Science 31 March 1995: Vol. 267. no. 5206, pp. 2003 - 2006 DOI: 10.1126/science.7701324

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Articles

Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy.

G. Francis, J. Martinez, W. Liu, T. Nguyen, A. Ayer, J. Fine, D. Zochodne, L. R. Hanson, W. H. Frey II, and C. Toth (2009)
Diabetes 58, 934-945
 |  Abstract »  |  Full Text »  |  PDF »

Src activation triggers capacitation and acrosome reaction but not motility in human spermatozoa.

G. Varano, A. Lombardi, G. Cantini, G. Forti, E. Baldi, and M. Luconi (2008)
Hum. Reprod. 23, 2652-2662
 |  Abstract »  |  Full Text »  |  PDF »

Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy.

G. J. Francis, J. A. Martinez, W. Q. Liu, K. Xu, A. Ayer, J. Fine, U. I. Tuor, G. Glazner, L. R. Hanson, W. H. Frey II, et al. (2008)
Brain 131, 3311-3334
 |  Abstract »  |  Full Text »  |  PDF »

Netrin-1 is a survival factor during commissural neuron navigation.

C. Furne, N. Rama, V. Corset, A. Chedotal, and P. Mehlen (2008)
PNAS 105, 14465-14470
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Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling.

H. Hayashi, Y. Tsuchiya, K. Nakayama, T. Satoh, and E. Nishida (2008)
Genes Cells 13, 941-947
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of Influenza A Virus NS1 Protein Interaction with the p85{beta}, but Not the p85{alpha}, Subunit of Phosphatidylinositol 3-Kinase (PI3K) and Up-regulation of PI3K Activity.

Y. Li, D. H. Anderson, Q. Liu, and Y. Zhou (2008)
J. Biol. Chem. 283, 23397-23409
 |  Abstract »  |  Full Text »  |  PDF »

PDGF- and Insulin/IGF-1-Specific Distinct Modes of Class IA PI 3-Kinase Activation in Normal Rat Retinas and RGC-5 Retinal Ganglion Cells.

S. K. Biswas, Y. Zhao, A. Nagalingam, T. W. Gardner, and L. Sandirasegarane (2008)
Invest. Ophthalmol. Vis. Sci. 49, 3687-3698
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor {beta} Induces Apoptosis through Repressing the Phosphoinositide 3-Kinase/AKT/Survivin Pathway in Colon Cancer Cells.

J. Wang, L. Yang, J. Yang, K. Kuropatwinski, W. Wang, X.-Q. Liu, J. Hauser, and M. G. Brattain (2008)
Cancer Res. 68, 3152-3160
 |  Abstract »  |  Full Text »  |  PDF »

The eIF4E RNA regulon promotes the Akt signaling pathway.

B. Culjkovic, K. Tan, S. Orolicki, A. Amri, S. Meloche, and K. L.B. Borden (2008)
J. Cell Biol. 181, 51-63
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Role of Insulin Receptor and Balance in Insulin Receptor Isoforms A and B in Regulation of Apoptosis in Simian Virus 40-immortalized Neonatal Hepatocytes.

C. Nevado, M. Benito, and A. M. Valverde (2008)
Mol. Biol. Cell 19, 1185-1198
 |  Abstract »  |  Full Text »  |  PDF »

SH3 Binding Motif 1 in Influenza A Virus NS1 Protein Is Essential for PI3K/Akt Signaling Pathway Activation.

Y.-K. Shin, Y. Li, Q. Liu, D. H. Anderson, L. A. Babiuk, and Y. Zhou (2007)
J. Virol. 81, 12730-12739
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Pro-apoptotic Scaffolding Protein POSH by Akt.

T. R. Lyons, J. Thorburn, P. W. Ryan, A. Thorburn, S. M. Anderson, and C. K. Kassenbrock (2007)
J. Biol. Chem. 282, 21987-21997
 |  Abstract »  |  Full Text »  |  PDF »

Mutant PIK3CA-Bearing Colon Cancer Cells Display Increased Metastasis in an Orthotopic Model.

X.-N. Guo, A. Rajput, R. Rose, J. Hauser, A. Beko, K. Kuropatwinski, C. LeVea, R. M. Hoffman, M. G. Brattain, and J. Wang (2007)
Cancer Res. 67, 5851-5858
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference Elucidates the Role of Focal Adhesion Kinase in HLA Class I-Mediated Focal Adhesion Complex Formation and Proliferation in Human Endothelial Cells.

Y.-P. Jin, Y. Korin, X. Zhang, P. T. Jindra, E. Rozengurt, and E. F. Reed (2007)
J. Immunol. 178, 7911-7922
 |  Abstract »  |  Full Text »  |  PDF »

Focal adhesion kinase mediates cell survival via NF-{kappa}B and ERK signaling pathways.

D. Huang, M. Khoe, M. Befekadu, S. Chung, Y. Takata, D. Ilic, and M. Bryer-Ash (2007)
Am J Physiol Cell Physiol 292, C1339-C1352
 |  Abstract »  |  Full Text »  |  PDF »

Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation.

Y.-K. Shin, Q. Liu, S. K. Tikoo, L. A. Babiuk, and Y. Zhou (2007)
J. Gen. Virol. 88, 942-950
 |  Abstract »  |  Full Text »  |  PDF »

Colon carcinoma cells harboring PIK3CA mutations display resistance to growth factor deprivation induced apoptosis.

J. Wang, K. Kuropatwinski, J. Hauser, M. R. Rossi, Y. Zhou, A. Conway, J. L.C. Kan, N. W. Gibson, J. K.V. Willson, J. K. Cowell, et al. (2007)
Mol. Cancer Ther. 6, 1143-1150
 |  Abstract »  |  Full Text »  |  PDF »

B7-DC/PD-L2 Cross-Linking Induces NF-{kappa}B-Dependent Protection of Dendritic Cells from Cell Death.

S. Radhakrishnan, L. T. Nguyen, B. Ciric, V. P. Van Keulen, and L. R. Pease (2007)
J. Immunol. 178, 1426-1432
 |  Abstract »  |  Full Text »  |  PDF »

Guanosine Inhibits CD40 Receptor Expression and Function Induced by Cytokines and beta Amyloid in Mouse Microglia Cells.

I. D'Alimonte, V. Flati, M. D'Auro, E. Toniato, S. Martinotti, M. P. Rathbone, S. Jiang, P. Ballerini, P. Di Iorio, F. Caciagli, et al. (2007)
J. Immunol. 178, 720-731
 |  Abstract »  |  Full Text »  |  PDF »

The Platelet-derived Growth Factor Receptor {alpha} Is Destabilized by Geldanamycins in Cancer Cells.

D. Matei, M. Satpathy, L. Cao, Y.-C. Lai, H. Nakshatri, and D. B. Donner (2007)
J. Biol. Chem. 282, 445-453
 |  Abstract »  |  Full Text »  |  PDF »

Loss of BCL-XL in Rod Photoreceptors: Increased Susceptibility to Bright Light Stress.

L. Zheng, R. E. Anderson, M.-P. Agbaga, E. B. Rucker III, and Y.-Z. Le (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5583-5589
 |  Abstract »  |  Full Text »  |  PDF »

MyD88 and NOS2 are essential for Toll-like receptor 4-mediated survival effect in cardiomyocytes.

X. Zhu, H. Zhao, A. R. Graveline, E. S. Buys, U. Schmidt, K. D. Bloch, A. Rosenzweig, and W. Chao (2006)
Am J Physiol Heart Circ Physiol 291, H1900-H1909
 |  Abstract »  |  Full Text »  |  PDF »

Biology of Platelet-Derived Growth Factor and Its Involvement in Disease.

R. H. Alvarez, H. M. Kantarjian, and J. E. Cortes (2006)
Mayo Clin. Proc. 81, 1241-1257
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A Novel Function of Plasminogen Activator Inhibitor-1 in Modulation of the AKT Pathway in Wild-type and Plasminogen Activator Inhibitor-1-deficient Endothelial Cells.

R. D. Balsara, F. J. Castellino, and V. A. Ploplis (2006)
J. Biol. Chem. 281, 22527-22536
 |  Abstract »  |  Full Text »  |  PDF »

The Anti-Inflammatory Drug, Nimesulide (4-Nitro-2-phenoxymethane-sulfoanilide), Uncouples Mitochondria and Induces Mitochondrial Permeability Transition in Human Hepatoma Cells: Protection by Albumin.

A. Berson, S. Cazanave, V. Descatoire, M. Tinel, A. Grodet, C. Wolf, G. Feldmann, and D. Pessayre (2006)
J. Pharmacol. Exp. Ther. 318, 444-454
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic and characteristic expression of phosphorylated Akt in human endometrium and decidual cells in vivo and in vitro.

A. Toyofuku, T. Hara, T. Taguchi, Y. Katsura, K. Ohama, and Y. Kudo (2006)
Hum. Reprod. 21, 1122-1128
 |  Abstract »  |  Full Text »  |  PDF »

Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways..

S.-L. Hsuan, H. M. Klintworth, and Z. Xia (2006)
J. Neurosci. 26, 4481-4491
 |  Abstract »  |  Full Text »  |  PDF »

Essential role of PI3K{delta} and PI3K{gamma} in thymocyte survival.

W. Swat, V. Montgrain, T. A. Doggett, J. Douangpanya, K. Puri, W. Vermi, and T. G. Diacovo (2006)
Blood 107, 2415-2422
 |  Abstract »  |  Full Text »  |  PDF »

Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NF{kappa}B.

M. A. Amin, C. S. Haas, K. Zhu, P. J. Mansfield, M. J. Kim, N. P. Lackowski, and A. E. Koch (2006)
Blood 107, 2252-2261
 |  Abstract »  |  Full Text »  |  PDF »

Coordination of intrinsic, extrinsic, and endoplasmic reticulum-mediated apoptosis by imatinib mesylate combined with arsenic trioxide in chronic myeloid leukemia.

Y. Du, K. Wang, H. Fang, J. Li, D. Xiao, P. Zheng, Y. Chen, H. Fan, X. Pan, C. Zhao, et al. (2006)
Blood 107, 1582-1590
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis-associated Tyrosine Kinase (AATYK) Has Differential Ca2+-dependent Phosphorylation States in Response to Survival and Apoptotic Conditions in Cerebellar Granule Cells.

M. Tomomura and T. Furuichi (2005)
J. Biol. Chem. 280, 35157-35163
 |  Abstract »  |  Full Text »  |  PDF »

Monokine Induced by Interferon-{gamma} Acts as a Neurotrophic Factor on PC12 Cells and Rat Primary Sympathetic Neurons.

K.-I. Uwabe, M. Matsumoto, and K. Nagata (2005)
J. Biol. Chem. 280, 34268-34277
 |  Abstract »  |  Full Text »  |  PDF »

Corneal Cell Survival in Adenovirus Type 19 Infection Requires Phosphoinositide 3-Kinase/Akt Activation.

M. S. Rajala, R. V. S. Rajala, R. A. Astley, A. L. Butt, and J. Chodosh (2005)
J. Virol. 79, 12332-12341
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor-Independent Neuronal Survival: A Role for NO Donors.

K. Akassoglou (2005)
Mol. Pharmacol. 68, 952-955
 |  Abstract »  |  Full Text »  |  PDF »

Distinct effectors of platelet-derived growth factor receptor-{alpha} signaling are required for cell survival during embryogenesis.

M. Van Stry, A. Kazlauskas, S. L. Schreiber, and K. Symes (2005)
PNAS 102, 8233-8238
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}-Melanocortin and Endothelin-1 Activate Antiapoptotic Pathways and Reduce DNA Damage in Human Melanocytes.

A. L. Kadekaro, R. Kavanagh, H. Kanto, S. Terzieva, J. Hauser, N. Kobayashi, S. Schwemberger, J. Cornelius, G. Babcock, H. G. Shertzer, et al. (2005)
Cancer Res. 65, 4292-4299
 |  Abstract »  |  Full Text »  |  PDF »

Capillary supply and gene expression of angiogenesis-related factors in murine skeletal muscle following denervation.

A. Wagatsuma, H. Tamaki, and F. Ogita (2005)
Exp Physiol 90, 403-409
 |  Abstract »  |  Full Text »  |  PDF »

Systematic Evaluation of Anti-apoptotic Growth Factor Signaling in Vascular Smooth Muscle Cells: ONLY PHOSPHATIDYLINOSITOL 3'-KINASE IS IMPORTANT.

M. Vantler, E. Caglayan, W. H. Zimmermann, A. T. Baumer, and S. Rosenkranz (2005)
J. Biol. Chem. 280, 14168-14176
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Gi/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons.

E. H. T. Wu and Y. H. Wong (2005)
Mol. Pharmacol. 67, 1195-1205
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Response to Surface IgM Cross-Linking Identifies Different Prognostic Groups of B-Chronic Lymphocytic Leukemia Patients.

S. Nedellec, Y. Renaudineau, A. Bordron, C. Berthou, N. Porakishvili, P. M. Lydyard, J.-O. Pers, and P. Youinou (2005)
J. Immunol. 174, 3749-3756
 |  Abstract »  |  Full Text »  |  PDF »

S100B Increases Proliferation in PC12 Neuronal Cells and Reduces Their Responsiveness to Nerve Growth Factor via Akt Activation.

C. Arcuri, R. Bianchi, F. Brozzi, and R. Donato (2005)
J. Biol. Chem. 280, 4402-4414
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of myosin light chain kinase provides prolonged attenuation of radial artery vasospasm.

F. Kerendi, M. E. Halkos, J. S. Corvera, H. Kin, Z.-Q. Zhao, M. Mosunjac, R. A. Guyton, and J. Vinten-Johansen (2004)
Eur. J. Cardiothorac. Surg. 26, 1149-1155
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures.

E. Maioli, V. Fortino, and A. Pacini (2004)
Biol Reprod 71, 1779-1784
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Nonsteroidal Anti-inflammatory Drug-activated Gene (NAG-1) as a Novel Downstream Target of Phosphatidylinositol 3-Kinase/AKT/GSK-3{beta} Pathway.

K. Yamaguchi, S.-H. Lee, T. E. Eling, and S. J. Baek (2004)
J. Biol. Chem. 279, 49617-49623
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Valproic Acid Coadministration on Plasma Efavirenz and Lopinavir Concentrations in Human Immunodeficiency Virus-Infected Adults.

R. DiCenzo, D. Peterson, K. Cruttenden, G. Morse, G. Riggs, H. Gelbard, and G. Schifitto (2004)
Antimicrob. Agents Chemother. 48, 4328-4331
 |  Abstract »  |  Full Text »  |  PDF »

Putting the Rap on Akt.

J. E. Thompson and C. B. Thompson (2004)
J. Clin. Oncol. 22, 4217-4226
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase (PI-3K)/Akt but Not PI-3K/p70 S6 Kinase Signaling Mediates IGF-1-Promoted Lens Epithelial Cell Survival.

G. Chandrasekher and D. Sailaja (2004)
Invest. Ophthalmol. Vis. Sci. 45, 3577-3588
 |  Abstract »  |  Full Text »  |  PDF »

Artifactual Insulin Release From Differentiated Embryonic Stem Cells.

M. Hansson, A. Tonning, U. Frandsen, A. Petri, J. Rajagopal, M. C.O. Englund, R. S. Heller, J. Hakansson, J. Fleckner, H. N. Skold, et al. (2004)
Diabetes 53, 2603-2609
 |  Abstract »  |  Full Text »  |  PDF »

Calmodulin-mediated Activation of Akt Regulates Survival of c-Myc-overexpressing Mouse Mammary Carcinoma Cells.

T. B. Deb, C. M. Coticchia, and R. B. Dickson (2004)
J. Biol. Chem. 279, 38903-38911
 |  Abstract »  |  Full Text »  |  PDF »

IC101 Induces Apoptosis by Akt Dephosphorylation via an Inhibition of Heat Shock Protein 90-ATP Binding Activity Accompanied by Preventing the Interaction with Akt in L1210 Cells.

H. Fujiwara, T. Yamakuni, M. Ueno, M. Ishizuka, T. Shinkawa, T. Isobe, and Y. Ohizumi (2004)
J. Pharmacol. Exp. Ther. 310, 1288-1295
 |  Abstract »  |  Full Text »  |  PDF »

Opposing Extracellular Signal-Regulated Kinase and Akt Pathways Control Schwann Cell Myelination.

T. Ogata, S. Iijima, S. Hoshikawa, T. Miura, S.-i. Yamamoto, H. Oda, K. Nakamura, and S. Tanaka (2004)
J. Neurosci. 24, 6724-6732
 |  Abstract »  |  Full Text »  |  PDF »

Differentiation-dependent Sensitivity to Apoptogenic Factors in PC12 Cells.

S. Vyas, P. Juin, D. Hancock, Y. Suzuki, R. Takahashi, A. Triller, and G. Evan (2004)
J. Biol. Chem. 279, 30983-30993
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 Binds to and Mediates Phosphorylation of Microtubule-associated Tau Protein by Ser9-phosphorylated Glycogen Synthase Kinase 3{beta} in the Brain.

Z. Yuan, A. Agarwal-Mawal, and H. K. Paudel (2004)
J. Biol. Chem. 279, 26105-26114
 |  Abstract »  |  Full Text »  |  PDF »

Correspondence Re S. S. Virtanen et al., Alendronate Inhibits Invasion of PC-3 Prostate Cancer Cells by Affecting the Mevalonate Pathway. Cancer Res 2002;62:2708-14. Re K. Sawada et al., Alendronate Inhibits Lysophosphatidic Acid-Induced Migration of Human Ovarian Cancer Cells by Attenuating the Activation of Rho. Cancer Res 2002;62:6015-20..

V. B. Andela, P. T. Lakkakorpi, H. K. Vaananen, P. L. Harkonen, K. Sawada, K.-i. Morishige, M. Tahara, R. Kawagishi, Y. Ikebuchi, K. Tasaka, et al. (2004)
Cancer Res. 64, 2934-2936
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Apoptosis and Dependence Receptors: A Molecular Basis for Cellular Addiction.

D. E. BREDESEN, P. MEHLEN, and S. RABIZADEH (2004)
Physiol Rev 84, 411-430
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Clinical Trial of the Farnesyltransferase Inhibitor BMS-214662 Given as a 1-Hour Intravenous Infusion in Patients with Advanced Solid Tumors.

D. P. Ryan, J. P. Eder Jr., T. Puchlaski, M. V. Seiden, T. J. Lynch, C. S. Fuchs, P. C. Amrein, D. Sonnichsen, J. G. Supko, and J. W. Clark (2004)
Clin. Cancer Res. 10, 2222-2230
 |  Abstract »  |  Full Text »  |  PDF »

Latent Membrane Protein 2A Inhibits Transforming Growth Factor-{beta}1-Induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt Pathway.

M. Fukuda and R. Longnecker (2004)
J. Virol. 78, 1697-1705
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Adriamycin-induced Apoptosis by Sustained Activation of the Phosphatidylinositol-3'-OH kinase-Akt Pathway.

K. Takeuchi and F. Ito (2004)
J. Biol. Chem. 279, 892-900
 |  Abstract »  |  Full Text »  |  PDF »

SH2-B Is a Positive Regulator of Nerve Growth Factor-mediated Activation of the Akt/Forkhead Pathway in PC12 Cells.

X. Wang, L. Chen, T. J. Maures, J. Herrington, and C. Carter-Su (2004)
J. Biol. Chem. 279, 133-141
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Phosphatidylinositol 3'-Kinase and Mammalian Target of Rapamycin/p70 Ribosomal Protein S6 Kinase in K-Ras-Mediated Transformation of Intestinal Epithelial Cells.

J. Shao, B. M. Evers, and H. Sheng (2004)
Cancer Res. 64, 229-235
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Like Growth Factor-1 Receptor Activation Inhibits Oxidized LDL-Induced Cytochrome C Release and Apoptosis via the Phosphatidylinositol 3 Kinase/Akt Signaling Pathway.

Y. Li, Y. Higashi, H. Itabe, Y.-H. Song, J. Du, and P. Delafontaine (2003)
Arterioscler Thromb Vasc Biol 23, 2178-2184
 |  Abstract »  |  Full Text »  |  PDF »

Growth Factor-Specific Regulation of Insulin Receptor Substrate-1 Expression in MCF-7 Breast Carcinoma Cells: Effects on the Insulin-Like Growth Factor Signaling Pathway.

C. Lassarre and J.-M. Ricort (2003)
Endocrinology 144, 4811-4819
 |  Abstract »  |  Full Text »  |  PDF »

Persistent TrkA Activity Is Necessary to Maintain Transcription in Neuronally Differentiated PC12 Cells.

J. H. Chang, E. Mellon, N. C. Schanen, and J. L. Twiss (2003)
J. Biol. Chem. 278, 42877-42885
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival.

B.-S. Li, W. Ma, H. Jaffe, Y. Zheng, S. Takahashi, L. Zhang, A. B. Kulkarni, and H. C. Pant (2003)
J. Biol. Chem. 278, 35702-35709
 |  Abstract »  |  Full Text »  |  PDF »

Migration Inhibitory Factor Mediates Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol Kinase.

M. A. Amin, O. V. Volpert, J. M. Woods, P. Kumar, L. A. Harlow, and A. E. Koch (2003)
Circ. Res. 93, 321-329
 |  Abstract »  |  Full Text »  |  PDF »

Calcium-Dependent Prevention of Neuronal Apoptosis by Lithium Ion: Essential Role of Phosphoinositide 3-Kinase and Phospholipase C{gamma}.

H. J. Kang, J. S. Noh, Y. S. Bae, and B. J. Gwag (2003)
Mol. Pharmacol. 64, 228-234
 |  Abstract »  |  Full Text »  |  PDF »

Loss of PTEN Promotes Tumor Development in Malignant Melanoma.

J. M. Stahl, M. Cheung, A. Sharma, N. R. Trivedi, S. Shanmugam, and G. P. Robertson (2003)
Cancer Res. 63, 2881-2890
 |  Abstract »  |  Full Text »  |  PDF »

Brain-Derived Neurotrophic Factor Protection of Cortical Neurons from Serum Withdrawal-Induced Apoptosis Is Inhibited by cAMP.

S. Poser, S. Impey, Z. Xia, and D. R. Storm (2003)
J. Neurosci. 23, 4420-4427
 |  Abstract »  |  Full Text »  |  PDF »

The PI3-Kinase-Akt Pathway Promotes Mesangial Cell Survival and Inhibits Apoptosis In Vitro via NF-{kappa}B and Bad.

H. Shimamura, Y. Terada, T. Okado, H. Tanaka, S. Inoshita, and S. Sasaki (2003)
J. Am. Soc. Nephrol. 14, 1427-1434
 |  Abstract »  |  Full Text »  |  PDF »

Src and phosphatidylinositol 3-kinase mediate soluble E-selectin-induced angiogenesis.

P. Kumar, M. A. Amin, L. A. Harlow, P. J. Polverini, and A. E. Koch (2003)
Blood 101, 3960-3968
 |  Abstract »  |  Full Text »  |  PDF »

Redox Regulation of cAMP-responsive Element-binding Protein and Induction of Manganous Superoxide Dismutase in Nerve Growth Factor-dependent Cell Survival.

B. Bedogni, G. Pani, R. Colavitti, A. Riccio, S. Borrello, M. Murphy, R. Smith, M. L. Eboli, and T. Galeotti (2003)
J. Biol. Chem. 278, 16510-16519
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen Enhances Depolarization-Induced Glutamate Release through Activation of Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase in Cultured Hippocampal Neurons.

D. Yokomaku, T. Numakawa, Y. Numakawa, S. Suzuki, T. Matsumoto, N. Adachi, C. Nishio, T. Taguchi, and H. Hatanaka (2003)
Mol. Endocrinol. 17, 831-844
 |  Abstract »  |  Full Text »  |  PDF »

Fluoride-induced apoptosis in human epithelial lung cells (A549 cells): role of different G protein-linked signal systems.

M. Refsnes, P. E Schwarze, J. A Holme, and M. Laeg (2003)
Human and Experimental Toxicology 22, 111-123
 |  Abstract »  |  PDF »

Role of Integrin-Linked Kinase in Nerve Growth Factor-Stimulated Neurite Outgrowth.

J. Mills, M. Digicaylioglu, A. T. Legg, C. E. Young, S. S. Young, A. M. Barr, L. Fletcher, T. P. O'Connor, and S. Dedhar (2003)
J. Neurosci. 23, 1638-1648
 |  Abstract »  |  Full Text »  |  PDF »

Redundancy of Radioresistant Signaling Pathways Originating from Insulin-like Growth Factor I Receptor.

D. Yu, H. Watanabe, H. Shibuya, and M. Miura (2003)
J. Biol. Chem. 278, 6702-6709
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages.

F. Francois and M. E. Klotman (2003)
J. Virol. 77, 2539-2549
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Insulin-Like Growth Factor (IGF)-Independent Effects of IGF Binding Protein-3 on Endothelial Cell Survival.

S. L. Franklin, R. J. Ferry Jr., and P. Cohen (2003)
J. Clin. Endocrinol. Metab. 88, 900-907
 |  Abstract »  |  Full Text »  |  PDF »

Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism.

L. Marucci, G. Alpini, S. S. Glaser, D. Alvaro, A. Benedetti, H. Francis, J. L. Phinizy, M. Marzioni, J. Mauldin, J. Venter, et al. (2003)
Am J Physiol Gastrointest Liver Physiol 284, G290-G301
 |  Abstract »  |  Full Text »  |  PDF »

Divergent NMDA Signals Leading to Proapoptotic and Antiapoptotic Pathways in the Rat Retina.

S.-i. Manabe and S. A. Lipton (2003)
Invest. Ophthalmol. Vis. Sci. 44, 385-392
 |  Abstract »  |  Full Text »  |  PDF »

Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase.

S. H. Kim, S. J. Won, S. Sohn, H. J. Kwon, J. Y. Lee, J. H. Park, and B. J. Gwag (2002)
J. Cell Biol. 159, 821-831
 |  Abstract »  |  Full Text »  |  PDF »

Embryonic Testis Cord Formation and Mesonephric Cell Migration Requires the Phosphotidylinositol 3-Kinase Signaling Pathway.

M. Uzumcu, S. D. Westfall, K. A. Dirks, and M. K. Skinner (2002)
Biol Reprod 67, 1927-1935
 |  Abstract »  |  Full Text »  |  PDF »

The death-promoting activity of p53 can be inhibited by distinct signaling pathways.

Y. Lin, L. Brown, D. W. Hedley, D. L. Barber, and S. Benchimol (2002)
Blood 100, 3990-4000
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Cyclic AMP Induces Transactivation of the Receptors for Epidermal Growth Factor and Nerve Growth Factor, Thereby Modulating Activation of MAP Kinase, Akt, and Neurite Outgrowth in PC12 Cells.

A. Piiper, I. Dikic, M. P. Lutz, J. Leser, B. Kronenberger, R. Elez, H. Cramer, W. Muller-Esterl, and S. Zeuzem (2002)
J. Biol. Chem. 277, 43623-43630
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Platelet-derived Growth Factor-mediated Proliferation of Osteosarcoma Cells by the Novel Tyrosine Kinase Inhibitor STI571.

E. C. McGary, K. Weber, L. Mills, M. Doucet, V. Lewis, D. C. Lev, I. J. Fidler, and M. Bar-Eli (2002)
Clin. Cancer Res. 8, 3584-3591
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Pentameric Symmetry of C-reactive Protein Is Associated with Delayed Apoptosis of Human Neutrophils.

T. Khreiss, L. Jozsef, S. Hossain, J. S. D. Chan, L. A. Potempa, and J. G. Filep (2002)
J. Biol. Chem. 277, 40775-40781
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Involvement of survival motor neuron (SMN) protein in cell death.

S. Vyas, C. Bechade, B. Riveau, J. Downward, and A. Triller (2002)
Hum. Mol. Genet. 11, 2751-2764
 |  Abstract »  |  Full Text »  |  PDF »

Growth Hormone (GH) and GH-Releasing Peptide-6 Increase Brain Insulin-Like Growth Factor-I Expression and Activate Intracellular Signaling Pathways Involved in Neuroprotection.

L. M. Frago, C. Paneda, S. L. Dickson, A. K. Hewson, J. Argente, and J. A. Chowen (2002)
Endocrinology 143, 4113-4122
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor Signals through TrkA, Phosphatidylinositol 3-Kinase, and Rac1 to Inactivate RhoA during the Initiation of Neuronal Differentiation of PC12 Cells.

N. Nusser, E. Gosmanova, Y. Zheng, and G. Tigyi (2002)
J. Biol. Chem. 277, 35840-35846
 |  Abstract »  |  Full Text »  |  PDF »

Elevated Akt Phosphorylation as an Indicator of Renal Tubular Epithelial Cell Stress.

T. Nishino, C. D. Pusey, and J. Domin (2002)
J. Biol. Chem. 277, 33943-33949
 |  Abstract »  |  Full Text »  |  PDF »

Angiotensin II Subtype 2 Receptor Activation Inhibits Insulin-Induced Phosphoinositide 3-Kinase and Akt and Induces Apoptosis in PC12W Cells.

T.-X. Cui, H. Nakagami, C. Nahmias, T. Shiuchi, Y. Takeda-Matsubara, J.-M. Li, L. Wu, M. Iwai, and M. Horiuchi (2002)
Mol. Endocrinol. 16, 2113-2123
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription.

N. Ghosh-Choudhury, S. L. Abboud, R. Nishimura, A. Celeste, L. Mahimainathan, and G. G. Choudhury (2002)
J. Biol. Chem. 277, 33361-33368
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Phosphorylation of BAD and Raf-1 by Akt Sensitizes Human Ovarian Cancer Cells to Paclitaxel.

S. Mabuchi, M. Ohmichi, A. Kimura, K. Hisamoto, J. Hayakawa, Y. Nishio, K. Adachi, K. Takahashi, E. Arimoto-Ishida, Y. Nakatsuji, et al. (2002)
J. Biol. Chem. 277, 33490-33500
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Like Growth Factor-1-Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3-Kinase/Akt Kinase and Role of This Pathway in Insulin-Like Growth Factor-1-Induced Survival of Cultured Hippocampal Neurons.

W.-H. Zheng, S. Kar, and R. Quirion (2002)
Mol. Pharmacol. 62, 225-233
 |  Abstract »  |  Full Text »  |  PDF »

Ras Mediates Radioresistance through Both Phosphatidylinositol 3-Kinase-dependent and Raf-dependent but Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase-independent Signaling Pathways.

T. M. Grana, E. V. Rusyn, H. Zhou, C. I. Sartor, and A. D. Cox (2002)
Cancer Res. 62, 4142-4150
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Src Family Kinases Blocks Epidermal Growth Factor (EGF)-induced Activation of Akt, Phosphorylation of c-Cbl, and Ubiquitination of the EGF Receptor.

C. K. Kassenbrock, S. Hunter, P. Garl, G. L. Johnson, and S. M. Anderson (2002)
J. Biol. Chem. 277, 24967-24975
 |  Abstract »  |  Full Text »  |  PDF »

The Inducible Expression of the Tumor Suppressor Gene PTEN Promotes Apoptosis and Decreases Cell Size by Inhibiting the PI3K/Akt Pathway in Jurkat T Cells.

Z. Xu, D. Stokoe, L. P. Kane, and A. Weiss (2002)
Cell Growth Differ. 13, 285-296
 |  Abstract »  |  Full Text »

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