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Science 17 March 1995:
Vol. 267. no. 5204, pp. 1662 - 1666
DOI: 10.1126/science.7886458

Articles

Science, Vol 267, Issue 5204, 1662-1666
Copyright © 1995 by American Association for the Advancement of Science


articles

Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF

RJ Cabelli, A Hohn, and CJ Shatz

Howard Hughes Medical Institute, University of California, Berkeley 94720.

During the development of the visual system of higher mammals, axons from the lateral geniculate nucleus (LGN) become segregated into eye-specific patches (the ocular dominance columns) within their target, layer 4 of the primary visual cortex. This occurs as a consequence of activity-dependent synaptic competition between axons representing the two eyes. The possibility that this competition could be mediated through neurotrophin-receptor interactions was tested. Infusion of neurotrophin-4/5 (NT-4/5) or brain-derived neurotrophic factor (BDNF) into cat primary visual cortex inhibited column formation within the immediate vicinity of the infusion site but not elsewhere in the visual cortex. Infusion of nerve growth factor, neurotrophin 3 (NT-3), or vehicle solution did not affect column formation. These observations implicate TrkB, the common receptor for BDNF and NT-4/5, in the segregation of LGN axons into ocular dominance columns in layer 4. Moreover, they suggest that in addition to their better known roles in the prevention of cell death, neurotrophins may also mediate the activity-dependent control of axonal branching during development of the central nervous system.


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The Regulated Secretion and Vectorial Targeting of Neurotrophins in Neuroendocrine and Epithelial Cells.
J. V. Heymach Jr., A. Kruttgen, U. Suter, and E. M. Shooter (1996)
J. Biol. Chem. 271, 25430-25437
   Abstract »    Full Text »    PDF »
Upregulation of BDNF mRNA Expression in the Barrel Cortex of Adult Mice after Sensory Stimulation.
N. Rocamora, E. Welker, M. Pascual, and E. Soriano (1996)
J. Neurosci. 16, 4411-4419
   Abstract »    Full Text »    PDF »
Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Stimulate Growth of Axonal Branches from Regenerating Retinal Ganglion Cells.
H. Sawai, D. B. Clarke, P. Kittlerova, G. M. Bray, and A. J. Aguayo (1996)
J. Neurosci. 16, 3887-3894
   Abstract »    Full Text »    PDF »
Neurotrophins and the Synapse.
S. Finkbeiner (1996)
Neuroscientist 2, 139-142
   Abstract »    PDF »
Combination of Gene Targeting and Gene Transfer by Adenoviral Vectors in the Analysis of Neurotrophin-mediated Neuronal Plasticity.
O. Griesbeck, M. Korte, V. Staiger, C. Gravel, P. Carroll, T. Bonhoeffer, and H. Thoenen (1996)
Cold Spring Harb Symp Quant Biol 61, 77-83
   Abstract »    PDF »
Neurotrophins in Cortical Development.
D.R. Riddle, A.K. McAllister, D.C. Lo, and L.C. Katz (1996)
Cold Spring Harb Symp Quant Biol 61, 85-93
   Abstract »    PDF »



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