Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 10 March 1995:
Vol. 267. no. 5203, pp. 1449 - 1456
DOI: 10.1126/science.7533326

Articles

Science, Vol 267, Issue 5203, 1449-1456
Copyright © 1995 by American Association for the Advancement of Science


articles

The Fas death factor

S Nagata and P Golstein

Osaka Bioscience Institute, Japan.

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Deletion of Fas in the pancreatic {beta}-cells leads to enhanced insulin secretion.
D. Choi, A. Radziszewska, S. A. Schroer, N. Liadis, Y. Liu, Y. Zhang, P. P. L. Lam, L. Sheu, Z. Hao, H. Y. Gaisano, et al. (2009)
Am J Physiol Endocrinol Metab 297, E1304-E1312
   Abstract »    Full Text »    PDF »
The E3 Ubiquitin Ligase Cbl-b Regulates Expansion but Not Functional Activity of Self-Reactive CD4 T Cells.
M.-C. St. Rose, H. Z. Qui, S. Bandyopadhyay, M. A. Mihalyo, A. T. Hagymasi, R. B. Clark, and A. J. Adler (2009)
J. Immunol. 183, 4975-4983
   Abstract »    Full Text »    PDF »
Immunologic Mechanisms of Corneal Allografts Reconstituted from Cultured Allogeneic Endothelial Cells in an Immune-Privileged Site.
T. Hayashi, S. Yamagami, K. Tanaka, S. Yokoo, T. Usui, S. Amano, and N. Mizuki (2009)
Invest. Ophthalmol. Vis. Sci. 50, 3151-3158
   Abstract »    Full Text »    PDF »
Hydrolysis of tumor cell lipids after CTL-mediated death.
B. Alves, J. Leong, D. L. Tamang, V. Elliott, M. Lowe, and D. Hudig (2009)
Int. Immunol. 21, 543-553
   Abstract »    Full Text »    PDF »
The Death Domain of FADD Is Essential for Embryogenesis, Lymphocyte Development, and Proliferation.
H. Z. Imtiyaz, X. Zhou, H. Zhang, D. Chen, T. Hu, and J. Zhang (2009)
J. Biol. Chem. 284, 9917-9926
   Abstract »    Full Text »    PDF »
The -670G>A polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis.
V Liakouli, M Manetti, A Pacini, B Tolusso, C Fatini, A Toscano, P Cipriani, S Guiducci, L Bazzichi, V Codullo, et al. (2009)
Ann Rheum Dis 68, 584-590
   Abstract »    Full Text »    PDF »
Lymphocytes with Aberrant Expression of Fas or Fas Ligand Attenuate Immune Bone Marrow Failure in a Mouse Model.
S. O. Omokaro, M. J. Desierto, M. A. Eckhaus, F. M. Ellison, J. Chen, and N. S. Young (2009)
J. Immunol. 182, 3414-3422
   Abstract »    Full Text »    PDF »
Defects in the regulatory clearance mechanisms favor the breakdown of self-tolerance during spontaneous autoimmune orchitis.
R.-M. Pelletier, S. R. Yoon, C. D. Akpovi, E. Silvas, and M. L. Vitale (2009)
Am J Physiol Regulatory Integrative Comp Physiol 296, R743-R762
   Abstract »    Full Text »    PDF »
Involvement of FLIP in 2-Methoxyestradiol-Induced Tumor Regression in Transgenic Adenocarcinoma of Mouse Prostate Model.
M. Ganapathy, R. Ghosh, X. Jianping, X. Zhang, R. Bedolla, J. Schoolfield, I-T. Yeh, D. A. Troyer, A. F. Olumi, and A. P. Kumar (2009)
Clin. Cancer Res. 15, 1601-1611
   Abstract »    Full Text »    PDF »
Polymorphisms in the FAS and FASL Genes and Survival of Early Stage Non-small Cell Lung Cancer.
J. Y. Park, W.-K. Lee, D.-K. Jung, J.-E. Choi, T.-I. Park, E.-B. Lee, S. Cho, J.-Y. Park, S.-I. Cha, C.-H. Kim, et al. (2009)
Clin. Cancer Res. 15, 1794-1800
   Abstract »    Full Text »    PDF »
Therapy-induced Toxicity of the Lungs: An Overview.
A. G. CHARPIDOU, I. GKIOZOS, S. TSIMPOUKIS, D. APOSTOLAKI, K. D. DILANA, E. M. KARAPANAGIOTOU, and K. N. SYRIGOS (2009)
Anticancer Res 29, 631-639
   Abstract »    Full Text »    PDF »
Dickkopf-Like1 Regulates Postpubertal Spermatocyte Apoptosis and Testosterone Production.
O. Dakhova, D. O'Day, N. Kinet, N. Yucer, M. Wiese, G. Shetty, and P. Ducy (2009)
Endocrinology 150, 404-412
   Abstract »    Full Text »    PDF »
A Role for cFLIP in B Cell Proliferation and Stress MAPK Regulation.
H. Zhang, S. Rosenberg, F. J. Coffey, Y.-W. He, T. Manser, R. R. Hardy, and J. Zhang (2009)
J. Immunol. 182, 207-215
   Abstract »    Full Text »    PDF »
B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.
V. A. Gupta, M. L. Hermiston, G. Cassafer, D. I. Daikh, and A. Weiss (2008)
J. Exp. Med. 205, 2755-2761
   Abstract »    Full Text »    PDF »
Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients.
J.-Y. Hsiao, M.-C. Hsieh, C.-T. Hsiao, H.-H. Weng, and D.-S. Ke (2008)
Eur. J. Endocrinol. 159, 617-621
   Abstract »    Full Text »    PDF »
A Novel Juxtamembrane Domain in Tumor Necrosis Factor Receptor Superfamily Molecules Activates Rac1 and Controls Neurite Growth.
W. Ruan, C. T. Lee, and J. Desbarats (2008)
Mol. Biol. Cell 19, 3192-3202
   Abstract »    Full Text »    PDF »
CD4 Help Regulates Expression of Crucial Genes Involved in CD8 T Cell Memory and Sensitivity to Regulatory Elements.
L. Rapetti, S. Meunier, C. Pontoux, and C. Tanchot (2008)
J. Immunol. 181, 299-308
   Abstract »    Full Text »    PDF »
Differential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditis..
S. Fountoulakis, G. Vartholomatos, N. Kolaitis, S. Frillingos, G. Philippou, and A. Tsatsoulis (2008)
Eur. J. Endocrinol. 158, 853-859
   Abstract »    Full Text »    PDF »
Fas System Activation in Perihematomal Areas After Spontaneous Intracerebral Hemorrhage.
P. Delgado, E. Cuadrado, A. Rosell, J. Alvarez-Sabin, A. Ortega-Aznar, M. Hernandez-Guillamon, A. Penalba, C. A. Molina, and J. Montaner (2008)
Stroke 39, 1730-1734
   Abstract »    Full Text »    PDF »
Relations of Inflammatory Biomarkers and Common Genetic Variants With Arterial Stiffness and Wave Reflection.
R. Schnabel, M. G. Larson, J. Dupuis, K. L. Lunetta, I. Lipinska, J. B. Meigs, X. Yin, J. Rong, J. A. Vita, C. Newton-Cheh, et al. (2008)
Hypertension 51, 1651-1657
   Abstract »    Full Text »    PDF »
Involvement of Fas Signalling in 7{beta}-Hydroxycholesterol-and Cholesterol-5{beta},6{beta}-Epoxide-Induced Apoptosis.
S. Lordan, J. J. Mackrill, and N. M. O'Brien (2008)
International Journal of Toxicology 27, 279-285
   Abstract »    Full Text »    PDF »
Pathways involved in testicular germ cell apoptosis in immature rats after FSH suppression.
S. M Ruwanpura, R. I McLachlan, P. G Stanton, K. L Loveland, and S. J Meachem (2008)
J. Endocrinol. 197, 35-43
   Abstract »    Full Text »    PDF »
Localization of Fas/CD95 into the Lipid Rafts on Down-Modulation of the Phosphatidylinositol 3-Kinase Signaling Pathway.
M. Beneteau, M. Pizon, B. Chaigne-Delalande, S. Daburon, P. Moreau, F. De Giorgi, F. Ichas, A. Rebillard, M.-T. Dimanche-Boitrel, J.-L. Taupin, et al. (2008)
Mol. Cancer Res. 6, 604-613
   Abstract »    Full Text »    PDF »
Follicle-Stimulating Hormone Affects Spermatogonial Survival by Regulating the Intrinsic Apoptotic Pathway in Adult Rats.
S. M. Ruwanpura, R. I. McLachlan, P. G. Stanton, and S. J. Meachem (2008)
Biol Reprod 78, 705-713
   Abstract »    Full Text »    PDF »
Mutation in the Fas Pathway Impairs CD8+ T Cell Memory.
R. Dudani, M. Russell, H. van Faassen, L. Krishnan, and S. Sad (2008)
J. Immunol. 180, 2933-2941
   Abstract »    Full Text »    PDF »
The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation.
L. Wang, N. Azad, L. Kongkaneramit, F. Chen, Y. Lu, B.-H. Jiang, and Y. Rojanasakul (2008)
J. Immunol. 180, 3072-3080
   Abstract »    Full Text »    PDF »
Construction of Optimized Bispecific Antibodies for Selective Activation of the Death Receptor CD95.
T. Herrmann, L. Grosse-Hovest, T. Otz, P. H. Krammer, H.-G. Rammensee, and G. Jung (2008)
Cancer Res. 68, 1221-1227
   Abstract »    Full Text »    PDF »
Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men.
S. M. Ruwanpura, R. I. McLachlan, K. L. Matthiesson, and S. J. Meachem (2008)
Hum. Reprod. 23, 403-411
   Abstract »    Full Text »    PDF »
FLICE-Like Inhibitory Protein Blocks Transforming Growth Factor {beta}1-Induced Caspase Activation and Apoptosis in Prostate Epithelial Cells.
K. L. Nastiuk, K. Yoo, K. Lo, K. Su, P. Yeung, J. Kutaka, D. Danielpour, and J. J. Krolewski (2008)
Mol. Cancer Res. 6, 231-242
   Abstract »    Full Text »    PDF »
Control of Ocular Tumor Growth and Metastatic Spread by Soluble and Membrane Fas Ligand.
M. S. Gregory, R. R. Saff, A. Marshak-Rothstein, and B. R. Ksander (2007)
Cancer Res. 67, 11951-11958
   Abstract »    Full Text »    PDF »
Differential activation of the death receptor pathway in human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing.
J. F. de Vries, P. A. von dem Borne, S. A.P. van Luxemburg-Heijs, M. H.M. Heemskerk, R. Willemze, J.H. F. Falkenburg, and R. M.Y. Barge (2007)
Haematologica 92, 1671-1678
   Abstract »    Full Text »    PDF »
The effects of progesterone on apoptosis in the human trophoblast-derived HTR-8/SV neo cells.
J. Liu, H. Matsuo, J. B. Laoag-Fernandez, Q. Xu, and T. Maruo (2007)
Mol. Hum. Reprod. 13, 869-874
   Abstract »    Full Text »    PDF »
Expression of Proliferative and Preapoptotic Molecules in Human Myometrium and Leiomyoma Throughout the Menstrual Cycle.
U. A. Kayisli, M. Berkkanoglu, G. Kizilay, L. Senturk, and A. Arici (2007)
Reproductive Sciences 14, 678-686
   Abstract »    PDF »
Fas-Negative Osteosarcoma Tumor Cells Are Selected during Metastasis to the Lungs: The Role of the Fas Pathway in the Metastatic Process of Osteosarcoma.
N. V. Koshkina, C. Khanna, A. Mendoza, H. Guan, L. DeLauter, and E. S. Kleinerman (2007)
Mol. Cancer Res. 5, 991-999
   Abstract »    Full Text »    PDF »
A New Class of Reverse Signaling Costimulators Belongs to the TNF Family.
M. Sun and P. J. Fink (2007)
J. Immunol. 179, 4307-4312
   Abstract »    Full Text »    PDF »
Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin.
V. Minas, U. Jeschke, S.N. Kalantaridou, D.U. Richter, T. Reimer, I. Mylonas, K. Friese, and A. Makrigiannakis (2007)
Mol. Hum. Reprod. 13, 663-673
   Abstract »    Full Text »    PDF »
Protection from Autoimmune Diabetes and T-Cell Lymphoproliferation Induced by FasL Mutation Are Differentially Regulated and Can Be Uncoupled Pharmacologically.
A. S. Mohamood, M. L. Guler, Z. Xiao, D. Zheng, A. Hess, Y. Wang, H. Yagita, J. P. Schneck, and A. R. A. Hamad (2007)
Am. J. Pathol. 171, 97-106
   Abstract »    Full Text »    PDF »
Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance.
T. Izawa, N. Ishimaru, K. Moriyama, M. Kohashi, R. Arakaki, and Y. Hayashi (2007)
Blood 110, 242-250
   Abstract »    Full Text »    PDF »
Restoration of Tissue Factor Pathway Inhibitor-2 in a Human Glioblastoma Cell Line Triggers Caspase-Mediated Pathway and Apoptosis.
J. George, C. S. Gondi, D. H. Dinh, M. Gujrati, and J. S. Rao (2007)
Clin. Cancer Res. 13, 3507-3517
   Abstract »    Full Text »    PDF »
Repression of IFN Regulatory Factor 8 by DNA Methylation Is a Molecular Determinant of Apoptotic Resistance and Metastatic Phenotype in Metastatic Tumor Cells.
D. Yang, M. Thangaraju, K. Greeneltch, D. D. Browning, P. V. Schoenlein, T. Tamura, K. Ozato, V. Ganapathy, S. I. Abrams, and K. Liu (2007)
Cancer Res. 67, 3301-3309
   Abstract »    Full Text »    PDF »
Effect of GnRH analogues on apoptosis and expression of Bcl-2, Bax, Fas and FasL proteins in endometrial epithelial cell cultures from patients with endometriosis and controls.
M. Bilotas, R.I. Baranao, R. Buquet, C. Sueldo, M. Tesone, and G. Meresman (2007)
Hum. Reprod. 22, 644-653
   Abstract »    Full Text »    PDF »
Murine FLIP Transgene Expressed on Thyroid Epithelial Cells Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis in DBA/1 Mice.
Y. Fang, Y. Wei, V. DeMarco, K. Chen, G. C. Sharp, and H. Braley-Mullen (2007)
Am. J. Pathol. 170, 875-887
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of FasL Expression and Participation of sTNF-{alpha} in Response to Sertoli Cell Injury.
P.-L. Yao, Y.-C. Lin, P. Sawhney, and J. H. Richburg (2007)
J. Biol. Chem. 282, 5420-5431
   Abstract »    Full Text »    PDF »
Ligands to Nucleic Acid-Specific Toll-Like Receptors and the Onset of Lupus Nephritis.
R. D. Pawar, P. S. Patole, A. Ellwart, M. Lech, S. Segerer, D. Schlondorff, and H.-J. Anders (2006)
J. Am. Soc. Nephrol. 17, 3365-3373
   Abstract »    Full Text »    PDF »
Invasive Trophoblasts Stimulate Vascular Smooth Muscle Cell Apoptosis by a Fas Ligand-Dependent Mechanism.
L. K. Harris, R. J. Keogh, M. Wareing, P. N. Baker, J. E. Cartwright, J. D. Aplin, and G. S. J. Whitley (2006)
Am. J. Pathol. 169, 1863-1874
   Abstract »    Full Text »    PDF »
Cytotoxic T Lymphocytes from Cathepsin B-deficient Mice Survive Normally in Vitro and in Vivo after Encountering and Killing Target Cells.
K. Baran, A. Ciccone, C. Peters, H. Yagita, P. I. Bird, J. A. Villadangos, and J. A. Trapani (2006)
J. Biol. Chem. 281, 30485-30491
   Abstract »    Full Text »    PDF »
Irradiation-Induced Pneumonitis Mediated by the CD95/CD95-Ligand System..
F. Heinzelmann, V. Jendrossek, K. Lauber, K. Nowak, T. Eldh, R. Boras, R. Handrick, M. Henkel, C. Martin, S. Uhlig, et al. (2006)
J Natl Cancer Inst 98, 1248-1251
   Abstract »    Full Text »    PDF »
The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension..
E. Gurbanov and X. Shiliang (2006)
Eur. J. Cardiothorac. Surg. 30, 499-507
   Abstract »    Full Text »    PDF »
A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome.
M. Del-Rey, J. Ruiz-Contreras, A. Bosque, S. Calleja, J. Gomez-Rial, E. Roldan, P. Morales, A. Serrano, A. Anel, E. Paz-Artal, et al. (2006)
Blood 108, 1306-1312
   Abstract »    Full Text »    PDF »
The Cytoplasmic Domain of Fas Ligand Costimulates TCR Signals.
M. Sun, K. T. Ames, I. Suzuki, and P. J. Fink (2006)
J. Immunol. 177, 1481-1491
   Abstract »    Full Text »    PDF »
Delayed Expansion and Contraction of CD8+ T Cell Response during Infection with Virulent Salmonella typhimurium.
R. A. Luu, K. Gurnani, R. Dudani, R. Kammara, H. van Faassen, J.-C. Sirard, L. Krishnan, and S. Sad (2006)
J. Immunol. 177, 1516-1525
   Abstract »    Full Text »    PDF »
Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization.
I. Semkova, S. Fauser, A. Lappas, N. Smyth, N. Kociok, B. Kirchhof, M. Paulsson, V. Poulaki, and A. M. Joussen (2006)
FASEB J 20, 1689-1691
   Abstract »    Full Text »    PDF »
Involvement of p38 Mitogen-Activated Protein Kinase and Inducible Nitric Oxide Synthase in Apoptotic Signaling of Murine and Human Male Germ Cells after Hormone Deprivation.
Y. Vera, K. Erkkila, C. Wang, C. Nunez, S. Kyttanen, Y. Lue, L. Dunkel, R. S. Swerdloff, and A. P. Sinha Hikim (2006)
Mol. Endocrinol. 20, 1597-1609
   Abstract »    Full Text »    PDF »
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.
Y. Liu, R. Pop, C. Sadegh, C. Brugnara, V. H. Haase, and M. Socolovsky (2006)
Blood 108, 123-133
   Abstract »    Full Text »    PDF »
FLIPping the Balance between Apoptosis and Proliferation in Thyroid Cancer..
R. Mathew and E. White (2006)
Clin. Cancer Res. 12, 3648-3651
   Full Text »    PDF »
Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis.
A. E. Schade, J. J. Powers, M. W. Wlodarski, and J. P. Maciejewski (2006)
Blood 107, 4834-4840
   Abstract »    Full Text »    PDF »
Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells..
J.-H. Choi, K.-C. Choi, N. Auersperg, and P. C K Leung (2006)
Endocr. Relat. Cancer 13, 641-651
   Abstract »    Full Text »    PDF »
Phosphatidylinositol 3-Kinase/Akt Positively Regulates Fas (CD95)-Mediated Apoptosis in Epidermal Cl41 Cells..
B. Lu, L. Wang, C. Stehlik, D. Medan, C. Huang, S. Hu, F. Chen, X. Shi, and Y. Rojanasakul (2006)
J. Immunol. 176, 6785-6793
   Abstract »    Full Text »    PDF »
The Fas-Associated Death Domain Protein Is Required in Apoptosis and TLR-Induced Proliferative Responses in B Cells..
H. Z. Imtiyaz, S. Rosenberg, Y. Zhang, Z. S. M. Rahman, Y.-J. Hou, T. Manser, and J. Zhang (2006)
J. Immunol. 176, 6852-6861
   Abstract »    Full Text »    PDF »
Alterations of Fas and Fas-Related Molecules in Patients with Silicosis..
T. Otsuki, Y. Miura, Y. Nishimura, F. Hyodoh, A. Takata, M. Kusaka, H. Katsuyama, M. Tomita, A. Ueki, and T. Kishimoto (2006)
Experimental Biology and Medicine 231, 522-533
   Abstract »    Full Text »    PDF »
Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-{kappa}B in regulated expression.
Y. Kang, S.-K. Kang, Y.-C. Lee, H.-J. Choi, Y.-S. Lee, S.-Y. Cho, Y.-S. Kim, J.-H. Ko, and C.-H. Kim (2006)
Glycobiology 16, 375-389
   Abstract »    Full Text »    PDF »
ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression.
Y. Li, Y.-H. Song, J. Mohler, and P. Delafontaine (2006)
Am J Physiol Heart Circ Physiol 290, H2116-H2123
   Abstract »    Full Text »    PDF »
Role of Endogenous Fas (CD95/Apo-1) Ligand in Balloon-Induced Apoptosis, Inflammation, and Neointima Formation.
C. M. Matter, C. E. Chadjichristos, P. Meier, T. von Lukowicz, C. Lohmann, P. K. Schuler, D. Zhang, B. Odermatt, E. Hofmann, T. Brunner, et al. (2006)
Circulation 113, 1879-1887
   Abstract »    Full Text »    PDF »
Radiation-Induced Caspase-8 Mediates p53-Independent Apoptosis in Glioma Cells..
G. Afshar, N. Jelluma, X. Yang, D. Basila, N. D. Arvold, A. Karlsson, G. L. Yount, T. B. Dansen, E. Koller, and D. A. Haas-Kogan (2006)
Cancer Res. 66, 4223-4232
   Abstract »    Full Text »    PDF »
Sex-Dependent Effect of Melatonin on Systemic Erythematosus Lupus Developed in Mrl/Mpj-Faslpr Mice: It Ameliorates the Disease Course in Females, whereas It Exacerbates It in Males.
A. J. Jimenez-Caliani, S. Jimenez-Jorge, P. Molinero, J. M. Fernandez-Santos, I. Martin-Lacave, A. Rubio, J. M. Guerrero, and C. Osuna (2006)
Endocrinology 147, 1717-1724
   Abstract »    Full Text »    PDF »
CTL Adoptive Immunotherapy Concurrently Mediates Tumor Regression and Tumor Escape.
K. Liu, S. A. Caldwell, K. M. Greeneltch, D. Yang, and S. I. Abrams (2006)
J. Immunol. 176, 3374-3382
   Abstract »    Full Text »    PDF »
Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity.
N. Cahuzac, W. Baum, V. Kirkin, F. Conchonaud, L. Wawrezinieck, D. Marguet, O. Janssen, M. Zornig, and A.-O. Hueber (2006)
Blood 107, 2384-2391
   Abstract »    Full Text »    PDF »
p38 Mitogen-Activated Protein Kinase Mediates the Fas-Induced Mitochondrial Death Pathway in CD8+ T Cells..
N. Farley, G. Pedraza-Alva, D. Serrano-Gomez, V. Nagaleekar, A. Aronshtam, T. Krahl, T. Thornton, and M. Rincon (2006)
Mol. Cell. Biol. 26, 2118-2129
   Abstract »    Full Text »    PDF »
Identification of {alpha}-tubulin as a granzyme B substrate during CTL-mediated apoptosis..
I. S. Goping, T. Sawchuk, D. A. Underhill, and R. C. Bleackley (2006)
J. Cell Sci. 119, 858-865
   Abstract »    Full Text »    PDF »
Role of CD95-Mediated Adipocyte Loss in Autoimmune Lipodystrophy.
P. Fischer-Posovszky, H. Hebestreit, A. K. Hofmann, G. Strauss, P. Moller, K.-M. Debatin, and M. Wabitsch (2006)
J. Clin. Endocrinol. Metab. 91, 1129-1135
   Abstract »    Full Text »    PDF »
Influence of a Leptin Deficiency on Testicular Morphology, Germ Cell Apoptosis, and Expression Levels of Apoptosis-Related Genes in the Mouse.
G. K. Bhat, T. L. Sea, M. O. Olatinwo, D. Simorangkir, G. D. Ford, B. D. Ford, and D. R. Mann (2006)
J Androl 27, 302-310
   Abstract »    Full Text »    PDF »
Identification and Characterization of Survival-Related Gene, a Novel Cell Survival Gene Controlling Apoptosis and Tumorigenesis.
Z.-R. Yuan, R. Wang, J. Solomon, X. Luo, H. Sun, L. Zhang, and Y. Shi (2005)
Cancer Res. 65, 10716-10724
   Abstract »    Full Text »    PDF »
Developmentally Regulated Expression of Sp1 in the Mouse Cornea.
H. Nakamura, J. Ueda, J. Sugar, and B. Y. J. T. Yue (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4092-4096
   Abstract »    Full Text »    PDF »
Addressing the "Fas Counterattack" Controversy: Blocking Fas Ligand Expression Suppresses Tumor Immune Evasion of Colon Cancer In vivo.
A. E. Ryan, F. Shanahan, J. O'Connell, and A. M. Houston (2005)
Cancer Res. 65, 9817-9823
   Abstract »    Full Text »    PDF »
Estrogens Up-Regulate the Fas/FasL Apoptotic Pathway in Lactotropes.
G. Jaita, M. Candolfi, V. Zaldivar, S. Zarate, L. Ferrari, D. Pisera, M. G. Castro, and A. Seilicovich (2005)
Endocrinology 146, 4737-4744
   Abstract »    Full Text »    PDF »
Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis.
S. H. Wang, Z. Cao, J. M. Wolf, M. Van Antwerp, and J. R. Baker Jr. (2005)
Endocrinology 146, 4721-4726
   Abstract »    Full Text »    PDF »
IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization.
M.-H. Lacombe, M.-P. Hardy, J. Rooney, and N. Labrecque (2005)
J. Immunol. 175, 4400-4407
   Abstract »    Full Text »    PDF »
Essential Roles of the Fas-Associated Death Domain in Autoimmune Encephalomyelitis.
J. Sun, B. Hilliard, L. Xu, and Y. H. Chen (2005)
J. Immunol. 175, 4783-4788
   Abstract »    Full Text »    PDF »
Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines.
Z. Guo, M. Zhang, H. Tang, and X. Cao (2005)
Blood 106, 2033-2041
   Abstract »    Full Text »    PDF »
Structural Requirements for Signal-induced Target Binding of FADD Determined by Functional Reconstitution of FADD Deficiency.
H. Z. Imtiyaz, Y. Zhang, and J. Zhang (2005)
J. Biol. Chem. 280, 31360-31367
   Abstract »    Full Text »    PDF »
Interleukin-17 as a Recruitment and Survival Factor for Airway Macrophages in Allergic Airway Inflammation.
S. Sergejeva, S. Ivanov, J. Lotvall, and A. Linden (2005)
Am. J. Respir. Cell Mol. Biol. 33, 248-253
   Abstract »    Full Text »    PDF »
Conditional Fas-Associated Death Domain Protein (FADD):GFP Knockout Mice Reveal FADD Is Dispensable in Thymic Development but Essential in Peripheral T Cell Homeostasis.
Y. Zhang, S. Rosenberg, H. Wang, H. Z. Imtiyaz, Y.-J. Hou, and J. Zhang (2005)
J. Immunol. 175, 3033-3044
   Abstract »    Full Text »    PDF »
Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation.
M. W. Cruise, H. M. Melief, J. Lukens, C. Soguero, and Y. S. Hahn (2005)
J. Leukoc. Biol. 78, 412-425
   Abstract »    Full Text »    PDF »
Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104.
C. Brando, S. Mukhopadhyay, E. Kovacs, R. Medina, P. Patel, T. L. Catina, K. S. Campbell, and D. Santoli (2005)
J. Leukoc. Biol. 78, 359-371
   Abstract »    Full Text »    PDF »
Apoptosis of Skeletal Muscle on Steroid-Induced Myopathy in Rats.
M.-C. Lee, G.-R. Wee, and J.-H. Kim (2005)
J. Nutr. 135, 1806S-1808S
   Abstract »    Full Text »    PDF »
Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.
G. Dotti, B. Savoldo, M. Pule, K. C. Straathof, E. Biagi, E. Yvon, S. Vigouroux, M. K. Brenner, and C. M. Rooney (2005)
Blood 105, 4677-4684
   Abstract »    Full Text »    PDF »
Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis.
B. Chen, Z. Tong, Q. Ye, S. Nakamura, U. Costabel, and J. Guzman (2005)
Eur. Respir. J. 25, 1039-1043
   Abstract »    Full Text »    PDF »
Involvement of Nitric Oxide-Mediated Intrinsic Pathway Signaling in Age-Related Increase in Germ Cell Apoptosis in Male Brown-Norway Rats.
A. P. S. Hikim, Y. Vera, D. Vernet, M. Castanares, M. Diaz-Romero, M. Ferrini, R. S. Swerdloff, N. F. Gonzalez-Cadavid, and C. Wang (2005)
J. Gerontol. A Biol. Sci. Med. Sci. 60, 702-708
   Abstract »    Full Text »    PDF »
Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer.
X Zhang, X Miao, T Sun, W Tan, S Qu, P Xiong, Y Zhou, and D Lin (2005)
J. Med. Genet. 42, 479-484
   Abstract »    Full Text »    PDF »
Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment.
N. Sofikitis, E. Pappas, A. Kawatani, D. Baltogiannis, D. Loutradis, N. Kanakas, D. Giannakis, F. Dimitriadis, K. Tsoukanelis, I. Georgiou, et al. (2005)
Hum. Reprod. Update 11, 229-259
   Abstract »    Full Text »    PDF »
Reducing the Stimulation of CD8+ T Cells during Infection with Intracellular Bacteria Promotes Differentiation Primarily into a Central (CD62LhighCD44high) Subset.
H. van Faassen, M. Saldanha, D. Gilbertson, R. Dudani, L. Krishnan, and S. Sad (2005)
J. Immunol. 174, 5341-5350
   Abstract »    Full Text »    PDF »
Ferritin Contributes to Melanoma Progression by Modulating Cell Growth and Sensitivity to Oxidative Stress.
A. Baldi, D. Lombardi, P. Russo, E. Palescandolo, A. De Luca, D. Santini, F. Baldi, L. Rossiello, M. L. Dell'Anna, A. Mastrofrancesco, et al. (2005)
Clin. Cancer Res. 11, 3175-3183
   Abstract »    Full Text »    PDF »
Corticosterone binding globulin regulation and thymus changes after thermal injury in mice.
M. D'Elia, J. Patenaude, C. Hamelin, D. R. Garrel, and J. Bernier (2005)
Am J Physiol Endocrinol Metab 288, E852-E860
   Abstract »    Full Text »    PDF »
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).
D. T. Teachey, C. S. Manno, K. M. Axsom, T. Andrews, J. K. Choi, B. H. Greenbaum, J. M. McMann, K. E. Sullivan, S. F. Travis, and S. A. Grupp (2005)
Blood 105, 2443-2448
   Abstract »    Full Text »    PDF »
The Mouse Cell Surface Protein TOSO Regulates Fas/Fas Ligand-induced Apoptosis through Its Binding to Fas-associated Death Domain.
Y. Song and C. O. Jacob (2005)
J. Biol. Chem. 280, 9618-9626
   Abstract »    Full Text »    PDF »
Apoptosis Contributes to Vascular Lumen Formation and Vascular Branching in Human Placental Vasculogenesis.
F. Tertemiz, U. A. Kayisli, A. Arici, and R. Demir (2005)
Biol Reprod 72, 727-735
   Abstract »    Full Text »    PDF »
Cooperative Disengagement of Fas and Intercellular Adhesion Molecule-1 Function in Neoplastic Cells Confers Enhanced Colonization Efficiency.
K. Liu, S. A. Caldwell, and S. I. Abrams (2005)
Cancer Res. 65, 1045-1054
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)