Science 31 March 1995: Vol. 267. no. 5206, pp. 1990 - 1994 DOI: 10.1126/science.7701321

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Articles

All-Trans Retinoic Acid Suppresses Stat3 Signaling during Skin Carcinogenesis.

Z. Syed, S. B. Cheepala, J. N. Gill, J. Stein, C. A. Nathan, J. DiGiovanni, V. Batra, P. Adegboyega, H. E. Kleiner, and J. L. Clifford (2009)
Cancer Prevention Research 2, 903-911
 |  Abstract »  |  Full Text »  |  PDF »

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

E. A. Nelson, S. R. Walker, A. Kepich, L. B. Gashin, T. Hideshima, H. Ikeda, D. Chauhan, K. C. Anderson, and D. A. Frank (2008)
Blood 112, 5095-5102
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway.

J.-H. Kim, J. E. Kim, H.-Y. Liu, W. Cao, and J. Chen (2008)
J. Biol. Chem. 283, 708-715
 |  Abstract »  |  Full Text »  |  PDF »

Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes.

O. Norkina, A. Dolganiuc, T. Shapiro, K. Kodys, P. Mandrekar, and G. Szabo (2007)
J. Leukoc. Biol. 82, 752-762
 |  Abstract »  |  Full Text »  |  PDF »

STAT1 Activation Causes Translocation of Bax to the Endoplasmic Reticulum during the Resolution of Airway Mucous Cell Hyperplasia by IFN-{gamma}.

B. A. Stout, K. Melendez, J. Seagrave, M. J. Holtzman, B. Wilson, J. Xiang, and Y. Tesfaigzi (2007)
J. Immunol. 178, 8107-8116
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-1{beta} Attenuates Renin Gene Expression Via a Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase and Signal Transducer and Activator of Transcription 3-Dependent Mechanism in As4.1 Cells.

X. Liu, Q. Shi, and C. D. Sigmund (2006)
Endocrinology 147, 6011-6018
 |  Abstract »  |  Full Text »  |  PDF »

Dual Ligand Stimulation of RAW 264.7 Cells Uncovers Feedback Mechanisms That Regulate TLR-Mediated Gene Expression.

X. Zhu, M. S. Chang, R. C. Hsueh, R. Taussig, K. D. Smith, M. I. Simon, and S. Choi (2006)
J. Immunol. 177, 4299-4310
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte 15-Lipoxygenase Expression Is Regulated by a Novel Cytosolic Signaling Complex with Protein Kinase C {delta} and Tyrosine-Phosphorylated Stat3.

A. Bhattacharjee, B. Xu, D. A. Frank, G. M. Feldman, and M. K. Cathcart (2006)
J. Immunol. 177, 3771-3781
 |  Abstract »  |  Full Text »  |  PDF »

Heparin Synergistically Enhances Interleukin-11 Signaling through Up-regulation of the MAPK Pathway.

R. Rajgopal, M. Butcher, J. I. Weitz, and S. G. Shaughnessy (2006)
J. Biol. Chem. 281, 20780-20787
 |  Abstract »  |  Full Text »  |  PDF »

Structure of the Unphosphorylated STAT5a Dimer.

D. Neculai, A. M. Neculai, S. Verrier, K. Straub, K. Klumpp, E. Pfitzner, and S. Becker (2005)
J. Biol. Chem. 280, 40782-40787
 |  Abstract »  |  Full Text »  |  PDF »

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance.

A. Pocai, K. Morgan, C. Buettner, R. Gutierrez-Juarez, S. Obici, and L. Rossetti (2005)
Diabetes 54, 3182-3189
 |  Abstract »  |  Full Text »  |  PDF »

Proline-, Glutamic Acid-, and Leucine-Rich Protein-1 Is Essential in Growth Factor Regulation of Signal Transducers and Activators of Transcription 3 Activation.

B. Manavathi, S. S. Nair, R.-A. Wang, R. Kumar, and R. K. Vadlamudi (2005)
Cancer Res. 65, 5571-5577
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Stat3 activation in the endometrium prevents implantation: A nonsteroidal approach to contraception.

R. D. Catalano, M. H. Johnson, E. A. Campbell, D. S. Charnock-Jones, S. K. Smith, and A. M. Sharkey (2005)
PNAS 102, 8585-8590
 |  Abstract »  |  Full Text »  |  PDF »

Farnesyl Transferase Inhibitor (R115777)-Induced Inhibition of STAT3(Tyr705) Phosphorylation in Human Pancreatic Cancer Cell Lines Require Extracellular Signal-Regulated Kinases.

K. Venkatasubbarao, A. Choudary, and J. W. Freeman (2005)
Cancer Res. 65, 2861-2871
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Nef Promotes Survival of TF-1 Macrophages by Inducing Bcl-XL Expression in an Extracellular Signal-regulated Kinase-dependent Manner.

H.-J. Choi and T. E. Smithgall (2004)
J. Biol. Chem. 279, 51688-51696
 |  Abstract »  |  Full Text »  |  PDF »

Differential roles of STAT1{alpha} and STAT1{beta} in fludarabine-induced cell cycle arrest and apoptosis in human B cells.

F. Baran-Marszak, J. Feuillard, I. Najjar, C. Le Clorennec, J.-M. Bechet, I. Dusanter-Fourt, G. W. Bornkamm, M. Raphael, and R. Fagard (2004)
Blood 104, 2475-2483
 |  Abstract »  |  Full Text »  |  PDF »

Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1.

Y. Zhang, Y.-Y. Cho, B. L. Petersen, F. Zhu, and Z. Dong (2004)
Carcinogenesis 25, 1165-1175
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6: ROLES FOR MULTIPLE PHOSPHORYLATION SITES AND Stat6 FUNCTION.

Y. Wang, M. G. Malabarba, Z. S. Nagy, and R. A. Kirken (2004)
J. Biol. Chem. 279, 25196-25203
 |  Abstract »  |  Full Text »  |  PDF »

Role of Protein Kinase C Isoforms in the Regulation of Interleukin-13-induced 15-Lipoxygenase Gene Expression in Human Monocytes.

B. Xu, A. Bhattacharjee, B. Roy, G. M. Feldman, and M. K. Cathcart (2004)
J. Biol. Chem. 279, 15954-15960
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of SOCS-3 Promoter Responses to Interferon {gamma}.

L. Gatto, C. Berlato, V. Poli, S. Tininini, I. Kinjyo, A. Yoshimura, M. A. Cassatella, and F. Bazzoni (2004)
J. Biol. Chem. 279, 13746-13754
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-{gamma}: an overview of signals, mechanisms and functions.

K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume (2004)
J. Leukoc. Biol. 75, 163-189
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis.

D. W. Sternberg and D. G. Gilliland (2004)
J. Clin. Oncol. 22, 361-371
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-11 and Interleukin-6 Protect Cultured Human Endothelial Cells from H2O2-Induced Cell Death.

A. B. Waxman, K. Mahboubi, R. G. Knickelbein, L. L. Mantell, N. Manzo, J. S. Pober, and J. A. Elias (2003)
Am. J. Respir. Cell Mol. Biol. 29, 513-522
 |  Abstract »  |  Full Text »  |  PDF »

STATs Dimerize in the Absence of Phosphorylation.

J. Braunstein, S. Brutsaert, R. Olson, and C. Schindler (2003)
J. Biol. Chem. 278, 34133-34140
 |  Abstract »  |  Full Text »  |  PDF »

Tudor and Nuclease-Like Domains Containing Protein p100 Function as Coactivators for Signal Transducer and Activator of Transcription 5.

K. Paukku, J. Yang, and O. Silvennoinen (2003)
Mol. Endocrinol. 17, 1805-1814
 |  Abstract »  |  Full Text »  |  PDF »

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3.

J. Zhang, J. Yang, S. K. Roy, S. Tininini, J. Hu, J. F. Bromberg, V. Poli, G. R. Stark, and D. V. Kalvakolanu (2003)
PNAS 100, 9342-9347
 |  Abstract »  |  Full Text »  |  PDF »

BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells.

P. Rajan, D. M. Panchision, L. F. Newell, and R. D.G. McKay (2003)
J. Cell Biol. 161, 911-921
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3.

B. Xu, A. Bhattacharjee, B. Roy, H.-M. Xu, D. Anthony, D. A. Frank, G. M. Feldman, and M. K. Cathcart (2003)
Mol. Cell. Biol. 23, 3918-3928
 |  Abstract »  |  Full Text »  |  PDF »

Signal transducer and activator of transcription proteins in leukemias.

M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler (2003)
Blood 101, 2940-2954
 |  Abstract »  |  Full Text »  |  PDF »

Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3.

Y. Zhang, Y.-Y. Cho, B. L. Petersen, A. M. Bode, F. Zhu, and Z. Dong (2003)
J. Biol. Chem. 278, 12650-12659
 |  Abstract »  |  Full Text »  |  PDF »

Protein Phosphatase 2A (PP2A) Regulates Interleukin-4-mediated STAT6 Signaling.

A. Woetmann, J. Brockdorff, P. Lovato, M. Nielsen, V. Leick, K. Rieneck, A. Svejgaard, C. Geisler, and N. Odum (2003)
J. Biol. Chem. 278, 2787-2791
 |  Abstract »  |  Full Text »  |  PDF »

JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes. ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION.

F. Legendre, J. Dudhia, J.-P. Pujol, and P. Bogdanowicz (2003)
J. Biol. Chem. 278, 2903-2912
 |  Abstract »  |  Full Text »  |  PDF »

Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2.

H.-H. Xue, D. W. Fink Jr, X. Zhang, J. Qin, C. W. Turck, and W. J. Leonard (2002)
Int. Immunol. 14, 1263-1271
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.

Z. S. Nagy, Y. Wang, R. A. Erwin-Cohen, J. Aradi, B. Monia, L. H. Wang, S. M. Stepkowski, H. Rui, and R. A. Kirken (2002)
J. Leukoc. Biol. 72, 819-828
 |  Abstract »  |  Full Text »  |  PDF »

Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation.

K. J. Walton, J. M. Duncan, P. Deschamps, and S. G. Shaughnessy (2002)
Blood 100, 2530-2536
 |  Abstract »  |  Full Text »  |  PDF »

IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats.

B. Roy, A. Bhattacharjee, B. Xu, D. Ford, A. L. Maizel, and M. K. Cathcart (2002)
J. Leukoc. Biol. 72, 580-589
 |  Abstract »  |  Full Text »  |  PDF »

Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation.

D. L. Hevehan, W. M. Miller, and E. T. Papoutsakis (2002)
Blood 99, 1627-1637
 |  Abstract »  |  Full Text »  |  PDF »

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.

S. M. Stepkowski, R. A. Erwin-Cohen, F. Behbod, M.-E. Wang, X. Qu, N. Tejpal, Z. S. Nagy, B. D. Kahan, and R. A. Kirken (2002)
Blood 99, 680-689
 |  Abstract »  |  Full Text »  |  PDF »

Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases.

M. Schaeffer, M. Schneiderbauer, S. Weidler, R. Tavares, M. Warmuth, G. de Vos, and M. Hallek (2001)
Mol. Cell. Biol. 21, 8068-8081
 |  Abstract »  |  Full Text »  |  PDF »

MSK1 and JNKs Mediate Phosphorylation of STAT3 in UVA-irradiated Mouse Epidermal JB6 Cells.

Y. Zhang, G. Liu, and Z. Dong (2001)
J. Biol. Chem. 276, 42534-42542
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors.

M. Federico, Z. Percario, E. Olivetta, G. Fiorucci, C. Muratori, A. Micheli, G. Romeo, and E. Affabris (2001)
Blood 98, 2752-2761
 |  Abstract »  |  Full Text »  |  PDF »

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation.

J. Frantsve, J. Schwaller, D. W. Sternberg, J. Kutok, and D. G. Gilliland (2001)
Mol. Cell. Biol. 21, 3547-3557
 |  Abstract »  |  Full Text »  |  PDF »

Concomitant Inhibition of Janus Kinase 3 and Calcineurin-Dependent Signaling Pathways Synergistically Prolongs the Survival of Rat Heart Allografts.

F. Behbod, R. A. Erwin-Cohen, M.-E. Wang, B. W. Trawick, X. Qu, R. Verani, B. D. Kahan, S. M. Stepkowski, and R. A. Kirken (2001)
J. Immunol. 166, 3724-3732
 |  Abstract »  |  Full Text »  |  PDF »

Ca2+ Mobilization, Tyrosine Hydroxylase Activity, and Signaling Mechanisms in Cultured Porcine Adrenal Medullary Chromaffin Cells: Effects of Leptin.

K. Takekoshi, K. Ishii, Y. Kawakami, K. Isobe, T. Nanmoku, and T. Nakai (2001)
Endocrinology 142, 290-298
 |  Abstract »  |  Full Text »  |  PDF »

SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways.

R. F. Duarte and D. A. Frank (2000)
Blood 96, 3422-3430
 |  Abstract »  |  Full Text »  |  PDF »

Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells.

R. A. Kirken, R. A. Erwin, L. Wang, Y. Wang, H. Rui, and W. L. Farrar (2000)
J. Immunol. 165, 5097-5104
 |  Abstract »  |  Full Text »  |  PDF »

Receptor for Activated C-Kinase (RACK-1), a WD Motif-Containing Protein, Specifically Associates with the Human Type I IFN Receptor.

E. Croze, A. Usacheva, D. Asarnow, R. D. Minshall, H. D. Perez, and O. Colamonici (2000)
J. Immunol. 165, 5127-5132
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways.

S. T. Ahmed and L. B. Ivashkiv (2000)
J. Immunol. 165, 5227-5237
 |  Abstract »  |  Full Text »  |  PDF »

Interferon gamma and interleukin 6 modulate the susceptibility of macrophages to human immunodeficiency virus type 1 infection.

M. Zaitseva, S. Lee, C. Lapham, R. Taffs, L. King, T. Romantseva, J. Manischewitz, and H. Golding (2000)
Blood 96, 3109-3117
 |  Abstract »  |  Full Text »  |  PDF »

Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

R. Visconti, M. Gadina, M. Chiariello, E. H. Chen, L. F. Stancato, J. S. Gutkind, and J. J. O'Shea (2000)
Blood 96, 1844-1852
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin.

Y.-B. Kim, S. Uotani, D. D. Pierroz, J. S. Flier, and B. B. Kahn (2000)
Endocrinology 141, 2328-2339
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function.

C. J. Auernhammer and S. Melmed (2000)
Endocr. Rev. 21, 313-345
 |  Abstract »  |  Full Text »

Induction of Relaxin Messenger RNA Expression in Response to Prolactin Receptor Activation Requires Protein Kinase C {delta} Signaling.

C. A. Peters, E. T. Maizels, M. C. Robertson, R. P.C. Shiu, M. S. Soloff, and M. Hunzicker-Dunn (2000)
Mol. Endocrinol. 14, 576-590
 |  Abstract »  |  Full Text »

IL-11 Activates Human Endothelial Cells to Resist Immune-Mediated Injury.

K. Mahboubi, B. C. Biedermann, J. M. Carroll, and J. S. Pober (2000)
J. Immunol. 164, 3837-3846
 |  Abstract »  |  Full Text »  |  PDF »

Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis.

A. Stephanou, B. K. Brar, T. M. Scarabelli, A. K. Jonassen, D. M. Yellon, M. S. Marber, R. A. Knight, and D. S. Latchman (2000)
J. Biol. Chem. 275, 10002-10008
 |  Abstract »  |  Full Text »  |  PDF »

Stat5a Serine Phosphorylation. SERINE 779 IS CONSTITUTIVELY PHOSPHORYLATED IN THE MAMMARY GLAND, AND SERINE 725 PHOSPHORYLATION INFLUENCES PROLACTIN-STIMULATED IN VITRO DNA BINDING ACTIVITY.

I. Beuvink, D. Hess, H. Flotow, J. Hofsteenge, B. Groner, and N. E. Hynes (2000)
J. Biol. Chem. 275, 10247-10255
 |  Abstract »  |  Full Text »  |  PDF »

Activation-Induced Inhibition of Interleukin 6-Mediated T Cell Survival and Signal Transducer and Activator of Transcription 1 Signaling.

T. K. Teague, B. C. Schaefer, D. Hildeman, J. Bender, T. Mitchell, J. W. Kappler, and P. Marrack (2000)
J. Exp. Med. 191, 915-926
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Stat3 Signaling Pathway Is Required for Differentiation by Interleukin-6 in PC12-E2 Cells.

Y. Y. Wu and R. A. Bradshaw (2000)
J. Biol. Chem. 275, 2147-2156
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6.

M. Pesu, K. Takaluoma, S. Aittomaki, A. Lagerstedt, K. Saksela, P. E. Kovanen, and O. Silvennoinen (2000)
Blood 95, 494-502
 |  Abstract »  |  Full Text »  |  PDF »

The Jak-Stat pathway in normal and perturbed hematopoiesis.

A. C. Ward, I. Touw, and A. Yoshimura (2000)
Blood 95, 19-29
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Serine Phosphorylation and Negative Regulation of Stat3 by JNK.

C. P. Lim and X. Cao (1999)
J. Biol. Chem. 274, 31055-31061
 |  Abstract »  |  Full Text »  |  PDF »

The Mitogen-activated Protein (MAP) Kinase p38 and Its Upstream Activator MAP Kinase Kinase 6 Are Involved in the Activation of Signal Transducer and Activator of Transcription by Hyperosmolarity.

J. G. Bode, P. Gatsios, S. Ludwig, U. R. Rapp, D. Haussinger, P. C. Heinrich, and L. Graeve (1999)
J. Biol. Chem. 274, 30222-30227
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.

A. Woetmann, M. Nielsen, S. T. Christensen, J. Brockdorff, K. Kaltoft, A.-M. Engel, S. Skov, C. Brender, C. Geisler, A. Svejgaard, et al. (1999)
PNAS 96, 10620-10625
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Kit Expression by IL-4 and IL-10 in Murine Mast Cells: Role of STAT6 and Phosphatidylinositol 3'-Kinase.

P. Mirmonsef, C. P. Shelburne, C. Fitzhugh Yeatman II, H. J. Chong, and J. J. Ryan (1999)
J. Immunol. 163, 2530-2539
 |  Abstract »  |  Full Text »  |  PDF »

Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells.

H. Kim and H. Baumann (1999)
Mol. Cell. Biol. 19, 5326-5338
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Cytoplasmic Domain of Interleukin-13 Receptor-alpha.

P. L. Orchansky, R. Kwan, F. Lee, and J. W. Schrader (1999)
J. Biol. Chem. 274, 20818-20825
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Angiotensin II-induced Phosphorylation of STAT3 in Vascular Smooth Muscle Cells.

H. Liang, V. J. Venema, X. Wang, H. Ju, R. C. Venema, and M. B. Marrero (1999)
J. Biol. Chem. 274, 19846-19851
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes.

M. Carballo, M. Conde, R. El Bekay, J. Martin-Nieto, M. J. Camacho, J. Monteseirin, J. Conde, F. J. Bedoya, and F. Sobrino (1999)
J. Biol. Chem. 274, 17580-17586
 |  Abstract »  |  Full Text »  |  PDF »

Activated G Protein-coupled Receptor Induces Tyrosine Phosphorylation of STAT3 and Agonist-selective Serine Phosphorylation via Sustained Stimulation of Mitogen-activated Protein Kinase. RESULTANT EFFECTS ON CELL PROLIFERATION.

L. A. Sellers, W. Feniuk, P. P. A. Humphrey, and H. Lauder (1999)
J. Biol. Chem. 274, 16423-16430
 |  Abstract »  |  Full Text »  |  PDF »

The Role of STAT3 in Granulocyte Colony-stimulating Factor-induced Enhancement of Neutrophilic Differentiation of Me2SO-treated HL-60 Cells. GM-CSF INHIBITS THE NUCLEAR TRANSLOCATION OF TYROSINE-PHOSPHORYLATED STAT3.

T. Yamaguchi, T. Mukasa, E. Uchida, T. Kanayasu-Toyoda, and T. Hayakawa (1999)
J. Biol. Chem. 274, 15575-15581
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Different Subtypes of Angiotensin II Receptors, AT1 and AT2 Receptors, Regulates STAT Activation by Negative Crosstalk.

M. Horiuchi, W. Hayashida, M. Akishita, K. Tamura, L. Daviet, J. Y. A. Lehtonen, and V. J. Dzau (1999)
Circ. Res. 84, 876-882
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis.

M. Nieborowska-Skorska, M. A. Wasik, A. Slupianek, P. Salomoni, T. Kitamura, B. Calabretta, and T. Skorski (1999)
J. Exp. Med. 189, 1229-1242
 |  Abstract »  |  Full Text »  |  PDF »

The Functional Synergy Between IL-12 and IL-2 Involves p38 Mitogen-Activated Protein Kinase and Is Associated with the Augmentation of STAT Serine Phosphorylation.

J. A. Gollob, C. P. Schnipper, E. A. Murphy, J. Ritz, and D. A. Frank (1999)
J. Immunol. 162, 4472-4481
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Signal-Regulated Kinase (ERK) Interacts with Signal Transducer and Activator of Transcription (STAT) 5a.

T. J. Pircher, H. Petersen, J.-A. Gustafsson, and L.-A. Haldosén (1999)
Mol. Endocrinol. 13, 555-565
 |  Abstract »  |  Full Text »

Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction.

J. A. Losman, X. P. Chen, D. Hilton, and P. Rothman (1999)
J. Immunol. 162, 3770-3774
 |  Abstract »  |  Full Text »  |  PDF »

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response.

L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, and W. L. Farrar (1999)
J. Immunol. 162, 3897-3904
 |  Abstract »  |  Full Text »  |  PDF »

A Functional DNA Binding Domain Is Required for Growth Hormone-induced Nuclear Accumulation of Stat5B.

J. Herrington, L. Rui, G. Luo, L.-y. Yu-Lee, and C. Carter-Su (1999)
J. Biol. Chem. 274, 5138-5145
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-alpha (PPARalpha ) Signaling Pathways. GROWTH HORMONE INHIBITION OF PPARalpha TRANSCRIPTIONAL ACTIVITY MEDIATED BY STAT5b.

Y.-C. Zhou and D. J. Waxman (1999)
J. Biol. Chem. 274, 2672-2681
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Identification of a Novel Stat3 Recruitment and Activation Motif Within the Granulocyte Colony-Stimulating Factor Receptor.

A. Chakraborty, K. F. Dyer, M. Cascio, T. A. Mietzner, and D. J. Tweardy (1999)
Blood 93, 15-24
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A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities.

C. Boucheron, S. Dumon, S. C. R. Santos, R. Moriggl, L. Hennighausen, S. Gisselbrecht, and F. Gouilleux (1998)
J. Biol. Chem. 273, 33936-33941
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Growth Hormone Stimulates Phosphorylation and Activation of Elk-1 and Expression of c-fos, egr-1, and junB through Activation of Extracellular Signal-regulated Kinases 1 and 2.

C. Hodge, J. Liao, M. Stofega, K. Guan, C. Carter-Su, and J. Schwartz (1998)
J. Biol. Chem. 273, 31327-31336
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Activation of Signal Transducers and Activators of Transcription 1 and 3 by Leukemia Inhibitory Factor, Oncostatin-M, and Interferon-gamma in Adipocytes.

J. M. Stephens, S. J. Lumpkin, and J. B. Fishman (1998)
J. Biol. Chem. 273, 31408-31416
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Differential Control of the Phosphorylation State of Proline-juxtaposed Serine Residues Ser725 of Stat5a and Ser730 of Stat5b in Prolactin-sensitive Cells.

H. Yamashita, J. Xu, R. A. Erwin, W. L. Farrar, R. A. Kirken, and H. Rui (1998)
J. Biol. Chem. 273, 30218-30224
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Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.

T. K. Sengupta, E. S. Talbot, P. A. Scherle, and L. B. Ivashkiv (1998)
PNAS 95, 11107-11112
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The mechanism of IL-5 signal transduction.

T. Adachi and R. Alam (1998)
Am J Physiol Cell Physiol 275, C623-C633
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Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes.

K. Kunisada, E. Tone, Y. Fujio, H. Matsui, K. Yamauchi-Takihara, and T. Kishimoto (1998)
Circulation 98, 346-352
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Activation of Raf-1 by Interferon gamma  and Oncostatin M Requires Expression of the Stat1 Transcription Factor.

L. F. Stancato, C.-R. Yu, E. F. Petricoin III, and A. C. Larner (1998)
J. Biol. Chem. 273, 18701-18704
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Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4.

C.-R. Yu, R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo (1998)
J. Immunol. 161, 218-227
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Regulation of IL-6 Signaling by p53: STAT3- and STAT5-Masking in p53-Val135-Containing Human Hepatoma Hep3B Cell Lines.

R. J. Rayanade, M. I. Ndubuisi, J. D. Etlinger, and P. B. Sehgal (1998)
J. Immunol. 161, 325-334
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Multiple Routes to Astrocytic Differentiation in the CNS.

P. Rajan and R. D. G. McKay (1998)
J. Neurosci. 18, 3620-3629
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Binding of STAT5a and STAT5b to a Single Element Resembling a {gamma}-Interferon-Activated Sequence Mediates the Growth Hormone Induction of the Mouse Acid-Labile Subunit Promoter in Liver Cells.

G. T. Ooi, K. R. Hurst, M. N. Poy, M. M. Rechler, and Y. R. Boisclair (1998)
Mol. Endocrinol. 12, 675-687
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Analysis of the IFN-{gamma}-Signaling Pathway in Macrophages at Different Stages of Maturation.

D. M. Lucas, M. A. Lokuta, M. A. McDowell, J. E. S. Doan, and D. M. Paulnock (1998)
J. Immunol. 160, 4337-4342
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A Role for the Insulin-Interleukin (IL)-4 Receptor Motif of the IL-4 Receptor alpha -Chain in Regulating Activation of the Insulin Receptor Substrate 2 and Signal Transducer and Activator of Transcription 6 Pathways. ANALYSIS BY MUTAGENESIS.

H. Y. Wang, J. Zamorano, and A. D. Keegan (1998)
J. Biol. Chem. 273, 9898-9905
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Prolonged STAT1 Activation Related to the Growth Arrest of Malignant Lymphoma Cells by Interferon-alpha.

P. M. Grimley, H. Fang, H. Rui, E. F. Petricoin III, S. Ray, F. Dong, K. H. Fields, R. Hu, K. C. Zoon, S. Audet, et al. (1998)
Blood 91, 3017-3027
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Testicular Leukemia Inhibitory Factor (LIF) and LIF Receptor Mediate Phosphorylation of Signal Transducers and Activators of Transcription (STAT)-3 and STAT-1 and Induce c-fos Transcription and Activator Protein-1 Activation in Rat Sertoli But Not Germ Cells.

S. Jenab and P. L. Morris (1998)
Endocrinology 139, 1883-1890
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Activation of STAT Proteins and Cytokine Genes in Human Th1 and Th2 Cells Generated in the Absence of IL-12 and IL-4.

R. Moriggl, C. Kristofic, B. Kinzel, S. Volarevic, B. Groner, and V. Brinkmann1 (1998)
J. Immunol. 160, 3385-3392
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Prolactin Receptor Regulates Stat5 Tyrosine Phosphorylation and Nuclear Translocation by Two Separate Pathways.

S. Ali and S. Ali (1998)
J. Biol. Chem. 273, 7709-7716
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Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor.

D. Guo, J. D. Dunbar, C. H. Yang, L. M. Pfeffer, and D. B. Donner (1998)
J. Immunol. 160, 2742-2750
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Coordinate Regulation of STAT Signaling and c-fos Expression by the Tyrosine Phosphatase SHP-2.

T. Servidei, Y. Aoki, S. E. Lewis, A. Symes, J. S. Fink, and S. A. Reeves (1998)
J. Biol. Chem. 273, 6233-6241
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Erythropoietin and Friend Virus gp55 Activate Different JAK/STAT Pathways through the Erythropoietin Receptor in Erythroid Cells.

Y. Yamamura, H. Senda, Y. Kageyama, T. Matsuzaki, M. Noda, and Y. Ikawa (1998)
Mol. Cell. Biol. 18, 1172-1180
 |  Abstract »  |  Full Text »  |  PDF »

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