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Science 14 April 1995:
Vol. 268. no. 5208, pp. 221 - 225
DOI: 10.1126/science.7716512
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Articles

Science, Vol 268, Issue 5208, 221-225
Copyright © 1995 by American Association for the Advancement of Science

articles

Protein lipidation in cell signaling

PJ Casey

Department of Molecular Cancer Biology, Duke University Medical Center, Durham, NC 27710-3686, USA.

The ability of cells to communicate with and respond to their external environment is critical for their continued existence. A universal feature of this communication is that the external signal must in some way penetrate the lipid bilayer surrounding the cell. In most cases of such signal acquisition, the signaling entity itself does not directly enter the cell but rather transmits its information to specific proteins present on the surface of the cell membrane. These proteins then communicate with additional proteins associated with the intracellular face of the membrane. Membrane localization and function of many of these proteins are dependent on their covalent modification by specific lipids, and it is the processes involved that form the focus of this article.


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V. Poupon, B. Begue, J. Gagnon, A. Dautry-Varsat, N. Cerf-Bensussan, and A. Benmerah (1999)
J. Biol. Chem. 274, 19188-19194
   Abstract »    Full Text »    PDF »
Oxidized LDL-Containing Immune Complexes Induce Fc Gamma Receptor I–Mediated Mitogen-Activated Protein Kinase Activation in THP-1 Macrophages.
Y. Huang, A. Jaffa, S. Koskinen, A. Takei, and M. F. Lopes-Virella (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 1600-1607
   Abstract »    Full Text »    PDF »
Gbeta gamma and Palmitate Target Newly Synthesized Galpha z to the Plasma Membrane.
C. S. Fishburn, P. Herzmark, J. Morales, and H. R. Bourne (1999)
J. Biol. Chem. 274, 18793-18800
   Abstract »    Full Text »    PDF »
N-Linked Glycosylation Is Required for Optimal AT1a Angiotensin Receptor Expression in COS-7 Cells.
S. Jayadev, R. D. Smith, G. Jagadeesh, A. J. Baukal, L. Hunyady, and K. J. Catt (1999)
Endocrinology 140, 2010-2017
   Abstract »    Full Text »
Activation of Go-proteins by Membrane Depolarization Traced by in Situ Photoaffinity Labeling of Galpha o-proteins with [alpha 32P]GTP-azidoanilide.
Y. Anis, B. Nurnberg, L. Visochek, N. Reiss, Z. Naor, and M. Cohen-Armon (1999)
J. Biol. Chem. 274, 7431-7440
   Abstract »    Full Text »    PDF »
Chemoattractant Receptor Cross-desensitization.
H. Ali, R. M. Richardson, B. Haribabu, and R. Snyderman (1999)
J. Biol. Chem. 274, 6027-6030
   Full Text »    PDF »
S-Myristoylation of a Glycosylphosphatidylinositol-specific Phospholipase C in Trypanosoma brucei.
D. A. Armah and K. Mensa-Wilmot (1999)
J. Biol. Chem. 274, 5931-5938
   Abstract »    Full Text »    PDF »
Microsomal Electron Transfer in Higher Plants: Cloning and Heterologous Expression of NADH-Cytochrome b5 Reductase from Arabidopsis.
M. Fukuchi-Mizutani, M. Mizutani, Y. Tanaka, T. Kusumi, and D. Ohta (1999)
Plant Physiology 119, 353-362
   Abstract »    Full Text »
Expression of a Novel Murine Phospholipase D Homolog Coincides with Late Neuronal Development in the Forebrain.
K. M. Pedersen, B. Finsen, J. E. Celis, and N. A. Jensen (1998)
J. Biol. Chem. 273, 31494-31504
   Abstract »    Full Text »    PDF »
Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase.
U. Laufs and J. K. Liao (1998)
J. Biol. Chem. 273, 24266-24271
   Abstract »    Full Text »    PDF »
Serotonin-Mediated Palmitoylation and Depalmitoylation of G Alpha Proteins in Rat Brain Cortical Membranes.
S. Bhamre, H.-Y. Wang, and E. Friedman (1998)
J. Pharmacol. Exp. Ther. 286, 1482-1489
   Abstract »    Full Text »
Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.
S. P. Srinivasa, L. S. Bernstein, K. J. Blumer, and M. E. Linder (1998)
PNAS 95, 5584-5589
   Abstract »    Full Text »    PDF »
Cholesterol Is Required for Surface Transport of Influenza Virus Hemagglutinin.
P. Keller and K. Simons (1998)
J. Cell Biol. 140, 1357-1367
   Abstract »    Full Text »    PDF »
Vac8p, a Vacuolar Protein with Armadillo Repeats, Functions in both Vacuole Inheritance and Protein Targeting from the Cytoplasm to Vacuole.
Y.-X. Wang, N. L. Catlett, and L. S. Weisman (1998)
J. Cell Biol. 140, 1063-1074
   Abstract »    Full Text »    PDF »


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