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Science 31 March 1995:
Vol. 267. no. 5206, pp. 1997 - 2000
DOI: 10.1126/science.7701323
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Articles

Science, Vol 267, Issue 5206, 1997-2000
Copyright © 1995 by American Association for the Advancement of Science

articles

Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation

HH Valdivia, JH Kaplan, GC Ellis-Davies, and WJ Lederer

Department of Physiology, University of Maryland Medical School, Baltimore 21201, USA.

Channel adaptation is a fundamental feature of sarcoplasmic reticulum calcium release channels (called ryanodine receptors, RyRs). It permits successive increases in the intracellular concentration of calcium (Ca2+) to repeatedly but transiently activate channels. Adaptation of RyRs in the absence of magnesium (Mg2+) and adenosine triphosphate is an extremely slow process (taking seconds). Photorelease of Ca2+ from nitrophenyl-EGTA, a photolabile Ca2+ chelator, demonstrated that RyR adaptation is rapid (milliseconds) in canine heart muscle when physiological Mg2+ concentrations are present. Phosphorylation of the RyR by protein kinase A increased the responsiveness of the channel to Ca2+ and accelerated the kinetics of adaptation. These properties of the RyR from heart may also be relevant to other cells in which multiple agonist-dependent triggering events regulate cellular functions.


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Circ. Res. 91, 1023-1030
   Abstract »    Full Text »    PDF »
Ryanodine Receptor Calcium Release Channels.
M. Fill and J. A. Copello (2002)
Physiol Rev 82, 893-922
   Abstract »    Full Text »    PDF »
Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes.
L F Santana, E G Chase, V S Votaw, M. T Nelson, and R Greven (2002)
J. Physiol. 544, 57-69
   Abstract »    Full Text »    PDF »
Myofilament-based relaxant effect of isoprenaline revealed during work-loop contractions in rat cardiac trabeculae.
J. Layland and J. C Kentish (2002)
J. Physiol. 544, 171-182
   Abstract »    Full Text »    PDF »
Role of creatine kinase in cardiac excitation-contraction coupling: studies in creatine kinase-deficient mice.
B. CROZATIER, T. BADOUAL, E. BOEHM, P.-V. ENNEZAT, T. GUENOUN, J. SU, V. VEKSLER, L. HITTINGER, and R. VENTURA-CLAPIER (2002)
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   Abstract »    Full Text »    PDF »
Calcium-induced Transitions between the Spontaneous Miniature Outward and the Transient Outward Currents in Retinal Amacrine Cells.
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   Abstract »    Full Text »    PDF »
Protein Kinase A Phosphorylation of the Ryanodine Receptor Does Not Affect Calcium Sparks in Mouse Ventricular Myocytes.
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Circ. Res. 90, 309-316
   Abstract »    Full Text »    PDF »
Cytosolic free magnesium modulates Na/Ca exchange currents in pig myocytes.
S.-k. Wei, J. F Quigley, S. U Hanlon, B. O'Rourke, and M. C.P Haigney (2002)
Cardiovasc Res 53, 334-340
   Abstract »    Full Text »    PDF »
Progression of Heart Failure: Is Protein Kinase A Hyperphosphorylation of the Ryanodine Receptor a Contributing Factor?.
A. R. Marks, S. Reiken, and S. O. Marx (2002)
Circulation 105, 272-275
   Full Text »    PDF »
Myocardial Disease in Failing Hearts: Defective Excitation-Contraction Coupling.
X.H.T. WEHRENS and A.R. MARKS (2002)
Cold Spring Harb Symp Quant Biol 67, 533-542
   Abstract »    PDF »
Local response of L-type Ca2+ current to nitric oxide in frog ventricular myocytes.
M. Dittrich, J. Jurevicius, M. Georget, F. Rochais, B. K. Fleischmann, J. Hescheler, and R. Fischmeister (2001)
J. Physiol. 534, 109-121
   Abstract »    Full Text »    PDF »
Modulation of the Ca2+-induced Ca2+ release cascade by {beta}-adrenergic stimulation in rat ventricular myocytes.
S. Viatchenko-Karpinski and S. Gyorke (2001)
J. Physiol. 533, 837-848
   Abstract »    Full Text »    PDF »
Microtubule Disruption by Colchicine Reversibly Enhances Calcium Signaling in Intact Rat Cardiac Myocytes.
B. G. Kerfant, G. Vassort, and A. M. Gomez (2001)
Circ. Res. 88 , e59-e65
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Cardiac Ryanodine Receptors and Accessory Proteins: Augmented Expression Does Not Necessarily Mean Big Function.
H. H. Valdivia (2001)
Circ. Res. 88, 134-136
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mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope.
M. S. Kapiloff, N. Jackson, and N. Airhart (2001)
J. Cell Sci. 114, 3167-3176
   Abstract »    Full Text »    PDF »
Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytes.
J.-M. Goaillard, P. Vincent, and R. Fischmeister (2001)
J. Physiol. 530, 79-91
   Abstract »    Full Text »    PDF »
Questions about Adaptation in Ryanodine Receptors.
G.D. Lamb, D.R. Laver, and D.G. Stephenson (2000)
J. Gen. Physiol. 116, 883-890
   Full Text »    PDF »
Ryanodine Receptor Adaptation.
M. Fill, A. Zahradnikova, C.A. Villalba-Galea, I. Zahradnik, A.L. Escobar, and S. Gyorke (2000)
J. Gen. Physiol. 116, 873-882
   Full Text »    PDF »
Dyssynchronous Ca2+ Sparks in Myocytes From Infarcted Hearts.
S. E. Litwin, D. Zhang, and J. H. B. Bridge (2000)
Circ. Res. 87, 1040-1047
   Abstract »    Full Text »    PDF »
Calcium handling and cell contraction in rat cardiomyocytes depleted of intracellular magnesium.
E. J Griffiths (2000)
Cardiovasc Res 47, 116-123
   Abstract »    Full Text »    PDF »
Functional coupling between glycolysis and excitation--contraction coupling underlies alternans in cat heart cells.
J. Huser, Y. G. Wang, K. A Sheehan, F. Cifuentes, S. L Lipsius, and L. A Blatter (2000)
J. Physiol. 524, 795-806
   Abstract »    Full Text »    PDF »
Regulation of contraction and relaxation by membrane potential in cardiac ventricular myocytes.
G. R. Ferrier, I. M. Redondo, C. A. Mason, C. Mapplebeck, and S. E. Howlett (2000)
Am J Physiol Heart Circ Physiol 278, H1618-H1626
   Abstract »    Full Text »    PDF »
Phosphorylation of phospholamban and troponin I in beta -adrenergic-induced acceleration of cardiac relaxation.
L. Li, J. Desantiago, G. Chu, E. G. Kranias, and D. M. Bers (2000)
Am J Physiol Heart Circ Physiol 278, H769-H779
   Abstract »    Full Text »    PDF »
Calcium sparks in smooth muscle.
J. H. Jaggar, V. A. Porter, W. J. Lederer, and M. T. Nelson (2000)
Am J Physiol Cell Physiol 278, C235-C256
   Abstract »    Full Text »    PDF »
Microtubule Disruption Modulates Ca2+ Signaling in Rat Cardiac Myocytes.
A. M. Gomez, B. G. Kerfant, and G. Vassort (2000)
Circ. Res. 86, 30-36
   Abstract »    Full Text »    PDF »
Mobilization of intracellular Ca2+ by endothelin-1 in rat intrapulmonary arterial smooth muscle cells.
L. A. Shimoda, J. T. Sylvester, and J. S. K. Sham (2000)
Am J Physiol Lung Cell Mol Physiol 278, L157-L164
   Abstract »    Full Text »    PDF »
Rapid Activation of the Cardiac Ryanodine Receptor by Submillisecond Calcium Stimuli.
A. Zahradnikova, I. Zahradnik, I. Gyorke, and S. Gyorke (1999)
J. Gen. Physiol. 114, 787-798
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Constitutive {beta}2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart.
Y.-Y. Zhou, L.-S. Song, E. G Lakatta, R.-P. Xiao, and H. Cheng (1999)
J. Physiol. 521, 351-361
   Abstract »    Full Text »    PDF »
Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias.
E. Carmeliet (1999)
Physiol Rev 79, 917-1017
   Abstract »    Full Text »    PDF »
Ca2+ Spark Termination: Inactivation and Adaptation May Be Manifestations of the Same Mechanism.
(1999)
J. Gen. Physiol. 114, 163-166
   Full Text »    PDF »
Ca2+ Waves During Triggered Propagated Contractions in Intact Trabeculae : Determinants of the Velocity of Propagation.
M. Miura, P. A. Boyden, and H. E. D. J. t. Keurs (1999)
Circ. Res. 84, 1459-1468
   Abstract »    Full Text »    PDF »
Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart.
R. C Fentzke, S. H Buck, J. R Patel, H. Lin, B. M Wolska, M. O Stojanovic, A. F Martin, R J. Solaro, R. L Moss, and J. M Leiden (1999)
J. Physiol. 517, 143-157
   Abstract »    Full Text »    PDF »
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release.
D. M Bers and E. Perez-Reyes (1999)
Cardiovasc Res 42, 339-360
   Abstract »    Full Text »    PDF »
Local Control Models of Cardiac Excitation-Contraction Coupling: A Possible Role for Allosteric Interactions between Ryanodine Receptors.
M. D. Stern, L.-S. Song, H. Cheng, J. S.K. Sham, H. T. Yang, K. R. Boheler, and E. Rios (1999)
J. Gen. Physiol. 113, 469-489
   Abstract »    Full Text »    PDF »
Bay K 8644 Increases Resting Ca2+ Spark Frequency in Ferret Ventricular Myocytes Independent of Ca Influx : Contrast With Caffeine and Ryanodine Effects.
H. Satoh, H. Katoh, P. Velez, M. Fill, and D. M. Bers (1998)
Circ. Res. 83, 1192-1204
   Abstract »    Full Text »    PDF »
Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes.
J. S. K. Sham, L.-S. Song, Y. Chen, L.-H. Deng, M. D. Stern, E. G. Lakatta, and H. Cheng (1998)
PNAS 95, 15096-15101
   Abstract »    Full Text »    PDF »
Detection and functional characterization of ryanodine receptors from sea urchin eggs.
A. J Lokuta, A. Darszon, C. Beltran, and H. H Valdivia (1998)
J. Physiol. 510, 155-164
   Abstract »    Full Text »    PDF »
The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation.
D.A Eisner, A.W Trafford, M.E Dnaz, C.L Overend, and S.C O'Neill (1998)
Cardiovasc Res 38, 589-604
   Abstract »    Full Text »    PDF »
Voltage change-induced gating transitions of the rabbit skeletal muscle Ca2+ release channel.
A Zahradnikova and L G Meszaros (1998)
J. Physiol. 509, 29-38
   Abstract »    Full Text »    PDF »
Frequency modulation of Ca2+ sparks is involved in regulation of arterial diameter by cyclic nucleotides.
V. A. Porter, A. D. Bonev, H. J. Knot, T. J. Heppner, A. S. Stevenson, T. Kleppisch, W. J. Lederer, and M. T. Nelson (1998)
Am J Physiol Cell Physiol 274, C1346-C1355
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Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca.
A.W Trafford, M.E Dieaz, and D.A Eisner (1998)
Cardiovasc Res 37, 710-717
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Ca2+ Flux Through Promiscuous Cardiac Na+ Channels: Slip-Mode Conductance.
L. F. Santana, A. M. Gómez, and W. J. Lederer (1998)
Science 279, 1027-1033
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Sarcoplasmic reticulum in heart failure: central player or bystander?.
R. M Phillips, P. Narayan, A. M Gomez, K. Dilly, L. R Jones, W.J. Lederer, and R. A Altschuld (1998)
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T. Ueyama, T. Ohkusa, Y. Hisamatsu, Y. Nakamura, T. Yamamoto, M. Yano, and M. Matsuzaki (1998)
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Expression of Ryanodine Receptors in the Pituitary Gland: Evidence for a Role in Gonadotropin-Releasing Hormone Signaling.
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   Abstract »    Full Text »    PDF »
Ca2+-induced Ca2+ Release in Chinese Hamster Ovary (CHO) Cells Co-expressing Dihydropyridine and Ryanodine Receptors.
N. Suda, D. Franzius, A. Fleig, S. Nishimura, M. Bodding, M. Hoth, H. Takeshima, and R. Penner (1997)
J. Gen. Physiol. 109, 619-631
   Abstract »    Full Text »    PDF »
The Sarcoplasmic Reticulum Ca2+ Channel/Ryanodine Receptor: Modulation by Endogenous Effectors, Drugs and Disease States.
R. Zucchi and S. Ronca-Testoni (1997)
Pharmacol. Rev. 49, 1-52
   Abstract »    Full Text »    PDF »
Peptide Probe of Ryanodine Receptor Function.
R. El-Hayek, A. J. Lokuta, C. Arévalo, and H. H. Valdivia (1995)
J. Biol. Chem. 270, 28696-28704
   Abstract »    Full Text »    PDF »
New Insights Into the Gating Mechanisms of Cardiac Ryanodine Receptors Revealed by Rapid Changes in Ligand Concentration.
R. Sitsapesan, R. A.P. Montgomery, and A. J. Williams (1995)
Circ. Res. 77, 765-772
   Abstract »    Full Text »
The control of calcium release in heart muscle.
M. Cannell, H Cheng, and W. Lederer (1995)
Science 268, 1045-1049
   Abstract »    PDF »
Contribution of Ryanodine Receptor Subtype 3 to Ca2+ Responses in Ca2+-overloaded Cultured Rat Portal Vein Myocytes.
J. Mironneau, F. Coussin, L. H. Jeyakumar, S. Fleischer, C. Mironneau, and N. Macrez (2001)
J. Biol. Chem. 276, 11257-11264
   Abstract »    Full Text »    PDF »
Calcium-induced Transitions between the Spontaneous Miniature Outward and the Transient Outward Currents in Retinal Amacrine Cells.
P. Mitra and M. M. Slaughter (2002)
J. Gen. Physiol. 119, 373-388
   Abstract »    Full Text »    PDF »


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