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Science 10 March 1995: Vol. 267. no. 5203, pp. 1449 - 1456 DOI: 10.1126/science.7533326
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Articles
Science, Vol 267, Issue 5203, 1449-1456
Copyright © 1995 by American Association for the Advancement of Science
The Fas death factor
S Nagata
and
P Golstein
Osaka Bioscience Institute, Japan.
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.
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- Addressing the "Fas Counterattack" Controversy: Blocking Fas Ligand Expression Suppresses Tumor Immune Evasion of Colon Cancer In vivo.
- A. E. Ryan, F. Shanahan, J. O'Connell, and A. M. Houston (2005)
Cancer Res.
65, 9817-9823
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- Estrogens Up-Regulate the Fas/FasL Apoptotic Pathway in Lactotropes.
- G. Jaita, M. Candolfi, V. Zaldivar, S. Zarate, L. Ferrari, D. Pisera, M. G. Castro, and A. Seilicovich (2005)
Endocrinology
146, 4737-4744
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- Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis.
- S. H. Wang, Z. Cao, J. M. Wolf, M. Van Antwerp, and J. R. Baker Jr. (2005)
Endocrinology
146, 4721-4726
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- IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization.
- M.-H. Lacombe, M.-P. Hardy, J. Rooney, and N. Labrecque (2005)
J. Immunol.
175, 4400-4407
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- Essential Roles of the Fas-Associated Death Domain in Autoimmune Encephalomyelitis.
- J. Sun, B. Hilliard, L. Xu, and Y. H. Chen (2005)
J. Immunol.
175, 4783-4788
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- Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines.
- Z. Guo, M. Zhang, H. Tang, and X. Cao (2005)
Blood
106, 2033-2041
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- Structural Requirements for Signal-induced Target Binding of FADD Determined by Functional Reconstitution of FADD Deficiency.
- H. Z. Imtiyaz, Y. Zhang, and J. Zhang (2005)
J. Biol. Chem.
280, 31360-31367
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- Interleukin-17 as a Recruitment and Survival Factor for Airway Macrophages in Allergic Airway Inflammation.
- S. Sergejeva, S. Ivanov, J. Lotvall, and A. Linden (2005)
Am. J. Respir. Cell Mol. Biol.
33, 248-253
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- Conditional Fas-Associated Death Domain Protein (FADD):GFP Knockout Mice Reveal FADD Is Dispensable in Thymic Development but Essential in Peripheral T Cell Homeostasis.
- Y. Zhang, S. Rosenberg, H. Wang, H. Z. Imtiyaz, Y.-J. Hou, and J. Zhang (2005)
J. Immunol.
175, 3033-3044
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- Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation.
- M. W. Cruise, H. M. Melief, J. Lukens, C. Soguero, and Y. S. Hahn (2005)
J. Leukoc. Biol.
78, 412-425
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- Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104.
- C. Brando, S. Mukhopadhyay, E. Kovacs, R. Medina, P. Patel, T. L. Catina, K. S. Campbell, and D. Santoli (2005)
J. Leukoc. Biol.
78, 359-371
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- Apoptosis of Skeletal Muscle on Steroid-Induced Myopathy in Rats.
- M.-C. Lee, G.-R. Wee, and J.-H. Kim (2005)
J. Nutr.
135, 1806S-1808S
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- Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.
- G. Dotti, B. Savoldo, M. Pule, K. C. Straathof, E. Biagi, E. Yvon, S. Vigouroux, M. K. Brenner, and C. M. Rooney (2005)
Blood
105, 4677-4684
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- Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis.
- B. Chen, Z. Tong, Q. Ye, S. Nakamura, U. Costabel, and J. Guzman (2005)
Eur. Respir. J.
25, 1039-1043
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- Involvement of Nitric Oxide-Mediated Intrinsic Pathway Signaling in Age-Related Increase in Germ Cell Apoptosis in Male Brown-Norway Rats.
- A. P. S. Hikim, Y. Vera, D. Vernet, M. Castanares, M. Diaz-Romero, M. Ferrini, R. S. Swerdloff, N. F. Gonzalez-Cadavid, and C. Wang (2005)
J. Gerontol. A Biol. Sci. Med. Sci.
60, 702-708
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- Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer.
- X Zhang, X Miao, T Sun, W Tan, S Qu, P Xiong, Y Zhou, and D Lin (2005)
J. Med. Genet.
42, 479-484
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- Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment.
- N. Sofikitis, E. Pappas, A. Kawatani, D. Baltogiannis, D. Loutradis, N. Kanakas, D. Giannakis, F. Dimitriadis, K. Tsoukanelis, I. Georgiou, et al. (2005)
Hum. Reprod. Update
11, 229-259
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- Reducing the Stimulation of CD8+ T Cells during Infection with Intracellular Bacteria Promotes Differentiation Primarily into a Central (CD62LhighCD44high) Subset.
- H. van Faassen, M. Saldanha, D. Gilbertson, R. Dudani, L. Krishnan, and S. Sad (2005)
J. Immunol.
174, 5341-5350
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- Ferritin Contributes to Melanoma Progression by Modulating Cell Growth and Sensitivity to Oxidative Stress.
- A. Baldi, D. Lombardi, P. Russo, E. Palescandolo, A. De Luca, D. Santini, F. Baldi, L. Rossiello, M. L. Dell'Anna, A. Mastrofrancesco, et al. (2005)
Clin. Cancer Res.
11, 3175-3183
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- Corticosterone binding globulin regulation and thymus changes after thermal injury in mice.
- M. D'Elia, J. Patenaude, C. Hamelin, D. R. Garrel, and J. Bernier (2005)
Am J Physiol Endocrinol Metab
288, E852-E860
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- Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).
- D. T. Teachey, C. S. Manno, K. M. Axsom, T. Andrews, J. K. Choi, B. H. Greenbaum, J. M. McMann, K. E. Sullivan, S. F. Travis, and S. A. Grupp (2005)
Blood
105, 2443-2448
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- The Mouse Cell Surface Protein TOSO Regulates Fas/Fas Ligand-induced Apoptosis through Its Binding to Fas-associated Death Domain.
- Y. Song and C. O. Jacob (2005)
J. Biol. Chem.
280, 9618-9626
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- Apoptosis Contributes to Vascular Lumen Formation and Vascular Branching in Human Placental Vasculogenesis.
- F. Tertemiz, U. A. Kayisli, A. Arici, and R. Demir (2005)
Biol Reprod
72, 727-735
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- Cooperative Disengagement of Fas and Intercellular Adhesion Molecule-1 Function in Neoplastic Cells Confers Enhanced Colonization Efficiency.
- K. Liu, S. A. Caldwell, and S. I. Abrams (2005)
Cancer Res.
65, 1045-1054
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