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Science 10 March 1995:
Vol. 267. no. 5203, pp. 1445 - 1449
DOI: 10.1126/science.7878463
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Articles

Science, Vol 267, Issue 5203, 1445-1449
Copyright © 1995 by American Association for the Advancement of Science

articles

Mechanisms and genes of cellular suicide

H Steller

Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.

Apoptosis is a morphologically distinct form of programmed cell death that plays a major role during development, homeostasis, and in many diseases including cancer, acquired immunodeficiency syndrome, and neurodegenerative disorders. Apoptosis occurs through the activation of a cell-intrinsic suicide program. The basic machinery to carry out apoptosis appears to be present in essentially all mammalian cells at all times, but the activation of the suicide program is regulated by many different signals that originate from both the intracellular and the extracellular milieu. Genetic studies in the nematode Caenorhabditis elegans and in the fruit fly Drosophila melanogaster have led to the isolation of genes that are specifically required for the induction of programmed cell death. At least some components of the apoptotic program have been conserved among worms, insects, and vertebrates.


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   Abstract »    Full Text »    PDF »
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J. Cell Biol. 164, 501-507
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Secreted Frizzled-related Protein 1 (SFRP1) Protects Fibroblasts from Ceramide-induced Apoptosis.
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Metronidazole induces programmed cell death in the protozoan parasite Blastocystis hominis.
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Role of Apoptosis in Sarcopenia.
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Apoptosis Genes in Human Alveolar Macrophages Infected with Virulent or Attenuated Mycobacterium tuberculosis: A Pivotal Role for Tumor Necrosis Factor.
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Crystal Structure of Caspase-2, Apical Initiator of the Intrinsic Apoptotic Pathway.
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Human Apurinic/Apyrimidinic Endonuclease (Ape1) and Its N-terminal Truncated Form (AN34) Are Involved in DNA Fragmentation during Apoptosis.
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The Y-box-binding Protein, YB1, Is a Potential Negative Regulator of the p53 Tumor Suppressor.
A. Lasham, S. Moloney, T. Hale, C. Homer, Y. F. Zhang, J. G. Murison, A. W. Braithwaite, and J. Watson (2003)
J. Biol. Chem. 278, 35516-35523
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Interleukin-4-Induced Apoptosis Entails Caspase Activation and Suppression of Extracellular Signal-Regulated Kinase Phosphorylation.
A. I. Doseff, J. H. Baker Jr., T. A. Bourgeois, and M. D. Wewers (2003)
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G. Chakrabarti, X. Zhou, and B. A. McClane (2003)
Infect. Immun. 71, 4260-4270
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Cell Death in Pseudomonas aeruginosa Biofilm Development.
J. S. Webb, L. S. Thompson, S. James, T. Charlton, T. Tolker-Nielsen, B. Koch, M. Givskov, and S. Kjelleberg (2003)
J. Bacteriol. 185, 4585-4592
   Abstract »    Full Text »    PDF »
Murine Macrophages Produce Secretory Leukocyte Protease Inhibitor During Clearance of Apoptotic Cells: Implications for Resolution of the Inflammatory Response.
C. Odaka, T. Mizuochi, J. Yang, and A. Ding (2003)
J. Immunol. 171, 1507-1514
   Abstract »    Full Text »    PDF »
Cardioplegic arrest induces apoptosis signal-pathway in myocardial endothelial cells and cardiac myocytes.
U. M. Fischer, O. Klass, U. Stock, J. Easo, H. J. Geissler, J. H. Fischer, W. Bloch, and U. Mehlhorn (2003)
Eur. J. Cardiothorac. Surg. 23, 984-990
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Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation.
M. PAXIAN, I. BAUER, H. RENSING, H. JAESCHKE, A. E. M. MAUTES, S. A. KOLB, B. WOLF, A. STOCKHAUSEN, S. JEBLICK, and M. BAUER (2003)
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Activation of the Programmed Cell Death Pathway by Inhibition of Proteasome Function in Plants.
M. Kim, J.-W. Ahn, U.-H. Jin, D. Choi, K.-H. Paek, and H.-S. Pai (2003)
J. Biol. Chem. 278, 19406-19415
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ARMER, Apoptotic Regulator in the Membrane of the Endoplasmic Reticulum, A Novel Inhibitor of Apoptosis.
H. M. Lui, J. Chen, L. Wang, and L. Naumovski (2003)
Mol. Cancer Res. 1, 508-518
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Ultrastructural changes in Neurospora cells undergoing senescence induced by kalilo plasmids.
J.-W. Bok, K.-I. Ishida, and A. J. F. Griffiths (2003)
Mycologia 95, 500-505
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AIM Inhibits Apoptosis of T Cells and NKT Cells in Corynebacterium-Induced Granuloma Formation in Mice.
K. Kuwata, H. Watanabe, S.-Y. Jiang, T. Yamamoto, C. Tomiyama-Miyaji, T. Abo, T. Miyazaki, and M. Naito (2003)
Am. J. Pathol. 162, 837-847
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Predominant Suppression of Apoptosome by Inhibitor of Apoptosis Protein in Non-Small Cell Lung Cancer H460 Cells: Therapeutic Effect of a Novel Polyarginine-conjugated Smac Peptide.
L. Yang, T. Mashima, S. Sato, M. Mochizuki, H. Sakamoto, T. Yamori, T. Oh-hara, and T. Tsuruo (2003)
Cancer Res. 63, 831-837
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Catalase Protects HepG2 Cells from Apoptosis Induced by DNA-damaging Agents by Accelerating the Degradation of p53.
J. Bai and A. I. Cederbaum (2003)
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An Investigation of Apoptosis in Androgenetic Alopecia.
M. B. Morgan and P. Rose (2003)
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Ann Rheum Dis 61, ii19-24
   Abstract »    Full Text »    PDF »
Book Review: Cellular Replacement Therapy for Parkinson's Disease--Where We Are Today?.
D. E. Redmond Jr. (2002)
Neuroscientist 8, 457-488
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Age-Related Changes in Human RPE Cell Density and Apoptosis Proportion In Situ.
L. V. Del Priore, Y.-H. Kuo, and T. H. Tezel (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3312-3318
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Kinetics of heat shock protein 70 synthesis in the human heart after cold cardioplegic arrest.
J.P. Schmitt, H. Schunkert, D.E. Birnbaum, and H. Aebert (2002)
Eur. J. Cardiothorac. Surg. 22, 415-420
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BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation.
Y. Kaluzhny, G. Yu, S. Sun, P. A. Toselli, B. Nieswandt, C. W. Jackson, and K. Ravid (2002)
Blood 100, 1670-1678
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Caspase-8 and Apaf-1-independent Caspase-9 Activation in Sendai Virus-infected Cells.
M. Bitzer, S. Armeanu, F. Prinz, G. Ungerechts, W. Wybranietz, M. Spiegel, C. Bernlohr, F. Cecconi, M. Gregor, W. J. Neubert, et al. (2002)
J. Biol. Chem. 277, 29817-29824
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p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells.
L. A. Martinez, J. Yang, E. S. Vazquez, M. del Carmen Rodriguez-Vargas, M. Olive, J.-T. Hsieh, C. J. Logothetis, and N. M. Navone (2002)
Carcinogenesis 23, 1289-1296
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Deficiency in Methionine, Tryptophan, Isoleucine, or Choline Induces Apoptosis in Cultured Cells.
C.-L. E. Yen, M.-H. Mar, C. N. Craciunescu, L. J. Edwards, and S. H. Zeisel (2002)
J. Nutr. 132, 1840-1847
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Potentiation by human serum of anti-inflammatory cytokine production by human macrophages in response to apoptotic cells.
K. Kurosaka, N. Watanabe, and Y. Kobayashi (2002)
J. Leukoc. Biol. 71, 950-956
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Induction and Regulation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand-mediated Apoptosis in Renal Cell Carcinoma.
T. S. Griffith, J. M. Fialkov, D. L. Scott, T. Azuhata, R. D. Williams, N. R. Wall, D. C. Altieri, and A. D. Sandler (2002)
Cancer Res. 62, 3093-3099
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Caspase Proteolysis of the Cohesin Component RAD21 Promotes Apoptosis.
F. Chen, M. Kamradt, M. Mulcahy, Y. Byun, H. Xu, M. J. McKay, and V. L. Cryns (2002)
J. Biol. Chem. 277, 16775-16781
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In Vivo Pharmacokinetic Features, Toxicity Profile, and Chemosensitizing Activity of {alpha}-Cyano-{beta}-hydroxy-{beta}- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a Novel Antileukemic Agent Targeting Bruton's Tyrosine Kinase.
F. M. Uckun, Y. Zheng, M. Cetkovic-Cvrlje, A. Vassilev, E. Lisowski, B. Waurzyniak, H. Chen, R. Carpenter, and C.-L. Chen (2002)
Clin. Cancer Res. 8, 1224-1233
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Oligomerization and activation of caspase-9, induced by Apaf-1 CARD.
E. N. Shiozaki, J. Chai, and Y. Shi (2002)
PNAS 99, 4197-4202
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Role of apoptosis in myocardial stunning after open heart surgery.
J. P. Schmitt, J. Schroder, H. Schunkert, D. E. Birnbaum, and H. Aebert (2002)
Ann. Thorac. Surg. 73, 1229-1235
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