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Science 14 April 1995:
Vol. 268. no. 5208, pp. 233 - 239
DOI: 10.1126/science.7716514

Articles

Science, Vol 268, Issue 5208, 233-239
Copyright © 1995 by American Association for the Advancement of Science


articles

Integrins and signal transduction pathways: the road taken

EA Clark and JS Brugge

ARIAD Pharmaceuticals, Cambridge, MA 02139, USA.

Adhesive interactions play critical roles in directing the migration, proliferation, and differentiation of cells; aberrations in such interactions can lead to pathological disorders. These adhesive interactions, mediated by cell surface receptors that bind to ligands on adjacent cells or in the extracellular matrix, also regulate intracellular signal transduction pathways that control adhesion-induced changes in cell physiology. Though the extracellular molecular interactions involving many adhesion receptors have been well characterized, the adhesion-dependent intracellular signaling events that regulate these physiological alterations have only begun to be elucidated. This article will focus on recent advances in our understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors.


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   Abstract »    Full Text »    PDF »
Human Thy-1 (CD90) on Activated Endothelial Cells Is a Counterreceptor for the Leukocyte Integrin Mac-1 (CD11b/CD18).
A. Wetzel, T. Chavakis, K. T. Preissner, M. Sticherling, U.-F. Haustein, U. Anderegg, and A. Saalbach (2004)
J. Immunol. 172, 3850-3859
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Aggretin, a snake venom-derived endothelial integrin {alpha}2{beta}1 agonist, induces angiogenesis via expression of vascular endothelial growth factor.
C.-H. Chung, W.-B. Wu, and T.-F. Huang (2004)
Blood 103, 2105-2113
   Abstract »    Full Text »    PDF »
Modulation of Thr Phosphorylation of Integrin {beta}1 during Muscle Differentiation.
S.-M. Kim, M. S. Kwon, C. S. Park, K.-R. Choi, J.-S. Chun, J. Ahn, and W. K. Song (2004)
J. Biol. Chem. 279, 7082-7090
   Abstract »    Full Text »    PDF »
Aggregation of {beta}2 integrins activates human neutrophils through the I{kappa}B/NF-{kappa}B pathway.
C. H. Kim, K.-H. Lee, C.-T. Lee, Y. W. Kim, S. K. Han, Y.-S. Shim, and C.-G. Yoo (2004)
J. Leukoc. Biol. 75, 286-292
   Abstract »    Full Text »    PDF »
Cytoskeletal Reorganization Dependence of Signaling by the Gonadotropin-releasing Hormone Receptor.
L. Davidson, A. J. Pawson, R. P. Millar, and S. Maudsley (2004)
J. Biol. Chem. 279, 1980-1993
   Abstract »    Full Text »    PDF »
Induction of Endothelial Cell Activation by a Triple Helical {alpha}2{beta}1 Integrin Ligand, Derived from Type I Collagen {alpha}1(I)496-507.
D. Baronas-Lowell, J. L. Lauer-Fields, and G. B. Fields (2004)
J. Biol. Chem. 279, 952-962
   Abstract »    Full Text »    PDF »
Ganglioside GM3 Blocks the Activation of Epidermal Growth Factor Receptor Induced by Integrin at Specific Tyrosine Sites.
X.-Q. Wang, P. Sun, and A. S. Paller (2003)
J. Biol. Chem. 278, 48770-48778
   Abstract »    Full Text »    PDF »
Stretch of {beta}1 Integrin Activates an Outwardly Rectifying Chloride Current via FAK and Src in Rabbit Ventricular Myocytes.
D. M. Browe and C. M. Baumgarten (2003)
J. Gen. Physiol. 122, 689-702
   Abstract »    Full Text »    PDF »
Stimulation of extracellular matrix remodeling by the first type III repeat in fibronectin.
R. M. Klein, M. Zheng, A. Ambesi, L. Van De Water, and P. J. McKeown-Longo (2003)
J. Cell Sci. 116, 4663-4674
   Abstract »    Full Text »    PDF »
Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase.
H. K. Avraham, T.-H. Lee, Y. Koh, T.-A. Kim, S. Jiang, M. Sussman, A. M. Samarel, and S. Avraham (2003)
J. Biol. Chem. 278, 36661-36668
   Abstract »    Full Text »    PDF »
Lymphocyte Function-associated Antigen-1-mediated T Cell Adhesion Is Impaired by Low Molecular Weight Phosphotyrosine Phosphatase-dependent Inhibition of FAK Activity.
E. Giannoni, P. Chiarugi, G. Cozzi, L. Magnelli, M. L. Taddei, T. Fiaschi, F. Buricchi, G. Raugei, and G. Ramponi (2003)
J. Biol. Chem. 278, 36763-36776
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Regulation of the Integrin Subunit {alpha}5 Gene Promoter by the Transcription Factors Sp1/Sp3 Is Influenced by the Cell Density in Rabbit Corneal Epithelial Cells.
M.-E. Gingras, K. Larouche, N. Larouche, S. Leclerc, C. Salesse, and S. L. Guerin (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3742-3755
   Abstract »    Full Text »    PDF »
Gingival epithelial cell signalling and cytoskeletal responses to Porphyromonas gingivalis invasion.
O. Yilmaz, P. A. Young, R. J. Lamont, and G. E. Kenny (2003)
Microbiology 149, 2417-2426
   Abstract »    Full Text »    PDF »
Forward Mandibular Positioning Up-regulates SOX9 and Type II Collagen Expression in the Glenoid Fossa.
A.B.M. Rabie, T.T. She, and V.R. Harley (2003)
Journal of Dental Research 82, 725-730
   Abstract »    Full Text »    PDF »
14-3-3{zeta} Mediates Integrin-induced Activation of Cdc42 and Rac: PLATELET GLYCOPROTEIN Ib-IX REGULATES INTEGRIN-INDUCED SIGNALING BY SEQUESTERING 14-3-3{zeta}.
K. Bialkowska, Y. Zaffran, S. C. Meyer, and J. E. B. Fox (2003)
J. Biol. Chem. 278, 33342-33350
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Age-related Changes in the Biomolecular Mechanisms of Clvarial Osteoblast Biology Affect Fibroblast Growth Factor-2 Signaling and Osteogenesis.
C. M. Cowan, N. Quarto, S. M. Warren, A. Salim, and M. T. Longaker (2003)
J. Biol. Chem. 278, 32005-32013
   Abstract »    Full Text »    PDF »
A role for Syk-kinase in the control of the binding cycle of the {beta}2 integrins (CD11/CD18) in human polymorphonuclear neutrophils.
T. Willeke, J. Schymeinsky, P. Prange, S. Zahler, and B. Walzog (2003)
J. Leukoc. Biol. 74, 260-269
   Abstract »    Full Text »    PDF »
Overexpression of Platelet-type 12-Lipoxygenase Promotes Tumor Cell Survival by Enhancing {alpha}v{beta}3 and {alpha}v{beta}5 Integrin Expression.
G. P. Pidgeon, K. Tang, Y. L. Cai, E. Piasentin, and K. V. Honn (2003)
Cancer Res. 63, 4258-4267
   Abstract »    Full Text »    PDF »
Neutrophil-activating potential of antineutrophil cytoplasm autoantibodies.
A. A. Rarok, P. C. Limburg, and C. G. M. Kallenberg (2003)
J. Leukoc. Biol. 74, 3-15
   Abstract »    Full Text »    PDF »
Functions of Pulmonary Epithelial Integrins: From Development to Disease.
D. SHEPPARD (2003)
Physiol Rev 83, 673-686
   Abstract »    Full Text »    PDF »



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