Related Content
Search Google Scholar for:
|
|
Science 10 March 1995: Vol. 267. no. 5203, pp. 1456 - 1462 DOI: 10.1126/science.7878464
|
|
Articles
Science, Vol 267, Issue 5203, 1456-1462
Copyright © 1995 by American Association for the Advancement of Science
Apoptosis in the pathogenesis and treatment of disease
CB Thompson
Howard Hughes Medical Institute, Department of Medicine, Chicago, IL 60637.
In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death. Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily through an evolutionarily conserved form of cell suicide termed apoptosis. The decision of a cell to undergo apoptosis can be influenced by a wide variety of regulatory stimuli. Recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of some of these diseases.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma.
- C. Gao and A.-Y. Wang (2009)
J. Histochem. Cytochem.
57, 1139-1148
| Abstract »
| Full Text »
| PDF »
- Evaluation of Cell Surface Expression of Phosphatidylserine in Ovarian Carcinoma Effusions Using the Annexin-V/7-AAD Assay: Clinical Relevance and Comparison With Other Apoptosis Parameters.
- H. P. Dong, A. Holth, L. Kleinberg, M. G. Ruud, M. B. Elstrand, C. G. Trope, B. Davidson, and B. Risberg (2009)
Am J Clin Pathol
132, 756-762
| Abstract »
| Full Text »
| PDF »
- Cell Death.
- R. S. Hotchkiss, A. Strasser, J. E. McDunn, and P. E. Swanson (2009)
N. Engl. J. Med.
361, 1570-1583
| Full Text »
| PDF »
- Kazrin F is involved in apoptosis and interacts with BAX and ARC.
- Q. Wang, M. Liu, X. Li, L. Chen, and H. Tang (2009)
Acta Biochim Biophys Sin
41, 763-772
| Abstract »
| Full Text »
| PDF »
- The VDAC2-BAK Rheostat Controls Thymocyte Survival.
- D. Ren, H. Kim, H.-C. Tu, T. D. Westergard, J. K. Fisher, J. A. Rubens, S. J. Korsmeyer, J. J.-D. Hsieh, and E. H.-Y. Cheng (2009)
Science Signaling
2, ra48
| Abstract »
| Full Text »
| PDF »
- Induction of Mitotic Arrest and Apoptosis by a Novel Synthetic Quinolone Analogue, CWC-8, via Intrinsic and Extrinsic Apoptotic Pathways in Human Osteogenic Sarcoma U-2 OS cells.
- Y.-H. CHANG, J.-S. YANG, S.-C. KUO, and J.-G. CHUNG (2009)
Anticancer Res
29, 3139-3148
| Abstract »
| Full Text »
| PDF »
- Polymorphisms and Haplotypes in the Caspase-3, Caspase-7, and Caspase-8 Genes and Risk for Endometrial Cancer: A Population-Based, Case-Control Study in a Chinese Population.
- H.-L. Xu, W.-H. Xu, Q. Cai, M. Feng, J. Long, W. Zheng, Y.-B. Xiang, and X.-O. Shu (2009)
Cancer Epidemiol. Biomarkers Prev.
18, 2114-2122
| Abstract »
| Full Text »
| PDF »
- Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium..
- Y.-H. Choi, D. B. Cowan, A. M. Moran, S. D. Colan, C. Stamm, K. Takeuchi, I. Friehs, P. J. del Nido, and F. X. McGowan Jr. (2009)
J. Thorac. Cardiovasc. Surg.
137, 1356-1362.e3
| Abstract »
| Full Text »
| PDF »
- The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.
- S. Abu-Hamad, N. Arbel, D. Calo, L. Arzoine, A. Israelson, N. Keinan, R. Ben-Romano, O. Friedman, and V. Shoshan-Barmatz (2009)
J. Cell Sci.
122, 1906-1916
| Abstract »
| Full Text »
| PDF »
- Chemopreventive Effect of 4-[3,5-Bis(trimethylsilyl) benzamido] Benzoic Acid (TAC-101) on MNU-induced Colon Carcinogenesis in a Rat Model.
- Y. NAKAYAMA, Y. INOUE, N. MINAGAWA, K. ONITSUKA, J. NAGATA, K. SHIBAO, K. HIRATA, T. SAKO, N. NAGATA, and K. YAMAGUCHI (2009)
Anticancer Res
29, 2059-2065
| Abstract »
| Full Text »
| PDF »
- Thiacremonone Augments Chemotherapeutic Agent-Induced Growth Inhibition in Human Colon Cancer Cells through Inactivation of Nuclear Factor-{kappa}B.
- J. O. Ban, H. S. Lee, H.-S. Jeong, S. Song, B. Y. Hwang, D. C. Moon, D. Y. Yoon, S. B. Han, and J. T. Hong (2009)
Mol. Cancer Res.
7, 870-879
| Abstract »
| Full Text »
| PDF »
- Identification of Flightless-I as a Substrate of the Cytokine-independent Survival Kinase CISK.
- J. Xu, L. Liao, J. Qin, J. Xu, D. Liu, and Z. Songyang (2009)
J. Biol. Chem.
284, 14377-14385
| Abstract »
| Full Text »
| PDF »
- Simultaneous exposure to dietary acrylamide and corn oil developed carcinogenesis through cell proliferation and inhibition of apoptosis by regulating p53-mediated mitochondria-dependent signaling pathway.
- X Zhang (2009)
Toxicology and Industrial Health
25, 101-109
| Abstract »
| PDF »
- The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
- A. Greenhough, H. J.M. Smartt, A. E. Moore, H. R. Roberts, A. C. Williams, C. Paraskeva, and A. Kaidi (2009)
Carcinogenesis
30, 377-386
| Abstract »
| Full Text »
| PDF »
- FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case-control studies.
- Z. Zhang, H. Xue, W. Gong, M. Wang, L. Yuan, S. Han, and Z. Zhang (2009)
Carcinogenesis
30, 487-493
| Abstract »
| Full Text »
| PDF »
- Polymorphisms in the FAS and FASL Genes and Survival of Early Stage Non-small Cell Lung Cancer.
- J. Y. Park, W.-K. Lee, D.-K. Jung, J.-E. Choi, T.-I. Park, E.-B. Lee, S. Cho, J.-Y. Park, S.-I. Cha, C.-H. Kim, et al. (2009)
Clin. Cancer Res.
15, 1794-1800
| Abstract »
| Full Text »
| PDF »
- The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage.
- H.-C. Tu, D. Ren, G. X. Wang, D. Y. Chen, T. D. Westergard, H. Kim, S. Sasagawa, J. J.-D. Hsieh, and E. H.-Y. Cheng (2009)
PNAS
106, 1093-1098
| Abstract »
| Full Text »
| PDF »
- The Novel Nuclear Factor-{kappa}B Inhibitor LC-1 Is Equipotent in Poor Prognostic Subsets of Chronic Lymphocytic Leukemia and Shows Strong Synergy with Fludarabine.
- S. Hewamana, T. T. Lin, C. Jenkins, A. K. Burnett, C. T. Jordan, C. Fegan, P. Brennan, C. Rowntree, and C. Pepper (2008)
Clin. Cancer Res.
14, 8102-8111
| Abstract »
| Full Text »
| PDF »
- Protection of Cardiomyocytes from Ischemic/Hypoxic Cell Death via Drbp1 and pMe2GlyDH in Cardio-specific ARC Transgenic Mice.
- J.-O. Pyo, J. Nah, H.-J. Kim, J.-W. Chang, Y.-W. Song, D.-K. Yang, D.-G. Jo, H.-R. Kim, H.-J. Chae, S.-W. Chae, et al. (2008)
J. Biol. Chem.
283, 30707-30714
| Abstract »
| Full Text »
| PDF »
- Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients.
- J.-Y. Hsiao, M.-C. Hsieh, C.-T. Hsiao, H.-H. Weng, and D.-S. Ke (2008)
Eur. J. Endocrinol.
159, 617-621
| Abstract »
| Full Text »
| PDF »
- Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species.
- J.-Q. Du, J. Wu, H.-J. Zhang, Y.-H. Zhang, B.-Y. Qiu, F. Wu, Y.-H. Chen, J.-Y. Li, F.-J. Nan, J.-P. Ding, et al. (2008)
J. Biol. Chem.
283, 30205-30215
| Abstract »
| Full Text »
| PDF »
- CED-9 and mitochondrial homeostasis in C. elegans muscle.
- F. J. Tan, M. Husain, C. M. Manlandro, M. Koppenol, A. Z. Fire, and R. B. Hill (2008)
J. Cell Sci.
121, 3373-3382
| Abstract »
| Full Text »
| PDF »
- Pivotal Role of Bcl-2 Family Proteins in the Regulation of Chondrocyte Apoptosis.
- Y. Oshima, T. Akiyama, A. Hikita, M. Iwasawa, Y. Nagase, M. Nakamura, H. Wakeyama, N. Kawamura, T. Ikeda, U.-i. Chung, et al. (2008)
J. Biol. Chem.
283, 26499-26508
| Abstract »
| Full Text »
| PDF »
- Oxidative Stress: A Common Factor in Testicular Dysfunction.
- T. T. Turner and J. J. Lysiak (2008)
J Androl
29, 488-498
| Abstract »
| Full Text »
| PDF »
- Regulation of cell survival by Na+/H+ exchanger-1.
- J. R. Schelling and B. G. Abu Jawdeh (2008)
Am J Physiol Renal Physiol
295, F625-F632
| Abstract »
| Full Text »
| PDF »
- Regulation of apoptosis by XIAP ubiquitin-ligase activity.
- A. J. Schile, M. Garcia-Fernandez, and H. Steller (2008)
Genes & Dev.
22, 2256-2266
| Abstract »
| Full Text »
| PDF »
- Rapid, Noninvasive Detection of Diabetes-Induced Retinal Metabolic Stress.
- M. G. Field, V. M. Elner, D. G. Puro, J. M. Feuerman, D. C. Musch, R. Pop-Busui, R. Hackel, J. R. Heckenlively, and H. R. Petty (2008)
Arch Ophthalmol
126, 934-938
| Abstract »
| Full Text »
| PDF »
- Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1{beta} Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis.
- Y. Fang and H. Braley-Mullen (2008)
Endocrinology
149, 3321-3329
| Abstract »
| Full Text »
| PDF »
- hScrib, a human homologue of Drosophila neoplastic tumor suppressor, is a novel death substrate targeted by caspase during the process of apoptosis..
- K. Sone, S. Nakagawa, K. Nakagawa, S. Takizawa, Y. Matsumoto, K. Nagasaka, T. Tsuruga, H. Hiraike, O. Hiraike-Wada, Y. Miyamoto, et al. (2008)
Genes Cells
13, 771-785
| Abstract »
| Full Text »
| PDF »
- Noninvasive Imaging of Apoptosis and Its Application in Cancer Therapeutics.
- J. M. Coppola, B. D. Ross, and A. Rehemtulla (2008)
Clin. Cancer Res.
14, 2492-2501
| Abstract »
| Full Text »
| PDF »
- Molecular Control of Bacterial Death and Lysis.
- K. C. Rice and K. W. Bayles (2008)
Microbiol. Mol. Biol. Rev.
72, 85-109
| Abstract »
| Full Text »
| PDF »
- Combined Effects of Sulindac and Suberoylanilide Hydroxamic Acid on Apoptosis Induction in Human Lung Cancer Cells.
- S.-K. Seo, H.-O. Jin, H.-C. Lee, S.-H. Woo, E.-S. Kim, D.-H. Yoo, S.-J. Lee, S. An, C.-H. Rhee, S.-I. Hong, et al. (2008)
Mol. Pharmacol.
73, 1005-1012
| Abstract »
| Full Text »
| PDF »
- 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer.
- G. Filomeni, P. Turella, M. L. Dupuis, O. Forini, M. R. Ciriolo, M. Cianfriglia, S. Pezzola, G. Federici, and A. M. Caccuri (2008)
Mol. Cancer Ther.
7, 371-379
| Abstract »
| Full Text »
| PDF »
- Apoptosis-Inducing Factor Is a Target for Ubiquitination through Interaction with XIAP.
- J. C. Wilkinson, A. S. Wilkinson, S. Galban, R. A. Csomos, and C. S. Duckett (2008)
Mol. Cell. Biol.
28, 237-247
| Abstract »
| Full Text »
| PDF »
- Dysembryoplastic neuroepithelial tumours: clinical, proliferative and apoptotic features.
- N Duggal, R Taylor, G Y Zou, and R R Hammond (2008)
J. Clin. Pathol.
61, 127-131
| Abstract »
| Full Text »
| PDF »
- An integrated systems biology approach to understanding the rules of keratinocyte colony formation.
- T. Sun, P. McMinn, S. Coakley, M. Holcombe, R. Smallwood, and S. MacNeil (2007)
J R Soc Interface
4, 1077-1092
| Abstract »
| Full Text »
| PDF »
- High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high-amylose maize starch.
- S. Toden, A. R. Bird, D. L. Topping, and M. A. Conlon (2007)
Carcinogenesis
28, 2355-2362
| Abstract »
| Full Text »
| PDF »
- The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer.
- D. Vucic and W. J. Fairbrother (2007)
Clin. Cancer Res.
13, 5995-6000
| Abstract »
| Full Text »
| PDF »
- Apoptosis in Gingival Overgrowth Tissues.
- A. Kantarci, P. Augustin, E. Firatli, M.C. Sheff, H. Hasturk, D.T. Graves, and P.C. Trackman (2007)
Journal of Dental Research
86, 888-892
| Abstract »
| Full Text »
| PDF »
- Activation of apoptotic processes during transition from hypertrophy to heart failure in guinea pigs.
- A. K. Sharma, S. Dhingra, N. Khaper, and P. K. Singal (2007)
Am J Physiol Heart Circ Physiol
293, H1384-H1390
| Abstract »
| Full Text »
| PDF »
- Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia.
- A. Troeger, M. Siepermann, G. Escherich, R. Meisel, R. Willers, S. Gudowius, T. Moritz, H.-J. Laws, H. Hanenberg, U. Goebel, et al. (2007)
Haematologica
92, 1043-1050
| Abstract »
| Full Text »
| PDF »
- The Nucleoside Analog Sangivamycin Induces Apoptotic Cell Death in Breast Carcinoma MCF7/Adriamycin-resistant Cells via Protein Kinase C{delta} and JNK Activation.
- S. A. Lee and M. Jung (2007)
J. Biol. Chem.
282, 15271-15283
| Abstract »
| Full Text »
| PDF »
- The Cytokine, Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Can Deliver Bcl-XL as an Extracellular Fusion Protein to Protect Cells from Apoptosis and Retain Differentiation Induction.
- A. Antignani and R. J. Youle (2007)
J. Biol. Chem.
282, 11246-11254
| Abstract »
| Full Text »
| PDF »
- Interactions of DNR1 with the apoptotic machinery of Drosophila melanogaster.
- D. A. Primrose, S. Chaudhry, A. G. D. Johnson, A. Hrdlicka, A. Schindler, D. Tran, and E. Foley (2007)
J. Cell Sci.
120, 1189-1199
| Abstract »
| Full Text »
| PDF »
- Effects of JC Virus Infection on Anti-Apoptotic Protein Survivin in Progressive Multifocal Leukoencephalopathy.
- S. Pina-Oviedo, K. Urbanska, S. Radhakrishnan, T. Sweet, K. Reiss, K. Khalili, and L. Del Valle (2007)
Am. J. Pathol.
170, 1291-1304
| Abstract »
| Full Text »
| PDF »
- Phorbol Esters Induce Intracellular Accumulation of the Anti-apoptotic Protein PED/PEA-15 by Preventing Ubiquitinylation and Proteasomal Degradation.
- A. Perfetti, F. Oriente, S. Iovino, A. T. Alberobello, A. P. M. Barbagallo, I. Esposito, F. Fiory, R. Teperino, P. Ungaro, C. Miele, et al. (2007)
J. Biol. Chem.
282, 8648-8657
| Abstract »
| Full Text »
| PDF »
- TLR4-Mediated Survival of Macrophages Is MyD88 Dependent and Requires TNF-{alpha} Autocrine Signalling.
- E. Lombardo, A. Alvarez-Barrientos, B. Maroto, L. Bosca, and U. G. Knaus (2007)
J. Immunol.
178, 3731-3739
| Abstract »
| Full Text »
| PDF »
- Seizure Suppression by top1 Mutations in Drosophila.
- J. Song, J. Hu, and M. Tanouye (2007)
J. Neurosci.
27, 2927-2937
| Abstract »
| Full Text »
| PDF »
- Osteopontin Promotes Integrin Activation through Outside-In and Inside-Out Mechanisms: OPN-CD44V Interaction Enhances Survival in Gastrointestinal Cancer Cells.
- J.-L. Lee, M.-J. Wang, P.-R. Sudhir, G.-D. Chen, C.-W. Chi, and J.-Y. Chen (2007)
Cancer Res.
67, 2089-2097
| Abstract »
| Full Text »
| PDF »
- Cordyceps sinensis Mycelium Extract Induces Human Premyelocytic Leukemia Cell Apoptosis Through Mitochondrion Pathway.
- Q. X. Zhang and J. Y. Wu (2007)
Experimental Biology and Medicine
232, 52-57
| Abstract »
| Full Text »
| PDF »
- Mitochondrial Membrane Permeabilization in Cell Death.
- G. Kroemer, L. Galluzzi, and C. Brenner (2007)
Physiol Rev
87, 99-163
| Abstract »
| Full Text »
| PDF »
- Identification of apoptotic genes mediating TGF-beta/Smad3-induced cell death in intestinal epithelial cells using a genomic approach.
- Y. Cao, L. Chen, W. Zhang, Y. Liu, H. T. Papaconstantinou, C. R. Bush, C. M. Townsend Jr., E. A. Thompson, and T. C. Ko (2007)
Am J Physiol Gastrointest Liver Physiol
292, G28-G38
| Abstract »
| Full Text »
| PDF »
- Bcl-2 Localized at the Nuclear Compartment Induces Apoptosis after Transient Overexpression.
- B. P. Portier and G. Taglialatela (2006)
J. Biol. Chem.
281, 40493-40502
| Abstract »
| Full Text »
| PDF »
- A neuroinductive biomaterial based on dopamine.
- J. Gao, Y. M. Kim, H. Coe, B. Zern, B. Sheppard, and Y. Wang (2006)
PNAS
103, 16681-16686
| Abstract »
| Full Text »
| PDF »
- Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts.
- W.-H. Chan (2006)
Hum. Reprod.
21, 2985-2995
| Abstract »
| Full Text »
| PDF »
- Colloquium Papers: Genomic analysis of the hierarchical structure of regulatory networks.
- H. Yu and M. Gerstein (2006)
PNAS
103, 14724-14731
| Abstract »
| Full Text »
| PDF »
- Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival..
- L.-Y. Li, M.-Y. Liu, H.-M. Shih, C.-H. Tsai, and J.-Y. Chen (2006)
J. Gen. Virol.
87, 2869-2878
| Abstract »
| Full Text »
| PDF »
- A Mechanistic Study on Reduced Toxicity of Irinotecan by Coadministered Thalidomide, a Tumor Necrosis Factor-{alpha} Inhibitor.
- X.-X. Yang, Z.-P. Hu, A.-L. Xu, W. Duan, Y.-Z. Zhu, M. Huang, F.-S. Sheu, Q. Zhang, J.-S. Bian, E. Chan, et al. (2006)
J. Pharmacol. Exp. Ther.
319, 82-104
| Abstract »
| Full Text »
| PDF »
- Constitutively Activated Nuclear Factor-{kappa}B, but not Induced NF-{kappa}B, Leads to TRAIL Resistance by Up-Regulation of X-Linked Inhibitor of Apoptosis Protein in Human Cancer Cells.
- S. J. Braeuer, C. Buneker, A. Mohr, and R. M. Zwacka (2006)
Mol. Cancer Res.
4, 715-728
| Abstract »
| Full Text »
| PDF »
- Toxicity of used orthodontic archwires assessed by three-dimensional cell culture.
- B. Vande Vannet, N. Mohebbian, and H. Wehrbein (2006)
Eur J Orthod
28, 426-432
| Abstract »
| Full Text »
| PDF »
- Epidermal Growth Factor Protects Prostate Cancer Cells from Apoptosis by Inducing BAD Phosphorylation via Redundant Signaling Pathways.
- K. S. R. Sastry, Y. Karpova, and G. Kulik (2006)
J. Biol. Chem.
281, 27367-27377
| Abstract »
| Full Text »
| PDF »
- Polymorphisms of FAS and FAS Ligand Genes Involved in the Death Pathway and Risk and Progression of Squamous Cell Carcinoma of the Head and Neck..
- Z. Zhang, L.-E Wang, E. M. Sturgis, A. K. El-Naggar, W. K. Hong, C. I. Amos, M. R. Spitz, and Q. Wei (2006)
Clin. Cancer Res.
12, 5596-5602
| Abstract »
| Full Text »
| PDF »
- Progesterone metabolites in breast cancer..
- J. P Wiebe (2006)
Endocr. Relat. Cancer
13, 717-738
| Abstract »
| Full Text »
| PDF »
- The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension..
- E. Gurbanov and X. Shiliang (2006)
Eur. J. Cardiothorac. Surg.
30, 499-507
| Abstract »
| Full Text »
| PDF »
- Specific Contribution of p19ARF to Nitric Oxide-Dependent Apoptosis..
- M. Zeini, P. G. Traves, R. Lopez-Fontal, C. Pantoja, A. Matheu, M. Serrano, L. Bosca, and S. Hortelano (2006)
J. Immunol.
177, 3327-3336
| Abstract »
| Full Text »
| PDF »
- Gene therapy with TRAIL against renal cell carcinoma..
- H. Matsubara, Y. Mizutani, F. Hongo, H. Nakanishi, Y. Kimura, S. Ushijima, A. Kawauchi, T. Tamura, T. Sakata, and T. Miki (2006)
Mol. Cancer Ther.
5, 2165-2171
| Abstract »
| Full Text »
| PDF »
- Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.
- A. Weigert, A. M. Johann, A. von Knethen, H. Schmidt, G. Geisslinger, and B. Brune (2006)
Blood
108, 1635-1642
| Abstract »
| Full Text »
| PDF »
- Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis.
- O. Yasuda, K. Fukuo, X. Sun, M. Nishitani, T. Yotsui, M. Higuchi, T. Suzuki, H. Rakugi, O. Smithies, N. Maeda, et al. (2006)
J. Biol. Chem.
281, 23899-23907
| Abstract »
| Full Text »
| PDF »
- Environmental Tobacco Smoke Suppresses Nuclear Factor-{kappa}B Signaling to Increase Apoptosis in Infant Monkey Lungs.
- C.-Y. Zhong, Y. M. Zhou, J. P. Joad, and K. E. Pinkerton (2006)
Am. J. Respir. Crit. Care Med.
174, 428-436
| Abstract »
| Full Text »
| PDF »
- PP2A Regulates BCL-2 Phosphorylation and Proteasome-mediated Degradation at the Endoplasmic Reticulum.
- S. S. Lin, M. C. Bassik, H. Suh, M. Nishino, J. D. Arroyo, W. C. Hahn, S. J. Korsmeyer, and T. M. Roberts (2006)
J. Biol. Chem.
281, 23003-23012
| Abstract »
| Full Text »
| PDF »
- Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease..
- P. I. Lin, E. R. Martin, P. G. Bronson, C. Browning-Large, G. W. Small, D. E. Schmechel, K. A. Welsh-Bohmer, J. L. Haines, J. R. Gilbert, and M. A. Pericak-Vance (2006)
Neurology
67, 64-68
| Abstract »
| Full Text »
| PDF »
- Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function.
- R. Shao, B. Weijdegard, K. Ljungstrom, A. Friberg, C. Zhu, X. Wang, Y. Zhu, J. Fernandez-Rodriguez, E. Egecioglu, E. Rung, et al. (2006)
Am J Physiol Endocrinol Metab
291, E59-E72
| Abstract »
| Full Text »
| PDF »
- Coxsackievirus Protein 2BC Blocks Host Cell Apoptosis by Inhibiting Caspase-3.
- M. A. Salako, M. J. Carter, and G. E. N. Kass (2006)
J. Biol. Chem.
281, 16296-16304
| Abstract »
| Full Text »
| PDF »
- Caspase 9 promoter polymorphisms and risk of primary lung cancer.
- J. Y. Park, J. M. Park, J. S. Jang, J. E. Choi, K. M. Kim, S. I. Cha, C. H. Kim, Y. M. Kang, W. K. Lee, S. Kam, et al. (2006)
Hum. Mol. Genet.
15, 1963-1971
| Abstract »
| Full Text »
| PDF »
- Distinct Domains for Anti- and Pro-apoptotic Activities of IEX-1.
- L. Shen, J. Guo, C. Santos-Berrios, and M. X. Wu (2006)
J. Biol. Chem.
281, 15304-15311
| Abstract »
| Full Text »
| PDF »
- CD45 regulates apoptosis in peripheral T lymphocytes.
- Z. Liu, R. Dawes, S. Petrova, P. C. Beverley, and E. Z Tchilian (2006)
Int. Immunol.
18, 959-966
| Abstract »
| Full Text »
| PDF »
- Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis.
- C. A. Pfrommer, W. Erl, and P. C. Weber (2006)
Am J Physiol Heart Circ Physiol
290, H2178-H2186
| Abstract »
| Full Text »
| PDF »
- The Stability and Anti-apoptotic Function of A1 Are Controlled by Its C Terminus.
- M. J. Herold, J. Zeitz, C. Pelzer, C. Kraus, A. Peters, G. Wohlleben, and I. Berberich (2006)
J. Biol. Chem.
281, 13663-13671
| Abstract »
| Full Text »
| PDF »
- Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein.
- K. Saito, K. Meyer, R. Warner, A. Basu, R. B. Ray, and R. Ray (2006)
J. Virol.
80, 4372-4379
| Abstract »
| Full Text »
| PDF »
- Fas Signaling Induces Raft Coalescence That Is Blocked by Cholesterol Depletion in Human RPE Cells Undergoing Apoptosis.
- J. E. Lincoln, M. Boling, A. N. Parikh, Y. Yeh, D. G. Gilchrist, and L. S. Morse (2006)
Invest. Ophthalmol. Vis. Sci.
47, 2172-2178
| Abstract »
| Full Text »
| PDF »
- Quantification of Macrophage Viability and Inflammatory Response to Dental Bonding Resins.
- L. O. Bailey, M. D. Weir, and N. R. Washburn (2006)
Journal of Bioactive and Compatible Polymers
21, 185-206
| Abstract »
| PDF »
- Platelet-Activating Factor Induces Up-regulation of Antiapoptotic Factors in a Melanoma Cell Line through Nuclear Factor-{kappa}B Activation..
- K. Heon Seo, H.-M. Ko, H.-A Kim, J.-H. Choi, S. Jun Park, K.-J. Kim, H.-K. Lee, and S.-Y. Im (2006)
Cancer Res.
66, 4681-4686
| Abstract »
| Full Text »
| PDF »
- RNA Aptamers Targeting the Cell Death Inhibitor CED-9 Induce Cell Killing in Caenorhabditis elegans.
- C. Yang, N. Yan, J. Parish, X. Wang, Y. Shi, and D. Xue (2006)
J. Biol. Chem.
281, 9137-9144
| Abstract »
| Full Text »
| PDF »
- The Affinity of a Major Ca2+ Binding Site on GRP78 Is Differentially Enhanced by ADP and ATP.
- H. K. Lamb, C. Mee, W. Xu, L. Liu, S. Blond, A. Cooper, I. G. Charles, and A. R. Hawkins (2006)
J. Biol. Chem.
281, 8796-8805
| Abstract »
| Full Text »
| PDF »
- From the Cover: Restriction of vaccinia virus replication by a ced-3 and ced-4-dependent pathway in Caenorhabditis elegans..
- W.-H. Liu, Y.-L. Lin, J.-P. Wang, W. Liou, R. F. Hou, Y.-C. Wu, and C.-L. Liao (2006)
PNAS
103, 4174-4179
| Abstract »
| Full Text »
| PDF »
- AIFsh, a Novel Apoptosis-inducing Factor (AIF) Pro-apoptotic Isoform with Potential Pathological Relevance in Human Cancer.
- C. Delettre, V. J. Yuste, R. S. Moubarak, M. Bras, J.-C. Lesbordes-Brion, S. Petres, J. Bellalou, and S. A. Susin (2006)
J. Biol. Chem.
281, 6413-6427
| Abstract »
| Full Text »
| PDF »
- The proteasome is required for rapid initiation of death receptor-induced apoptosis..
- D. Sohn, G. Totzke, F. Essmann, K. Schulze-Osthoff, B. Levkau, and R. U. Janicke (2006)
Mol. Cell. Biol.
26, 1967-1978
| Abstract »
| Full Text »
| PDF »
- Sex hormones and the genesis of autoimmunity..
- L. S. Ackerman (2006)
Arch Dermatol
142, 371-376
| Abstract »
| Full Text »
| PDF »
- Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
- F.-Y. Li, P. D. Jeffrey, J. W. Yu, and Y. Shi (2006)
J. Biol. Chem.
281, 2960-2968
| Abstract »
| Full Text »
| PDF »
- Identification of a Lipid Peroxidation Product as a Potential Trigger of the p53 Pathway.
- T. Shibata, K. Iio, Y. Kawai, N. Shibata, M. Kawaguchi, S. Toi, M. Kobayashi, M. Kobayashi, K. Yamamoto, and K. Uchida (2006)
J. Biol. Chem.
281, 1196-1204
| Abstract »
| Full Text »
| PDF »
- Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging.
- A. P. N. Majumdar and J. Du (2006)
Am J Physiol Gastrointest Liver Physiol
290, G49-G55
| Abstract »
| Full Text »
| PDF »
- Regulation of Caspase 9 through Phosphorylation by Protein Kinase C Zeta in Response to Hyperosmotic Stress.
- S. C. Brady, L. A. Allan, and P. R. Clarke (2005)
Mol. Cell. Biol.
25, 10543-10555
| Abstract »
| Full Text »
| PDF »
- Neonatal Brain Protection and Deep Hypothermic Circulatory Arrest: Pathophysiology of Ischemic Neuronal Injury and Protective Strategies.
- G. Amir, C. Ramamoorthy, R. K. Riemer, V. M. Reddy, and F. L. Hanley (2005)
Ann. Thorac. Surg.
80, 1955-1964
| Abstract »
| Full Text »
| PDF »
- Developmentally Regulated Expression of Sp1 in the Mouse Cornea.
- H. Nakamura, J. Ueda, J. Sugar, and B. Y. J. T. Yue (2005)
Invest. Ophthalmol. Vis. Sci.
46, 4092-4096
| Abstract »
| Full Text »
| PDF »
- Apoptotic Stress Is Counterbalanced by Survival Elements Preventing Programmed Cell Death of Dorsal Root Ganglions in Subacute Type 1 Diabetic BB/Wor Rats.
- H. Kamiya, W. Zhangm, and A. A.F. Sima (2005)
Diabetes
54, 3288-3295
| Abstract »
| Full Text »
| PDF »
- Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).
- E. M. Jung, J. H. Lim, T. J. Lee, J.-W. Park, K. S. Choi, and T. K. Kwon (2005)
Carcinogenesis
26, 1905-1913
| Abstract »
| Full Text »
| PDF »
- CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5.
- E. C. Dietze, M. L. Bowie, K. Mrozek, L. E. Caldwell, C. Neal, R. J. Marjoram, M. M. Troch, G. R. Bean, K. K. Yokoyama, C. A. Ibarra, et al. (2005)
J. Cell Sci.
118, 5005-5022
| Abstract »
| Full Text »
| PDF »
- Age-related apoptotic responses to stretch-induced hypertrophy in quail slow-tonic skeletal muscle.
- P. M. Siu and S. E. Alway (2005)
Am J Physiol Cell Physiol
289, C1105-C1113
| Abstract »
| Full Text »
| PDF »
|
|