Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 April 1995:
Vol. 268. no. 5207, pp. 106 - 111
DOI: 10.1126/science.7535476
Prev | Table of Contents | Next

Articles

Science, Vol 268, Issue 5207, 106-111
Copyright © 1995 by American Association for the Advancement of Science

articles

Antigen-specific development of primary and memory T cells in vivo

MG McHeyzer-Williams and MM Davis

Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA.

The expansion and contraction of specific helper T cells in the draining lymph nodes of normal mice after injection with antigen was followed. T cell receptors from purified primary and memory responder cells had highly restricted junctional regions, indicating antigen-driven selection. Selection for homogeneity in the length of the third complementarity-determining region (CDR3) occurs before selection for some of the characteristic amino acids, indicating the importance of this parameter in T cell receptor recognition. Ultimately, particular T cell receptor sequences come to predominate in the secondary response and others disappear, showing the selective preservation or expansion of specific T cell clones.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells.
R. Geiger, T. Duhen, A. Lanzavecchia, and F. Sallusto (2009)
J. Exp. Med. 206, 1525-1534
   Abstract »    Full Text »    PDF »
The application of real-time PCR to the analysis of T cell repertoires.
P. Wettstein, M. Strausbauch, T. Therneau, and N. Borson (2008)
Nucleic Acids Res. 36, e140
   Abstract »    Full Text »    PDF »
Homogenization of TCR Repertoires within Secondary CD62Lhigh and CD62Llow Virus-Specific CD8+ T Cell Populations.
K. Kedzierska, V. Venturi, S. A. Valkenburg, M. P. Davenport, S. J. Turner, and P. C. Doherty (2008)
J. Immunol. 180, 7938-7947
   Abstract »    Full Text »    PDF »
Decay Accelerating Factor Can Control T Cell Differentiation into IFN-{gamma}-Producing Effector Cells via Regulating Local C5a-Induced IL-12 Production.
P. N. Lalli, M. G. Strainic, F. Lin, M. E. Medof, and P. S. Heeger (2007)
J. Immunol. 179, 5793-5802
   Abstract »    Full Text »    PDF »
TCR Affinity Promotes CD8+ T Cell Expansion by Regulating Survival.
M. Hommel and P. D. Hodgkin (2007)
J. Immunol. 179, 2250-2260
   Abstract »    Full Text »    PDF »
Repertoires of T cell receptors expressed by graft-infiltrating T cells evolve during long-term recall responses to single minor histocompatibility antigens.
P. J. Wettstein, M. Strausbauch, and N. Borson (2007)
Int. Immunol. 19, 523-534
   Abstract »    Full Text »    PDF »
Epigenetic Remodeling of the IL-2 and IFN-{gamma} Loci in Memory CD8 T Cells Is Influenced by CD4 T Cells.
J. K. Northrop, R. M. Thomas, A. D. Wells, and H. Shen (2006)
J. Immunol. 177, 1062-1069
   Abstract »    Full Text »    PDF »
CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells.
D. M. Catron, L. K. Rusch, J. Hataye, A. A. Itano, and M. K. Jenkins (2006)
J. Exp. Med. 203, 1045-1054
   Abstract »    Full Text »    PDF »
Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection..
K. E. Foulds and H. Shen (2006)
J. Immunol. 176, 3037-3043
   Abstract »    Full Text »    PDF »
Ex Vivo Characterization of Allo-MHC-Restricted T Cells Specific for a Single MHC-Peptide Complex.
M. J. Pittet, A. Gati, F.-A. Le Gal, G. Bioley, P. Guillaume, M. de Smedt, J. Plum, D. E. Speiser, J.-C. Cerottini, P.-Y. Dietrich, et al. (2006)
J. Immunol. 176, 2330-2336
   Abstract »    Full Text »    PDF »
Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses.
D. A. Price, J. M. Brenchley, L. E. Ruff, M. R. Betts, B. J. Hill, M. Roederer, R. A. Koup, S. A. Migueles, E. Gostick, L. Wooldridge, et al. (2005)
J. Exp. Med. 202, 1349-1361
   Abstract »    Full Text »    PDF »
Selection of T Cell Clones Expressing High-Affinity Public TCRs within Human Cytomegalovirus-Specific CD8 T Cell Responses.
L. Trautmann, M. Rimbert, K. Echasserieau, X. Saulquin, B. Neveu, J. Dechanet, V. Cerundolo, and M. Bonneville (2005)
J. Immunol. 175, 6123-6132
   Abstract »    Full Text »    PDF »
Host Lymphodepletion Augments T Cell Adoptive Immunotherapy through Enhanced Intratumoral Proliferation of Effector Cells.
L.-X. Wang, S. Shu, and G. E. Plautz (2005)
Cancer Res. 65, 9547-9554
   Abstract »    Full Text »    PDF »
Malaria-specific transgenic CD4+ T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance.
R. Stephens, F. R. Albano, S. Quin, B. J. Pascal, V. Harrison, B. Stockinger, D. Kioussis, H.-U. Weltzien, and J. Langhorne (2005)
Blood 106, 1676-1684
   Abstract »    Full Text »    PDF »
Delayed expansion of a restricted T cell repertoire by low-density TCR ligands.
P. M. Lavoie, A. R. Dumont, H. McGrath, A.-E. Kernaleguen, and R.-P. Sekaly (2005)
Int. Immunol. 17, 931-941
   Abstract »    Full Text »    PDF »
Antigen Recognition Determinants of {gamma}{delta} T Cell Receptors.
S. Shin, R. El-Diwany, S. Schaffert, E. J. Adams, K. C. Garcia, P. Pereira, and Y.-h. Chien (2005)
Science 308, 252-255
   Abstract »    Full Text »    PDF »
T Cells in G1 Provide a Memory-Like Response to Secondary Stimulation.
I. Munitic, P. E. Ryan, and J. D. Ashwell (2005)
J. Immunol. 174, 4010-4018
   Abstract »    Full Text »    PDF »
V{alpha} and V{beta} Public Repertoires Are Highly Conserved in Terminal Deoxynucleotidyl Transferase-Deficient Mice.
N. Fazilleau, J.-P. Cabaniols, F. Lemaitre, I. Motta, P. Kourilsky, and J. M. Kanellopoulos (2005)
J. Immunol. 174, 345-355
   Abstract »    Full Text »    PDF »
In vivo selection of a TCR V{beta} repertoire directed against an immunodominant influenza virus CTL epitope.
W. Zhong and E. L. Reinherz (2004)
Int. Immunol. 16, 1549-1559
   Abstract »    Full Text »    PDF »
IL-15/IL-15R{alpha}-mediated avidity maturation of memory CD8+ T cells.
S. Oh, L. P. Perera, D. S. Burke, T. A. Waldmann, and J. A. Berzofsky (2004)
PNAS 101, 15154-15159
   Abstract »    Full Text »    PDF »
MHC Class II Isotype- and Allele-Specific Attenuation of Experimental Autoimmune Encephalomyelitis.
K. L. de Graaf, S. Barth, M. M. Herrmann, M. K. Storch, C. Otto, T. Olsson, A. Melms, G. Jung, K.-H. Wiesmuller, and R. Weissert (2004)
J. Immunol. 173, 2792-2802
   Abstract »    Full Text »    PDF »
Limited T Cell Receptor Diversity of HCV-specific T Cell Responses Is Associated with CTL Escape.
D. Meyer-Olson, N. H. Shoukry, K. W. Brady, H. Kim, D. P. Olson, K. Hartman, A. K. Shintani, C. M. Walker, and S. A. Kalams (2004)
J. Exp. Med. 200, 307-319
   Abstract »    Full Text »    PDF »
Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells.
Y. Hayashi, S.-i. Tsukumo, H. Shiota, K. Kishihara, and K. Yasutomo (2004)
J. Immunol. 172, 5240-5248
   Abstract »    Full Text »    PDF »
Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.
K. Kedzierska, S. J. Turner, and P. C. Doherty (2004)
PNAS 101, 4942-4947
   Abstract »    Full Text »    PDF »
Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy.
L.-X. Wang, J. Kjaergaard, P. A. Cohen, S. Shu, and G. E. Plautz (2004)
J. Immunol. 172, 3462-3468
   Abstract »    Full Text »    PDF »
Aggregations of Lymphoid Cells in the Airways of Nonsmokers, Smokers, and Subjects with Asthma.
J. G. Elliot, C. M. Jensen, S. Mutavdzic, J. P. Lamb, N. G. Carroll, and A. L. James (2004)
Am. J. Respir. Crit. Care Med. 169, 712-718
   Abstract »    Full Text »    PDF »
Recall Helper T Cell Response: T Helper 1 Cell-resistant Allergic Susceptibility without Biasing Uncommitted CD4 T Cells.
M. A. Aronica, S. McCarthy, S. Swaidani, D. Mitchell, M. Goral, J. R. Sheller, and M. Boothby (2004)
Am. J. Respir. Crit. Care Med. 169, 587-595
   Abstract »    Full Text »    PDF »
Conservation of Babesia bovis Small Heat Shock Protein (Hsp20) among Strains and Definition of T Helper Cell Epitopes Recognized by Cattle with Diverse Major Histocompatibility Complex Class II Haplotypes.
J. Norimine, J. Mosqueda, G. H. Palmer, H. A. Lewin, and W. C. Brown (2004)
Infect. Immun. 72, 1096-1106
   Abstract »    Full Text »    PDF »
Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response.
K. A. Pape, V. Kouskoff, D. Nemazee, H. L. Tang, J. G. Cyster, L. E. Tze, K. L. Hippen, T. W. Behrens, and M. K. Jenkins (2003)
J. Exp. Med. 197, 1677-1687
   Abstract »    Full Text »    PDF »
Prevalent Role of TCR {alpha}-Chain in the Selection of the Preimmune Repertoire Specific for a Human Tumor-Associated Self-Antigen.
P.-Y. Dietrich, F.-A. Le Gal, V. Dutoit, M. J. Pittet, L. Trautman, A. Zippelius, I. Cognet, V. Widmer, P. R. Walker, O. Michielin, et al. (2003)
J. Immunol. 170, 5103-5109
   Abstract »    Full Text »    PDF »
A Fractal Clonotype Distribution in the CD8+ Memory T Cell Repertoire Could Optimize Potential for Immune Responses.
Y. N. Naumov, E. N. Naumova, K. T. Hogan, L. K. Selin, and J. Gorski (2003)
J. Immunol. 170, 3994-4001
   Abstract »    Full Text »    PDF »
Degenerate specificity of HTLV-1-specific CD8+ T cells during viral replication in patients with HTLV-1-associated myelopathy (HAM/TSP).
R. Kubota, Y. Furukawa, S. Izumo, K. Usuku, and M. Osame (2003)
Blood 101, 3074-3081
   Abstract »    Full Text »    PDF »
H2-M3-Restricted Memory T Cells: Persistence and Activation Without Expansion.
K. M. Kerksiek, A. Ploss, I. Leiner, D. H. Busch, and E. G. Pamer (2003)
J. Immunol. 170, 1862-1869
   Abstract »    Full Text »    PDF »
Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy.
M. K. Slifka, J. N. Blattman, D. J. D. Sourdive, F. Liu, D. L. Huffman, T. Wolfe, A. Hughes, M. B. A. Oldstone, R. Ahmed, and M. G. von Herrath (2003)
J. Immunol. 170, 1231-1239
   Abstract »    Full Text »    PDF »
Commitment of Activated T Cells to Secondary Responsiveness Is Enhanced by Signals Mediated by cAMP-Dependent Protein Kinase A-I.
M. Vig, A. George, R. Sen, J. Durdik, S. Rath, and V. Bal (2002)
Mol. Pharmacol. 62, 1471-1481
   Abstract »    Full Text »    PDF »
Adoptive Immunotherapy of Advanced Tumors with CD62 L-Selectinlow Tumor-Sensitized T Lymphocytes Following Ex Vivo Hyperexpansion.
L.-X. Wang, B.-G. Chen, and G. E. Plautz (2002)
J. Immunol. 169, 3314-3320
   Abstract »    Full Text »    PDF »
Streptococcus sanguis Modulates Type II Collagen-Induced Arthritis in DBA/1J Mice.
M. Costalonga, J. S. Hodges, and M. C. Herzberg (2002)
J. Immunol. 169, 2189-2195
   Abstract »    Full Text »    PDF »
Induction of CD4 T Cell Changes in Murine AIDS Is Dependent on Costimulation and Involves a Dysregulation of Homeostasis.
M. H. Yen, N. Lepak, and S. L. Swain (2002)
J. Immunol. 169, 722-731
   Abstract »    Full Text »    PDF »
Infusion of CD4+ Donor Lymphocytes Induces the Expansion of CD8+ Donor T Cells with Cytolytic Activity Directed against Recipient Hematopoietic Cells.
E. Zorn, K. S. Wang, E. P. Hochberg, C. Canning, E. P. Alyea, R. J. Soiffer, and J. Ritz (2002)
Clin. Cancer Res. 8, 2052-2060
   Abstract »    Full Text »    PDF »
Expansion of a CD28-Intermediate Subset among CD8 T Cells in Patients with Infectious Mononucleosis.
H. Uda, T. Mima, N. Yamaguchi, Y. Katada, M. Fukuda, N. Fujii, K. Nakamura, and O. Saiki (2002)
J. Virol. 76, 6602-6608
   Abstract »    Full Text »    PDF »
Orally Tolerized T Cells Are Only Able to Enter B Cell Follicles Following Challenge with Antigen in Adjuvant, but They Remain Unable to Provide B Cell Help.
K. M. Smith, F. McAskill, and P. Garside (2002)
J. Immunol. 168, 4318-4325
   Abstract »    Full Text »    PDF »
Adapting a transforming growth factor beta -related tumor protection strategy to enhance antitumor immunity.
C. M. Bollard, C. Rossig, M. J. Calonge, M. H. Huls, H.-J. Wagner, J. Massague, M. K. Brenner, H. E. Heslop, and C. M. Rooney (2002)
Blood 99, 3179-3187
   Abstract »    Full Text »    PDF »
Clonal Selection, Clonal Senescence, and Clonal Succession: The Evolution of the T Cell Response to Infection with a Persistent Virus.
M. P. Davenport, C. Fazou, A. J. McMichael, and M. F. C. Callan (2002)
J. Immunol. 168, 3309-3317
   Abstract »    Full Text »    PDF »
CD4 T Cells Selected by Antigen Under Th2 Polarizing Conditions Favor an Elongated TCR{alpha} Chain Complementarity-Determining Region 3.
R. J. Boyton, N. Zaccai, E. Y. Jones, and D. M. Altmann (2002)
J. Immunol. 168, 1018-1027
   Abstract »    Full Text »    PDF »
Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells.
J. Harbertson, E. Biederman, K. E. Bennett, R. M. Kondrack, and L. M. Bradley (2002)
J. Immunol. 168, 1095-1102
   Abstract »    Full Text »    PDF »
Homeostatic Competition Among T Cells Revealed by Conditional Inactivation of the Mouse Cd4 Gene.
Q. Wang, J. Strong, and N. Killeen (2001)
J. Exp. Med. 194, 1721-1730
   Abstract »    Full Text »    PDF »
Sustained Activation of p34cdc2 Is Required for Noscapine-induced Apoptosis.
K. Ye, J. Zhou, J. W. Landen, E. M. Bradbury, and H. C. Joshi (2001)
J. Biol. Chem. 276, 46697-46700
   Abstract »    Full Text »    PDF »
Influenza A antigen exposure selects dominant V{beta}17+ TCR in human CD8+ cytotoxic T cell responses.
T. M. Lawson, S. Man, S. Williams, A. C. M. Boon, M. Zambon, and L. K. Borysiewicz (2001)
Int. Immunol. 13, 1373-1381
   Abstract »    Full Text »    PDF »
Functional differences between influenza A-specific cytotoxic T lymphocyte clones expressing dominant and subdominant TCR.
T. M. Lawson, S. Man, E. C. Y. Wang, S. Williams, N. Amos, G. M. Gillespie, P. A. Moss, and L. K. Borysiewicz (2001)
Int. Immunol. 13, 1383-1390
   Abstract »    Full Text »    PDF »
Interleukin-10 promotes the maintenance of antitumor CD8+ T-cell effector function in situ.
S.-i. Fujii, K. Shimizu, T. Shimizu, and M. T. Lotze (2001)
Blood 98, 2143-2151
   Abstract »    Full Text »    PDF »
Plaque T-Cell Activity : Not So Specific?.
S. Stemme (2001)
Arterioscler. Thromb. Vasc. Biol. 21, 1099-1101
   Full Text »    PDF »
CD4 positive peripheral T cells from patients with systemic lupus erythematosus (SLE) are clonally expanded.
W Kolowos, U S Gaipl, R E Voll, C Frank, J P Haas, T D Beyer, J R Kalden, and M Herrmann (2001)
Lupus 10, 321-331
   Abstract »    PDF »
Kinetics of TCR Use in Response to Repeated Epitope-Specific Immunization.
V. Monsurro, M.-B. Nielsen, A. Perez-Diez, M. E. Dudley, E. Wang, S. A. Rosenberg, and F. M. Marincola (2001)
J. Immunol. 166, 5817-5825
   Abstract »    Full Text »    PDF »
Longitudinal analysis of T cells responding to tetanus toxoid in healthy subjects as well as in pediatric patients after bone marrow transplantation: the identification of identical TCR-CDR3 regions in time suggests long-term stability of at least part of the antigen-specific TCR repertoire.
B. C. Godthelp, M. J. D. van Tol, J. M. Vossen, and P. J. van den Elsen (2001)
Int. Immunol. 13, 507-518
   Abstract »    Full Text »    PDF »
T Cell Receptor (TCR)-mediated Repertoire Selection and Loss of TCR V{beta} Diversity during the Initiation of a CD4+ T Cell Response In Vivo.
M. Fasso, N. Anandasabapathy, F. Crawford, J. Kappler, C. G. Fathman, and W. M. Ridgway (2000)
J. Exp. Med. 192, 1719-1730
   Abstract »    Full Text »    PDF »
Evolution of the T Cell Repertoire During Primary, Memory, and Recall Responses to Viral Infection.
J. N. Blattman, D. J. D. Sourdive, K. Murali-Krishna, R. Ahmed, and J. D. Altman (2000)
J. Immunol. 165, 6081-6090
   Abstract »    Full Text »    PDF »
Antigen-specific T Helper Cell Function: Differential Cytokine Expression in Primary and Memory Responses.
J. F. Panus, L. J. McHeyzer-Williams, and M. G. McHeyzer-Williams (2000)
J. Exp. Med. 192, 1301-1316
   Abstract »    Full Text »    PDF »
Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers.
C. G. Radu, S. M. Anderton, M. Firan, D. C. Wraith, and E. S. Ward (2000)
Int. Immunol. 12, 1553-1560
   Abstract »    Full Text »    PDF »
Changing Patterns of Dominant TCR Usage with Maturation of an EBV-Specific Cytotoxic T Cell Response.
N. E. Annels, M. F. C. Callan, L. Tan, and A. B. Rickinson (2000)
J. Immunol. 165, 4831-4841
   Abstract »    Full Text »    PDF »
T Cells Compete for Access to Antigen-bearing Antigen-presenting Cells.
R. M. Kedl, W. A. Rees, D. A. Hildeman, B. Schaefer, T. Mitchell, J. Kappler, and P. Marrack (2000)
J. Exp. Med. 192, 1105-1114
   Abstract »    Full Text »    PDF »
Prospective Determination of T-Cell Responses to S-Antigen in Behcet's Disease Patients and Controls.
M. D. de Smet and M. Dayan (2000)
Invest. Ophthalmol. Vis. Sci. 41, 3480-3484
   Abstract »    Full Text »
Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors.
G. E. Plautz, S. Mukai, P. A. Cohen, and S. Shu (2000)
J. Immunol. 165, 3656-3662
   Abstract »    Full Text »    PDF »
Frequent Contribution of T Cell Clonotypes with Public TCR Features to the Chronic Response Against a Dominant EBV-Derived Epitope: Application to Direct Detection of Their Molecular Imprint on the Human Peripheral T Cell Repertoire.
A. Lim, L. Trautmann, M.-A. Peyrat, C. Couedel, F. Davodeau, F. Romagne, P. Kourilsky, and M. Bonneville (2000)
J. Immunol. 165, 2001-2011
   Abstract »    Full Text »    PDF »
Murine {gamma}-herpesvirus infection causes V{beta}4-specific CDR3-restricted clonal expansions within CD8+ peripheral blood T lymphocytes.
C. L. Hardy, S. L. Silins, David. L. Woodland, and M. A. Blackman (2000)
Int. Immunol. 12, 1193-1204
   Abstract »    Full Text »    PDF »
Hyaluronan Anchoring and Regulation on the Surface of Vascular Endothelial Cells Is Mediated through the Functionally Active Form of CD44.
A. Nandi, P. Estess, and M. H. Siegelman (2000)
J. Biol. Chem. 275, 14939-14948
   Abstract »    Full Text »    PDF »
Antigen-Experienced CD4 T Cells Display a Reduced Capacity for Clonal Expansion In Vivo That Is Imposed by Factors Present in the Immune Host.
R. Merica, A. Khoruts, K. A. Pape, R. L. Reinhardt, and M. K. Jenkins (2000)
J. Immunol. 164, 4551-4557
   Abstract »    Full Text »    PDF »
Antigen-specific B Cell Memory: Expression and Replenishment of a Novel B220- Memory B Cell Compartment.
L. J. McHeyzer-Williams, M. Cool, and M. G. McHeyzer-Williams (2000)
J. Exp. Med. 191, 1149-1166
   Abstract »    Full Text »    PDF »
Qualitative Changes Accompany Memory T Cell Generation: Faster, More Effective Responses at Lower Doses of Antigen.
P. R. Rogers, C. Dubey, and S. L. Swain (2000)
J. Immunol. 164, 2338-2346
   Abstract »    Full Text »    PDF »
Interleukin 4-producing CD4 T Cells Arise from Different Precursors Depending on the Conditions of Antigen Exposure In Vivo.
G. Foucras, L. Gapin, C. Coureau, J. M. Kanellopoulos, and J.-C. Guery (2000)
J. Exp. Med. 191, 683-694
   Abstract »    Full Text »    PDF »
Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus.
C. M. Jones, S. C. Cose, J. M. McNally, S. R. Jennings, W. R. Heath, and F. R. Carbone (2000)
J. Gen. Virol. 81, 407-414
   Abstract »    Full Text »
Antigen-Driven Selection of TCR In Vivo: Related TCR {alpha}-Chains Pair with Diverse TCR {beta}-Chains.
J. A. Mikszta, L. J. McHeyzer-Williams, and M. G. McHeyzer-Williams (1999)
J. Immunol. 163, 5978-5988
   Abstract »    Full Text »    PDF »
Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice.
K. Murali-Krishna, L. L. Lau, S. Sambhara, F. Lemonnier, J. Altman, and R. Ahmed (1999)
Science 286, 1377-1381
   Abstract »    Full Text »
Selective Expansion of Cross-reactive CD8+ Memory T Cells by Viral Variants.
J. B.A.G. Haanen, M. C. Wolkers, A. M. Kruisbeek, and T. N.M. Schumacher (1999)
J. Exp. Med. 190, 1319-1328
   Abstract »    Full Text »    PDF »
In Vivo-activated CD4 T Cells Upregulate CXC Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines.
K. M. Ansel, L. J. McHeyzer-Williams, V. N. Ngo, M. G. McHeyzer-Williams, and J. G. Cyster (1999)
J. Exp. Med. 190, 1123-1134
   Abstract »    Full Text »    PDF »
The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope.
R. Wang, Y. Wang-Zhu, C. R. Gabaglia, K. Kimachi, and H. M. Grey (1999)
J. Exp. Med. 190, 983-994
   Abstract »    Full Text »    PDF »
Effector CD4 T Cells Are Biochemically Distinct from the Memory Subset: Evidence for Long-Term Persistence of Effectors In Vivo.
M. Ahmadzadeh, S. F. Hussain, and D. L. Farber (1999)
J. Immunol. 163, 3053-3063
   Abstract »    Full Text »    PDF »
Astrocytoma infiltrating lymphocytes include major T cell clonal expansions confined to the CD8 subset.
G. Perrin, V. Schnuriger, A.-L. Quiquerez, P. Saas, C. Pannetier, N. de Tribolet, J.-M. Tiercy, J.-P. Aubry, P.-Y. Dietrich, and P. R. Walker (1999)
Int. Immunol. 11, 1337-1350
   Abstract »    Full Text »    PDF »
Negative Selection of T Cells Occurs Throughout Thymic Development.
K. K. Baldwin, B. P. Trenchak, J. D. Altman, and M. M. Davis3 (1999)
J. Immunol. 163, 689-698
   Abstract »    Full Text »    PDF »
Human Virus-Specific CD8+ CTL Clones Revert from CD45ROhigh to CD45RAhigh In Vivo: CD45RAhighCD8+ T Cells Comprise Both Naive and Memory Cells.
M. R. Wills, A. J. Carmichael, M. P. Weekes, K. Mynard, G. Okecha, R. Hicks, and J. G. P. Sissons (1999)
J. Immunol. 162, 7080-7087
   Abstract »    Full Text »    PDF »
Biased TCR Repertoire in HIV-1-Infected Patients Due to Clonal Expansion of HIV-1-Reverse Transcriptase-Specific CTL Clones.
W. Kolowos, M. Schmitt, M. Herrman, E. Harrer, P. Low, J. R. Kalden, and T. Harrer (1999)
J. Immunol. 162, 7525-7533
   Abstract »    Full Text »    PDF »
Evolution of Antigen-specific T Cell Receptors In Vivo: Preimmune and Antigen-driven Selection of Preferred Complementarity-determining Region 3 (CDR3) Motifs.
L. J. McHeyzer-Williams, J. F. Panus, J. A. Mikszta, and M. G. McHeyzer-Williams (1999)
J. Exp. Med. 189, 1823-1838
   Abstract »    Full Text »    PDF »
Developmental Regulation of Lck Targeting to the CD8 Coreceptor Controls Signaling in Naive and Memory T Cells.
M. F. Bachmann, A. Gallimore, S. Linkert, V. Cerundolo, A. Lanzavecchia, M. Kopf, and A. Viola (1999)
J. Exp. Med. 189, 1521-1530
   Abstract »    Full Text »    PDF »
The Composition of a Primary T Cell Response Is Largely Determined by the Timing of Recruitment of Individual T Cell Clones.
P. Bousso, J.-P. Levraud, P. Kourilsky, and J.-P. Abastado (1999)
J. Exp. Med. 189, 1591-1600
   Abstract »    Full Text »    PDF »
Memory CD44int CD8 T cells show increased proliferative responses and IFN-{gamma} production following antigenic challenge in vitro.
M. Pihlgren, C. Arpin, T. Walzer, M. Tomkowiak, A. Thomas, J. Marvel, and P. M. Dubois (1999)
Int. Immunol. 11, 699-706
   Abstract »    Full Text »    PDF »
Altered Ligands Reveal Limited Plasticity in the T Cell Response to a Pathogenic Epitope.
S. Pingel, P. Launois, D. J. Fowell, C. W. Turck, S. Southwood, A. Sette, N. Glaichenhaus, J. A. Louis, and R. M. Locksley (1999)
J. Exp. Med. 189, 1111-1120
   Abstract »    Full Text »    PDF »
Activation of CD4 T Cells by Somatic Transgenesis Induces Generalized Immunity of Uncommitted T Cells and Immunologic Memory.
M. Gerloni, K. T. Miner, S. Xiong, M. Croft, and M. Zanetti (1999)
J. Immunol. 162, 3782-3789
   Abstract »    Full Text »    PDF »
Selection of CD8+ T Cells with Highly Focused Specificity During Viral Persistence in the Central Nervous System.
N. W. Marten, S. A. Stohlman, W. Smith-Begolka, S. D. Miller, E. Dimacali, Q. Yao, S. Stohl, J. Goverman, and C. C. Bergmann (1999)
J. Immunol. 162, 3905-3914
   Abstract »    Full Text »    PDF »
Adjuvant-Guided Type-1 and Type-2 Immunity: Infectious/Noninfectious Dichotomy Defines the Class of Response.
H. C. Yip, A. Y. Karulin, M. Tary-Lehmann, M. D. Hesse, H. Radeke, P. S. Heeger, R. P. Trezza, F. P. Heinzel, T. Forsthuber, and P. V. Lehmann (1999)
J. Immunol. 162, 3942-3949
   Abstract »    Full Text »    PDF »
Functional differences between memory and naive CD8 T cells.
B. K. Cho, C. Wang, S. Sugawa, H. N. Eisen, and J. Chen (1999)
PNAS 96, 2976-2981
   Abstract »    Full Text »    PDF »
Evidence of T cell receptor beta -chain patterns in inflammatory and noninflammatory bowel disease states.
L. J. Saubermann, C. S. J. Probert, A. D. Christ, A. Chott, J. R. Turner, A. C. Stevens, S. P. Balk, and R. S. Blumberg (1999)
Am J Physiol Gastrointest Liver Physiol 276, G613-G621
   Abstract »    Full Text »    PDF »
T Cell Affinity Maturation by Selective Expansion during Infection.
D. H. Busch and E. G. Pamer (1999)
J. Exp. Med. 189, 701-710
   Abstract »    Full Text »    PDF »
Clonal Expansion of CD4+ TCR{beta}{beta}+ T Cells in TCR {alpha}-Chain- Deficient Mice by Gut-Derived Antigens.
I. Takahashi, H. Iijima, R. Katashima, M. Itakura, and H. Kiyono (1999)
J. Immunol. 162, 1843-1850
   Abstract »    Full Text »    PDF »
Two-Domain MHC Class II Molecules Form Stable Complexes with Myelin Basic Protein 69-89 Peptide That Detect and Inhibit Rat Encephalitogenic T Cells and Treat Experimental Autoimmune Encephalomyelitis.
G. G. Burrows, B. F. Bebo Jr., K. L. Adlard, A. A. Vandenbark, and H. Offner (1998)
J. Immunol. 161, 5987-5996
   Abstract »    Full Text »    PDF »
In Vivo Function of an Interleukin 2 Receptor beta  Chain (IL-2Rbeta )/IL-4Ralpha Cytokine Receptor Chimera Potentiates Allergic Airway Disease.
J. Youn, J. Chen, S. Goenka, M. A. Aronica, A. L. Mora, V. Correa, J. R. Sheller, and M. Boothby (1998)
J. Exp. Med. 188, 1803-1816
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)