Science 17 March 1995: Vol. 267. no. 5204, pp. 1655 - 1658 DOI: 10.1126/science.7886456

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Articles

Helicobacter pylori Vaccine: From Past to Future.

K. Agarwal and S. Agarwal (2008)
Mayo Clin. Proc. 83, 169-175
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Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain.

K. A. Gangwer, D. J. Mushrush, D. L. Stauff, B. Spiller, M. S. McClain, T. L. Cover, and D. B. Lacy (2007)
PNAS 104, 16293-16298
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Concanavalin A Protects Mice from a Lethal Inoculation of Intragastric Klebsiella pneumoniae and Reduces the Induced Liver Damage.

C.-F. Kuo, Y.-H. Wang, H.-Y. Lei, C.-H. Wang, and N. Tsao (2007)
Antimicrob. Agents Chemother. 51, 3122-3130
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Animal Models of Stomach Carcinogenesis.

T. Tsukamoto, T. Mizoshita, and M. Tatematsu (2007)
Toxicol Pathol 35, 636-648
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The Neutrophil-Activating Protein of Helicobacter pylori Crosses Endothelia to Promote Neutrophil Adhesion In Vivo.

A. Polenghi, F. Bossi, F. Fischetti, P. Durigutto, A. Cabrelle, N. Tamassia, M. A. Cassatella, C. Montecucco, F. Tedesco, and M. de Bernard (2007)
J. Immunol. 178, 1312-1320
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Helicobacter pylori Persistence: an Overview of Interactions between H. pylori and Host Immune Defenses.

H. M. S. Algood and T. L. Cover (2006)
Clin. Microbiol. Rev. 19, 597-613
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Inhibitors of Helicobacter pylori ATPase Cag{alpha} block CagA transport and cag virulence..

M. Hilleringmann, W. Pansegrau, M. Doyle, S. Kaufman, M. L. MacKichan, C. Gianfaldoni, P. Ruggiero, and A. Covacci (2006)
Microbiology 152, 2919-2930
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Pathogenesis of Helicobacter pylori Infection.

J. G. Kusters, A. H. M. van Vliet, and E. J. Kuipers (2006)
Clin. Microbiol. Rev. 19, 449-490
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Polyphenols Reduce Gastritis Induced by Helicobacter pylori Infection or VacA Toxin Administration in Mice..

P. Ruggiero, F. Tombola, G. Rossi, L. Pancotto, L. Lauretti, G. Del Giudice, and M. Zoratti (2006)
Antimicrob. Agents Chemother. 50, 2550-2552
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Paired cysteine residues are required for high levels of the Helicobacter pylori autotransporter VacA..

D. P. Letley, J. L. Rhead, K. Bishop, and J. C. Atherton (2006)
Microbiology 152, 1319-1325
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Induction of CTLA-4-Mediated Anergy Contributes to Persistent Colonization in the Murine Model of Gastric Helicobacter pylori Infection.

K. M. Anderson, S. J. Czinn, R. W. Redline, and T. G. Blanchard (2006)
J. Immunol. 176, 5306-5313
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Helicobacter pylori Vacuolating Cytotoxin Induces Activation of the Proapoptotic Proteins Bax and Bak, Leading to Cytochrome c Release and Cell Death, Independent of Vacuolation.

E. Yamasaki, A. Wada, A. Kumatori, I. Nakagawa, J. Funao, M. Nakayama, J. Hisatsune, M. Kimura, J. Moss, and T. Hirayama (2006)
J. Biol. Chem. 281, 11250-11259
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A Helicobacter pylori Vacuolating Toxin Mutant That Fails To Oligomerize Has a Dominant Negative Phenotype.

C. Genisset, C. L. Galeotti, P. Lupetti, D. Mercati, D. A. G. Skibinski, S. Barone, R. Battistutta, M. de Bernard, and J. L. Telford (2006)
Infect. Immun. 74, 1786-1794
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The Cell-Specific Phenotype of the Polymorphic vacA Midregion Is Independent of the Appearance of the Cell Surface Receptor Protein Tyrosine Phosphatase {beta}.

D. A. G. Skibinski, C. Genisset, S. Barone, and J. L. Telford (2006)
Infect. Immun. 74, 49-55
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Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice.

C. M. Elso, X. Lu, C. T. Culiat, J. C. Rutledge, N. L.A. Cacheiro, W. M. Generoso, and L. J. Stubbs (2004)
Hum. Mol. Genet. 13, 2813-2821
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Development of a Noninvasive Method for Detecting and Monitoring the Time Course of Helicobacter pylori Infection.

D. C. Nyan, A. R. Welch, A. Dubois, and W. G. Coleman Jr. (2004)
Infect. Immun. 72, 5358-5364
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Helicobacter pylori Infection of Human and Murine Primary Gastric Cells.

M. Clyne and B. Drumm (2004)
Infect. Immun. 72, 5464-5469
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Therapeutic Vaccination against Helicobacter pylori in the Beagle Dog Experimental Model: Safety, Immunogenicity, and Efficacy.

G. Rossi, P. Ruggiero, S. Peppoloni, L. Pancotto, D. Fortuna, L. Lauretti, G. Volpini, S. Mancianti, M. Corazza, E. Taccini, et al. (2004)
Infect. Immun. 72, 3252-3259
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Characterization of Monospecies Biofilm Formation by Helicobacter pylori.

S. P. Cole, J. Harwood, R. Lee, R. She, and D. G. Guiney (2004)
J. Bacteriol. 186, 3124-3132
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Helicobacter pylori outer-membrane proteins AlpA and AlpB in colonization of the guinea pig stomach.

R. de Jonge, Z. Durrani, S. G. Rijpkema, E. J. Kuipers, A. H.M. van Vliet, and J. G. Kusters (2004)
J. Med. Microbiol. 53, 375-379
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Helicobacter pylori VacA Activates the p38/Activating Transcription Factor 2-mediated Signal Pathway in AZ-521 Cells.

M. Nakayama, M. Kimura, A. Wada, K. Yahiro, K.-i. Ogushi, T. Niidome, A. Fujikawa, D. Shirasaka, N. Aoyama, H. Kurazono, et al. (2004)
J. Biol. Chem. 279, 7024-7028
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Effect of heparin binding on Helicobacter pylori resistance to serum.

J. D. Dubreuil, P. Ruggiero, R. Rappuoli, and G. Del Giudice (2004)
J. Med. Microbiol. 53, 9-12
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Cellular Vacuolation and Mitochondrial Cytochrome c Release Are Independent Outcomes of Helicobacter pylori Vacuolating Cytotoxin Activity That Are Each Dependent on Membrane Channel Formation.

D. C. Willhite, T. L. Cover, and S. R. Blanke (2003)
J. Biol. Chem. 278, 48204-48209
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Protective immunity against Helicobacter is characterized by a unique transcriptional signature.

A. Mueller, J. O'Rourke, P. Chu, C. C. Kim, P. Sutton, A. Lee, and S. Falkow (2003)
PNAS 100, 12289-12294
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Determinants of Non-toxicity in the Gastric Pathogen Helicobacter pylori.

D. P. Letley, J. L. Rhead, R. J. Twells, B. Dove, and J. C. Atherton (2003)
J. Biol. Chem. 278, 26734-26741
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Protein-tyrosine Phosphatase {alpha}, RPTP{alpha}, Is a Helicobacter pylori VacA Receptor.

K. Yahiro, A. Wada, M. Nakayama, T. Kimura, K.-i. Ogushi, T. Niidome, H. Aoyagi, K.-i. Yoshino, K. Yonezawa, J. Moss, et al. (2003)
J. Biol. Chem. 278, 19183-19189
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Modification in the ppk Gene of Helicobacterpylori during Single and Multiple Experimental Murine Infections.

S. Ayraud, B. Janvier, L. Salaun, and J.-L. Fauchere (2003)
Infect. Immun. 71, 1733-1739
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Generation of Helicobacter pylori Ghosts by PhiX Protein E-Mediated Inactivation and Their Evaluation as Vaccine Candidates.

K. Panthel, W. Jechlinger, A. Matis, M. Rohde, M. Szostak, W. Lubitz, and R. Haas (2003)
Infect. Immun. 71, 109-116
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Multiparameter Selection of Helicobacter pylori Antigens Identifies Two Novel Antigens with High Protective Efficacy.

N. Sabarth, R. Hurwitz, T. F. Meyer, and D. Bumann (2002)
Infect. Immun. 70, 6499-6503
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Two Predicted Chemoreceptors of Helicobacter pylori Promote Stomach Infection.

T. M. Andermann, Y.-T. Chen, and K. M. Ottemann (2002)
Infect. Immun. 70, 5877-5881
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Real-Time Quantitative PCR for Detection of Helicobacter pylori.

Q. He, J.-P. Wang, M. Osato, and L. B. Lachman (2002)
J. Clin. Microbiol. 40, 3720-3728
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Plasma Membrane Cholesterol Modulates Cellular Vacuolation Induced by the Helicobacter pylori Vacuolating Cytotoxin.

H. K. Patel, D. C. Willhite, R. M. Patel, D. Ye, C. L. Williams, E. M. Torres, K. B. Marty, R. A. MacDonald, and S. R. Blanke (2002)
Infect. Immun. 70, 4112-4123
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Effects of Oral Vaccination and Immunomodulation by Cholera Toxin on Experimental Helicobacter pylori Infection, Reinfection, and Gastritis.

S. Raghavan, A.-M. Svennerholm, and J. Holmgren (2002)
Infect. Immun. 70, 4621-4627
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Fluorescence Resonance Energy Transfer Microscopy of the Helicobacter pylori Vacuolating Cytotoxin within Mammalian Cells.

D. C. Willhite, D. Ye, and S. R. Blanke (2002)
Infect. Immun. 70, 3824-3832
 |  Abstract »  |  Full Text »  |  PDF »

Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice.

B. P. Guo and J. J. Mekalanos (2002)
PNAS 99, 8354-8359
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori Does Not Require Lewis X or Lewis Y Expression To Colonize C3H/HeJ mice.

T. Takata, E. El-Omar, M. Camorlinga, S. A. Thompson, Y. Minohara, P. B. Ernst, and M. J. Blaser (2002)
Infect. Immun. 70, 3073-3079
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Role of Tumor Necrosis Factor Alpha in Helicobacter pylori Gastritis in Tumor Necrosis Factor Receptor 1-Deficient Mice.

U. Thalmaier, N. Lehn, K. Pfeffer, M. Stolte, M. Vieth, and W. Schneider-Brachert (2002)
Infect. Immun. 70, 3149-3155
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Effects of Metronidazole, Tetracycline, and Bismuth-Metronidazole-Tetracycline Triple Therapy in the Helicobacter pylori SS1 Mouse Model after 1 Day of Dosing: Development of an H. pylori Lead Selection Model.

C. F. Sizemore, J. D. Quispe, K. M. Amsler, T. C. Modzelewski, J. J. Merrill, D. A. Stevenson, L. A. Foster, and A. M. Slee (2002)
Antimicrob. Agents Chemother. 46, 1435-1440
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Isogenic mutants of the cag pathogenicity island of Helicobacter pylori in the mouse model of infection: effects on colonization efficiency.

M. Marchetti and R. Rappuoli (2002)
Microbiology 148, 1447-1456
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Putative effect of Helicobacter pylori and gastritis on gastric acid secretion in cat.

I. Sobhani, S. Canedo, B. Alchepo, C. Vissuzaine, C. Chevalier, M. Buyse, L. Moizo, J. P. Laigneau, M. Mignon, J. M. Lewin, et al. (2002)
Am J Physiol Gastrointest Liver Physiol 282, G727-G734
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Cutting Edge: VacA, a Vacuolating Cytotoxin of Helicobacter pylori, Directly Activates Mast Cells for Migration and Production of Proinflammatory Cytokines.

V. Supajatura, H. Ushio, A. Wada, K. Yahiro, K. Okumura, H. Ogawa, T. Hirayama, and C. Ra (2002)
J. Immunol. 168, 2603-2607
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Identification of an Antigenic Epitope in Helicobacter pylori Urease That Induces Neutralizing Antibody Production.

K. Hirota, K. Nagata, Y. Norose, S. Futagami, Y. Nakagawa, H. Senpuku, M. Kobayashi, and H. Takahashi (2001)
Infect. Immun. 69, 6597-6603
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role for Tumor Necrosis Factor Alpha in Controlling the Number of Lumenal Pathogenic Bacteria and Immunopathology in Infectious Colitis.

N. S. Goncalves, M. Ghaem-Maghami, G. Monteleone, G. Frankel, G. Dougan, D. J. M. Lewis, C. P. Simmons, and T. T. MacDonald (2001)
Infect. Immun. 69, 6651-6659
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Helicobacter pylori-induced Gastritis in Experimentally Infected Conventional Piglets.

T. Poutahidis, T. Tsangaris, G. Kanakoudis, I. Vlemmas, N. Iliadis, and D. Sofianou (2001)
Vet. Pathol. 38, 667-678
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Human gastric B cell responses can be induced by intestinal immunisation.

M Quiding-Jarbrink, H Lonroth, I Ahlstedt, J Holmgren, and A-M Svennerholm (2001)
Gut 49, 512-518
 |  Abstract »  |  Full Text »  |  PDF »

Antigenic Diversity among Helicobacter pylori Vacuolating Toxins.

A. D. Vinion-Dubiel, M. S. McClain, P. Cao, R. L. Mernaugh, and T. L. Cover (2001)
Infect. Immun. 69, 4329-4336
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Safety and Immunogenicity of Oral Inactivated Whole-Cell Helicobacter pylori Vaccine with Adjuvant among Volunteers with or without Subclinical Infection.

K. L. Kotloff, M. B. Sztein, S. S. Wasserman, G. A. Losonsky, S. C. DiLorenzo, and R. I. Walker (2001)
Infect. Immun. 69, 3581-3590
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{gamma}-Glutamyltransferase Is a Helicobacter pylori Virulence Factor but Is Not Essential for Colonization.

K. J. McGovern, T. G. Blanchard, J. A. Gutierrez, S. J. Czinn, S. Krakowka, and P. Youngman (2001)
Infect. Immun. 69, 4168-4173
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the heparan sulphate-binding proteins of Helicobacter pylori in its adherence to HeLa S3 and Kato III cell lines.

M. A. GUZMAN-MURILLO, E. RUIZ-BUSTOS, B. HO, and F. ASCENCIO (2001)
J. Med. Microbiol. 50, 320-329
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori Pore-Forming Cytolysin Orthologue TlyA Possesses In Vitro Hemolytic Activity and Has a Role in Colonization of the Gastric Mucosa.

M. C. Martino, R. A. Stabler, Z. W. Zhang, M. J. G. Farthing, B. W. Wren, and N. Dorrell (2001)
Infect. Immun. 69, 1697-1703
 |  Abstract »  |  Full Text »  |  PDF »

Adoptive Transfer of CD4+ T Cells Specific for Subunit A of Helicobacter pylori Urease Reduces H. pylori Stomach Colonization in Mice in the Absence of Interleukin-4 (IL-4)/IL-13 Receptor Signaling.

B. Lucas, D. Bumann, A. Walduck, J. Koesling, L. Develioglu, T. F. Meyer, and T. Aebischer (2001)
Infect. Immun. 69, 1714-1721
 |  Abstract »  |  Full Text »  |  PDF »

Emergence of Diverse Helicobacter Species in the Pathogenesis of Gastric and Enterohepatic Diseases.

J. V. Solnick and D. B. Schauer (2001)
Clin. Microbiol. Rev. 14, 59-97
 |  Abstract »  |  Full Text »  |  PDF »

A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains.

N. Salama, K. Guillemin, T. K. McDaniel, G. Sherlock, L. Tompkins, and S. Falkow (2000)
PNAS 97, 14668-14673
 |  Abstract »  |  Full Text »  |  PDF »

Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil.

K. Ogura, S. Maeda, M. Nakao, T. Watanabe, M. Tada, T. Kyutoku, H. Yoshida, Y. Shiratori, and M. Omata (2000)
J. Exp. Med. 192, 1601-1610
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Mouse-Colonizing Helicobacter pylori SS1 Is Unusually Susceptible to Metronidazole Due to Two Complementary Reductase Activities.

J.-Y. Jeong and D. E. Berg (2000)
Antimicrob. Agents Chemother. 44, 3127-3132
 |  Abstract »  |  Full Text »

comH, a Novel Gene Essential for Natural Transformation of Helicobacter pylori.

L. C. Smeets, J. J. E. Bijlsma, S. Y. Boomkens, C. M. J. E. Vandenbroucke-Grauls, and J. G. Kusters (2000)
J. Bacteriol. 182, 3948-3954
 |  Abstract »  |  Full Text »

Helicobacter pylori-Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-{gamma}, Gene-Deficient Mice.

L. E. Smythies, K. B. Waites, J. R. Lindsey, P. R. Harris, P. Ghiara, and P. D. Smith (2000)
J. Immunol. 165, 1022-1029
 |  Abstract »  |  Full Text »  |  PDF »

Mutational Analysis of the Helicobacter pylori Vacuolating Toxin Amino Terminus: Identification of Amino Acids Essential for Cellular Vacuolation.

D. Ye and S. R. Blanke (2000)
Infect. Immun. 68, 4354-4357
 |  Abstract »  |  Full Text »  |  PDF »

Immune Response to an 18-Kilodalton Outer Membrane Antigen Identifies Lipoprotein 20 as a Helicobacter pylori Vaccine Candidate.

J. Keenan, J. Oliaro, N. Domigan, H. Potter, G. Aitken, R. Allardyce, and J. Roake (2000)
Infect. Immun. 68, 3337-3343
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Differences in Genotypes of Helicobacter pylori from Different Human Populations.

D. Kersulyte, A. K. Mukhopadhyay, B. Velapatiño, W. Su, Z. Pan, C. Garcia, V. Hernandez, Y. Valdez, R. S. Mistry, R. H. Gilman, et al. (2000)
J. Bacteriol. 182, 3210-3218
 |  Abstract »  |  Full Text »

Immunization with Recombinant Helicobacter pylori Urease in Specific-Pathogen-Free Rhesus Monkeys (Macaca mulatta).

J. V. Solnick, D. R. Canfield, L. M. Hansen, and S. Z. Torabian (2000)
Infect. Immun. 68, 2560-2565
 |  Abstract »  |  Full Text »  |  PDF »

Parenteral Adjuvant Activities of Escherichia coli Heat-Labile Toxin and Its B Subunit for Immunization of Mice against Gastric Helicobacter pylori Infection.

R. Weltzin, B. Guy, W. D. Thomas Jr., P. J. Giannasca, and T. P. Monath (2000)
Infect. Immun. 68, 2775-2782
 |  Abstract »  |  Full Text »  |  PDF »

The Neutrophil-activating Protein (HP-NAP) of Helicobacter pylori Is a Protective Antigen and a Major Virulence Factor.

B. Satin, G. Del Giudice, V. Della Bianca, S. Dusi, C. Laudanna, F. Tonello, D. Kelleher, R. Rappuoli, C. Montecucco, and F. Rossi (2000)
J. Exp. Med. 191, 1467-1476
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori CagA Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells.

M. Asahi, T. Azuma, S. Ito, Y. Ito, H. Suto, Y. Nagai, M. Tsubokawa, Y. Tohyama, S. Maeda, M. Omata, et al. (2000)
J. Exp. Med. 191, 593-602
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori Activates the Histidine Decarboxylase Promoter through a Mitogen-activated Protein Kinase Pathway Independent of Pathogenicity Island-encoded Virulence Factors.

S. Wessler, M. Hocker, W. Fischer, T. C. Wang, S. Rosewicz, R. Haas, B. Wiedenmann, T. F. Meyer, and M. Naumann (2000)
J. Biol. Chem. 275, 3629-3636
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation.

M. Stein, R. Rappuoli, and A. Covacci (2000)
PNAS 97, 1263-1268
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Activator Protein 1 and Stress Response Kinases in Epithelial Cells Colonized by Helicobacter pylori Encoding the cag Pathogenicity Island.

M. Naumann, S. Wessler, C. Bartsch, B. Wieland, A. Covacci, R. Haas, and T. F. Meyer (1999)
J. Biol. Chem. 274, 31655-31662
 |  Abstract »  |  Full Text »  |  PDF »

Replication-Defective Adenovirus Infection Reduces Helicobacter felis Colonization in the Mouse in a Gamma Interferon- and Interleukin-12-Dependent Manner.

B. Jiang, M. Jordana, Z. Xing, F. Smaill, D. P. Snider, R. Borojevic, D. Steele-Norwood, R. H. Hunt, and K. Croitoru (1999)
Infect. Immun. 67, 4539-4544
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of Recombinant Protective Helicobacter pylori Antigens.

D. Hocking, E. Webb, F. Radcliff, L. Rothel, S. Taylor, G. Pinczower, C. Kapouleas, H. Braley, A. Lee, and C. Doidge (1999)
Infect. Immun. 67, 4713-4719
 |  Abstract »  |  Full Text »  |  PDF »

Detection of Anti-VacA Antibody Responses in Serum and Gastric Juice Samples Using Type s1/m1 and s2/m2 Helicobacter pylori VacA Antigens.

G. I. Perez-Perez, R. M. Peek Jr., J. C. Atherton, M. J. Blaser, and T. L. Cover (1999)
Clin. Vaccine Immunol. 6, 489-493
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori-Associated Gastritis in Mice is Host and Strain Specific.

N. E. M. van Doorn, F. Namavar, M. Sparrius, J. Stoof, E. P. van Rees, L.-J. van Doorn, and C. M. J. E. Vandenbroucke-Grauls (1999)
Infect. Immun. 67, 3040-3046
 |  Abstract »  |  Full Text »  |  PDF »

A Conventional Beagle Dog Model for Acute and Chronic Infection with Helicobacter pylori.

G. Rossi, M. Rossi, C. G. Vitali, D. Fortuna, D. Burroni, L. Pancotto, S. Capecchi, S. Sozzi, G. Renzoni, G. Braca, et al. (1999)
Infect. Immun. 67, 3112-3120
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori Virulence and Genetic Geography.

A. Covacci, J. L. Telford, G. D. Giudice, J. Parsonnet, and R. Rappuoli (1999)
Science 284, 1328-1333
 |  Abstract »  |  Full Text »

Identification of the Minimal Intracellular Vacuolating Domain of the Helicobacter pylori Vacuolating Toxin.

D. Ye, D. C. Willhite, and S. R. Blanke (1999)
J. Biol. Chem. 274, 9277-9282
 |  Abstract »  |  Full Text »  |  PDF »

Human Embryonic Gastric Xenografts in Nude Mice: a New Model of Helicobacter pylori Infection.

A. Lozniewski, F. Muhale, R. Hatier, A. Marais, M.-C. Conroy, D. Edert, A. le Faou, M. Weber, and A. Duprez (1999)
Infect. Immun. 67, 1798-1805
 |  Abstract »  |  Full Text »  |  PDF »

Environmental factors as regulators and effectors of multistep carcinogenesis.

T. Minamoto, M. Mai, and Z.'e. Ronai (1999)
Carcinogenesis 20, 519-527
 |  Abstract »  |  Full Text »  |  PDF »

Role of Gamma Interferon in Helicobacter pylori-Induced Gastric Inflammatory Responses in a Mouse Model.

N. Sawai, M. Kita, T. Kodama, T. Tanahashi, Y. Yamaoka, Y.-i. Tagawa, Y. Iwakura, and J. Imanishi (1999)
Infect. Immun. 67, 279-285
 |  Abstract »  |  Full Text »  |  PDF »

Immunization of Mice with Urease Vaccine Affords Protection against Helicobacter pylori Infection in the Absence of Antibodies and Is Mediated by MHC Class II-restricted Responses.

T. H. Ermak, P. J. Giannasca, R. Nichols, G. A. Myers, J. Nedrud, R. Weltzin, C. K. Lee, H. Kleanthous, and T. P. Monath (1998)
J. Exp. Med. 188, 2277-2288
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Identification of the Helicobacter pylori VacA Toxin Domain Active in the Cell Cytosol.

M. de Bernard, D. Burroni, E. Papini, R. Rappuoli, J. Telford, and C. Montecucco (1998)
Infect. Immun. 66, 6014-6016
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Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology.

P. G. Falk, L. V. Hooper, T. Midtvedt, and J. I. Gordon (1998)
Microbiol. Mol. Biol. Rev. 62, 1157-1170
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Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains.

H.-P. Wirth, M. H. Beins, M. Yang, K. T. Tham, and M. J. Blaser (1998)
Infect. Immun. 66, 4856-4866
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Immunization against Natural Helicobacter pylori Infection in Nonhuman Primates.

A. Dubois, C. K. Lee, N. Fiala, H. Kleanthous, P. T. Mehlman, and T. Monath (1998)
Infect. Immun. 66, 4340-4346
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The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.

C. Pagliaccia, M. de Bernard, P. Lupetti, X. Ji, D. Burroni, T. L. Cover, E. Papini, R. Rappuoli, J. L. Telford, and J.-M. Reyrat (1998)
PNAS 95, 10212-10217
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Affinity Purification of Helicobacter pylori Urease. RELEVANCE TO GASTRIC MUCIN ADHERENCE BY UREASE PROTEIN.

F. C. Icatlo Jr., M. Kuroki, C. Kobayashi, H. Yokoyama, Y. Ikemori, T. Hashi, and Y. Kodama (1998)
J. Biol. Chem. 273, 18130-18138
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A Euthymic Hairless Mouse Model of Helicobacter pylori Colonization and Adherence to Gastric Epithelial Cells In Vivo.

N. Kimura, M. Ariga, F. C. Icatlo Jr., M. Kuroki, M. Ohsugi, Y. Ikemori, K. Umeda, and Y. Kodama (1998)
Clin. Vaccine Immunol. 5, 578-582
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Eradication of chronic Helicobacter pylori infection by therapeutic vaccination.

J E CRABTREE (1998)
Gut 43, 7-8
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Rectal and Intranasal Immunizations with Recombinant Urease Induce Distinct Local and Serum Immune Responses in Mice and Protect against Helicobacter pylori Infection.

H. Kleanthous, G. A. Myers, K. M. Georgakopoulos, T. J. Tibbitts, J. W. Ingrassia, H. L. Gray, R. Ding, Z.-Z. Zhang, W. Lei, R. Nichols, et al. (1998)
Infect. Immun. 66, 2879-2886
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Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity.

M. M. Giuliani, G. Del Giudice, V. Giannelli, G. Dougan, G. Douce, R. Rappuoli, and M. Pizza (1998)
J. Exp. Med. 187, 1123-1132
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Immune Responses of Specific-Pathogen-Free Mice to Chronic Helicobacter pylori (Strain SS1) Infection.

R. L. Ferrero, J.-M. Thiberge, M. Huerre, and A. Labigne (1998)
Infect. Immun. 66, 1349-1355
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vacA Genotypes and Genetic Diversity in Clinical Isolates of Helicobacter pylori.

S.-R. Han, H.-J. Schreiber, S. Bhakdi, M. Loos, and M. J. Maeurer (1998)
Clin. Vaccine Immunol. 5, 139-145
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Mice Are Protected from Helicobacter pylori Infection by Nasal Immunization with Attenuated Salmonella typhimurium phoPc Expressing Urease A and B Subunits.

I. E. Corthesy-Theulaz, S. Hopkins, D. Bachmann, P. F. Saldinger, N. Porta, R. Haas, Y. Zheng-Xin, T. Meyer, H. Bouzourene, A. L. Blum, et al. (1998)
Infect. Immun. 66, 581-586
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Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging.

D. Ilver, A. Arnqvist, J. Ögren, I. Frick, D. Kersulyte, E. T. Incecik, D. E. Berg, A. Covacci, L. Engstrand, and T. Borén (1998)
Science 279, 373-377
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Immunopathogenesis of Gastrointestinal and Hepatobiliary Diseases.

C. Galperin and M. E. Gershwin (1997)
JAMA 278, 1946-1955
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Vaccine against Helicobacter pylori: fact or fiction?.

P. MICHETTI (1997)
Gut 41, 728-730
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Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers.

M. Molinari, C. Galli, N. Norais, J. L. Telford, R. Rappuoli, J. P. Luzio, and C. Montecucco (1997)
J. Biol. Chem. 272, 25339-25344
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Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly.

T. L. Cover, P. I. Hanson, and J. E. Heuser (1997)
J. Cell Biol. 138, 759-769
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Pervasive Occult Gastrointestinal Bleeding in an Alaska Native Population With Prevalent Iron Deficiency: Role of Helicobacter pylori Gastritis.

R. Yip, P. J. Limburg, D. A. Ahlquist, H. A. Carpenter, A. O'Neill, D. Kruse, S. Stitham, B. D. Gold, E. W. Gunter, A. C. Looker, et al. (1997)
JAMA 277, 1135-1139
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cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.

S. Censini, C. Lange, Z. Xiang, J. E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli, and A. Covacci (1996)
PNAS 93, 14648-14653
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Low pH Activates the Vacuolating Toxin of Helicobacter pylori, Which Becomes Acid and Pepsin Resistant.

M. de Bernard, E. Papini, V. de Filippis, E. Gottardi, J. Telford, R. Manetti, A. Fontana, R. Rappuoli, and C. Montecucco (1995)
J. Biol. Chem. 270, 23937-23940
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The crystal structure of urease from Klebsiella aerogenes.

E Jabri, M. Carr, R. Hausinger, and P. Karplus (1995)
Science 268, 998-1004
 |  Abstract »  |  PDF »

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