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Science 7 April 1995:
Vol. 268. no. 5207, pp. 94 - 97
DOI: 10.1126/science.7701348
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Articles

Science, Vol 268, Issue 5207, 94-97
Copyright © 1995 by American Association for the Advancement of Science

articles

A morbillivirus that caused fatal disease in horses and humans

K Murray, P Selleck, P Hooper, A Hyatt, A Gould, L Gleeson, H Westbury, L Hiley, L Selvey, B Rodwell, and al. et

CSIRO Australian Animal Health Laboratory, East Geelong, Victoria.

A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.


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J. Virol. 83, 5148-5155
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Determination of the henipavirus phosphoprotein gene mRNA editing frequencies and detection of the C, V and W proteins of Nipah virus in virus-infected cells.
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J. Gen. Virol. 90, 398-404
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Host cell recognition by the henipaviruses: Crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.
K. Xu, K. R. Rajashankar, Y.-P. Chan, J. P. Himanen, C. C. Broder, and D. B. Nikolov (2008)
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Henipavirus V Protein Association with Polo-Like Kinase Reveals Functional Overlap with STAT1 Binding and Interferon Evasion.
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Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus).
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Single Amino Acid Changes in the Nipah and Hendra Virus Attachment Glycoproteins Distinguish EphrinB2 from EphrinB3 Usage.
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J. Virol. 81, 10804-10814
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Molecular Determinants of Antiviral Potency of Paramyxovirus Entry Inhibitors.
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A Conserved Region in the F2 Subunit of Paramyxovirus Fusion Proteins Is Involved In Fusion Regulation.
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A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans.
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SARS molecular epidemiology: a Chinese fairy tale of controlling an emerging zoonotic disease in the genomics era.
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Inhibition of henipavirus infection by Nipah virus attachment glycoprotein occurs without cell-surface downregulation of ephrin-B2 or ephrin-B3.
B. Sawatsky, A. Grolla, N. Kuzenko, H. Weingartl, and M. Czub (2007)
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A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species.
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Potent Neutralization of Hendra and Nipah Viruses by Human Monoclonal Antibodies.
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Bats Are Natural Reservoirs of SARS-Like Coronaviruses.
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Science 310, 676-679
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Cathepsin L Is Involved in Proteolytic Processing of the Hendra Virus Fusion Protein.
C. T. Pager and R. E. Dutch (2005)
J. Virol. 79, 12714-12720
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Location of, immunogenicity of and relationships between neutralization epitopes on the attachment protein (G) of Hendra virus.
J. R. White, V. Boyd, G. S. Crameri, C. J. Duch, R. K. van Laar, L.-F. Wang, and B. T. Eaton (2005)
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The Complete Genome Sequence of J Virus Reveals a Unique Genome Structure in the Family Paramyxoviridae.
P. J. M. Jack, D. B. Boyle, B. T. Eaton, and L.-F. Wang (2005)
J. Virol. 79, 10690-10700
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Ubiquitous Activation of the Nipah Virus Fusion Protein Does Not Require a Basic Amino Acid at the Cleavage Site.
M. Moll, S. Diederich, H.-D. Klenk, M. Czub, and A. Maisner (2004)
J. Virol. 78, 9705-9712
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Subcellular Localization and Calcium and pH Requirements for Proteolytic Processing of the Hendra Virus Fusion Protein.
C. T. Pager, M. A. Wurth, and R. E. Dutch (2004)
J. Virol. 78, 9154-9163
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Mapping of domains responsible for nucleocapsid protein-phosphoprotein interaction of henipaviruses.
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Hendra Virus V Protein Inhibits Interferon Signaling by Preventing STAT1 and STAT2 Nuclear Accumulation.
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A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome.
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Severe acute respiratory syndrome (SARS).
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Late clinical and magnetic resonance imaging follow up of Nipah virus infection.
C C T Lim, W L Lee, Y S Leo, K E Lee, K P Chan, A E Ling, H Oh, A P Auchus, N I Paton, F Hui, et al. (2003)
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Nipah virus infection among abattoir workers in Malaysia, 1998-1999.
M. Sahani, U. D Parashar, R. Ali, P. Das, M. Lye, M. M Isa, M. T Arif, T. G Ksiazek, and M Sivamoorthy (2001)
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Detection of avian oncogenic Marek's disease herpesvirus DNA in human sera.
S. Laurent, E. Esnault, G. Dambrine, A. Goudeau, D. Choudat, and D. Rasschaert (2001)
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The Exceptionally Large Genome of Hendra Virus: Support for Creation of a New Genus within the Family Paramyxoviridae.
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J. Virol. 74, 9972-9979
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Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus.
K. Halpin, P. L. Young, H. E. Field, and J. S. Mackenzie (2000)
J. Gen. Virol. 81, 1927-1932
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Equine Viral Arteritis.
F. Del Piero (2000)
Vet. Pathol. 37, 287-296
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Nipah Viral Encephalitis or Japanese Encephalitis? MR Findings in a New Zoonotic Disease.
C. C. T. Lim, Y. Y. Sitoh, F. Hui, K. E. Lee, B. S. P. Ang, E. Lim, W. E. H. Lim, H. M. L. Oh, P. A. Tambyah, J. S. L. Wong, et al. (2000)
AJNR Am. J. Neuroradiol. 21, 455-461
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Emerging Infectious Diseases of Wildlife-- Threats to Biodiversity and Human Health.
P. Daszak, A. A. Cunningham, and A. D. Hyatt (2000)
Science 287, 443-449
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Detection of Canine Distemper Virus Nucleoprotein RNA by Reverse Transcription-PCR Using Serum, Whole Blood, and Cerebrospinal Fluid from Dogs with Distemper.
A. L. Frisk, M. König, A. Moritz, and W. Baumgärtner (1999)
J. Clin. Microbiol. 37, 3634-3643
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Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.
L. M. Wise, T. Veikkola, A. A. Mercer, L. J. Savory, S. B. Fleming, C. Caesar, A. Vitali, T. Makinen, K. Alitalo, and S. A. Stacker (1999)
PNAS 96, 3071-3076
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Persistent Infection Promotes Cross-Species Transmissibility of Mouse Hepatitis Virus.
R. S. Baric, E. Sullivan, L. Hensley, B. Yount, and W. Chen (1999)
J. Virol. 73, 638-649
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Respiratory Health Hazards in Agriculture.
M. Schenker (1998)
Am. J. Respir. Crit. Care Med. 158, S1-S76
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A Novel P/V/C Gene in a New Member of the Paramyxoviridae Family, Which Causes Lethal Infection in Humans, Horses, and Other Animals.
L.-F. Wang, W. P. Michalski, M. Yu, L. I. Pritchard, G. Crameri, B. Shiell, and B. T. Eaton (1998)
J. Virol. 72, 1482-1490
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World Health Organization Strategy for Emerging Infectious Diseases.
J. W. LeDuc (1996)
JAMA 275, 318-320
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Cause of fatal outbreak in horses and humans traced.
R Nowak (1995)
Science 268, 32
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Nipah Virus Encephalitis: Serial MR Study of an Emerging Disease.
C. C. T. Lim, K. E. Lee, W. L. Lee, P. A. Tambyah, C. C. Lee, Y. Y. Sitoh, A. P. Auchus, B. K. Michael Lin, and F. Hui (2002)
Radiology 222, 219-226
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