Related Content
Search Google Scholar for:
|
|
Science 10 March 1995: Vol. 267. no. 5203, pp. 1485 - 1488 DOI: 10.1126/science.7878466
|
|
Articles
Science, Vol 267, Issue 5203, 1485-1488
Copyright © 1995 by American Association for the Advancement of Science
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
K Brown,
S Gerstberger,
L Carlson,
G Franzoso,
and
U Siebenlist
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1876.
I kappa B-alpha inhibits transcription factor NF-kappa B by retaining it in the cytoplasm. Various stimuli, typically those associated with stress or pathogens, rapidly inactivate I kappa B-alpha. This liberates NF-kappa B to translocate to the nucleus and initiate transcription of genes important for the defense of the organism. Activation of NF-kappa B correlates with phosphorylation of I kappa B-alpha and requires the proteolysis of this inhibitor. When either serine-32 or serine-36 of I kappa B-alpha was mutated, the protein did not undergo signal-induced phosphorylation or degradation, and NF-kappa B could not be activated. These results suggest that phosphorylation at one or both of these residues is critical for activation of NF-kappa B.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Increased I{kappa}B{alpha} expression is essential for the tolerogenic property of TGF-{beta}-exposed APCs.
- P. Ghafoori, T. Yoshimura, B. Turpie, and S. Masli (2009)
FASEB J
23, 2226-2234
| Abstract »
| Full Text »
| PDF »
- Hepatitis B Virus X Protein Modulates Apoptosis in Primary Rat Hepatocytes by Regulating both NF-{kappa}B and the Mitochondrial Permeability Transition Pore.
- A. J. Clippinger, T. L. Gearhart, and M. J. Bouchard (2009)
J. Virol.
83, 4718-4731
| Abstract »
| Full Text »
| PDF »
- Role of clathrin-mediated endocytosis of surfactant protein A by alveolar macrophages in intracellular signaling.
- C. Moulakakis and C. Stamme (2009)
Am J Physiol Lung Cell Mol Physiol
296, L430-L441
| Abstract »
| Full Text »
| PDF »
- A Role for Protein Phosphorylation in Cytochrome P450 3A4 Ubiquitin-dependent Proteasomal Degradation.
- Y. Wang, M. Liao, N. Hoe, P. Acharya, C. Deng, A. N. Krutchinsky, and M. A. Correia (2009)
J. Biol. Chem.
284, 5671-5684
| Abstract »
| Full Text »
| PDF »
- Carbon Monoxide Inhibits TLR-Induced Dendritic Cell Immunogenicity.
- S. Remy, P. Blancou, L. Tesson, V. Tardif, R. Brion, P. J. Royer, R. Motterlini, R. Foresti, M. Painchaut, S. Pogu, et al. (2009)
J. Immunol.
182, 1877-1884
| Abstract »
| Full Text »
| PDF »
- Follistatin-Like Protein 1 Promotes Arthritis by Up-Regulating IFN-{gamma}.
- S. D. Clutter, D. C. Wilson, A. D. Marinov, and R. Hirsch (2009)
J. Immunol.
182, 234-239
| Abstract »
| Full Text »
| PDF »
- Synergistic Up-Regulation of Prostaglandin E Synthase Expression in Breast Cancer Cells by 17{beta}-Estradiol and Proinflammatory Cytokines.
- J. Frasor, A. E. Weaver, M. Pradhan, and K. Mehta (2008)
Endocrinology
149, 6272-6279
| Abstract »
| Full Text »
| PDF »
- Salmonella virulence factor SpiC is involved in expression of flagellin protein and mediates activation of the signal transduction pathways in macrophages.
- K.-i. Uchiya and T. Nikai (2008)
Microbiology
154, 3491-3502
| Abstract »
| Full Text »
| PDF »
- Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-{kappa}B pathway.
- G. Gatto, A. Rossi, D. Rossi, S. Kroening, S. Bonatti, and M. Mallardo (2008)
Nucleic Acids Res.
36, 6608-6619
| Abstract »
| Full Text »
| PDF »
- Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF-{kappa}B Activation via the DNA-Dependent Activator of IFN Regulatory Factors.
- W. J. Kaiser, J. W. Upton, and E. S. Mocarski (2008)
J. Immunol.
181, 6427-6434
| Abstract »
| Full Text »
| PDF »
- Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF-{kappa}B.
- J. Zheng, J. Meng, S. Zhao, R. Singh, and W. Song (2008)
Infect. Immun.
76, 4498-4508
| Abstract »
| Full Text »
| PDF »
- Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins.
- T. Kohno, T. Daa, H. Otani, I. Shimokawa, S. Yokoyama, and T. Matsuyama (2008)
Genes Cells
13, 1061-1073
| Abstract »
| Full Text »
| PDF »
- Hepatitis B Virus HBx Protein Localizes to Mitochondria in Primary Rat Hepatocytes and Modulates Mitochondrial Membrane Potential.
- A. J. Clippinger and M. J. Bouchard (2008)
J. Virol.
82, 6798-6811
| Abstract »
| Full Text »
| PDF »
- Divergent roles of endothelial NF-{kappa}B in multiple organ injury and bacterial clearance in mouse models of sepsis.
- X. Ye, J. Ding, X. Zhou, G. Chen, and S. F. Liu (2008)
J. Exp. Med.
205, 1303-1315
| Abstract »
| Full Text »
| PDF »
- RelA Ser276 Phosphorylation Is Required for Activation of a Subset of NF-{kappa}B-Dependent Genes by Recruiting Cyclin-Dependent Kinase 9/Cyclin T1 Complexes.
- D. E. Nowak, B. Tian, M. Jamaluddin, I. Boldogh, L. A. Vergara, S. Choudhary, and A. R. Brasier (2008)
Mol. Cell. Biol.
28, 3623-3638
| Abstract »
| Full Text »
| PDF »
- Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.
- J. Chen, M. Petrus, B. R. Bryant, V. Phuc Nguyen, M. Stamer, C. K. Goldman, R. Bamford, J. C. Morris, J. E. Janik, and T. A. Waldmann (2008)
Blood
111, 5163-5172
| Abstract »
| Full Text »
| PDF »
- Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models.
- B. Mellstrom, M. Savignac, R. Gomez-Villafuertes, and J. R. Naranjo (2008)
Physiol Rev
88, 421-449
| Abstract »
| Full Text »
| PDF »
- EET Displays Anti-Inflammatory Effects in TNF-{alpha} Stimulated Human Bronchi: Putative Role of CPI-17.
- C. Morin, M. Sirois, V. Echave, M. M. Gomes, and E. Rousseau (2008)
Am. J. Respir. Cell Mol. Biol.
38, 192-201
| Abstract »
| Full Text »
| PDF »
- Signal processing by its coil zipper domain activates IKK{gamma}.
- S. Bloor, G. Ryzhakov, S. Wagner, P. J. G. Butler, D. L. Smith, R. Krumbach, I. Dikic, and F. Randow (2008)
PNAS
105, 1279-1284
| Abstract »
| Full Text »
| PDF »
- Protein kinases, TNF-{alpha}, and proteasome contribute in the inhibition of fructose intestinal transport by sepsis in vivo.
- J. Garcia-Herrera, M. C. Marca, E. Brot-Laroche, N. Guillen, S. Acin, M. A. Navarro, J. Osada, and M. J. Rodriguez-Yoldi (2008)
Am J Physiol Gastrointest Liver Physiol
294, G155-G164
| Abstract »
| Full Text »
| PDF »
- I{kappa}B-{alpha} Represses the Transcriptional Activity of the HIV-1 Tat Transactivator by Promoting Its Nuclear Export.
- A. Puca, G. Fiume, C. Palmieri, F. Trimboli, F. Olimpico, G. Scala, and I. Quinto (2007)
J. Biol. Chem.
282, 37146-37157
| Abstract »
| Full Text »
| PDF »
- Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin.
- C. Chassin, M. W. Hornef, M. Bens, M. Lotz, J.-M. Goujon, S. Vimont, G. Arlet, A. Hertig, E. Rondeau, and A. Vandewalle (2007)
J. Exp. Med.
204, 2837-2852
| Abstract »
| Full Text »
| PDF »
- Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network: Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction.
- L.-Y. Tang, N. Deng, L.-S. Wang, J. Dai, Z.-L. Wang, X.-S. Jiang, S.-J. Li, L. Li, Q.-H. Sheng, D.-Q. Wu, et al. (2007)
Mol. Cell. Proteomics
6, 1952-1967
| Abstract »
| Full Text »
| PDF »
- Id-1 activation of PI3K/Akt/NF{kappa}B signaling pathway and its significance in promoting survival of esophageal cancer cells.
- B. Li, P. Y. Cheung, X. Wang, S. W. Tsao, M. T. Ling, Y. C. Wong, and A. L.M. Cheung (2007)
Carcinogenesis
28, 2313-2320
| Abstract »
| Full Text »
| PDF »
- Cardioprotection Afforded by Inducible Nitric Oxide Synthase Gene Therapy Is Mediated by Cyclooxygenase-2 via a Nuclear Factor-{kappa}B Dependent Pathway.
- Q. Li, Y. Guo, W. Tan, Q. Ou, W.-J. Wu, D. Sturza, B. Dawn, G. Hunt, C. Cui, and R. Bolli (2007)
Circulation
116, 1577-1584
| Abstract »
| Full Text »
| PDF »
- Surfactant Protein A Activation of Atypical Protein Kinase C {zeta} in I{kappa}B-{alpha}-Dependent Anti-Inflammatory Immune Regulation.
- C. Moulakakis, S. Adam, U. Seitzer, A. B. Schromm, M. Leitges, and C. Stamme (2007)
J. Immunol.
179, 4480-4491
| Abstract »
| Full Text »
| PDF »
- Doxorubicin Enhances the Expression of Transgene Under Control of the CMV Promoter in Anaplastic Thyroid Carcinoma Cells.
- K. I. Kim, J. H. Kang, J.-K. Chung, Y. J. Lee, J. M. Jeong, D. S. Lee, and M. C. Lee (2007)
J. Nucl. Med.
48, 1553-1561
| Abstract »
| Full Text »
| PDF »
- Dual Role of Mitochondrial Reactive Oxygen Species in Hypoxia Signaling: Activation of Nuclear Factor-{kappa}B via c-SRC and Oxidant-Dependent Cell Death.
- J. M. Lluis, F. Buricchi, P. Chiarugi, A. Morales, and J. C. Fernandez-Checa (2007)
Cancer Res.
67, 7368-7377
| Abstract »
| Full Text »
| PDF »
- The differential expression of corticosteroid receptor isoforms in corticosteroid-resistant and -sensitive patients with rheumatoid arthritis.
- D. L. Kozaci, Y. Chernajovsky, and I. C. Chikanza (2007)
Rheumatology
46, 579-585
| Abstract »
| Full Text »
| PDF »
- Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells.
- A. Dutton, C. B. Woodman, M. B. Chukwuma, J. I. K. Last, W. Wei, M. Vockerodt, K. R. N. Baumforth, J. R. Flavell, M. Rowe, A. M. R. Taylor, et al. (2007)
Blood
109, 2597-2603
| Abstract »
| Full Text »
| PDF »
- Keratinocyte Growth Factor/Fibroblast Growth Factor-7-regulated Cell Migration and Invasion through Activation of NF-{kappa}B Transcription Factors.
- J. Niu, Z. Chang, B. Peng, Q. Xia, W. Lu, P. Huang, M.-S. Tsao, and P. J. Chiao (2007)
J. Biol. Chem.
282, 6001-6011
| Abstract »
| Full Text »
| PDF »
- A Novel Ankyrin-Repeat Membrane Protein, IGN1, Is Required for Persistence of Nitrogen-Fixing Symbiosis in Root Nodules of Lotus japonicus.
- H. Kumagai, T. Hakoyama, Y. Umehara, S. Sato, T. Kaneko, S. Tabata, and H. Kouchi (2007)
Plant Physiology
143, 1293-1305
| Abstract »
| Full Text »
| PDF »
- mda-9/Syntenin Regulates the Metastatic Phenotype in Human Melanoma Cells by Activating Nuclear Factor-{kappa}B.
- H. Boukerche, Z.-z. Su, L. Emdad, D. Sarkar, and P. B. Fisher (2007)
Cancer Res.
67, 1812-1822
| Abstract »
| Full Text »
| PDF »
- I{kappa}B Kinase Subunits {alpha} and {gamma} Are Required for Activation of NF-{kappa}B and Induction of Apoptosis by Mammalian Reovirus.
- M. W. Hansberger, J. A. Campbell, P. Danthi, P. Arrate, K. N. Pennington, K. B. Marcu, D. W. Ballard, and T. S. Dermody (2007)
J. Virol.
81, 1360-1371
| Abstract »
| Full Text »
| PDF »
- cis-9,trans-11-Conjugated linoleic acid down-regulates phorbol ester-induced NF-{kappa}B activation and subsequent COX-2 expression in hairless mouse skin by targeting I{kappa}B kinase and PI3K-Akt.
- D.-M. Hwang, J. K. Kundu, J.-W. Shin, J.-C. Lee, H. J. Lee, and Y.-J. Surh (2007)
Carcinogenesis
28, 363-371
| Abstract »
| Full Text »
| PDF »
- Sustained activation of protein kinase C downregulates nuclear factor-{kappa}B signaling by dissociation of IKK-{gamma} and Hsp90 complex in human colonic epithelial cells.
- K. A. Park, H. S. Byun, M. Won, K.-J. Yang, S. Shin, L. Piao, J. M. Kim, W.-H. Yoon, E. Junn, J. Park, et al. (2007)
Carcinogenesis
28, 71-80
| Abstract »
| Full Text »
| PDF »
- Down Syndrome Candidate Region 1 Increases the Stability of the I{kappa}B{alpha} Protein: IMPLICATIONS FOR ITS ANTI-INFLAMMATORY EFFECTS.
- Y. S. Kim, K.-O. Cho, H. J. Lee, S. Y. Kim, Y. Sato, and Y.-J. Cho (2006)
J. Biol. Chem.
281, 39051-39061
| Abstract »
| Full Text »
| PDF »
- Regions of I{kappa}B{alpha} that are critical for its inhibition of NF-{kappa}B{middle dot}DNA interaction fold upon binding to NF-{kappa}B.
- S. M. E. Truhlar, J. W. Torpey, and E. A. Komives (2006)
PNAS
103, 18951-18956
| Abstract »
| Full Text »
| PDF »
- Transglutaminase 2 Mediates Polymer Formation of I-{kappa}B{alpha} through C-terminal Glutamine Cluster.
- S.-S. Park, J.-M. Kim, D.-S. Kim, I.-H. Kim, and S.-Y. Kim (2006)
J. Biol. Chem.
281, 34965-34972
| Abstract »
| Full Text »
| PDF »
- Regulation and Function of IKK and IKK-Related Kinases.
- H. Hacker and M. Karin (2006)
Sci. STKE
2006, re13
| Abstract »
| Full Text »
| PDF »
- NF-{kappa}B/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity..
- A. O'Mahony, J. Raber, M. Montano, E. Foehr, V. Han, S.-m. Lu, H. Kwon, A. LeFevour, S. Chakraborty-Sett, and W. C. Greene (2006)
Mol. Cell. Biol.
26, 7283-7298
| Abstract »
| Full Text »
| PDF »
- Mullerian Inhibiting Substance Regulates Androgen-Induced Gene Expression and Growth in Prostate Cancer Cells through a Nuclear Factor-{kappa}B-Dependent Smad-Independent Mechanism.
- T. T. Tran, D. L. Segev, V. Gupta, H. Kawakubo, G. Yeo, P. K. Donahoe, and S. Maheswaran (2006)
Mol. Endocrinol.
20, 2382-2391
| Abstract »
| Full Text »
| PDF »
- Renal Collecting Duct Epithelial Cells React to Pyelonephritis-Associated Escherichia coli by Activating Distinct TLR4-Dependent and -Independent Inflammatory Pathways.
- C. Chassin, J.-M. Goujon, S. Darche, L. du Merle, M. Bens, F. Cluzeaud, C. Werts, E. Ogier-Denis, C. Le Bouguenec, D. Buzoni-Gatel, et al. (2006)
J. Immunol.
177, 4773-4784
| Abstract »
| Full Text »
| PDF »
- ABIN-1 Binds to NEMO/IKK{gamma} and Co-operates with A20 in Inhibiting NF-{kappa}B.
- C. Mauro, F. Pacifico, A. Lavorgna, S. Mellone, A. Iannetti, R. Acquaviva, S. Formisano, P. Vito, and A. Leonardi (2006)
J. Biol. Chem.
281, 18482-18488
| Abstract »
| Full Text »
| PDF »
- Variant IRAK-1 Haplotype Is Associated with Increased Nuclear Factor-{kappa}B Activation and Worse Outcomes in Sepsis.
- J. Arcaroli, E. Silva, J. P. Maloney, Q. He, D. Svetkauskaite, J. R. Murphy, and E. Abraham (2006)
Am. J. Respir. Crit. Care Med.
173, 1335-1341
| Abstract »
| Full Text »
| PDF »
- The ubiquitin-proteasome system: Focus on the heart.
- O. Zolk, C. Schenke, and A. Sarikas (2006)
Cardiovasc Res
70, 410-421
| Abstract »
| Full Text »
| PDF »
- An Alternative Splice Product of I{kappa}B Kinase (IKK{gamma}), IKK{gamma}-{Delta}, Differentially Mediates Cytokine and Human T-Cell Leukemia Virus Type 1 Tax-Induced NF-{kappa}B Activation.
- T. Hai, M.-L. Yeung, T. G. Wood, Y. Wei, S. Yamaoka, Z. Gatalica, K.-T. Jeang, and A. R. Brasier (2006)
J. Virol.
80, 4227-4241
| Abstract »
| Full Text »
| PDF »
- Nonstructural protein of infectious bursal disease virus inhibits apoptosis at the early stage of virus infection..
- M. Liu and V. N. Vakharia (2006)
J. Virol.
80, 3369-3377
| Abstract »
| Full Text »
| PDF »
- Spermatogonial Cell-Mediated Activation of an I{kappa}B{zeta}-Independent Nuclear Factor-{kappa}B Pathway in Sertoli Cells Induces Transcription of the Lipocalin-2 Gene.
- R.-S. Fujino, K. Tanaka, M. Morimatsu, K. Tamura, H. Kogo, and T. Hara (2006)
Mol. Endocrinol.
20, 904-915
| Abstract »
| Full Text »
| PDF »
- A Novel NF-{kappa}B Binding Site Controls Human Granzyme B Gene Transcription.
- C. Huang, E. Bi, Y. Hu, W. Deng, Z. Tian, C. Dong, Y. Hu, and B. Sun (2006)
J. Immunol.
176, 4173-4181
| Abstract »
| Full Text »
| PDF »
- Conditional and specific NF-{kappa}B blockade protects pancreatic beta cells from diabetogenic agents.
- R. Eldor, A. Yeffet, K. Baum, V. Doviner, D. Amar, Y. Ben-Neriah, G. Christofori, A. Peled, J. C. Carel, C. Boitard, et al. (2006)
PNAS
103, 5072-5077
| Abstract »
| Full Text »
| PDF »
- 7,12-Dimethylbenz(a)Anthracene Treatment of a c-rel Mouse Mammary Tumor Cell Line Induces Epithelial to Mesenchymal Transition via Activation of Nuclear Factor-{kappa}B..
- S. R. Shin, N. Sanchez-Velar, D. H. Sherr, and G. E. Sonenshein (2006)
Cancer Res.
66, 2570-2575
| Abstract »
| Full Text »
| PDF »
- Activation of the Nuclear Factor {kappa}B Pathway by Astrocyte Elevated Gene-1: Implications for Tumor Progression and Metastasis.
- L. Emdad, D. Sarkar, Z.-z. Su, A. Randolph, H. Boukerche, K. Valerie, and P. B. Fisher (2006)
Cancer Res.
66, 1509-1516
| Abstract »
| Full Text »
| PDF »
- 3-Phosphoinositide-dependent Protein Kinase-1-mediated I{kappa}B Kinase {beta} (IKKB) Phosphorylation Activates NF-{kappa}B Signaling.
- H. Tanaka, N. Fujita, and T. Tsuruo (2005)
J. Biol. Chem.
280, 40965-40973
| Abstract »
| Full Text »
| PDF »
- SIRT1 Protects against Microglia-dependent Amyloid-{beta} Toxicity through Inhibiting NF-{kappa}B Signaling.
- J. Chen, Y. Zhou, S. Mueller-Steiner, L.-F. Chen, H. Kwon, S. Yi, L. Mucke, and L. Gan (2005)
J. Biol. Chem.
280, 40364-40374
| Abstract »
| Full Text »
| PDF »
- RelB/p52 NF-{kappa}B Complexes Rescue an Early Delay in Mammary Gland Development in Transgenic Mice with Targeted Superrepressor I{kappa}B-{alpha} Expression and Promote Carcinogenesis of the Mammary Gland.
- E. G. Demicco, K. T. Kavanagh, R. Romieu-Mourez, X. Wang, S. R. Shin, E. Landesman-Bollag, D. C. Seldin, and G. E. Sonenshein (2005)
Mol. Cell. Biol.
25, 10136-10147
| Abstract »
| Full Text »
| PDF »
- Dual Pathways for Nuclear Factor {kappa}B Activation by Angiotensin II in Vascular Smooth Muscle: Phosphorylation of p65 by I{kappa}B Kinase and Ribosomal Kinase.
- L. Zhang, J. Cheng, Y. Ma, W. Thomas, J. Zhang, and J. Du (2005)
Circ. Res.
97, 975-982
| Abstract »
| Full Text »
| PDF »
- Identifying Components of the NF-{kappa}B Pathway in the Beneficial Euprymna scolopes-Vibrio fischeri Light Organ Symbiosis.
- M. S. Goodson, M. Kojadinovic, J. V. Troll, T. E. Scheetz, T. L. Casavant, M. B. Soares, and M. J. McFall-Ngai (2005)
Appl. Envir. Microbiol.
71, 6934-6946
| Abstract »
| Full Text »
| PDF »
- Up-regulation of CXCR4 Expression in PC-3 Cells by Stromal-Derived Factor-1{alpha} (CXCL12) Increases Endothelial Adhesion and Transendothelial Migration: Role of MEK/ERK Signaling Pathway-Dependent NF-{kappa}B Activation.
- P. Kukreja, A. B. Abdel-Mageed, D. Mondal, K. Liu, and K. C. Agrawal (2005)
Cancer Res.
65, 9891-9898
| Abstract »
| Full Text »
| PDF »
- Phosphorylation of {beta}-Catenin by Cyclic AMP-Dependent Protein Kinase Stabilizes {beta}-Catenin through Inhibition of Its Ubiquitination.
- S.-i. Hino, C. Tanji, K. I. Nakayama, and A. Kikuchi (2005)
Mol. Cell. Biol.
25, 9063-9072
| Abstract »
| Full Text »
| PDF »
- NF-{kappa}B activation in Kupffer cells after partial hepatectomy.
- L. Yang, S. T. Magness, R. Bataller, R. A. Rippe, and D. A. Brenner (2005)
Am J Physiol Gastrointest Liver Physiol
289, G530-G538
| Abstract »
| Full Text »
| PDF »
- Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1{alpha}.
- D. A. Chan, P. D. Sutphin, S.-E. Yen, and A. J. Giaccia (2005)
Mol. Cell. Biol.
25, 6415-6426
| Abstract »
| Full Text »
| PDF »
- Prevention of Cancer Cachexia by a Novel Nuclear Factor {kappa}B Inhibitor in Prostate Cancer.
- K. Kuroda, Y. Horiguchi, J. Nakashima, E. Kikuchi, K. Kanao, A. Miyajima, T. Ohigashi, K. Umezawa, and M. Murai (2005)
Clin. Cancer Res.
11, 5590-5594
| Abstract »
| Full Text »
| PDF »
- Polyamine Depletion Reduces TNF{alpha}/MG132-Induced Apoptosis in Bone Marrow Stromal Cells.
- C. Muscari, F. Bonafe, I. Stanic, F. Flamigni, C. Stefanelli, G. Farruggia, C. Guarnieri, and C. M. Caldarera (2005)
Stem Cells
23, 983-991
| Abstract »
| Full Text »
| PDF »
- Bruton's Tyrosine Kinase Is Involved in p65-mediated Transactivation and Phosphorylation of p65 on Serine 536 during NF{kappa}B Activation by Lipopolysaccharide.
- S. L. Doyle, C. A. Jefferies, and L. A. O'Neill (2005)
J. Biol. Chem.
280, 23496-23501
| Abstract »
| Full Text »
| PDF »
- Breast Cancer Metastasis Suppressor 1 Inhibits Gene Expression by Targeting Nuclear Factor-{kappa}B Activity.
- M. Cicek, R. Fukuyama, D. R. Welch, N. Sizemore, and G. Casey (2005)
Cancer Res.
65, 3586-3595
| Abstract »
| Full Text »
| PDF »
- Inhibition of Mammalian Target of Rapamycin Potentiates Thrombin-Induced Intercellular Adhesion Molecule-1 Expression by Accelerating and Stabilizing NF-{kappa}B Activation in Endothelial Cells.
- M. Minhajuddin, F. Fazal, K. M. Bijli, Md. R. Amin, and A. Rahman (2005)
J. Immunol.
174, 5823-5829
| Abstract »
| Full Text »
| PDF »
- Secretion of the Human T Cell Leukemia Virus Type I Transactivator Protein Tax.
- T. Alefantis, K. Mostoller, P. Jain, E. Harhaj, C. Grant, and B. Wigdahl (2005)
J. Biol. Chem.
280, 17353-17362
| Abstract »
| Full Text »
| PDF »
- Nuclear Factor-{kappa}B-Dependent Mechanisms in Breast Cancer Cells Regulate Tumor Burden and Osteolysis in Bone.
- A. H. Gordon, R. J. O'Keefe, E. M. Schwarz, R. N. Rosier, and J. E. Puzas (2005)
Cancer Res.
65, 3209-3217
| Abstract »
| Full Text »
| PDF »
- Role for the Nuclear Factor {kappa}B Pathway in Transforming Growth Factor-{beta}1 Production in Idiopathic Myelofibrosis: Possible Relationship with FK506 Binding Protein 51 Overexpression.
- E. Komura, C. Tonetti, V. Penard-Lacronique, H. Chagraoui, C. Lacout, J. P. LeCouedic, P. Rameau, N. Debili, W. Vainchenker, and S. Giraudier (2005)
Cancer Res.
65, 3281-3289
| Abstract »
| Full Text »
| PDF »
- Direct Effects of Polymyxin B on Human Dendritic Cells Maturation: THE ROLE OF I{kappa}B-{alpha}/NF-{kappa}B AND ERK1/2 PATHWAYS AND ADHESION.
- B. Valentinis, A. Bianchi, D. Zhou, A. Cipponi, F. Catalanotti, V. Russo, and C. Traversari (2005)
J. Biol. Chem.
280, 14264-14271
| Abstract »
| Full Text »
| PDF »
- MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-{kappa}B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells.
- L. Ho, R. E. Davis, B. Conne, R. Chappuis, M. Berczy, P. Mhawech, L. M. Staudt, and J. Schwaller (2005)
Blood
105, 2891-2899
| Abstract »
| Full Text »
| PDF »
- Identification of Target Genes Involved in the Antiproliferative Effect of Glucocorticoids Reveals a Role for Nuclear Factor-{kappa}B Repression.
- L.-G. Bladh, J. Liden, A. Pazirandeh, I. Rafter, K. Dahlman-Wright, S. Nilsson, and S. Okret (2005)
Mol. Endocrinol.
19, 632-643
| Abstract »
| Full Text »
| PDF »
- NF-{kappa}B activation can mediate inhibition of human cytomegalovirus replication.
- J. E. Eickhoff and M. Cotten (2005)
J. Gen. Virol.
86, 285-295
| Abstract »
| Full Text »
| PDF »
- Antiapoptotic Effect of Serum and Glucocorticoid-Inducible Protein Kinase Is Mediated by Novel Mechanism Activating I{kappa}B Kinase.
- L. Zhang, R. Cui, X. Cheng, and J. Du (2005)
Cancer Res.
65, 457-464
| Abstract »
| Full Text »
| PDF »
- Antisense Suppression of the Chloride Intracellular Channel Family Induces Apoptosis, Enhances Tumor Necrosis Factor {alpha}-Induced Apoptosis, and Inhibits Tumor Growth.
- K. S. Suh, M. Mutoh, M. Gerdes, J. M. Crutchley, T. Mutoh, L. E. Edwards, R. A. Dumont, P. Sodha, C. Cheng, A. Glick,, et al. (2005)
Cancer Res.
65, 562-571
| Abstract »
| Full Text »
| PDF »
- Induction of the RelB NF-{kappa}B Subunit by the Cytomegalovirus IE1 Protein Is Mediated via Jun Kinase and c-Jun/Fra-2 AP-1 Complexes.
- X. Wang and G. E. Sonenshein (2005)
J. Virol.
79, 95-105
| Abstract »
| Full Text »
| PDF »
- Inhibition of Nuclear Translocation of Nuclear Factor-{kappa}B Contributes to 3,3'-Diindolylmethane-Induced Apoptosis in Breast Cancer Cells.
- K. W. Rahman and F. H. Sarkar (2005)
Cancer Res.
65, 364-371
| Abstract »
| Full Text »
| PDF »
- Nuclear Factor-{kappa}B Activity in {beta}-Cells Is Required for Glucose-Stimulated Insulin Secretion.
- S. Norlin, U. Ahlgren, and H. Edlund (2005)
Diabetes
54, 125-132
| Abstract »
| Full Text »
| PDF »
- Oncogenic and Anti-apoptotic Activity of NF-{kappa}B in Human Thyroid Carcinomas.
- F. Pacifico, C. Mauro, C. Barone, E. Crescenzi, S. Mellone, M. Monaco, G. Chiappetta, G. Terrazzano, D. Liguoro, P. Vito, et al. (2004)
J. Biol. Chem.
279, 54610-54619
| Abstract »
| Full Text »
| PDF »
- T-cell Activation Leads to Poor Activation of the HIV-1 Clade E Long Terminal Repeat and Weak Association of Nuclear Factor-{kappa}B and NFAT with Its Enhancer Region.
- A.-M. Lemieux, M.-E. Pare, B. Audet, E. Legault, S. Lefort, N. Boucher, S. Landry, T. van Opijnen, B. Berkhout, M. H. Naghavi, et al. (2004)
J. Biol. Chem.
279, 52949-52960
| Abstract »
| Full Text »
| PDF »
- The Viral Protein A238L Inhibits Cyclooxygenase-2 Expression through a Nuclear Factor of Activated T Cell-dependent Transactivation Pathway.
- A. G. Granja, M. L. Nogal, C. Hurtado, V. Vila, A. L. Carrascosa, M. L. Salas, M. Fresno, and Y. Revilla (2004)
J. Biol. Chem.
279, 53736-53746
| Abstract »
| Full Text »
| PDF »
- Accumulation of Inhibitory {kappa}B-{alpha} as a Mechanism Contributing to the Anti-Inflammatory Effects of Surfactant Protein-A.
- Y. Wu, S. Adam, L. Hamann, H. Heine, A. J. Ulmer, U. Buwitt-Beckmann, and C. Stamme (2004)
Am. J. Respir. Cell Mol. Biol.
31, 587-594
| Abstract »
| Full Text »
| PDF »
- RhoA/Rho-Associated Kinase Pathway Selectively Regulates Thrombin-Induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells via Activation of I{kappa}B Kinase {beta} and Phosphorylation of RelA/p65.
- K. N. Anwar, F. Fazal, A. B. Malik, and A. Rahman (2004)
J. Immunol.
173, 6965-6972
| Abstract »
| Full Text »
| PDF »
- Recruitment of I{kappa}B{alpha} to the hes1 promoter is associated with transcriptional repression.
- C. Aguilera, R. Hoya-Arias, G. Haegeman, L. Espinosa, and A. Bigas (2004)
PNAS
101, 16537-16542
| Abstract »
| Full Text »
| PDF »
- cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-{kappa}B activation and ICAM-1 expression in endothelial cells.
- A. Rahman, K. N. Anwar, Mohd. Minhajuddin, K. M. Bijli, K. Javaid, A. L. True, and A. B. Malik (2004)
Am J Physiol Lung Cell Mol Physiol
287, L1017-L1024
| Abstract »
| Full Text »
| PDF »
- HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells.
- R. Kroismayr, U. Baranyi, C. Stehlik, A. Dorfleutner, B. R. Binder, and J. Lipp (2004)
J. Cell Sci.
117, 4749-4756
| Abstract »
| Full Text »
| PDF »
- NF-{kappa}B and AP-1 Connection: Mechanism of NF-{kappa}B-Dependent Regulation of AP-1 Activity.
- S. Fujioka, J. Niu, C. Schmidt, G. M. Sclabas, B. Peng, T. Uwagawa, Z. Li, D. B. Evans, J. L. Abbruzzese, and P. J. Chiao (2004)
Mol. Cell. Biol.
24, 7806-7819
| Abstract »
| Full Text »
| PDF »
- Myocyte hypertrophy and apoptosis: a balancing act.
- V. P.M van Empel and L. J De Windt (2004)
Cardiovasc Res
63, 487-499
| Abstract »
| Full Text »
| PDF »
- Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants.
- S. Mitra-Kaushik, J. C. Harding, J. L. Hess, and L. Ratner (2004)
Blood
104, 802-809
| Abstract »
| Full Text »
| PDF »
- Transcriptional Mechanisms Regulating Alveolar Epithelial Cell-specific CCL5 Secretion in Pulmonary Tuberculosis.
- M. I. Wickremasinghe, L. H. Thomas, C. M. O'Kane, J. Uddin, and J. S. Friedland (2004)
J. Biol. Chem.
279, 27199-27210
| Abstract »
| Full Text »
| PDF »
- NF-{kappa}B Activation by the Chemopreventive Dithiolethione Oltipraz Is Exerted through Stimulation of MEKK3 Signaling.
- C. W. Nho and P. J. O'Dwyer (2004)
J. Biol. Chem.
279, 26019-26027
| Abstract »
| Full Text »
| PDF »
- p53 Induces NF-{kappa}B Activation by an I{kappa}B Kinase-independent Mechanism Involving Phosphorylation of p65 by Ribosomal S6 Kinase 1.
- J. Bohuslav, L.-f. Chen, H. Kwon, Y. Mu, and W. C. Greene (2004)
J. Biol. Chem.
279, 26115-26125
| Abstract »
| Full Text »
| PDF »
- {beta}-Arrestin inhibits NF-{kappa}B activity by means of its interaction with the NF-{kappa}B inhibitor I{kappa}B{alpha}.
- D. S. Witherow, T. R. Garrison, W. E. Miller, and R. J. Lefkowitz (2004)
PNAS
101, 8603-8607
| Abstract »
| Full Text »
| PDF »
- Activation of the NF-{kappa}B Pathway in Human Cytomegalovirus-Infected Cells Is Necessary for Efficient Transactivation of the Major Immediate-Early Promoter.
- I. B. DeMeritt, L. E. Milford, and A. D. Yurochko (2004)
J. Virol.
78, 4498-4507
| Abstract »
| Full Text »
| PDF »
- Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-{kappa}B Requires I{kappa}B Kinase-1-mediated Phosphorylation of RelA/p65.
- A. M. O'Mahony, M. Montano, K. Van Beneden, L.-F. Chen, and W. C. Greene (2004)
J. Biol. Chem.
279, 18137-18145
| Abstract »
| Full Text »
| PDF »
- Identification of an Autoregulatory Feedback Pathway Involving Interleukin-1{alpha} in Induction of Constitutive NF-{kappa}B Activation in Pancreatic Cancer Cells.
- J. Niu, Z. Li, B. Peng, and P. J. Chiao (2004)
J. Biol. Chem.
279, 16452-16462
| Abstract »
| Full Text »
| PDF »
|
|