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Science 14 April 1995: Vol. 268. no. 5208, pp. 239 - 247 DOI: 10.1126/science.7716515
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Articles
Science, Vol 268, Issue 5208, 239-247
Copyright © 1995 by American Association for the Advancement of Science
Calcium signaling in neurons: molecular mechanisms and cellular consequences
A Ghosh
and
ME Greenberg
Department of Neurology, Children's Hospital, Boston, MA 02115, USA.
Neuronal activity can lead to marked increases in the concentration of cytosolic calcium, which then functions as a second messenger that mediates a wide range of cellular responses. Calcium binds to calmodulin and stimulates the activity of a variety of enzymes, including calcium-calmodulin kinases and calcium-sensitive adenylate cyclases. These enzymes transduce the calcium signal and effect short-term biological responses, such as the modification of synaptic proteins and long-lasting neuronal responses that require changes in gene expression. Recent studies of calcium signal-transduction mechanisms have revealed that, depending on the route of entry into a neuron, calcium differentially affects processes that are central to the development and plasticity of the nervous system, including activity-dependent cell survival, modulation of synaptic strength, and calcium-mediated cell death.
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
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| Abstract »
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| Abstract »
| Full Text »
| PDF »
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- A. Lilienbaum and A. Israel (2003)
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| Abstract »
| Full Text »
| PDF »
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- Q. Gu, K. Kwong, and L.-Y. Lee (2003)
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| Abstract »
| Full Text »
| PDF »
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- H. Hibino, R. Pironkova, O. Onwumere, M. Rousset, P. Charnet, A. J. Hudspeth, and F. Lesage (2003)
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| Abstract »
| Full Text »
| PDF »
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277, 34375-34382
| Abstract »
| Full Text »
| PDF »
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- M. A. FEBBRAIO and B. K. PEDERSEN (2002)
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16, 1335-1347
| Abstract »
| Full Text »
| PDF »
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- R. Basheer, E. Arrigoni, H. S. Thatte, R. W. Greene, I. S. Ambudkar, and R. W. McCarley (2002)
J. Neurosci.
22, 7680-7686
| Abstract »
| Full Text »
| PDF »
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- L. Mao and J. Q. Wang (2002)
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62, 473-484
| Abstract »
| Full Text »
| PDF »
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- K. Minami, M. Yokokura, N. Ishizuka, and S. Seino (2002)
J. Biol. Chem.
277, 25277-25282
| Abstract »
| Full Text »
| PDF »
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- A. Bhargava, R. S. Mathias, J. A. McCormick, M. F. Dallman, and D. Pearce (2002)
Mol. Endocrinol.
16, 1629-1637
| Abstract »
| Full Text »
| PDF »
- Distinct Intracellular Calcium Transients in Neurites and Somata Integrate Neuronal Signals.
- F. W. Johenning, M. Zochowski, S. J. Conway, A. B. Holmes, P. Koulen, and B. E. Ehrlich (2002)
J. Neurosci.
22, 5344-5353
| Abstract »
| Full Text »
| PDF »
- D1 Dopamine Receptor Supersensitivity in the Dopamine-Depleted Striatum Results from a Switch in the Regulation of ERK1/2/MAP Kinase.
- C. R. Gerfen, S. Miyachi, R. Paletzki, and P. Brown (2002)
J. Neurosci.
22, 5042-5054
| Abstract »
| Full Text »
| PDF »
- Bidirectional Alterations in Cerebellar Synaptic Transmission of tottering and rolling Ca2+ Channel Mutant Mice.
- K. Matsushita, M. Wakamori, I. J. Rhyu, T. Arii, S.-i. Oda, Y. Mori, and K. Imoto (2002)
J. Neurosci.
22, 4388-4398
| Abstract »
| Full Text »
| PDF »
- Nuclear Calcium Signaling Evoked by Cholinergic Stimulation in Hippocampal CA1 Pyramidal Neurons.
- J. M. Power and P. Sah (2002)
J. Neurosci.
22, 3454-3462
| Abstract »
| Full Text »
| PDF »
- Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability.
- P. Calabresi, E. Saulle, D. Centonze, A. Pisani, G. A. Marfia, and G. Bernardi (2002)
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125, 844-860
| Abstract »
| Full Text »
| PDF »
- Synaptic Mechanisms Regulating the Activation of a Ca2+-Mediated Plateau Potential in Developing Relay Cells of the LGN.
- F.-S. Lo, J. Ziburkus, and W. Guido (2002)
J Neurophysiol
87, 1175-1185
| Abstract »
| Full Text »
| PDF »
- Brain-derived Neurotrophic Factor-induced Potentiation of Ca2+ Oscillations in Developing Cortical Neurons.
- T. Numakawa, S. Yamagishi, N. Adachi, T. Matsumoto, D. Yokomaku, M. Yamada, and H. Hatanaka (2002)
J. Biol. Chem.
277, 6520-6529
| Abstract »
| Full Text »
| PDF »
- Cerebral Expression and Serum Detectability of Secretagogin, a Recently Cloned EF-hand Ca2+ -binding Protein.
- W. Gartner, W. Lang, F. Leutmetzer, H. Domanovits, W. Waldhausl, and L. Wagner (2001)
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11, 1161-1169
| Abstract »
| Full Text »
| PDF »
- Phosphorylation of cAMP Response Element-Binding Protein in Hippocampal Neurons as a Protective Response after Exposure to Glutamate In Vitro and Ischemia In Vivo.
- T. Mabuchi, K. Kitagawa, K. Kuwabara, K. Takasawa, T. Ohtsuki, Z. Xia, D. Storm, T. Yanagihara, M. Hori, and M. Matsumoto (2001)
J. Neurosci.
21, 9204-9213
| Abstract »
| Full Text »
| PDF »
- Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells.
- E. Bernal-Mizrachi, W. Wen, S. Srinivasan, A. Klenk, D. Cohen, and M. A. Permutt (2001)
Am J Physiol Endocrinol Metab
281, E1286-E1299
| Abstract »
| Full Text »
| PDF »
- alpha 1-Adrenergic Modulation of Metabotropic Glutamate Receptor-induced Calcium Oscillations and Glutamate Release in Astrocytes.
- H. Muyderman, M. Angehagen, M. Sandberg, U. Bjorklund, T. Olsson, E. Hansson, and M. Nilsson (2001)
J. Biol. Chem.
276, 46504-46514
| Abstract »
| Full Text »
| PDF »
- Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
- S. Tahara, K. Fukuda, H. Kodama, T. Kato, S. Miyoshi, and S. Ogawa (2001)
J. Am. Coll. Cardiol.
38, 1554-1563
| Abstract »
| Full Text »
| PDF »
- Ultrastructural Distribution of the {alpha}7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus.
- R. Fabian-Fine, P. Skehel, M. L. Errington, H. A. Davies, E. Sher, M. G. Stewart, and A. Fine (2001)
J. Neurosci.
21, 7993-8003
| Abstract »
| Full Text »
| PDF »
- Activation of Metabotropic Glutamate Receptor Subtype 1/Protein Kinase C/Mitogen-Activated Protein Kinase Pathway Is Required for Postischemic Long-Term Potentiation in the Striatum.
- P. Calabresi, E. Saulle, G. A. Marfia, D. Centonze, R. Mulloy, B. Picconi, R. A. Hipskind, F. Conquet, and G. Bernardi (2001)
Mol. Pharmacol.
60, 808-815
| Abstract »
| Full Text »
| PDF »
- Calcium regulation of neuronal gene expression.
- A. E. West, W. G. Chen, M. B. Dalva, R. E. Dolmetsch, J. M. Kornhauser, A. J. Shaywitz, M. A. Takasu, X. Tao, and M. E. Greenberg (2001)
PNAS
98, 11024-11031
| Abstract »
| Full Text »
| PDF »
- Electrical Stimuli Patterned After the Theta-Rhythm Induce Multiple Forms of LTP.
- S. L. Morgan and T. J. Teyler (2001)
J Neurophysiol
86, 1289-1296
| Abstract »
| Full Text »
| PDF »
- Requirement of Ras for the Activation of Mitogen-Activated Protein Kinase by Calcium Influx, cAMP, and Neurotrophin in Hippocampal Neurons.
- N. Iida, K. Namikawa, H. Kiyama, H. Ueno, S. Nakamura, and S. Hattori (2001)
J. Neurosci.
21, 6459-6466
| Abstract »
| Full Text »
| PDF »
- Modulation of a voltage-gated calcium channel linked to activation of glutamate receptors and calcium-induced calcium release in the catfish retina.
- C. L Linn and A. C Gafka (2001)
J. Physiol.
535, 47-63
| Abstract »
| Full Text »
| PDF »
- Inhibition of Mitochondrial Complex II Induces a Long-Term Potentiation of NMDA-Mediated Synaptic Excitation in the Striatum Requiring Endogenous Dopamine.
- P. Calabresi, P. Gubellini, B. Picconi, D. Centonze, A. Pisani, P. Bonsi, P. Greengard, R. A. Hipskind, E. Borrelli, and G. Bernardi (2001)
J. Neurosci.
21, 5110-5120
| Abstract »
| Full Text »
| PDF »
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- M. Sato, K. Suzuki, and S. Nakanishi (2001)
J. Neurosci.
21, 3797-3805
| Abstract »
| Full Text »
| PDF »
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- R. S. Klein, J. B. Rubin, H. D. Gibson, E. N. DeHaan, X. Alvarez-Hernandez, R. A. Segal, and A. D. Luster (2001)
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- Q. N. Diep, M. El Mabrouk, R. M. Touyz, and E. L. Schiffrin (2001)
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| Abstract »
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- W Ding, S Gao, and R. Scott (2001)
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| Abstract »
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- S. I. McDonough, Z. Cseresnyes, and M. F. Schneider (2000)
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| Abstract »
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- S. Sallmann, E. Juttler, S. Prinz, N. Petersen, U. Knopf, T. Weiser, and M. Schwaninger (2000)
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| Full Text »
| PDF »
- Cellular Responses to Mechanical Stress: Invited Review: Mechanisms of ventilator-induced lung injury: a perspective.
- C. C. Dos Santos and A. S. Slutsky (2000)
J Appl Physiol
89, 1645-1655
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- Dendritic Cytoskeletal Protein Expression in Mental Retardation: An Immunohistochemical Study of the Neocortex in Rett Syndrome.
- W. E. Kaufmann, S. M. MacDonald, and C. R. Altamura (2000)
Cereb Cortex
10, 992-1004
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- Serotonergic Inhibition of Action Potential Evoked Calcium Transients in NOS-Containing Mesopontine Cholinergic Neurons.
- C. S. Leonard, S. R. Rao, and T. Inoue (2000)
J Neurophysiol
84, 1558-1572
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- Competitive Inhibition of NMDA Receptor-Mediated Currents by Extracellular Calcium Chelators.
- N. Chen, T. H. Murphy, and L. A. Raymond (2000)
J Neurophysiol
84, 693-697
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- Oxidative Stress in the Context of Acute Cerebrovascular Stroke.
- M. M. H. El Kossi and M. M. Zakhary (2000)
Stroke
31, 1889-1892
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- Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism.
- M. Sasaki, M. Gonzalez-Zulueta, H. Huang, W. J. Herring, S. Ahn, D. D. Ginty, V. L. Dawson, and T. M. Dawson (2000)
PNAS
97, 8617-8622
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- Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons.
- S. Ackerley, A. J. Grierson, J. Brownlees, P. Thornhill, B. H. Anderton, P. N. Leigh, C. E. Shaw, and C. C.J. Miller (2000)
J. Cell Biol.
150, 165-176
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- ALTERATIONS IN PREIMPLANTATION IN VIVO DEVELOPMENT AFTER PRECONCEPTIONAL CHRONIC MODERATE ALCOHOL CONSUMPTION IN FEMALE MICE.
- E. Cebral, A. Lasserre, V. Rettori, and M. A. de Gimeno (2000)
Alcohol Alcohol.
35, 336-343
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- Sarco-Endoplasmic ATPase Blocker 2,5-Di(tert-butyl)-1,4-benzohydroquinone Inhibits N-, P-, and Q- but Not T-, L-, or R-Type Calcium Currents in Central and Peripheral Neurons.
- F. Scamps, S. Vigues, S. Restituito, B. Campo, A. Roig, P. Charnet, and J. Valmier (2000)
Mol. Pharmacol.
58, 18-26
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- Intracellular Ca2+ Dynamics During Spontaneous and Evoked Activity of Leech Heart Interneurons: Low-Threshold Ca Currents and Graded Synaptic Transmission.
- A. I. Ivanov and R. L. Calabrese (2000)
J. Neurosci.
20, 4930-4943
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- Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease.
- M. W. Berchtold, H. Brinkmeier, and M. Muntener (2000)
Physiol Rev
80, 1215-1265
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- A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis.
- I. Hwang, H. Sze, and J. F. Harper (2000)
PNAS
97, 6224-6229
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- Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons.
- C. Sala, S. Rudolph-Correia, and M. Sheng (2000)
J. Neurosci.
20, 3529-3536
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- Brain-Derived Neurotrophic Factor Causes cAMP Response Element-Binding Protein Phosphorylation in Absence of Calcium Increases in Slices and Cultured Neurons from Rat Visual Cortex.
- T. Pizzorusso, G. M. Ratto, E. Putignano, and L. Maffei (2000)
J. Neurosci.
20, 2809-2816
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- Voltage-Gated Calcium Currents in Axotomized Adult Rat Cutaneous Afferent Neurons.
- M. L. Baccei and J. D. Kocsis (2000)
J Neurophysiol
83, 2227-2238
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- Surviving Granule Cells of the Sclerotic Human Hippocampus Have Reduced Ca2+ Influx Because of a Loss of Calbindin-D28k in Temporal Lobe Epilepsy.
- U. V. Nagerl, I. Mody, M. Jeub, A. A. Lie, C. E. Elger, and H. Beck (2000)
J. Neurosci.
20, 1831-1836
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- L-type calcium channel activity regulates sodium channel levels in rat pituitary GH3 cells.
- E Monjaraz, A Navarrete, L F Lopez-Santiago, A V Vega, J A Arias-Montano, and G Cota (2000)
J. Physiol.
523, 45-55
| Abstract »
| Full Text »
| PDF »
- Target-Cell Contact Activates a Highly Selective Capacitative Calcium Entry Pathway in Cytotoxic T Lymphocytes.
- A. Zweifach (2000)
J. Cell Biol.
148, 603-614
| Abstract »
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- Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase.
- S. S. Grewal, A. M. Horgan, R. D. York, G. S. Withers, G. A. Banker, and P. J. S. Stork (2000)
J. Biol. Chem.
275, 3722-3728
| Abstract »
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- Reactive Oxygen Species Activate p90 Ribosomal S6 Kinase via Fyn and Ras.
- J.-i. Abe, M. Okuda, Q. Huang, M. Yoshizumi, and B. C. Berk (2000)
J. Biol. Chem.
275, 1739-1748
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- Imaging patterns of calcium transients during neural induction in Xenopus laevis embryos.
- C Leclerc, S. Webb, C Daguzan, M Moreau, and A. Miller (2000)
J. Cell Sci.
113, 3519-3529
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