Science 10 March 1995: Vol. 267. no. 5203, pp. 1506 - 1510 DOI: 10.1126/science.7878471

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Articles

Islet {beta}-Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli.

E. M. Carrington, M. D. McKenzie, E. Jansen, M. Myers, S. Fynch, C. Kos, A. Strasser, T. W. Kay, C. L. Scott, and J. Allison (2009)
Diabetes 58, 2316-2323
 |  Abstract »  |  Full Text »  |  PDF »

GATA-1 associates with and inhibits p53.

C. D. Trainor, C. Mas, P. Archambault, P. Di Lello, and J. G. Omichinski (2009)
Blood 114, 165-173
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-xL increases mitochondrial fission, fusion, and biomass in neurons.

S. B. Berman, Y.-b. Chen, B. Qi, J. M. McCaffery, E. B. Rucker III, S. Goebbels, K.-A. Nave, B. A. Arnold, E. A. Jonas, F. J. Pineda, et al. (2009)
J. Cell Biol. 184, 707-719
 |  Abstract »  |  Full Text »  |  PDF »

Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation.

M. Nagata, T. Ito, N. Arimitsu, H. Koyama, and K. Sekimizu (2009)
Genes Cells 14, 371-380
 |  Abstract »  |  Full Text »  |  PDF »

Promoter Knock-In Mutations Reveal a Role of Mcl-1 in Thymocyte-Positive Selection and Tissue or Cell Lineage-Specific Regulation of Mcl-1 Expression.

C.-Y. Yang, N.-H. Lin, J.-M. Lee, C.-Y. Huang, H.-J. Min, J. J.-Y. Yen, N.-S. Liao, and H.-F. Yang-Yen (2009)
J. Immunol. 182, 2959-2968
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

J. I. Fletcher, S. Meusburger, C. J. Hawkins, D. T. Riglar, E. F. Lee, W. D. Fairlie, D. C. S. Huang, and J. M. Adams (2008)
PNAS 105, 18081-18087
 |  Abstract »  |  Full Text »  |  PDF »

Loss of BH3-only Protein Bim Inhibits Apoptosis of Hemopoietic Cells in the Fetal Liver and Male Germ Cells but Not Neuronal Cells in Bcl-x-deficient Mice.

R. S. Akhtar, B. J. Klocke, A. Strasser, and K. A. Roth (2008)
J. Histochem. Cytochem. 56, 921-927
 |  Abstract »  |  Full Text »  |  PDF »

Removing the cloak of invisibility: phenotyping the mouse.

M. J. Justice (2008)
Dis. Model. Mech. 1, 109-112
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TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice.

M. Tang, X. Wei, Y. Guo, P. Breslin, S. Zhang, S. Zhang, W. Wei, Z. Xia, M. Diaz, S. Akira, et al. (2008)
J. Exp. Med. 205, 1611-1619
 |  Abstract »  |  Full Text »  |  PDF »

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages.

I. Dzhagalov, A. Dunkle, and Y.-W. He (2008)
J. Immunol. 181, 521-528
 |  Abstract »  |  Full Text »  |  PDF »

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage.

N. Arbour, J. L. Vanderluit, J. N. Le Grand, A. Jahani-Asl, V. A. Ruzhynsky, E. C. C. Cheung, M. A. Kelly, A. E. MacKenzie, D. S. Park, J. T. Opferman, et al. (2008)
J. Neurosci. 28, 6068-6078
 |  Abstract »  |  Full Text »  |  PDF »

A G-tract element in apoptotic agents-induced alternative splicing.

Y. Hai, W. Cao, G. Liu, S.-P. Hong, S. A. Elela, R. Klinck, J. Chu, and J. Xie (2008)
Nucleic Acids Res. 36, 3320-3331
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse..

M. Shirane, M. Ogawa, J. Motoyama, and K. I. Nakayama (2008)
Genes Cells 13, 635-651
 |  Abstract »  |  Full Text »  |  PDF »

Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin.

A. Newbold, R. K. Lindemann, L. A. Cluse, K. F. Whitecross, A. E. Dear, and R. W. Johnstone (2008)
Mol. Cancer Ther. 7, 1066-1079
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Bcl-x in Ph+ B-ALL increases cellular proliferation and does not inhibit leukemogenesis.

J. G. Harb, B. I. Chyla, and C. S. Huettner (2008)
Blood 111, 3760-3769
 |  Abstract »  |  Full Text »  |  PDF »

Nucleolin Stabilizes Bcl-XL Messenger RNA in Response to UVA Irradiation.

J. Zhang, G. Tsaprailis, and G. T. Bowden (2008)
Cancer Res. 68, 1046-1054
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Calcineurin A for the Survival of Naive T Cells.

S. Manicassamy, S. Gupta, Z. Huang, J. D. Molkentin, W. Shang, and Z. Sun (2008)
J. Immunol. 180, 106-112
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Expression of Bcl-xL or Bcl-2 by Murine B Cells Enhances the In Vivo Antipolysaccharide, but Not Antiprotein, Response to Intact Streptococcus pneumoniae.

G. Chattopadhyay, A. Q. Khan, G. Sen, J. Colino, W. duBois, A. Rubtsov, R. M. Torres, M. Potter, and C. M. Snapper (2007)
J. Immunol. 179, 7523-7534
 |  Abstract »  |  Full Text »  |  PDF »

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells.

A. Maraver, C. E. Tadokoro, M. L. Badura, J. Shen, M. Serrano, and J. J. Lafaille (2007)
Blood 110, 3218-3225
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-w Protects Hippocampus during Experimental Status Epilepticus.

B. Murphy, M. Dunleavy, S. Shinoda, C. Schindler, R. Meller, C. Bellver-Estelles, S. Hatazaki, P. Dicker, A. Yamamoto, I. Koegel, et al. (2007)
Am. J. Pathol. 171, 1258-1268
 |  Abstract »  |  Full Text »  |  PDF »

Serum Response Factor Contributes Selectively to Lymphocyte Development.

A. Fleige, S. Alberti, L. Grobe, U. Frischmann, R. Geffers, W. Muller, A. Nordheim, and A. Schippers (2007)
J. Biol. Chem. 282, 24320-24328
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-XL/Bax Proteins Direct the Fate of Embryonic Cortical Precursor Cells.

M.-Y. Chang, W. Sun, W. Ochiai, K. Nakashima, S.-Y. Kim, C.-H. Park, J. S. Kang, J.-W. Shim, A-Y. Jo, C.-S. Kang, et al. (2007)
Mol. Cell. Biol. 27, 4293-4305
 |  Abstract »  |  Full Text »  |  PDF »

Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure.

F. Zwerts, F. Lupu, A. De Vriese, S. Pollefeyt, L. Moons, R. A. Altura, Y. Jiang, P. H. Maxwell, P. Hill, H. Oh, et al. (2007)
Blood 109, 4742-4752
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous bcl-2 is not required for the development of E{micro}-myc induced B-cell lymphoma.

P. N. Kelly, H. Puthalakath, J. M. Adams, and A. Strasser (2007)
Blood 109, 4907-4913
 |  Abstract »  |  Full Text »  |  PDF »

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.

A. Diwan, A. G. Koesters, A. M. Odley, S. Pushkaran, C. P. Baines, B. T. Spike, D. Daria, A. G. Jegga, H. Geiger, B. J. Aronow, et al. (2007)
PNAS 104, 6794-6799
 |  Abstract »  |  Full Text »  |  PDF »

The Cytokine, Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Can Deliver Bcl-XL as an Extracellular Fusion Protein to Protect Cells from Apoptosis and Retain Differentiation Induction.

A. Antignani and R. J. Youle (2007)
J. Biol. Chem. 282, 11246-11254
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 family members and apoptosis, taken to heart.

A. B. Gustafsson and R. A. Gottlieb (2007)
Am J Physiol Cell Physiol 292, C45-C51
 |  Abstract »  |  Full Text »  |  PDF »

Loss of BCL-XL in Rod Photoreceptors: Increased Susceptibility to Bright Light Stress.

L. Zheng, R. E. Anderson, M.-P. Agbaga, E. B. Rucker III, and Y.-Z. Le (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5583-5589
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Is Required for Cytoprotection of the Respiratory Epithelium during Adenoviral Infection.

Y. Matsuzaki, Y. Xu, M. Ikegami, V. Besnard, K.-S. Park, W. M. Hull, S. E. Wert, and J. A. Whitsett (2006)
J. Immunol. 177, 527-537
 |  Abstract »  |  Full Text »  |  PDF »

Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita..

A. Yoon, G. Peng, Y. Brandenburg, O. Zollo, W. Xu, E. Rego, and D. Ruggero (2006)
Science 312, 902-906
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Elongation Factor S-II Is Required for Definitive Hematopoiesis.

T. Ito, N. Arimitsu, M. Takeuchi, N. Kawamura, M. Nagata, K. Saso, N. Akimitsu, H. Hamamoto, S. Natori, A. Miyajima, et al. (2006)
Mol. Cell. Biol. 26, 3194-3203
 |  Abstract »  |  Full Text »  |  PDF »

WT p53, but Not Tumor-derived Mutants, Bind to Bcl2 via the DNA Binding Domain and Induce Mitochondrial Permeabilization.

Y. Tomita, N. Marchenko, S. Erster, A. Nemajerova, A. Dehner, C. Klein, H. Pan, H. Kessler, P. Pancoska, and U. M. Moll (2006)
J. Biol. Chem. 281, 8600-8606
 |  Abstract »  |  Full Text »  |  PDF »

Low K+ Promotes NF-{kappa}B/DNA Binding in Neuronal Apoptosis Induced by K+ Loss.

Y. Tao, D. Yan, Q. Yang, R. Zeng, and Y. Wang (2006)
Mol. Cell. Biol. 26, 1038-1050
 |  Abstract »  |  Full Text »  |  PDF »

Premature Expression of Chemokine Receptor CCR9 Impairs T Cell Development.

S. Uehara, S. M. Hayes, L. Li, D. El-Khoury, M. Canelles, B. J. Fowlkes, and P. E. Love (2006)
J. Immunol. 176, 75-84
 |  Abstract »  |  Full Text »  |  PDF »

Stabilized {beta}-Catenin Extends Thymocyte Survival by Up-Regulating Bcl-xL.

H. Xie, Z. Huang, M. S. Sadim, and Z. Sun (2005)
J. Immunol. 175, 7981-7988
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric peptide nucleic acid compounds modulate splicing of the bcl-x gene in vitro and in vivo.

J. E. Wilusz, S. C. Devanney, and M. Caputi (2005)
Nucleic Acids Res. 33, 6547-6554
 |  Abstract »  |  Full Text »  |  PDF »

ROR{gamma}t Recruits Steroid Receptor Coactivators to Ensure Thymocyte Survival.

H. Xie, M. S. Sadim, and Z. Sun (2005)
J. Immunol. 175, 3800-3809
 |  Abstract »  |  Full Text »  |  PDF »

PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53.

J. E. Chipuk, L. Bouchier-Hayes, T. Kuwana, D. D. Newmeyer, and D. R. Green (2005)
Science 309, 1732-1735
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-xL prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin.

M. M. Rhodes, P. Kopsombut, M. C. Bondurant, J. O. Price, and M. J. Koury (2005)
Blood 106, 1857-1863
 |  Abstract »  |  Full Text »  |  PDF »

Repression of c-Kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation.

V. Munugalavadla, L. C. Dore, B. L. Tan, L. Hong, M. Vishnu, M. J. Weiss, and R. Kapur (2005)
Mol. Cell. Biol. 25, 6747-6759
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role for Survivin in Early Brain Development.

Y. Jiang, A. de Bruin, H. Caldas, J. Fangusaro, J. Hayes, E. M. Conway, M. L. Robinson, and R. A. Altura (2005)
J. Neurosci. 25, 6962-6970
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-x Is Required for Proper Development of the Mouse Substantia Nigra.

J. M. Savitt, S. S. Jang, W. Mu, V. L. Dawson, and T. M. Dawson (2005)
J. Neurosci. 25, 6721-6728
 |  Abstract »  |  Full Text »  |  PDF »

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis.

J. Hutcheson, J. C. Scatizzi, E. Bickel, N. J. Brown, P. Bouillet, A. Strasser, and H. Perlman (2005)
J. Exp. Med. 201, 1949-1960
 |  Abstract »  |  Full Text »  |  PDF »

Graded Levels of GATA-1 Expression Modulate Survival, Proliferation, and Differentiation of Erythroid Progenitors.

X. Pan, O. Ohneda, K. Ohneda, F. Lindeboom, F. Iwata, R. Shimizu, M. Nagano, N. Suwabe, S. Philipsen, K.-C. Lim, et al. (2005)
J. Biol. Chem. 280, 22385-22394
 |  Abstract »  |  Full Text »  |  PDF »

The Antiapoptotic Protein Bcl-xL Is Dispensable for the Development of Effector and Memory T Lymphocytes.

N. Zhang and Y.-W. He (2005)
J. Immunol. 174, 6967-6973
 |  Abstract »  |  Full Text »  |  PDF »

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

S. N. Willis, L. Chen, G. Dewson, A. Wei, E. Naik, J. I. Fletcher, J. M. Adams, and D. C.S. Huang (2005)
Genes & Dev. 19, 1294-1305
 |  Abstract »  |  Full Text »  |  PDF »

Efficiency of RNA Interference in the Mouse Hematopoietic System Varies between Cell Types and Developmental Stages.

P. Oberdoerffer, C. Kanellopoulou, V. Heissmeyer, C. Paeper, C. Borowski, I. Aifantis, A. Rao, and K. Rajewsky (2005)
Mol. Cell. Biol. 25, 3896-3905
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.

D. M. Langenau, C. Jette, S. Berghmans, T. Palomero, J. P. Kanki, J. L. Kutok, and A. T. Look (2005)
Blood 105, 3278-3285
 |  Abstract »  |  Full Text »  |  PDF »

Brn-3a Transcription Factor Blocks p53-mediated Activation of Proapoptotic Target Genes Noxa and Bax in Vitro and in Vivo to Determine Cell Fate.

C. D. Hudson, P. J. Morris, D. S. Latchman, and V. S. Budhram-Mahadeo (2005)
J. Biol. Chem. 280, 11851-11858
 |  Abstract »  |  Full Text »  |  PDF »

Specific Cleavage of Mcl-1 by Caspase-3 in Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis in Jurkat Leukemia T Cells.

C. Weng, Y. Li, D. Xu, Y. Shi, and H. Tang (2005)
J. Biol. Chem. 280, 10491-10500
 |  Abstract »  |  Full Text »  |  PDF »

Neurons Exclusively Express N-Bak, a BH3 Domain-only Bak Isoform That Promotes Neuronal Apoptosis.

T. Uo, Y. Kinoshita, and R. S. Morrison (2005)
J. Biol. Chem. 280, 9065-9073
 |  Abstract »  |  Full Text »  |  PDF »

Magnetic Resonance Diffusion Tensor Microimaging Reveals a Role for Bcl-x in Brain Development and Homeostasis.

J. Zhang, Y.-b. Chen, J. M. Hardwick, M. I. Miller, C. Plachez, L. J. Richards, P. Yarowsky, P. van Zijl, and S. Mori (2005)
J. Neurosci. 25, 1881-1888
 |  Abstract »  |  Full Text »  |  PDF »

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

M. Mandal, C. Borowski, T. Palomero, A. A. Ferrando, P. Oberdoerffer, F. Meng, A. Ruiz-Vela, M. Ciofani, J.-C. Zuniga-Pflucker, I. Screpanti, et al. (2005)
J. Exp. Med. 201, 603-614
 |  Abstract »  |  Full Text »  |  PDF »

Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells.

J. T. Opferman, H. Iwasaki, C. C. Ong, H. Suh, S.-i. Mizuno, K. Akashi, and S. J. Korsmeyer (2005)
Science 307, 1101-1104
 |  Abstract »  |  Full Text »  |  PDF »

GATA1 Function, a Paradigm for Transcription Factors in Hematopoiesis.

R. Ferreira, K. Ohneda, M. Yamamoto, and S. Philipsen (2005)
Mol. Cell. Biol. 25, 1215-1227
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Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands.

C. L. Day, L. Chen, S. J. Richardson, P. J. Harrison, D. C. S. Huang, and M. G. Hinds (2005)
J. Biol. Chem. 280, 4738-4744
 |  Abstract »  |  Full Text »  |  PDF »

Defining the Role of the Bcl-2 Family of Proteins in the Nervous System.

T. Lindsten, W.-X. Zong, and C. B. Thompson (2005)
Neuroscientist 11, 10-15
 |  Abstract »  |  PDF »

Expression of Cellular Oncogene Bcl-xL Prevents Coronavirus-Induced Cell Death and Converts Acute Infection to Persistent Infection in Progenitor Rat Oligodendrocytes.

Y. Liu and X. Zhang (2005)
J. Virol. 79, 47-56
 |  Abstract »  |  Full Text »  |  PDF »

Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1.

K. W. Harder, C. Quilici, E. Naik, M. Inglese, N. Kountouri, A. Turner, K. Zlatic, D. M. Tarlinton, and M. L. Hibbs (2004)
Blood 104, 3901-3910
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.

A. K. Wiggins, G. Wei, E. Doxakis, C. Wong, A. A. Tang, K. Zang, E. J. Luo, R. L. Neve, L. F. Reichardt, and E. J. Huang (2004)
J. Cell Biol. 167, 257-267
 |  Abstract »  |  Full Text »  |  PDF »

bcl-xL Is Critical for Dendritic Cell Survival In Vivo.

H. Hon, E. B. Rucker III, L. Hennighausen, and J. Jacob (2004)
J. Immunol. 173, 4425-4432
 |  Abstract »  |  Full Text »  |  PDF »

Differentiation-dependent Sensitivity to Apoptogenic Factors in PC12 Cells.

S. Vyas, P. Juin, D. Hancock, Y. Suzuki, R. Takahashi, A. Triller, and G. Evan (2004)
J. Biol. Chem. 279, 30983-30993
 |  Abstract »  |  Full Text »  |  PDF »

The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression.

C. Orelio, K. N. Harvey, C. Miles, R. A. J. Oostendorp, K. van der Horn, and E. Dzierzak (2004)
Blood 103, 4084-4092
 |  Abstract »  |  Full Text »  |  PDF »

Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth.

F. Cecconi, K. A. Roth, O. Dolgov, E. Munarriz, K. Anokhin, P. Gruss, and M. Salminen (2004)
Development 131, 2125-2135
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Cytokine-induced Antiapoptotic Molecule Anamorsin Essential for Definitive Hematopoiesis.

H. Shibayama, E. Takai, I. Matsumura, M. Kouno, E. Morii, Y. Kitamura, J. Takeda, and Y. Kanakura (2004)
J. Exp. Med. 199, 581-592
 |  Abstract »  |  Full Text »  |  PDF »

Preventing Retinal Detachment-Associated Photoreceptor Cell Loss in Bax-Deficient Mice.

L. Yang, D. Bula, J. G. Arroyo, and D. F. Chen (2004)
Invest. Ophthalmol. Vis. Sci. 45, 648-654
 |  Abstract »  |  Full Text »  |  PDF »

The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-{kappa}B and induction of bcl-2.

M. A. Guthridge, E. F. Barry, F. A. Felquer, B. J. McClure, F. C. Stomski, H. Ramshaw, and A. F. Lopez (2004)
Blood 103, 820-827
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced In Vitro Midbrain Dopamine Neuron Differentiation, Dopaminergic Function, Neurite Outgrowth, and 1-Methyl-4-Phenylpyridium Resistance in Mouse Embryonic Stem Cells Overexpressing Bcl-XL.

J.-W. Shim, H.-C. Koh, M.-Y. Chang, E. Roh, C.-Y. Choi, Y. J. Oh, H. Son, Y.-S. Lee, L. Studer, and S.-H. Lee (2004)
J. Neurosci. 24, 843-852
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma.

W.-L. Zhao, M. E. Daneshpouy, N. Mounier, J. Briere, C. Leboeuf, L.-F. Plassa, E. Turpin, J.-M. Cayuela, J.-C. Ameisen, C. Gisselbrecht, et al. (2004)
Blood 103, 695-697
 |  Abstract »  |  Full Text »  |  PDF »

The Proapoptotic Activities of Bax and Bak Limit the Size of the Neural Stem Cell Pool.

T. Lindsten, J. A. Golden, W.-X. Zong, J. Minarcik, M. H. Harris, and C. B. Thompson (2003)
J. Neurosci. 23, 11112-11119
 |  Abstract »  |  Full Text »  |  PDF »

New Insights Into Erythropoietin and Epoetin Alfa: Mechanisms of Action, Target Tissues, and Clinical Applications.

M. J. Weiss (2003)
Oncologist 8, 18-29
 |  Abstract »  |  Full Text »  |  PDF »

TEL, a Putative Tumor Suppressor, Induces Apoptosis and Represses Transcription of Bcl-XL.

B. J. Irvin, L. D. Wood, L. Wang, R. Fenrick, C. G. Sansam, G. Packham, M. Kinch, E. Yang, and S. W. Hiebert (2003)
J. Biol. Chem. 278, 46378-46386
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes.

R. Karlsson, M. Engstrom, M. Jonsson, P. Karlberg, C. J.H. Pronk, J. Richter, and J.-I. Jonsson (2003)
J. Leukoc. Biol. 74, 923-931
 |  Abstract »  |  Full Text »  |  PDF »

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL.

K. H. Maclean, U. B. Keller, C. Rodriguez-Galindo, J. A. Nilsson, and J. L. Cleveland (2003)
Mol. Cell. Biol. 23, 7256-7270
 |  Abstract »  |  Full Text »  |  PDF »

Different antiapoptotic pathways between wild-type and mutated FLT3: insights into therapeutic targets in leukemia.

Y. Minami, K. Yamamoto, H. Kiyoi, R. Ueda, H. Saito, and T. Naoe (2003)
Blood 102, 2969-2975
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Oligonucleotide Inhibition of Bcl-xL and Bid Expression in Liver Regulates Responses in a Mouse Model of Fas-Induced Fulminant Hepatitis.

H. Zhang, J. Taylor, D. Luther, J. Johnston, S. Murray, J. R. Wyatt, A. T. Watt, S. Koo, C. York-DeFalco, K. Stecker, et al. (2003)
J. Pharmacol. Exp. Ther. 307, 24-33
 |  Abstract »  |  Full Text »  |  PDF »

The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice.

C. J. Zeiss (2003)
Vet. Pathol. 40, 481-495
 |  Abstract »  |  Full Text »  |  PDF »

Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools.

R. Greil, G. Anether, K. Johrer, and I. Tinhofer (2003)
J. Leukoc. Biol. 74, 311-330
 |  Abstract »  |  Full Text »  |  PDF »

Plasma Cell Survival Is Mediated by Synergistic Effects of Cytokines and Adhesion-Dependent Signals.

G. Cassese, S. Arce, A. E. Hauser, K. Lehnert, B. Moewes, M. Mostarac, G. Muehlinghaus, M. Szyska, A. Radbruch, and R. A. Manz (2003)
J. Immunol. 171, 1684-1690
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BCL-2 and BCL-XL Restrict Lineage Choice during Hematopoietic Differentiation.

L. Haughn, R. G. Hawley, D. K. Morrison, H. von Boehmer, and D. M. Hockenbery (2003)
J. Biol. Chem. 278, 25158-25165
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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.

D. Nijhawan, M. Fang, E. Traer, Q. Zhong, W. Gao, F. Du, and X. Wang (2003)
Genes & Dev. 17, 1475-1486
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In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis.

J. UMEDA, S. SANO, K. KOGAWA, N. MOTOYAMA, K. YOSHIKAWA, S. ITAMI, G. KONDOH, T. WATANABE, and J. TAKEDA (2003)
FASEB J 17, 610-620
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Bcl-XL is required for heme synthesis during the chemical induction of erythroid differentiation of murine erythroleukemia cells independently of its antiapoptotic function.

K. Hafid-Medheb, Y. Augery-Bourget, M.-N. Minatchy, N. Hanania, and J. Robert-Lezenes (2003)
Blood 101, 2575-2583
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Functional and Biochemical Consequences of Abrogating the Activation of Multiple Diverse Early Signaling Pathways in Kit. ROLE FOR Src KINASE PATHWAY IN KIT-INDUCED COOPERATION WITH ERYTHROPOIETIN RECEPTOR.

B. L. Tan, L. Hong, V. Munugalavadla, and R. Kapur (2003)
J. Biol. Chem. 278, 11686-11695
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The function of the bcl-x promoter in erythroid progenitor cells.

C. Tian, P. Gregoli, and M. Bondurant (2003)
Blood 101, 2235-2242
 |  Abstract »  |  Full Text »  |  PDF »

Erythropoietin receptor signalling is required for normal brain development.

X. Yu, J. J. Shacka, J. B. Eells, C. Suarez-Quian, R. M. Przygodzki, B. Beleslin-Cokic, C.-S. Lin, V. M. Nikodem, B. Hempstead, K. C. Flanders, et al. (2003)
Development 129, 505-516
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane.

T. Kaufmann, S. Schlipf, J. Sanz, K. Neubert, R. Stein, and C. Borner (2003)
J. Cell Biol. 160, 53-64
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Signal-Transducing Adaptor Molecules STAM1 and STAM2 Are Required for T-Cell Development and Survival.

M. Yamada, N. Ishii, H. Asao, K. Murata, C. Kanazawa, H. Sasaki, and K. Sugamura (2002)
Mol. Cell. Biol. 22, 8648-8658
 |  Abstract »  |  Full Text »  |  PDF »

CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation.

H. Hase, Y. Kanno, H. Kojima, C. Morimoto, K. Okumura, and T. Kobata (2002)
J. Biol. Chem. 277, 46950-46958
 |  Abstract »  |  Full Text »  |  PDF »

p73 Is Required for Survival and Maintenance of CNS Neurons.

C. D. Pozniak, F. Barnabe-Heider, V. V. Rymar, A. F. Lee, A. F. Sadikot, and F. D. Miller (2002)
J. Neurosci. 22, 9800-9809
 |  Abstract »  |  Full Text »  |  PDF »

Murine Ovarian Development Is Not Affected by Inactivation of the Bcl-2 Family Member Diva.

H. R. Russell, Y. Lee, H. L. Miller, J. Zhao, and P. J. McKinnon (2002)
Mol. Cell. Biol. 22, 6866-6870
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Orphan nuclear receptors in T lymphocyte development.

Y.-W. He (2002)
J. Leukoc. Biol. 72, 440-446
 |  Abstract »  |  Full Text »  |  PDF »

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

I. M. Pedersen, S. Kitada, L. M. Leoni, J. M. Zapata, J. G. Karras, N. Tsukada, T. J. Kipps, Y. S. Choi, F. Bennett, and J. C. Reed (2002)
Blood 100, 1795-1801
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis.

G. Cao, W. Pei, H. Ge, Q. Liang, Y. Luo, F. R. Sharp, A. Lu, R. Ran, S. H. Graham, and J. Chen (2002)
J. Neurosci. 22, 5423-5431
 |  Abstract »  |  Full Text »  |  PDF »

Antisense therapy for malignant mesothelioma with oligonucleotides targeting the bcl-xl gene product.

W. R. Smythe, I. Mohuiddin, M. Ozveran, and X. X. Cao (2002)
J. Thorac. Cardiovasc. Surg. 123, 1191-1198
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive nuclear factor-kappa B activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins.

F. Bureau, A. Vanderplasschen, F. Jaspar, F. Minner, P.-P. Pastoret, M.-P. Merville, V. Bours, and P. Lekeux (2002)
Blood 99, 3683-3691
 |  Abstract »  |  Full Text »  |  PDF »

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