Science 24 March 1995: Vol. 267. no. 5205, pp. 1825 - 1828 DOI: 10.1126/science.7892607

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Articles

Replacement of I{gamma}3 germ-line promoter by I{gamma}1 inhibits class-switch recombination to IgG3.

Z. Oruc, A. Boumediene, M. Le Bert, and A. A. Khamlichi (2007)
PNAS 104, 20484-20489
 |  Abstract »  |  Full Text »  |  PDF »

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.

K. Xue, C. Rada, and M. S. Neuberger (2006)
J. Exp. Med. 203, 2085-2094
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The Histone Methyltransferase Suv39h1 Increases Class Switch Recombination Specifically to IgA.

S. P. Bradley, D. A. Kaminski, A. H. F. M. Peters, T. Jenuwein, and J. Stavnezer (2006)
J. Immunol. 177, 1179-1188
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Germ line transcription in mice bearing neor gene downstream of I{gamma}3 exon in the Ig heavy chain locus.

M. Samara, Z. Oruc, H.-L. Dougier, T. Essawi, M. Cogne, and A. A. Khamlichi (2006)
Int. Immunol. 18, 581-589
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AID-dependent histone acetylation is detected in immunoglobulin S regions.

L. Wang, N. Whang, R. Wuerffel, and A. L. Kenter (2006)
J. Exp. Med. 203, 215-226
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Germline Transcription and Switch Recombination of a Transgene Containing the Entire H Chain Constant Region Locus: Effect of a Mutation in a STAT6 Binding Site in the {gamma}1 Promoter.

W. A. Dunnick, J. Shi, K. A. Graves, and J. T. Collins (2004)
J. Immunol. 173, 5531-5539
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Endogenous Expression of Activation-Induced Cytidine Deaminase in Cell Line WEHI-231.

F. J. X. Spillmann and M. Wabl (2004)
J. Immunol. 173, 1858-1867
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DNA Acrobats of the Ig Class Switch.

C. L. Wang and M. Wabl (2004)
J. Immunol. 172, 5815-5821
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S{epsilon}S{micro} and S{epsilon}S{gamma} Switch Circles in Human Nasal Mucosa Following Ex Vivo Allergen Challenge: Evidence for Direct as Well as Sequential Class Switch Recombination.

L. Cameron, A. S. Gounni, S. Frenkiel, F. Lavigne, D. Vercelli, and Q. Hamid (2003)
J. Immunol. 171, 3816-3822
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Accessibility control and machinery of immunoglobulin class switch recombination.

K. Zhang (2003)
J. Leukoc. Biol. 73, 323-332
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Molecular Visualization of Immunoglobulin Switch Region RNA/DNA Complex by Atomic Force Microscope.

R. Mizuta, K. Iwai, M. Shigeno, M. Mizuta, T. Uemura, T. Ushiki, and D. Kitamura (2003)
J. Biol. Chem. 278, 4431-4434
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitously Expressed DNA-Binding Protein Late SV40 Factor Binds Ig Switch Regions and Represses Class Switching to IgA.

E. E. Drouin, C. E. Schrader, J. Stavnezer, and U. Hansen (2002)
J. Immunol. 168, 2847-2856
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Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination.

X. Chen, K. Kinoshita, and T. Honjo (2001)
PNAS 98, 13860-13865
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Regulation of Class Switch Recombination by Switch Region Transcription.

C.-G. Lee, K. Kinoshita, A. Arudchandran, S. M. Cerritelli, R. J. Crouch, and T. Honjo (2001)
J. Exp. Med. 194, 365-374
 |  Abstract »  |  Full Text »  |  PDF »

Differential Regulation of Mouse Germline Ig {gamma}1 and {epsilon} Promoters by IL-4 and CD40.

C.-s. Mao and J. Stavnezer (2001)
J. Immunol. 167, 1522-1534
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Ets proteins, NF-{{kappa}}B and nocodazole in regulating induction of transcription of mouse germline Ig {{alpha}} RNA by transforming growth factor-{beta}1.

M.-J. Shi, S.-R. Park, P.-H. Kim, and J. Stavnezer (2001)
Int. Immunol. 13, 733-746
 |  Abstract »  |  Full Text »  |  PDF »

Nongenic, bidirectional transcription precedes and may promote developmental DNA deletion in Tetrahymena thermophila.

D. L. Chalker and M.-C. Yao (2001)
Genes & Dev. 15, 1287-1298
 |  Abstract »  |  Full Text »

The {micro} Switch Region Tandem Repeats Are Important, but Not Required, for Antibody Class Switch Recombination.

T. M. Luby, C. E. Schrader, J. Stavnezer, and E. Selsing (2001)
J. Exp. Med. 193, 159-168
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Mouse Ig Germline {{epsilon}} Promoter by IL-4 Is Dependent on AP-1 Transcription Factors.

C.-H. Shen and J. Stavnezer (2001)
J. Immunol. 166, 411-423
 |  Abstract »  |  Full Text »  |  PDF »

A DNase I hypersensitive site near the murine {gamma}1 switch region contributes to insertion site independence of transgenes and modulates the amount of transcripts induced by CD40 ligation.

K. Adams, H. Ackerly, K. Cunningham, and W. Dunnick (2000)
Int. Immunol. 12, 1705-1713
 |  Abstract »  |  Full Text »  |  PDF »

The Road to the Production of IgE Is Long and Winding.

A. KARNOWSKI, P. YU, G. ACHATZ, and M. C. LAMERS (2000)
Am. J. Respir. Crit. Care Med. 162, S71-75
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One Cytokine, Two Isotypes . A Trojan Horse, Pandora's Box, and an Evolving Paradigm.

D. VERCELLI (2000)
Am. J. Respir. Crit. Care Med. 162, S86-90
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Stable RNA/DNA Hybrids in the Mammalian Genome: Inducible Intermediates in Immunoglobulin Class Switch Recombination.

R. B. Tracy, C. Hsieh, and M. R. Lieber (2000)
Science 288, 1058-1061
 |  Abstract »  |  Full Text »

Evidence for Class-specific Factors in Immunoglobulin Isotype Switching.

A. Shanmugam, M.-J. Shi, L. Yauch, J. Stavnezer, and A. L. Kenter (2000)
J. Exp. Med. 191, 1365-1380
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Normal Isotype Switching in B Cells Lacking the I{micro} Exon Splice Donor Site: Evidence for Multiple I{micro}-Like Germline Transcripts.

I. I. Kuzin, G. D. Ugine, D. Wu, F. Young, J. Chen, and A. Bottaro (2000)
J. Immunol. 164, 1451-1457
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Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage.

G. J. Vanasse, P. Concannon, and D. M. Willerford (1999)
Blood 94, 3997-4010
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Switching to IgG3, IgG2b, and IgA Is Division Linked and Independent, Revealing a Stochastic Framework for Describing Differentiation.

E. K. Deenick, J. Hasbold, and P. D. Hodgkin (1999)
J. Immunol. 163, 4707-4714
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The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination.

E. Sakai, A. Bottaro, and F. W. Alt (1999)
Int. Immunol. 11, 1709-1713
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Switch Recombination in a Transfected Plasmid Occurs Preferentially in a B Cell Line That Undergoes Switch Recombination of Its Chromosomal Ig Heavy Chain Genes.

J. Stavnezer, S. P. Bradley, N. Rousseau, T. Pearson, A. Shanmugam, D. J. Waite, P. R. Rogers, and A. L. Kenter (1999)
J. Immunol. 163, 2028-2040
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Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells.

M. Muramatsu, V. S. Sankaranand, S. Anant, M. Sugai, K. Kinoshita, N. O. Davidson, and T. Honjo (1999)
J. Biol. Chem. 274, 18470-18476
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An extrachromosomal switch recombination substrate reveals kinetics and substrate requirements of switch recombination in primary murine B cells.

K. Petry, G. Siebenkotten, R. Christine, K. Hein, and A. Radbruch (1999)
Int. Immunol. 11, 753-763
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The Evolutionarily Conserved Sequence Upstream of the Human Ig Heavy Chain S{gamma}3 Region Is an Inducible Promoter: Synergistic Activation by CD40 Ligand and IL-4 Via Cooperative NF-{kappa}B and STAT-6 Binding Sites.

A. Schaffer, A. Cerutti, S. Shah, H. Zan, and P. Casali (1999)
J. Immunol. 162, 5327-5336
 |  Abstract »  |  Full Text »  |  PDF »

Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.

K. J. Seidl, J. P. Manis, A. Bottaro, J. Zhang, L. Davidson, A. Kisselgof, H. Oettgen, and F. W. Alt (1999)
PNAS 96, 3000-3005
 |  Abstract »  |  Full Text »  |  PDF »

I{alpha} exon-replacement mice synthesize a spliced HPRT–C{alpha} transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice.

G. Qiu, G. R. Harriman, and J. Stavnezer (1999)
Int. Immunol. 11, 37-46
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Processing of Switch Transcripts Is Required for Targeting of Antibody Class Switch Recombination.

K. Hein, M. G.O. Lorenz, G. Siebenkotten, K. Petry, R. Christine, and A. Radbruch (1998)
J. Exp. Med. 188, 2369-2374
 |  Abstract »  |  Full Text »  |  PDF »

CBF{alpha}3 (AML2) Is Induced by TGF-{beta}1 to Bind and Activate the Mouse Germline Ig {alpha} Promoter.

M.-J. Shi and J. Stavnezer (1998)
J. Immunol. 161, 6751-6760
 |  Abstract »  |  Full Text »  |  PDF »

Class Switching in B Cells Lacking 3' Immunoglobulin Heavy Chain Enhancers.

J. P. Manis, N. van der Stoep, M. Tian, R. Ferrini, L. Davidson, A. Bottaro, and F. W. Alt (1998)
J. Exp. Med. 188, 1421-1431
 |  Abstract »  |  Full Text »  |  PDF »

Localization of Splenic B Cells Activated for Switch Recombination by In Situ Hybridization with I{gamma}1 Switch Transcript and Rad51 Probes.

M.-C. Peakman and N. Maizels (1998)
J. Immunol. 161, 4008-4015
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of BSAP/Pax-5 Inhibits Switching to IgA and Enhances Switching to IgE in the I.29{micro} B Cell Line.

G. Qiu and J. Stavnezer (1998)
J. Immunol. 161, 2906-2918
 |  Abstract »  |  Full Text »  |  PDF »

The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-kappa B/Rel Proteins.

S.-C. Lin, H. H. Wortis, and J. Stavnezer (1998)
Mol. Cell. Biol. 18, 5523-5532
 |  Abstract »  |  Full Text »

Efficient Recombination of a Switch Substrate Retrovector in CD40-Activated B Lymphocytes: Implications for the Control of CH Gene Switch Recombination.

J. Ballantyne, D. L. Henry, J. R. Muller, F. Briere, C. M. Snapper, M. Kehry, and K. B. Marcu (1998)
J. Immunol. 161, 1336-1347
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Switch Hybrid DNA Between Ig Heavy Chain-{micro} and Downstream Switch Regions in B Lymphocytes.

J. R. Muller, T. Giese, D. L. Henry, J. F. Mushinski, and K. B. Marcu (1998)
J. Immunol. 161, 1354-1362
 |  Abstract »  |  Full Text »  |  PDF »

STAT6 Is Required for IL-4-Induced Germline Ig Gene Transcription and Switch Recombination.

L. A. Linehan, W. D. Warren, P. A. Thompson, M. J. Grusby, and M. T. Berton (1998)
J. Immunol. 161, 302-310
 |  Abstract »  |  Full Text »  |  PDF »

T Helper 1 (Th1) and Th2 Characteristics Start to Develop During T Cell Priming and Are Associated with an Immediate Ability to Induce Immunoglobulin Class Switching.

K.-M. Toellner, S. A. Luther, D. M.-Y. Sze, R. K.-W. Choy, D. R. Taylor, I. C.M. MacLennan, and H. Acha-Orbea (1998)
J. Exp. Med. 187, 1193-1204
 |  Abstract »  |  Full Text »  |  PDF »

Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.

L. A. Hanakahi, L. A. Dempsey, M.-J. Li, and N. Maizels (1997)
PNAS 94, 3605-3610
 |  Abstract »  |  Full Text »  |  PDF »

The Promotion of  V Region Hypermutation.

M. D. Scharff, V. Poltoratsky, and N. S. Green (1997)
J. Exp. Med. 185, 185-188
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