Science 3 March 1995: Vol. 267. no. 5202, pp. 1353 - 1356 DOI: 10.1126/science.7871434

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Articles

Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway.

K. Machida, J.-C. Liu, G. McNamara, A. Levine, L. Duan, and M. M. C. Lai (2009)
J. Virol. 83, 12590-12600
 |  Abstract »  |  Full Text »  |  PDF »

Wild-Type p53 Enhances Efficiency of Simian Virus 40 Large-T-Antigen-Induced Cellular Transformation.

A. Hermannstadter, C. Ziegler, M. Kuhl, W. Deppert, and G. V. Tolstonog (2009)
J. Virol. 83, 10106-10118
 |  Abstract »  |  Full Text »  |  PDF »

The Mouse Lymphoma Assay Detects Recombination, Deletion, and Aneuploidy.

J. Wang, J. R. Sawyer, L. Chen, T. Chen, M. Honma, N. Mei, and M. M. Moore (2009)
Toxicol. Sci. 109, 96-105
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The consequences of tetraploidy and aneuploidy.

Z. Storchova and C. Kuffer (2008)
J. Cell Sci. 121, 3859-3866
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Cell Proliferation, Cell Cycle Abnormalities, and Cancer Outcome in Patients with Barrett's Esophagus: A Long-term Prospective Study.

D. L. Chao, C. A. Sanchez, P. C. Galipeau, P. L. Blount, T. G. Paulson, D. S. Cowan, K. Ayub, R. D. Odze, P. S. Rabinovitch, and B. J. Reid (2008)
Clin. Cancer Res. 14, 6988-6995
 |  Abstract »  |  Full Text »  |  PDF »

The Kinetics of p53 Activation Versus Cyclin E Accumulation Underlies the Relationship between the Spindle-assembly Checkpoint and the Postmitotic Checkpoint.

Y. W. Chan, K. F. On, W. M. Chan, W. Wong, H. O. Siu, P. M. Hau, and R. Y. C. Poon (2008)
J. Biol. Chem. 283, 15716-15723
 |  Abstract »  |  Full Text »  |  PDF »

DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation.

K. Hastak, R. K. Paul, M. K. Agarwal, V. S. Thakur, A. R. M. R. Amin, S. Agrawal, R. M. Sramkoski, J. W. Jacobberger, M. W. Jackson, G. R. Stark, et al. (2008)
PNAS 105, 6314-6319
 |  Abstract »  |  Full Text »  |  PDF »

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression.

I. Ivanovska, A. S. Ball, R. L. Diaz, J. F. Magnus, M. Kibukawa, J. M. Schelter, S. V. Kobayashi, L. Lim, J. Burchard, A. L. Jackson, et al. (2008)
Mol. Cell. Biol. 28, 2167-2174
 |  Abstract »  |  Full Text »  |  PDF »

MdmX Promotes Bipolar Mitosis To Suppress Transformation and Tumorigenesis in p53-Deficient Cells and Mice.

Z. Matijasevic, H. A. Steinman, K. Hoover, and S. N. Jones (2008)
Mol. Cell. Biol. 28, 1265-1273
 |  Abstract »  |  Full Text »  |  PDF »

p53 Activation in Response to Mitotic Spindle Damage Requires Signaling via BubR1-Mediated Phosphorylation.

G.-H. Ha, K.-H. Baek, H.-S. Kim, S.-J. Jeong, C.-M. Kim, F. McKeon, and C.-W. Lee (2007)
Cancer Res. 67, 7155-7164
 |  Abstract »  |  Full Text »  |  PDF »

Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2.

Y. Gui, H. Yin, J.-Y. He, S.-H. Yang, M. P. Walsh, and X.-L. Zheng (2007)
Am J Physiol Heart Circ Physiol 292, H1313-H1320
 |  Abstract »  |  Full Text »  |  PDF »

Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors.

M. K. Agarwal, K. Hastak, M. W. Jackson, S. N. Breit, G. R. Stark, and M. L. Agarwal (2006)
PNAS 103, 16278-16283
 |  Abstract »  |  Full Text »  |  PDF »

Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype.

K. A. Hill, V. L. Buettner, A. Heidt, L.-L. Chen, W. Li, K. D. Gonzalez, J.-C. Wang, W. A. Scaringe, and S. S. Sommer (2006)
Carcinogenesis 27, 1860-1866
 |  Abstract »  |  Full Text »  |  PDF »

Tumour proliferation, angiogenesis, and ploidy status in human colon cancer.

E Cristi, G Perrone, G Toscano, A Verzi, S Nori, D Santini, G Tonini, A Vetrani, A Fabiano, and C Rabitti (2005)
J. Clin. Pathol. 58, 1170-1174
 |  Abstract »  |  Full Text »  |  PDF »

ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development.

K. C. Shen, H. Heng, Y. Wang, S. Lu, G. Liu, C.-X. Deng, S.C. Brooks, and Y. A. Wang (2005)
Cancer Res. 65, 8747-8753
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Control of BubR1 by p53 and Suppression of Centrosome Amplification by BubR1.

T. Oikawa, M. Okuda, Z. Ma, R. Goorha, H. Tsujimoto, H. Inokuma, and K. Fukasawa (2005)
Mol. Cell. Biol. 25, 4046-4061
 |  Abstract »  |  Full Text »  |  PDF »

Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.

J. Wesierska-Gadek, M. Gueorguieva, and M. Horky (2005)
Mol. Cancer Ther. 4, 113-124
 |  Abstract »  |  Full Text »  |  PDF »

Function of Drg1/Rit42 in p53-dependent Mitotic Spindle Checkpoint.

K.-t. Kim, P. P. Ongusaha, Y.-K. Hong, S. K. Kurdistani, M. Nakamura, K. P. Lu, and S. W. Lee (2004)
J. Biol. Chem. 279, 38597-38602
 |  Abstract »  |  Full Text »  |  PDF »

Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth.

J. W. Landen, V. Hau, M. Wang, T. Davis, B. Ciliax, B. H. Wainer, E. G. Van Meir, J. D. Glass, H. C. Joshi, and D. R. Archer (2004)
Clin. Cancer Res. 10, 5187-5201
 |  Abstract »  |  Full Text »  |  PDF »

Expression of a Dominant Negative Heat Shock Factor-1 Construct Inhibits Aneuploidy in Prostate Carcinoma Cells*.

Y. Wang, J. R. Theriault, H. He, J. Gong, and S. K. Calderwood (2004)
J. Biol. Chem. 279, 32651-32659
 |  Abstract »  |  Full Text »  |  PDF »

Transmission of {gamma}-ray-induced unstable chromosomal aberrations through successive mitotic divisions in human lymphocytes in vitro.

A.P. Krishnaja and N.K. Sharma (2004)
Mutagenesis 19, 299-305
 |  Abstract »  |  Full Text »  |  PDF »

Triggering p53 after cytokinesis failure.

P. T. Stukenberg (2004)
J. Cell Biol. 165, 607-608
 |  Abstract »  |  Full Text »  |  PDF »

Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death.

H. Okada, C. Bakal, A. Shahinian, A. Elia, A. Wakeham, W.-K. Suh, G. S. Duncan, M. Ciofani, R. Rottapel, J. C. Zuniga-Pflucker, et al. (2004)
J. Exp. Med. 199, 399-410
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the cell cycle regulatory proteins p34cdc2, p21waf1, and p53 in node negative invasive ductal breast carcinoma.

H P Kourea, A K Koutras, C D Scopa, M N Marangos, E Tzoracoeleftherakis, D Koukouras, and H P Kalofonos (2003)
Mol. Pathol. 56, 328-335
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Response Elements and Differential p53 Binding Control Perp Expression During Apoptosis.

E. E. Reczek, E. R. Flores, A. S. Tsay, L. D. Attardi, and T. Jacks (2003)
Mol. Cancer Res. 1, 1048-1057
 |  Abstract »  |  Full Text »  |  PDF »

DNA Damage during the Spindle-Assembly Checkpoint Degrades CDC25A, Inhibits Cyclin-CDC2 Complexes, and Reverses Cells to Interphase.

J. P.H. Chow, W. Y. Siu, T. K. Fung, W. M. Chan, A. Lau, T. Arooz, C.-P. Ng, K. Yamashita, and R. Y.C. Poon (2003)
Mol. Biol. Cell 14, 3989-4002
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of Mitotic Checkpoint Gene MAD1 by p53.

A. C. S. Chun and D.-Y. Jin (2003)
J. Biol. Chem. 278, 37439-37450
 |  Abstract »  |  Full Text »  |  PDF »

Hyperproliferation and p53 Status of Lens Epithelial Cells Derived from {alpha}B-crystallin Knockout Mice.

F. Bai, J. H. Xi, E. F. Wawrousek, T. P. Fleming, and U. P. Andley (2003)
J. Biol. Chem. 278, 36876-36886
 |  Abstract »  |  Full Text »  |  PDF »

Aneuploidy and Telomere Attrition Are Independent Determinants of Crisis in SV40-transformed Epithelial Cells.

M. Velicescu, J. Yu, B.-S. Herbert, J. W. Shay, E. Granada, and L. Dubeau (2003)
Cancer Res. 63, 5813-5820
 |  Abstract »  |  Full Text »  |  PDF »

Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells.

T. F. Burns, P. Fei, K. A. Scata, D. T. Dicker, and W. S. El-Deiry (2003)
Mol. Cell. Biol. 23, 5556-5571
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Phenotype of Spontaneously Arising 4N (G2-Tetraploid) Intermediates of Neoplastic Progression in Barrett's Esophagus.

M. T. Barrett, D. Pritchard, C. Palanca-Wessels, J. Anderson, B. J. Reid, and P. S. Rabinovitch (2003)
Cancer Res. 63, 4211-4217
 |  Abstract »  |  Full Text »  |  PDF »

p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest.

K.-H. Baek, H.-J. Shin, J.-K. Yoo, J.-H. Cho, Y.-H. Choi, Y.-C. Sung, F. McKeon, and C.-W. Lee (2003)
J. Leukoc. Biol. 73, 850-861
 |  Abstract »  |  Full Text »  |  PDF »

p53 Interacts with hRAD51 and hRAD54, and Directly Modulates Homologous Recombination.

S. P. Linke, S. Sengupta, N. Khabie, B. A. Jeffries, S. Buchhop, S. Miska, W. Henning, R. Pedeux, X. W. Wang, L. J. Hofseth, et al. (2003)
Cancer Res. 63, 2596-2605
 |  Abstract »  |  Full Text »  |  PDF »

Immortal, telomerase-negative cell lines derived from a Li-Fraumeni syndrome patient exhibit telomere length variability and chromosomal and minisatellite instabilities.

T. Tsutsui, S.-i. Kumakura, Y. Tamura, T. W. Tsutsui, M. Sekiguchi, T. Higuchi, and J.C. Barrett (2003)
Carcinogenesis 24, 953-965
 |  Abstract »  |  Full Text »  |  PDF »

Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53.

O. D. Lohez, C. Reynaud, F. Borel, P. R. Andreassen, and R. L. Margolis (2003)
J. Cell Biol. 161, 67-77
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of eNOS gene transfer inhibition of vascular smooth muscle cell proliferation.

F. M. D'Souza, R. L. Sparks, H. Chen, P. J. Kadowitz, and J. R. Jeter Jr. (2003)
Am J Physiol Cell Physiol 284, C191-C199
 |  Abstract »  |  Full Text »  |  PDF »

Detection and characterization of mechanisms of action of aneugenic chemicals.

E.M. Parry, J.M. Parry, C. Corso, A. Doherty, F. Haddad, T.F. Hermine, G. Johnson, M. Kayani, E. Quick, T. Warr, et al. (2002)
Mutagenesis 17, 509-521
 |  Abstract »  |  Full Text »  |  PDF »

Benzylamide Sulindac Analogues Induce Changes in Cell Shape, Loss of Microtubules and G2-M Arrest in a Chronic Lymphocytic Leukemia (CLL) Cell Line and Apoptosis in Primary CLL Cells.

E.-Y. Moon and A. Lerner (2002)
Cancer Res. 62, 5711-5719
 |  Abstract »  |  Full Text »  |  PDF »

Growth Retardation, Polyploidy, and Multinucleation Induced by Clast3, a Novel Cell Cycle-regulated Protein.

R. Bahar, J. O-Wang, K. Kawamura, M. Seimiya, Y. Wang, M. Hatano, S. Okada, T. Tokuhisa, T. Watanabe, and M. Tagawa (2002)
J. Biol. Chem. 277, 40012-40019
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated Progression of Asbestos-Induced Mesotheliomas in Heterozygous p53+/- Mice.

C. A. Vaslet, N. J. Messier, and A. B. Kane (2002)
Toxicol. Sci. 68, 331-338
 |  Abstract »  |  Full Text »  |  PDF »

Variable Levels of Chromosomal Instability and Mitotic Spindle Checkpoint Defects in Breast Cancer.

D.-S. Yoon, R. P. Wersto, W. Zhou, F. J. Chrest, E. S. Garrett, T. K. Kwon, and E. Gabrielson (2002)
Am. J. Pathol. 161, 391-397
 |  Abstract »  |  Full Text »  |  PDF »

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells.

F. Borel, O. D. Lohez, F. B. Lacroix, and R. L. Margolis (2002)
PNAS 99, 9819-9824
 |  Abstract »  |  Full Text »  |  PDF »

Noscapine Alters Microtubule Dynamics in Living Cells and Inhibits the Progression of Melanoma.

J. W. Landen, R. Lang, S. J. McMahon, N. M. Rusan, A.-M. Yvon, A. W. Adams, M. D. Sorcinelli, R. Campbell, P. Bonaccorsi, J. C. Ansel, et al. (2002)
Cancer Res. 62, 4109-4114
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence.

G. Ferbeyre, E. de Stanchina, A. W. Lin, E. Querido, M. E. McCurrach, G. J. Hannon, and S. W. Lowe (2002)
Mol. Cell. Biol. 22, 3497-3508
 |  Abstract »  |  Full Text »  |  PDF »

Transduction of Interphase Cells by Avian Sarcoma Virus.

R. A. Katz, J. G. Greger, K. Darby, P. Boimel, G. F. Rall, and A. M. Skalka (2002)
J. Virol. 76, 5422-5434
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Mitotic Spindle Checkpoint Protein hsMAD1 Correlates with Cellular Proliferation and Is Activated by a Gain-of-Function p53 Mutant.

Y. Iwanaga and K.-T. Jeang (2002)
Cancer Res. 62, 2618-2624
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix-induced apoptosis.

V. L. Seewaldt, K. Mrozek, R. Sigle, E. C. Dietze, K. Heine, D. M. Hockenbery, K. B. Hobbs, and L. E. Caldwell (2001)
J. Cell Biol. 155, 471-486
 |  Abstract »  |  Full Text »  |  PDF »

Persistent Increase in Chromosome Instability in Lung Cancer : Possible Indirect Involvement of p53 Inactivation.

N. Haruki, T. Harano, A. Masuda, T. Kiyono, T. Takahashi, Y. Tatematsu, S. Shimizu, T. Mitsudomi, H. Konishi, H. Osada, et al. (2001)
Am. J. Pathol. 159, 1345-1352
 |  Abstract »  |  Full Text »

Aberrant cell cycle checkpoint function in transformed hepatocytes and WB-F344 hepatic epithelial stem-like cells.

W. K. Kaufmann, C. I. Behe, V. M. Golubovskaya, L. L. Byrd, C. D. Albright, K. M. Borchet, S. C. Presnell, W. B. Coleman, J. W. Grisham, and G. J. Smith (2001)
Carcinogenesis 22, 1257-1269
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-induced chromosome aberrations in human euchromatic (17cen-p53) and heterochromatic (1cen-1q12) regions.

S. Puerto, M.J. Ramirez, R. Marcos, A. Creus, and J. Surralles (2001)
Mutagenesis 16, 291-296
 |  Abstract »  |  Full Text »  |  PDF »

The c-Jun NH2-terminal Protein Kinase/AP-1 Pathway Is Required for Efficient Apoptosis Induced by Vinblastine.

M. Fan, M. E. Goodwin, M. J. Birrer, and T. C. Chambers (2001)
Cancer Res. 61, 4450-4458
 |  Abstract »  |  Full Text »  |  PDF »

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1.

P. R. Andreassen, O. D. Lohez, F. B. Lacroix, and R. L. Margolis (2001)
Mol. Biol. Cell 12, 1315-1328
 |  Abstract »  |  Full Text »

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.

C. M. Simbulan-Rosenthal, D. S. Rosenthal, R. Luo, J.-H. Li, J. Zhang, and M. E. Smulson (2001)
Nucleic Acids Res. 29, 841-849
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Induced p53 Downregulation Precedes Vascular Smooth Muscle Cell Migration From Healthy Tunica Media and Proliferation.

A. Rodriguez-Campos, P. Ruiz-Enriquez, S. Faraudo, and L. Badimon (2001)
Arterioscler Thromb Vasc Biol 21, 214-219
 |  Abstract »  |  Full Text »  |  PDF »

Lens epithelial cells derived from {alpha}B-crystallin knockout mice demonstrate hyperproliferation and genomic instability.

U. P. ANDLEY, Z. SONG, E. F. WAWROUSEK, J. P. BRADY, S. BASSNETT, and T. P. FLEMING (2001)
FASEB J 15, 221-229
 |  Abstract »  |  Full Text »  |  PDF »

Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells.

T. M. GOEPFERT, M. MCCARTHY, F. S. KITTRELL, C. STEPHENS, R. L. ULLRICH, B. R. BRINKLEY, and D. MEDINA (2000)
FASEB J 14, 2221-2229
 |  Abstract »  |  Full Text »

Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.

M. D. Vodenicharov, F. R. Sallmann, M. S. Satoh, and G. G. Poirier (2000)
Nucleic Acids Res. 28, 3887-3896
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.

B. O. Petersen, C. Wagener, F. Marinoni, E. R. Kramer, M. Melixetian, E. L. Denchi, C. Gieffers, C. Matteucci, J.-M. Peters, and K. Helin (2000)
Genes & Dev. 14, 2330-2343
 |  Abstract »  |  Full Text »

Aberrant Regulation and Function of Wild-Type p53 in Radioresistant Melanoma Cells.

K. Satyamoorthy, N. H. Chehab, M. J. F. Waterman, M. C. Lien, W. S. El-Deiry, M. Herlyn, and T. D. Halazonetis (2000)
Cell Growth Differ. 11, 467-474
 |  Abstract »  |  Full Text »

Multicolour FISH detection of radioactive iodine-induced 17cen-p53 chromosomal breakage in buccal cells from therapeutically exposed patients.

M.J. Ramirez, S. Puerto, P. Galofre, E.M. Parry, J.M. Parry, A. Creus, R. Marcos, and J. Surralles (2000)
Carcinogenesis 21, 1581-1586
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Risk and the ATM Gene: a Continuing Debate.

K. K. Khanna (2000)
J Natl Cancer Inst 92, 795-802
 |  Abstract »  |  Full Text »  |  PDF »

Cell-Specific Modulation of Papovavirus Replication by Tumor Suppressor Protein p53.

D. Lepik and M. Ustav (2000)
J. Virol. 74, 4688-4697
 |  Abstract »  |  Full Text »

Rapid induction of uterine tumors with p53 point mutations in heterozygous p53-deficient CBA mice given a single intraperitoneal administration of N-ethyl-N-nitrosourea.

K. Mitsumori, H. Onodera, T. Shimo, K. Yasuhara, H. Takagi, T. Koujitani, M. Hirose, C. Maruyama, and S. Wakana (2000)
Carcinogenesis 21, 1039-1042
 |  Abstract »  |  Full Text »  |  PDF »

Productive Replication of Adeno-Associated Virus Can Occur in Human Papillomavirus Type 16 (HPV-16) Episome-Containing Keratinocytes and Is Augmented by the HPV-16 E2 Protein.

P. Ogston, K. Raj, and P. Beard (2000)
J. Virol. 74, 3494-3504
 |  Abstract »  |  Full Text »

Flavopiridol, a Cyclin-dependent Kinase Inhibitor, Prevents Spindle Inhibitor-induced Endoreduplication in Human Cancer Cells.

M. Motwani, X.-k. Li, and G. K. Schwartz (2000)
Clin. Cancer Res. 6, 924-932
 |  Abstract »  |  Full Text »

The Human Cdc14 Phosphatases Interact with and Dephosphorylate the Tumor Suppressor Protein p53.

L. Li, M. Ljungman, and J. E. Dixon (2000)
J. Biol. Chem. 275, 2410-2414
 |  Abstract »  |  Full Text »  |  PDF »

Role of DNA Break-sensing Molecule Poly(ADP-ribose) Polymerase (PARP) in Cellular Function and Radiation Toxicity.

W.-M. TONG, D. GALENDO, and Z.-Q. WANG (2000)
Cold Spring Harb Symp Quant Biol 65, 583-592
 |  Abstract »  |  PDF »

Correlations Among p53, Her-2/neu, and ras Overexpression and Aneuploidy by Multiparameter Flow Cytometry in Human Breast Cancer: Evidence for a Common Phenotypic Evolutionary Pattern in Infiltrating Ductal Carcinomas.

C. A. Smith, A. A. Pollice, L.-P. Gu, K. A. Brown, S. G. Singh, L. E. Janocko, R. Johnson, T. Julian, D. Hyams, N. Wolmark, et al. (2000)
Clin. Cancer Res. 6, 112-126
 |  Abstract »  |  Full Text »

Defects in transforming growth factor-beta signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes.

A. Glick, N. Popescu, V. Alexander, H. Ueno, E. Bottinger, and S. H. Yuspa (1999)
PNAS 96, 14949-14954
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the p53 Tumor Suppressor Protein.

M. Oren (1999)
J. Biol. Chem. 274, 36031-36034
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Identification and classification of p53-regulated genes.

J. Yu, L. Zhang, P. M. Hwang, C. Rago, K. W. Kinzler, and B. Vogelstein (1999)
PNAS 96, 14517-14522
 |  Abstract »  |  Full Text »  |  PDF »

Fractional allele loss indicates distinct genetic populations in the development of squamous cell carcinoma of the head and neck (SCCHN).

J. Nunn, A.G.M. Scholes, T. Liloglou, S. Nagini, A.S. Jones, E.D. Vaughan, J.R. Gosney, S. Rogers, S. Fear, and J.K. Field (1999)
Carcinogenesis 20, 2219-2228
 |  Abstract »  |  Full Text »  |  PDF »

Altered Centrosome Structure Is Associated with Abnormal Mitoses in Human Breast Tumors.

W. L. Lingle and J. L. Salisbury (1999)
Am. J. Pathol. 155, 1941-1951
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal aberrations in PARP-/- mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.

C. M. Simbulan-Rosenthal, B. R. Haddad, D. S. Rosenthal, Z. Weaver, A. Coleman, R. Luo, H. M. Young, Z.-Q. Wang, T. Ried, and M. E. Smulson (1999)
PNAS 96, 13191-13196
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of G2 Arrest in Response to Overexpression of p53.

W. R. Taylor, S. E. DePrimo, A. Agarwal, M. L. Agarwal, A. H. Schönthal, K. S. Katula, and G. R. Stark (1999)
Mol. Biol. Cell 10, 3607-3622
 |  Abstract »  |  Full Text »

Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice.

V. L. Cressman, D. C. Backlund, A. V. Avrutskaya, S. A. Leadon, V. Godfrey, and B. H. Koller (1999)
Mol. Cell. Biol. 19, 7061-7075
 |  Abstract »  |  Full Text »  |  PDF »

p53 Controls Low DNA Damage-dependent Premeiotic Checkpoint and Facilitates DNA Repair during Spermatogenesis.

D. Schwartz, N. Goldfinger, Z. Kam, and V. Rotter (1999)
Cell Growth Differ. 10, 665-675
 |  Abstract »  |  Full Text »

Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole.

B. Verdoodt, I. Decordier, K. Geleyns, M. Cunha, E. Cundari, and M. Kirsch-Volders (1999)
Mutagenesis 14, 513-520
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c-Myc Overexpression Uncouples DNA Replication from Mitosis.

Q. Li and C. V. Dang (1999)
Mol. Cell. Biol. 19, 5339-5351
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Defective G1-S Cell Cycle Checkpoint Function Sensitizes Cells to Microtubule Inhibitor-induced Apoptosis.

Z. A. Stewart, D. Mays, and J. A. Pietenpol (1999)
Cancer Res. 59, 3831-3837
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Taxol, vincristine or nocodazole induces lethality in G1-checkpoint-defective human astrocytoma U373MG cells by triggering hyperploid progression.

F. D. Hong, J. Chen, S. Donovan, N. Schneider, and P. D. Nisen (1999)
Carcinogenesis 20, 1161-1168
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The Cancer Antiapoptosis Mouse Survivin Gene: Characterization of Locus and Transcriptional Requirements of Basal and Cell Cycle-dependent Expression.

F. Li and D. C. Altieri (1999)
Cancer Res. 59, 3143-3151
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Apoptotic and Mitotic Indices Predict Survival Rates in Lymph Node-negative Colon Carcinomas.

F. A. Sinicrope, J. Hart, H.-A. Hsu, M. Lemoine, F. Michelassi, and L. C. Stephens (1999)
Clin. Cancer Res. 5, 1793-1804
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Paclitaxel Resistance in Non-Small-Cell Lung Cancer Associated With Beta-Tubulin Gene Mutations.

M. Monzo, R. Rosell, J. J. Sanchez, J. S. Lee, A. O'Brate, J. L. Gonzalez-Larriba, V. Alberola, J. C. Lorenzo, L. Nunez, J. Y. Ro, et al. (1999)
J. Clin. Oncol. 17, 1786
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The Ability of p53 to Activate Downstream Genes p21WAF1/cip1 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase.

L. A. Kachnic, B. Wu, H. Wunsch, K. L. Mekeel, J. S. DeFrank, W. Tang, and S. N. Powell (1999)
J. Biol. Chem. 274, 13111-13117
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GADD45 induction of a G2/M cell cycle checkpoint.

X. W. Wang, Q. Zhan, J. D. Coursen, M. A. Khan, H. U. Kontny, L. Yu, M. C. Hollander, P. M. O'Connor, A. J. Fornace Jr., and C. C. Harris (1999)
PNAS 96, 3706-3711
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p53 regulates a G2 checkpoint through cyclin B1.

S. A. Innocente, J. L. A. Abrahamson, J. P. Cogswell, and J. M. Lee (1999)
PNAS 96, 2147-2152
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p21cip-1/waf-1 Deficiency Causes Deformed Nuclear Architecture, Centriole Overduplication, Polyploidy, and Relaxed Microtubule Damage Checkpoints in Human Hematopoietic Cells.

C. Mantel, S. E. Braun, S. Reid, O. Henegariu, L. Liu, G. Hangoc, and H. E. Broxmeyer (1999)
Blood 93, 1390-1398
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p21Waf1/Cip1 Inhibition of Cyclin E/Cdk2 Activity Prevents Endoreduplication after Mitotic Spindle Disruption.

Z. A. Stewart, S. D. Leach, and J. A. Pietenpol (1999)
Mol. Cell. Biol. 19, 205-215
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Ectopic Expression of cdc2/cdc28 Kinase Subunit Homo sapiens 1 Uncouples Cyclin B Metabolism from the Mitotic Spindle Cell Cycle Checkpoint.

M. L. Hixon, A. I. Flores, M. W. Wagner, and A. Gualberto (1998)
Mol. Cell. Biol. 18, 6224-6237
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Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2.

K. Iwabuchi, B. Li, H. F. Massa, B. J. Trask, T. Date, and S. Fields (1998)
J. Biol. Chem. 273, 26061-26068
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Specific K-ras2 Mutations in Human Sporadic Colorectal Adenomas Are Associated with DNA Near-Diploid Aneuploidy and Inhibition of Proliferation.

W. Giaretti, A. Rapallo, E. Geido, A. Sciutto, F. Merlo, M. Risio, and F. P. Rossini (1998)
Am. J. Pathol. 153, 1201-1209
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Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53.

L. Resnick-Silverman, S. St. Clair, M. Maurer, K. Zhao, and J. J. Manfredi (1998)
Genes & Dev. 12, 2102-2107
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Cell Cycle Progression : New Therapeutic Target for Vascular Proliferative Disease.

R. C. Braun-Dullaeus, M. J. Mann, and V. J. Dzau (1998)
Circulation 98, 82-89
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Review : p53 in the pathogenesis, diagnosis, and treatment of cancer.

E. Perz and J. G. Kuhn (1998)
Journal of Oncology Pharmacy Practice 4, 75-102
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Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage.

T. G. Paulson, A. Almasan, L. L. Brody, and G. M. Wahl (1998)
Mol. Cell. Biol. 18, 3089-3100
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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.

A. Gualberto, K. Aldape, K. Kozakiewicz, and T. D. Tlsty (1998)
PNAS 95, 5166-5171
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Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity.

W. L. Lingle, W. H. Lutz, J. N. Ingle, N. J. Maihle, and J. L. Salisbury (1998)
PNAS 95, 2950-2955
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Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint.

J. T. Thomas and L. A. Laimins (1998)
J. Virol. 72, 1131-1137
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