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Science 10 March 1995:
Vol. 267. no. 5203, pp. 1456 - 1462
DOI: 10.1126/science.7878464

Articles

Science, Vol 267, Issue 5203, 1456-1462
Copyright © 1995 by American Association for the Advancement of Science


articles

Apoptosis in the pathogenesis and treatment of disease

CB Thompson

Howard Hughes Medical Institute, Department of Medicine, Chicago, IL 60637.

In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death. Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily through an evolutionarily conserved form of cell suicide termed apoptosis. The decision of a cell to undergo apoptosis can be influenced by a wide variety of regulatory stimuli. Recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of some of these diseases.


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Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster.
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A. Weigert, A. M. Johann, A. von Knethen, H. Schmidt, G. Geisslinger, and B. Brune (2006)
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Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis.
O. Yasuda, K. Fukuo, X. Sun, M. Nishitani, T. Yotsui, M. Higuchi, T. Suzuki, H. Rakugi, O. Smithies, N. Maeda, et al. (2006)
J. Biol. Chem. 281, 23899-23907
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Environmental Tobacco Smoke Suppresses Nuclear Factor-{kappa}B Signaling to Increase Apoptosis in Infant Monkey Lungs.
C.-Y. Zhong, Y. M. Zhou, J. P. Joad, and K. E. Pinkerton (2006)
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S. S. Lin, M. C. Bassik, H. Suh, M. Nishino, J. D. Arroyo, W. C. Hahn, S. J. Korsmeyer, and T. M. Roberts (2006)
J. Biol. Chem. 281, 23003-23012
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R. Shao, B. Weijdegard, K. Ljungstrom, A. Friberg, C. Zhu, X. Wang, Y. Zhu, J. Fernandez-Rodriguez, E. Egecioglu, E. Rung, et al. (2006)
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Invest. Ophthalmol. Vis. Sci. 47, 2172-2178
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Quantification of Macrophage Viability and Inflammatory Response to Dental Bonding Resins.
L. O. Bailey, M. D. Weir, and N. R. Washburn (2006)
Journal of Bioactive and Compatible Polymers 21, 185-206
   Abstract »    PDF »
Platelet-Activating Factor Induces Up-regulation of Antiapoptotic Factors in a Melanoma Cell Line through Nuclear Factor-{kappa}B Activation..
K. Heon Seo, H.-M. Ko, H.-A Kim, J.-H. Choi, S. Jun Park, K.-J. Kim, H.-K. Lee, and S.-Y. Im (2006)
Cancer Res. 66, 4681-4686
   Abstract »    Full Text »    PDF »
RNA Aptamers Targeting the Cell Death Inhibitor CED-9 Induce Cell Killing in Caenorhabditis elegans.
C. Yang, N. Yan, J. Parish, X. Wang, Y. Shi, and D. Xue (2006)
J. Biol. Chem. 281, 9137-9144
   Abstract »    Full Text »    PDF »
The Affinity of a Major Ca2+ Binding Site on GRP78 Is Differentially Enhanced by ADP and ATP.
H. K. Lamb, C. Mee, W. Xu, L. Liu, S. Blond, A. Cooper, I. G. Charles, and A. R. Hawkins (2006)
J. Biol. Chem. 281, 8796-8805
   Abstract »    Full Text »    PDF »
From the Cover: Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans..
W.-H. Liu, Y.-L. Lin, J.-P. Wang, W. Liou, R. F. Hou, Y.-C. Wu, and C.-L. Liao (2006)
PNAS 103, 4174-4179
   Abstract »    Full Text »    PDF »
AIFsh, a Novel Apoptosis-inducing Factor (AIF) Pro-apoptotic Isoform with Potential Pathological Relevance in Human Cancer.
C. Delettre, V. J. Yuste, R. S. Moubarak, M. Bras, J.-C. Lesbordes-Brion, S. Petres, J. Bellalou, and S. A. Susin (2006)
J. Biol. Chem. 281, 6413-6427
   Abstract »    Full Text »    PDF »
The proteasome is required for rapid initiation of death receptor-induced apoptosis..
D. Sohn, G. Totzke, F. Essmann, K. Schulze-Osthoff, B. Levkau, and R. U. Janicke (2006)
Mol. Cell. Biol. 26, 1967-1978
   Abstract »    Full Text »    PDF »
Sex hormones and the genesis of autoimmunity..
L. S. Ackerman (2006)
Arch Dermatol 142, 371-376
   Abstract »    Full Text »    PDF »
Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
F.-Y. Li, P. D. Jeffrey, J. W. Yu, and Y. Shi (2006)
J. Biol. Chem. 281, 2960-2968
   Abstract »    Full Text »    PDF »
Identification of a Lipid Peroxidation Product as a Potential Trigger of the p53 Pathway.
T. Shibata, K. Iio, Y. Kawai, N. Shibata, M. Kawaguchi, S. Toi, M. Kobayashi, M. Kobayashi, K. Yamamoto, and K. Uchida (2006)
J. Biol. Chem. 281, 1196-1204
   Abstract »    Full Text »    PDF »
Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging.
A. P. N. Majumdar and J. Du (2006)
Am J Physiol Gastrointest Liver Physiol 290, G49-G55
   Abstract »    Full Text »    PDF »
Regulation of Caspase 9 through Phosphorylation by Protein Kinase C Zeta in Response to Hyperosmotic Stress.
S. C. Brady, L. A. Allan, and P. R. Clarke (2005)
Mol. Cell. Biol. 25, 10543-10555
   Abstract »    Full Text »    PDF »
Neonatal Brain Protection and Deep Hypothermic Circulatory Arrest: Pathophysiology of Ischemic Neuronal Injury and Protective Strategies.
G. Amir, C. Ramamoorthy, R. K. Riemer, V. M. Reddy, and F. L. Hanley (2005)
Ann. Thorac. Surg. 80, 1955-1964
   Abstract »    Full Text »    PDF »
Developmentally Regulated Expression of Sp1 in the Mouse Cornea.
H. Nakamura, J. Ueda, J. Sugar, and B. Y. J. T. Yue (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4092-4096
   Abstract »    Full Text »    PDF »
Apoptotic Stress Is Counterbalanced by Survival Elements Preventing Programmed Cell Death of Dorsal Root Ganglions in Subacute Type 1 Diabetic BB/Wor Rats.
H. Kamiya, W. Zhangm, and A. A.F. Sima (2005)
Diabetes 54, 3288-3295
   Abstract »    Full Text »    PDF »
Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).
E. M. Jung, J. H. Lim, T. J. Lee, J.-W. Park, K. S. Choi, and T. K. Kwon (2005)
Carcinogenesis 26, 1905-1913
   Abstract »    Full Text »    PDF »
CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5.
E. C. Dietze, M. L. Bowie, K. Mrozek, L. E. Caldwell, C. Neal, R. J. Marjoram, M. M. Troch, G. R. Bean, K. K. Yokoyama, C. A. Ibarra, et al. (2005)
J. Cell Sci. 118, 5005-5022
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