M. Yokoyama (1999)
J. Immunol. 162, 1318-1323
 |  Abstract »  |  Full Text »  |  PDF »

Protein Interactions of Src Homology 2 (SH2) Domain-Containing Inositol Phosphatase (SHIP): Association with Shc Displaces SHIP from Fc{gamma}RIIb in B Cells.

S. Tridandapani, M. Pradhan, J. R. LaDine, S. Garber, C. L. Anderson, and K. M. Coggeshall (1999)
J. Immunol. 162, 1408-1414
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Maternal Antibodies on Protection and Development of Antibody Responses to Human Rotavirus in Gnotobiotic Pigs.

D. C. Hodgins, S. Y. Kang, L. deArriba, V. Parreno, L. A. Ward, L. Yuan, T. To, and L. J. Saif (1999)
J. Virol. 73, 186-197
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitory Receptors and Their Modes of Action.

D.C. FONG and J.C. CAMBIER (1999)
Cold Spring Harb Symp Quant Biol 64, 329-334
 |  Abstract »  |  PDF »

The Carboxyl-terminal Region of Biliary Glycoprotein Controls Its Tyrosine Phosphorylation and Association with Protein-tyrosine Phosphatases SHP-1 and SHP-2 in Epithelial Cells.

M. Huber, L. Izzi, P. Grondin, C. Houde, T. Kunath, A. Veillette, and N. Beauchemin (1999)
J. Biol. Chem. 274, 335-344
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for an Upper Affinity Threshold for Anti-IgM-Induced Apoptosis in a Human B-Cell Lymphoma.

P. K.A. Mongini, Q. Liu, M. A. Vilensky, P. F. Highet, and J. K. Inman (1998)
Blood 92, 3756-3771
 |  Abstract »  |  Full Text »  |  PDF »

Effector and predisposing genes in murine lupus.

A N Theofilopoulos (1998)
Lupus 7, 575-584
 |  Abstract »  |  PDF »

Recruitment and Activation of SHP-1 Protein-tyrosine Phosphatase by Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1). IDENTIFICATION OF IMMUNORECEPTOR TYROSINE-BASED INHIBITORY MOTIF-LIKE BINDING MOTIFS AND SUBSTRATES.

C. T. Hua, J. R. Gamble, M. A. Vadas, and D. E. Jackson (1998)
J. Biol. Chem. 273, 28332-28340
 |  Abstract »  |  Full Text »  |  PDF »

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling.

Q. Liu, A. J. Oliveira-Dos-Santos, S. Mariathasan, D. Bouchard, J. Jones, R. Sarao, I. Kozieradzki, P. S. Ohashi, J. M. Penninger, and D. J. Dumont (1998)
J. Exp. Med. 188, 1333-1342
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine 112 of Latent Membrane Protein 2A Is Essential for Protein Tyrosine Kinase Loading and Regulation of Epstein-Barr Virus Latency.

S. Fruehling, R. Swart, K. M. Dolwick, E. Kremmer, and R. Longnecker (1998)
J. Virol. 72, 7796-7806
 |  Abstract »  |  Full Text »  |  PDF »

Superclustering of B Cell Receptor and Fc{gamma}RIIB1 Activates Src Homology 2-Containing Protein Tyrosine Phosphatase-1.

K. Sato and A. Ochi (1998)
J. Immunol. 161, 2716-2722
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Fc{gamma}RII-B1 Regulates the Presentation of B Cell Receptor-Bound Antigens.

S. A. Minskoff, K. Matter, and I. Mellman (1998)
J. Immunol. 161, 2079-2083
 |  Abstract »  |  Full Text »  |  PDF »

High Expression of Inhibitory Receptor SHPS-1 and Its Association with Protein-tyrosine Phosphatase SHP-1 in Macrophages.

A. Veillette, E. Thibaudeau, and S. Latour (1998)
J. Biol. Chem. 273, 22719-22728
 |  Abstract »  |  Full Text »  |  PDF »

Functional Involvement of PTP-U2L in Apoptosis Subsequent to Terminal Differentiation of Monoblastoid Leukemia Cells.

H. Seimiya and T. Tsuruo (1998)
J. Biol. Chem. 273, 21187-21193
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Casein Kinase 2 by Direct Interaction with Cell Surface Receptor CD5.

C. Raman, A. Kuo, J. Deshane, D. W. Litchfield, and R. P. Kimberly (1998)
J. Biol. Chem. 273, 19183-19189
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by Fe{gamma}RIIB1-BCR Coligation.

K. Nakamura and J. C. Cambier (1998)
J. Immunol. 161, 684-691
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Apoptosis by Tyrosine-Containing Domains of IL-4R{alpha}: Y497 and Y713, But Not the STAT6-Docking Tyrosines, Signal Protection from Apoptosis.

J. Zamorano and A. D. Keegan (1998)
J. Immunol. 161, 859-867
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases.

M. Y. Cao, M. Huber, N. Beauchemin, J. Famiglietti, S. M. Albelda, and A. Veillette (1998)
J. Biol. Chem. 273, 15765-15772
 |  Abstract »  |  Full Text »  |  PDF »

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.

L. R. Carpenter, T. J. Farruggella, A. Symes, M. L. Karow, G. D. Yancopoulos, and N. Stahl (1998)
PNAS 95, 6061-6066
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: The B Cell Surface Protein CD72 Recruits the Tyrosine Phosphatase SHP-1 upon Tyrosine Phosphorylation.

T. Adachi, H. Flaswinkel, H. Yakura, M. Reth, and T. Tsubata (1998)
J. Immunol. 160, 4662-4665
 |  Abstract »  |  Full Text »  |  PDF »

SHP-1 Phosphatase C-Terminus Interacts With Novel Substrates p32/p30 During Erythropoietin and Interleukin-3 Mitogenic Responses.

W. Yang, M. Tabrizi, K. Berrada, and T. Yi (1998)
Blood 91, 3746-3755
 |  Abstract »  |  Full Text »  |  PDF »

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor-mediated Signals.

H. Nishizumi, K. Horikawa, I. Mlinaric-Rascan, and T. Yamamoto (1998)
J. Exp. Med. 187, 1343-1348
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of SH2-containing Protein Tyrosine Phosphatases SHP-1 and SHP-2 for Paired Immunoglobulin-like Receptor B (PIR-B)-mediated Inhibitory Signal.

A. Maeda, M. Kurosaki, M. Ono, T. Takai, and T. Kurosaki (1998)
J. Exp. Med. 187, 1355-1360
 |  Abstract »  |  Full Text »  |  PDF »

Roles of the Complex Formation of SHPS-1 with SHP-2 in Insulin-stimulated Mitogen-activated Protein Kinase Activation.

T. Takada, T. Matozaki, H. Takeda, K. Fukunaga, T. Noguchi, Y. Fujioka, I. Okazaki, M. Tsuda, T. Yamao, F. Ochi, et al. (1998)
J. Biol. Chem. 273, 9234-9242
 |  Abstract »  |  Full Text »  |  PDF »

Neutralizing Antibodies Protect against Lethal Flavivirus Challenge but Allow for the Development of Active Humoral Immunity to a Nonstructural Virus Protein.

T. R. Kreil, E. Maier, S. Fraiss, and M. M. Eibl (1998)
J. Virol. 72, 3076-3081
 |  Abstract »  |  Full Text »  |  PDF »

SHP-1 Binds and Negatively Modulates the c-Kit Receptor by Interaction with Tyrosine 569 in the c-Kit Juxtamembrane Domain.

M. Kozlowski, L. Larose, F. Lee, D. M. Le, R. Rottapel, and K. A. Siminovitch (1998)
Mol. Cell. Biol. 18, 2089-2099
 |  Abstract »  |  Full Text »  |  PDF »

sst2 Somatostatin Receptor Mediates Negative Regulation of Insulin Receptor Signaling through the Tyrosine Phosphatase SHP-1.

C. Bousquet, N. Delesque, F. Lopez, N. Saint-Laurent, J.-P. Esteve, K. Bedecs, L. Buscail, N. Vaysse, and C. Susini (1998)
J. Biol. Chem. 273, 7099-7106
 |  Abstract »  |  Full Text »  |  PDF »

The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1.

M. Blery, H. Kubagawa, C.-C. Chen, F. Vely, M. D. Cooper, and E. Vivier (1998)
PNAS 95, 2446-2451
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Fcgamma Receptor-Mediated Phagocytosis by a Nonphagocytic Fcgamma Receptor.

S. Hunter, Z. K. Indik, M.-K. Kim, M. D. Cauley, J.-G. Park, and A. D. Schreiber (1998)
Blood 91, 1762-1768
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Lyn-Mediated Down-Regulation of B Cell Antigen Receptor Signaling: Inhibition of Protein Kinase C Activation by Lyn in a Kinase-Independent Fashion.

H. Katsuta, S. Tsuji, Y. Niho, T. Kurosaki, and D. Kitamura (1998)
J. Immunol. 160, 1547-1551
 |  Abstract »  |  Full Text »  |  PDF »

Fc{epsilon} Receptor I-Associated lyn-Dependent Phosphorylation of Fc{gamma} Receptor IIB During Negative Regulation of Mast Cell Activation.

O. Malbec, D. C. Fong, M. Turner, V. L. J. Tybulewicz, J. C. Cambier, W. H. Fridman, and M. Daeron (1998)
J. Immunol. 160, 1647-1658
 |  Abstract »  |  Full Text »  |  PDF »

SHP-1 Associates with Both Platelet-derived Growth Factor Receptor and the p85 Subunit of Phosphatidylinositol 3-Kinase.

Z. Yu, L. Su, O. Hoglinger, M. L. Jaramillo, D. Banville, and S.-H. Shen (1998)
J. Biol. Chem. 273, 3687-3694
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Src Homology 2-containing Tyrosine Phosphatase SHP-2 in Growth Hormone Signaling.

S.-O. Kim, J. Jiang, W. Yi, G.-S. Feng, and S. J. Frank (1998)
J. Biol. Chem. 273, 2344-2354
 |  Abstract »  |  Full Text »  |  PDF »

Association of Tyrosine Phosphatases SHP-1 and SHP-2, Inositol 5-Phosphatase SHIP with gp49B1, and Chromosomal Assignment of the Gene.

A. Kuroiwa, Y. Yamashita, M. Inui, T. Yuasa, M. Ono, A. Nagabukuro, Y. Matsuda, and T. Takai (1998)
J. Biol. Chem. 273, 1070-1074
 |  Abstract »  |  Full Text »  |  PDF »

The Protein-tyrosine Phosphatase SHP-2 Associates with Tyrosine-phosphorylated Adhesion Molecule PECAM-1 (CD31).

K. Sagawa, T. Kimura, M. Swieter, and R. P. Siraganian (1997)
J. Biol. Chem. 272, 31086-31091
 |  Abstract »  |  Full Text »  |  PDF »

What Goes Up Must Come Down: The Emerging Spectrum of Inhibitory Receptors.

W. M. Yokoyama (1997)
J. Exp. Med. 186, 1803-1808
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Btk dosage determines sensitivity to B cell antigen receptor cross-linking.

A. B. Satterthwaite, H. Cheroutre, W. N. Khan, P. Sideras, and O. N. Witte (1997)
PNAS 94, 13152-13157
 |  Abstract »  |  Full Text »  |  PDF »

Downregulated Expression of SHP-1 in Burkitt Lymphomas and Germinal Center B Lymphocytes.

C. C. Delibrias, J. E. Floettmann, M. Rowe, and D. T. Fearon (1997)
J. Exp. Med. 186, 1575-1583
 |  Abstract »  |  Full Text »  |  PDF »

The Tyrosine Phosphatase SHP-1 Associates with the sst2 Somatostatin Receptor and Is an Essential Component of sst2-mediated Inhibitory Growth Signaling.

F. Lopez, J.-P. Esteve, L. Buscail, N. Delesque, N. Saint-Laurent, M. Theveniau, C. Nahmias, N. Vaysse, and C. Susini (1997)
J. Biol. Chem. 272, 24448-24454
 |  Abstract »  |  Full Text »  |  PDF »

Hematopoietic Cell Phosphatase Negatively Regulates Erythropoietin-Induced Hemoglobinization in Erythroleukemic SKT6 Cells.

E. R. Sharlow, R. Pacifici, J. Crouse, J. Batac, K. Todokoro, and D.M. Wojchowski (1997)
Blood 90, 2175-2187
 |  Abstract »  |  Full Text »  |  PDF »

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