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Science 3 March 1995:
Vol. 267. no. 5202, pp. 1360 - 1363
DOI: 10.1126/science.7871435

Articles

Science, Vol 267, Issue 5202, 1360-1363
Copyright © 1995 by American Association for the Advancement of Science


articles

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

CJ Schoenherr and DJ Anderson

Division of Biology 216-76, California Institute of Technology, Pasadena 91125.

The neuron-restrictive silencer factor (NRSF) binds a DNA sequence element, called the neuron-restrictive silencer element (NRSE), that represses neuronal gene transcription in nonneuronal cells. Consensus NRSEs have been identified in 18 neuron-specific genes. Complementary DNA clones encoding a functional fragment of NRSF were isolated and found to encode a novel protein containing eight noncanonical zinc fingers. Expression of NRSF mRNA was detected in most nonneuronal tissues at several developmental stages. In the nervous system, NRSF mRNA was detected in undifferentiated neuronal progenitors, but not in differentiated neurons. NRSF represents the first example of a vertebrate silencer protein that potentially regulates a large battery of cell type-specific genes, and therefore may function as a master negative regulator of neurogenesis.


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J. Biol. Chem. 275, 8161-8168
   Abstract »    Full Text »    PDF »
Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.
F Cammas, M Mark, P Dolle, A Dierich, P Chambon, and R Losson (2000)
Development 127, 2955-2963
   Abstract »    PDF »
Purification and Identification of a Tissue-specific Repressor Involved in Serum Amyloid A1 Gene Expression.
Y. Ren, S. A. G. Reddy, and W. S.-L. Liao (1999)
J. Biol. Chem. 274, 37154-37160
   Abstract »    Full Text »    PDF »
Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes.
Y. Naruse, T. Aoki, T. Kojima, and N. Mori (1999)
PNAS 96, 13691-13696
   Abstract »    Full Text »    PDF »
Identification of Nuclear Orphan Receptors as Regulators of Expression of a Neurotransmitter Receptor Gene.
L.-J. Chew, F. Huang, J.-M. Boutin, and V. Gallo (1999)
J. Biol. Chem. 274, 29366-29375
   Abstract »    Full Text »    PDF »
Protein Kinase A Regulates Cholinergic Gene Expression in PC12 Cells: REST4 Silences the Silencing Activity of Neuron-Restrictive Silencer Factor/REST.
M. Shimojo, A. J. Paquette, D. J. Anderson, and L. B. Hersh (1999)
Mol. Cell. Biol. 19, 6788-6795
   Abstract »    Full Text »    PDF »
Arginine Vasopressin Promoter Regulation Is Mediated by a Neuron-restrictive Silencer Element in Small Cell Lung Cancer.
J. M. Coulson, C. E. Fiskerstrand, P. J. Woll, and J. P. Quinn (1999)
Cancer Res. 59, 5123-5127
   Abstract »    Full Text »    PDF »
Neurosecretory cells without neurosecretion: evidence of an independently regulated trait of the cell phenotype.
M L Malosio, R Benfante, G Racchetti, B Borgonovo, P Rosa, and J Meldolesi (1999)
J. Physiol. 520, 43-52
   Abstract »    Full Text »    PDF »
CoREST: A functional corepressor required for regulation of neural-specific gene expression.
M. E. Andres, C. Burger, M. J. Peral-Rubio, E. Battaglioli, M. E. Anderson, J. Grimes, J. Dallman, N. Ballas, and G. Mandel (1999)
PNAS 96, 9873-9878
   Abstract »    Full Text »    PDF »
A Silencer Element in the Regulatory Region of Glutamine Synthetase Controls Cell Type-specific Repression of Gene Induction by Glucocorticoids.
N. Avisar, L. Shiftan, I. Ben-Dror, N. Havazelet, and L. Vardimon (1999)
J. Biol. Chem. 274, 11399-11407
   Abstract »    Full Text »    PDF »
A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins.
R. Meech, P. Kallunki, G. M. Edelman, and F. S. Jones (1999)
PNAS 96, 2420-2425
   Abstract »    Full Text »    PDF »
Cloning from Insulinoma Cells of Synapsin I Associated with Insulin Secretory Granules.
K. Matsumoto, K. Ebihara, H. Yamamoto, H. Tabuchi, K. Fukunaga, M. Yasunami, H. Ohkubo, M. Shichiri, and E. Miyamoto (1999)
J. Biol. Chem. 274, 2053-2059
   Abstract »    Full Text »    PDF »



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