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Science 17 March 1995:
Vol. 267. no. 5204, pp. 1658 - 1662
DOI: 10.1126/science.7886457

Articles

Science, Vol 267, Issue 5204, 1658-1662
Copyright © 1995 by American Association for the Advancement of Science


articles

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

H Kang and EM Schuman

Division of Biology 216-76, California Institute of Technology, Pasadena 91125.

The neurotrophins are signaling factors important for the differentiation and survival of distinct neuronal populations during development. To test whether the neurotrophins also function in the mature nervous system, the effects of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophic factor 3 (NT-3) on the strength of synaptic transmission in hippocampal slices were determined. Application of BDNF or NT-3 produced a dramatic and sustained (2 to 3 hours) enhancement of synaptic strength at the Schaffer collateral-CA1 synapses; NGF was without significant effect. The enhancement was blocked by K252a, an inhibitor of receptor tyrosine kinases. BDNF and NT-3 decreased paired-pulse facilitation, which is consistent with a possible presynaptic modification. Long-term potentiation could still be elicited in slices previously potentiated by exposure to the neurotrophic factors, which implies that these two forms of plasticity may use at least partially independent cellular mechanisms.


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V. C. Kotak, C. DiMattina, and D. H. Sanes (2001)
J Neurophysiol 86, 536-540
   Abstract »    Full Text »    PDF »
Nerve Growth Factor Rapidly Induces Prolonged Acetylcholine Release from Cultured Basal Forebrain Neurons: Differentiation between Neuromodulatory and Neurotrophic Influences.
D. S. Auld, F. Mennicken, and R. Quirion (2001)
J. Neurosci. 21, 3375-3382
   Abstract »    Full Text »    PDF »
Neurotrophins and synaptic plasticity in the mammalian spinal cord.
L. M Mendell, J. B Munson, and V. L Arvanian (2001)
J. Physiol. 533, 91-97
   Abstract »    Full Text »    PDF »
Neurotrophin-4/5 Alters Responses and Blocks the Effect of Monocular Deprivation in Cat Visual Cortex during the Critical Period.
D. C. Gillespie, M. C. Crair, and M. P. Stryker (2000)
J. Neurosci. 20, 9174-9186
   Abstract »    Full Text »    PDF »
Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo Techniques.
J. L. Jankowsky, B. E. Derrick, and P. H. Patterson (2000)
Learn. Mem. 7, 400-412
   Abstract »    Full Text »
A Glia-Derived Signal Regulating Neuronal Differentiation.
O. Blondel, C. Collin, W. J. McCarran, S. Zhu, R. Zamostiano, I. Gozes, D. E. Brenneman, and R. D. G. McKay (2000)
J. Neurosci. 20, 8012-8020
   Abstract »    Full Text »    PDF »
Activity-Dependent Release of Endogenous Brain-Derived Neurotrophic Factor from Primary Sensory Neurons Detected by ELISA In Situ.
A. Balkowiec and D. M. Katz (2000)
J. Neurosci. 20, 7417-7423
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The Role of Brain-Derived Neurotrophic Factor Receptors in the Mature Hippocampus: Modulation of Long-Term Potentiation through a Presynaptic Mechanism involving TrkB.
B. Xu, W. Gottschalk, A. Chow, R. I. Wilson, E. Schnell, K. Zang, D. Wang, R. A. Nicoll, B. Lu, and L. F. Reichardt (2000)
J. Neurosci. 20, 6888-6897
   Abstract »    Full Text »    PDF »
Involvement of Brain-Derived Neurotrophic Factor in Spatial Memory Formation and Maintenance in a Radial Arm Maze Test in Rats.
M. Mizuno, K. Yamada, A. Olariu, H. Nawa, and T. Nabeshima (2000)
J. Neurosci. 20, 7116-7121
   Abstract »    Full Text »    PDF »
Actions of brain-derived neurotrophic factor on evoked and spontaneous EPSCs dissociate with maturation of neurones cultured from rat visual cortex.
N. Taniguchi, N. Takada, F. Kimura, and T. Tsumoto (2000)
J. Physiol. 527, 579-592
   Abstract »    Full Text »    PDF »
NT-3 Evokes an LTP-Like Facilitation of AMPA/Kainate Receptor-Mediated Synaptic Transmission in the Neonatal Rat Spinal Cord.
V. L. Arvanov, B. S. Seebach, and L. M. Mendell (2000)
J Neurophysiol 84, 752-758
   Abstract »    Full Text »    PDF »
TrkB Receptor Ligands Promote Activity-Dependent Inhibitory Synaptogenesis.
F. J. Seil and R. Drake-Baumann (2000)
J. Neurosci. 20, 5367-5373
   Abstract »    Full Text »    PDF »
BDNF-Induced Potentiation of Spontaneous Twitching in Innervated Myocytes Requires Calcium Release From Intracellular Stores.
R. J. Kleiman, N. Tian, D. Krizaj, T. N. Hwang, D. R. Copenhagen, and L. F. Reichardt (2000)
J Neurophysiol 84, 472-483
   Abstract »    Full Text »    PDF »



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