Science 3 March 1995: Vol. 267. no. 5202, pp. 1349 - 1353 DOI: 10.1126/science.7871433

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Articles

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130.

Y. Tanaka, N. Tanaka, Y. Saeki, K. Tanaka, M. Murakami, T. Hirano, N. Ishii, and K. Sugamura (2008)
Mol. Cell. Biol. 28, 4805-4818
 |  Abstract »  |  Full Text »  |  PDF »

Box 2 Region of the Oncostatin M Receptor Determines Specificity for Recruitment of Janus Kinases and STAT5 Activation.

C. Hintzen, C. Evers, B. E. Lippok, R. Volkmer, P. C. Heinrich, S. Radtke, and H. M. Hermanns (2008)
J. Biol. Chem. 283, 19465-19477
 |  Abstract »  |  Full Text »  |  PDF »

The Role of TRAF2 Binding to the Type I Interferon Receptor in Alternative NF{kappa}B Activation and Antiviral Response.

C. H. Yang, A. Murti, S. R. Pfeffer, M. Fan, Z. Du, and L. M. Pfeffer (2008)
J. Biol. Chem. 283, 14309-14316
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A Conserved IFN-{alpha} Receptor Tyrosine Motif Directs the Biological Response to Type I IFNs.

W. Zhao, C. Lee, R. Piganis, C. Plumlee, N. de Weerd, P. J. Hertzog, and C. Schindler (2008)
J. Immunol. 180, 5483-5489
 |  Abstract »  |  Full Text »  |  PDF »

Oxysterol and Diabetes Activate STAT3 and Control Endothelial Expression of Profilin-1 via OSBP1.

G. R. Romeo and A. Kazlauskas (2008)
J. Biol. Chem. 283, 9595-9605
 |  Abstract »  |  Full Text »  |  PDF »

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.

D. de Totero, R. Meazza, M. Capaia, M. Fabbi, B. Azzarone, E. Balleari, M. Gobbi, G. Cutrona, M. Ferrarini, and S. Ferrini (2008)
Blood 111, 517-524
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ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3.

Y.-S. Bong, H.-S. Lee, L. Carim-Todd, K. Mood, T. G. Nishanian, L. Tessarollo, and I. O. Daar (2007)
PNAS 104, 17305-17310
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients.

R. Dutta, J. McDonough, A. Chang, L. Swamy, A. Siu, G. J. Kidd, R. Rudick, K. Mirnics, and B. D. Trapp (2007)
Brain 130, 2566-2576
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 stimulates {alpha}-MG uptake in renal proximal tubule cells: involvement of STAT3, PI3K/Akt, MAPKs, and NF-{kappa}B.

Y. J. Lee, J. S. Heo, H. N. Suh, M. Y. Lee, and H. J. Han (2007)
Am J Physiol Renal Physiol 293, F1036-F1046
 |  Abstract »  |  Full Text »  |  PDF »

The molecular basis of IL-21-mediated proliferation.

R. Zeng, R. Spolski, E. Casas, W. Zhu, D. E. Levy, and W. J. Leonard (2007)
Blood 109, 4135-4142
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Antagonizes Interleukin-6 Signaling and Is Anti-inflammatory in 3T3-L1 Adipocytes.

C. X. Andersson, V. R. Sopasakis, E. Wallerstedt, and U. Smith (2007)
J. Biol. Chem. 282, 9430-9435
 |  Abstract »  |  Full Text »  |  PDF »

An Essential Role for gp130 in Neointima Formation Following Arterial Injury.

D. Wang, Z. Liu, Q. Li, M. Karpurapu, V. Kundumani-Sridharan, H. Cao, N. Dronadula, F. Rizvi, A. K. Bajpai, C. Zhang, et al. (2007)
Circ. Res. 100, 807-816
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Constitutively Active STAT3 Can Replicate the Cytokine-suppressive Activity of Interleukin-10 in Human Primary Macrophages.

L. M. Williams, U. Sarma, K. Willets, T. Smallie, F. Brennan, and B. M. J. Foxwell (2007)
J. Biol. Chem. 282, 6965-6975
 |  Abstract »  |  Full Text »  |  PDF »

Identification of CXCL11 as a STAT3-Dependent Gene Induced by IFN.

C. H. Yang, L. Wei, S. R. Pfeffer, Z. Du, A. Murti, W. J. Valentine, Y. Zheng, and L. M. Pfeffer (2007)
J. Immunol. 178, 986-992
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction by Human Herpesvirus 8 Viral Interleukin-6 (vIL-6) Is Modulated by the Nonsignaling gp80 Subunit of the IL-6 Receptor Complex and Is Distinct from Signaling Induced by Human IL-6.

F. Hu and J. Nicholas (2006)
J. Virol. 80, 10874-10878
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte 15-Lipoxygenase Expression Is Regulated by a Novel Cytosolic Signaling Complex with Protein Kinase C {delta} and Tyrosine-Phosphorylated Stat3.

A. Bhattacharjee, B. Xu, D. A. Frank, G. M. Feldman, and M. K. Cathcart (2006)
J. Immunol. 177, 3771-3781
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of porcine signal transducer and activator of transcription 3 cDNA and its expression in reproductive tissues..

L. Wen, J. Craig, P. W Dyce, and J. Li (2006)
Reproduction 132, 511-518
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

F. Rousseau, J.-F. Gauchat, J. G. McLeod, S. Chevalier, C. Guillet, F. Guilhot, I. Cognet, J. Froger, A. F. Hahn, P. M. Knappskog, et al. (2006)
PNAS 103, 10068-10073
 |  Abstract »  |  Full Text »  |  PDF »

Unique structural determinants for stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744..

H. Shao, X. Xu, N. Jing, and D. J. Tweardy (2006)
J. Immunol. 176, 2933-2941
 |  Abstract »  |  Full Text »  |  PDF »

Absence of Suppressor of Cytokine Signalling 3 Reduces Self-Renewal and Promotes Differentiation in Murine Embryonic Stem Cells.

A. Forrai, K. Boyle, A. H. Hart, L. Hartley, S. Rakar, T. A. Willson, K. M. Simpson, A. W. Roberts, W. S. Alexander, A. K. Voss, et al. (2006)
Stem Cells 24, 604-614
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk among gp130 Cytokines in Adipocytes.

S. Zvonic, J. E. Baugh Jr., P. Arbour-Reily, R. L. Mynatt, and J. M. Stephens (2005)
J. Biol. Chem. 280, 33856-33863
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation: CONTRIBUTIONS OF Src- AND RECEPTOR-TYROSINE KINASES.

U. Sommer, C. Schmid, R. M. Sobota, U. Lehmann, N. J. Stevenson, J. A. Johnston, F. Schaper, P. C. Heinrich, and S. Haan (2005)
J. Biol. Chem. 280, 31478-31488
 |  Abstract »  |  Full Text »  |  PDF »

IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells.

K.-T. Chang, C.-M. Tsai, Y.-C. Chiou, C.-H. Chiu, K.-S. Jeng, and C.-Y. F. Huang (2005)
Am J Physiol Lung Cell Mol Physiol 289, L446-L453
 |  Abstract »  |  Full Text »  |  PDF »

Proline-, Glutamic Acid-, and Leucine-Rich Protein-1 Is Essential in Growth Factor Regulation of Signal Transducers and Activators of Transcription 3 Activation.

B. Manavathi, S. S. Nair, R.-A. Wang, R. Kumar, and R. K. Vadlamudi (2005)
Cancer Res. 65, 5571-5577
 |  Abstract »  |  Full Text »  |  PDF »

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis.

B. J. Jenkins, A. W. Roberts, M. Najdovska, D. Grail, and M. Ernst (2005)
Blood 105, 3512-3520
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant Stat3 Signaling by Interleukin-4 in Malignant Glioma Cells: Involvement of IL-13R{alpha}2.

S. O. Rahaman, M. A. Vogelbaum, and S. J. Haque (2005)
Cancer Res. 65, 2956-2963
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGF{beta}-activated kinase 1 for STAT3 Ser-727 phosphorylation.

H. Kojima, T. Sasaki, T. Ishitani, S.-i. Iemura, H. Zhao, S. Kaneko, H. Kunimoto, T. Natsume, K. Matsumoto, and K. Nakajima (2005)
PNAS 102, 4524-4529
 |  Abstract »  |  Full Text »  |  PDF »

RET-Familial Medullary Thyroid Carcinoma Mutants Y791F and S891A Activate a Src/JAK/STAT3 Pathway, Independent of Glial Cell Line-Derived Neurotrophic Factor.

I. Plaza Menacho, R. Koster, A. M. van der Sloot, W. J. Quax, J. Osinga, T. van der Sluis, H. Hollema, G. M. Burzynski, O. Gimm, C. H.C.M. Buys, et al. (2005)
Cancer Res. 65, 1729-1737
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue.

Z.-l. Yuan, Y.-j. Guan, D. Chatterjee, and Y. E. Chin (2005)
Science 307, 269-273
 |  Abstract »  |  Full Text »  |  PDF »

LIF/STAT3 Signaling Fails to Maintain Self-Renewal of Human Embryonic Stem Cells.

L. Daheron, S. L. Opitz, H. Zaehres, W. M. Lensch, P. W. Andrews, J. Itskovitz-Eldor, and G. Q. Daley (2004)
Stem Cells 22, 770-778
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Signaling Capacities of the Novel gp130-like Cytokine Receptor.

A. Dreuw, S. Radtke, S. Pflanz, B. E. Lippok, P. C. Heinrich, and H. M. Hermanns (2004)
J. Biol. Chem. 279, 36112-36120
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Inhibition of Interleukin-10 by the Immunomodulator AS101 Reduces Mesangial Cell Proliferation in Experimental Mesangioproliferative Glomerulonephritis: ASSOCIATION WITH DEPHOSPHORYLATION OF STAT3.

Y. Kalechman, U. Gafter, T. Weinstein, A. Chagnac, I. Freidkin, A. Tobar, M. Albeck, and B. Sredni (2004)
J. Biol. Chem. 279, 24724-24732
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role for Hematopoietic Cell Kinase (Hck)-mediated Phosphorylation of Gab1 and Gab2 Docking Proteins in Interleukin 6-induced Proliferation and Survival of Multiple Myeloma Cells.

K. Podar, G. Mostoslavsky, M. Sattler, Y.-T. Tai, T. Hayashi, L. P. Catley, T. Hideshima, R. C. Mulligan, D. Chauhan, and K. C. Anderson (2004)
J. Biol. Chem. 279, 21658-21665
 |  Abstract »  |  Full Text »  |  PDF »

Structural Requirements for Signal Transducer and Activator of Transcription 3 Binding to Phosphotyrosine Ligands Containing the YXXQ Motif.

H. Shao, X. Xu, M.-A. A. Mastrangelo, N. Jing, R. G. Cook, G. B. Legge, and D. J. Tweardy (2004)
J. Biol. Chem. 279, 18967-18973
 |  Abstract »  |  Full Text »  |  PDF »

Functional Expression of the Interleukin-11 Receptor {alpha}-Chain and Evidence of Antiapoptotic Effects in Human Colonic Epithelial Cells.

S. Kiessling, G. Muller-Newen, S. N. Leeb, M. Hausmann, H. C. Rath, J. Strater, T. Spottl, K. Schlottmann, J. Grossmann, F. A. Montero-Julian, et al. (2004)
J. Biol. Chem. 279, 10304-10315
 |  Abstract »  |  Full Text »  |  PDF »

Cytoplasmic c-Fos induced by the YXXQ-derived STAT3 signal requires the co-operative MEK/ERK signal for its nuclear translocation.

N. Higashi, H. Kunimoto, S. Kaneko, T. Sasaki, M. Ishii, H. Kojima, and K. Nakajima (2004)
Genes Cells 9, 233-242
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation.

K. Brocke-Heidrich, A. K. Kretzschmar, G. Pfeifer, C. Henze, D. Loffler, D. Koczan, H.-J. Thiesen, R. Burger, M. Gramatzki, and F. Horn (2004)
Blood 103, 242-251
 |  Abstract »  |  Full Text »  |  PDF »

GPL, a Novel Cytokine Receptor Related to GP130 and Leukemia Inhibitory Factor Receptor.

C. Diveu, E. Lelievre, D. Perret, A.-H. L. Lak-Hal, J. Froger, C. Guillet, S. Chevalier, F. Rousseau, A. Wesa, L. Preisser, et al. (2003)
J. Biol. Chem. 278, 49850-49859
 |  Abstract »  |  Full Text »  |  PDF »

The WD Motif-Containing Protein RACK-1 Functions as a Scaffold Protein Within the Type I IFN Receptor-Signaling Complex.

A. Usacheva, X. Tian, R. Sandoval, D. Salvi, D. Levy, and O. R. Colamonici (2003)
J. Immunol. 171, 2989-2994
 |  Abstract »  |  Full Text »  |  PDF »

New Programming of IL-4 Receptor Signal Transduction in Activated T Cells: Stat6 Induction and Th2 Differentiation Mediated by IL-4R{alpha} Lacking Cytoplasmic Tyrosines.

A. L. Mora, L. M. Stephenson, B. Enerson, J. Youn, A. D. Keegan, and M. Boothby (2003)
J. Immunol. 171, 1891-1900
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Src Family Kinase-independent Signal Transduction and Gene Induction by Leukemia Inhibitory Factor.

G. S. Laszlo and N. M. Nathanson (2003)
J. Biol. Chem. 278, 27750-27757
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Signal Transducer and Activator of Transcription 3 Recruitment Sites within the Epidermal Growth Factor Receptor.

H. Shao, H. Y. Cheng, R. G. Cook, and D. J. Tweardy (2003)
Cancer Res. 63, 3923-3930
 |  Abstract »  |  Full Text »  |  PDF »

TNF-{alpha} Induces Tyrosine Phosphorylation and Recruitment of the Src Homology Protein-Tyrosine Phosphatase 2 to the gp130 Signal-Transducing Subunit of the IL-6 Receptor Complex.

J. G. Bode, J. Schweigart, J. Kehrmann, C. Ehlting, F. Schaper, P. C. Heinrich, and D. Haussinger (2003)
J. Immunol. 171, 257-266
 |  Abstract »  |  Full Text »  |  PDF »

Novel Variants of the IL-10 Receptor 1 Affect Inhibition of Monocyte TNF-{alpha} Production.

C. Gasche, P. Grundtner, P. Zwirn, W. Reinisch, S. H. Shaw, A. Zdanov, U. Sarma, L. M. Williams, B. M. Foxwell, and A. Gangl (2003)
J. Immunol. 170, 5578-5582
 |  Abstract »  |  Full Text »  |  PDF »

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin.

H. Munzberg, L. Huo, E. A. Nillni, A. N. Hollenberg, and C. Bjorbaek (2003)
Endocrinology 144, 2121-2131
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Suppression of Dopamine-beta -hydroxylase by Extracellular Signal-regulated Kinase-dependent and -independent Pathways.

S. Dziennis and B. A. Habecker (2003)
J. Biol. Chem. 278, 15897-15904
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Phosphopeptide Motifs Specific for the Src Homology 2 Domains of Signal Transducer and Activator of Transcription 1 (STAT1) and STAT3.

M. Wiederkehr-Adam, P. Ernst, K. Muller, E. Bieck, F. O. Gombert, J. Ottl, P. Graff, F. Grossmuller, and M. H. Heim (2003)
J. Biol. Chem. 278, 16117-16128
 |  Abstract »  |  Full Text »  |  PDF »

Transactivation of gp130 in Myeloma Cells.

J. D. French, D. K. Walters, and D. F. Jelinek (2003)
J. Immunol. 170, 3717-3723
 |  Abstract »  |  Full Text »  |  PDF »

Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3.

C. Niemand, A. Nimmesgern, S. Haan, P. Fischer, F. Schaper, R. Rossaint, P. C. Heinrich, and G. Muller-Newen (2003)
J. Immunol. 170, 3263-3272
 |  Abstract »  |  Full Text »  |  PDF »

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130.

U. Lehmann, J. Schmitz, M. Weissenbach, R. M. Sobota, M. Hortner, K. Friederichs, I. Behrmann, W. Tsiaris, A. Sasaki, J. Schneider-Mergener, et al. (2003)
J. Biol. Chem. 278, 661-671
 |  Abstract »  |  Full Text »  |  PDF »

The Unsolved Enigmas of Leukemia Inhibitory Factor.

D. Metcalf (2003)
Stem Cells 21, 5-14
 |  Abstract »  |  Full Text »  |  PDF »

STAT5a Activation Mediates the Epithelial to Mesenchymal Transition Induced by Oncogenic RhoA..

S. A. Benitah, P. F. Valeron, H. Rui, and J. C. Lacal (2003)
Mol. Biol. Cell 14, 40-53
 |  Abstract »  |  Full Text »

Protein Kinase C delta Associates with the Interleukin-6 Receptor Subunit Glycoprotein (gp) 130 via Stat3 and Enhances Stat3-gp130 Interaction.

V. Novotny-Diermayr, T. Zhang, L. Gu, and X. Cao (2002)
J. Biol. Chem. 277, 49134-49142
 |  Abstract »  |  Full Text »  |  PDF »

Ciliary Neurotrophic Factor (CNTF) Enhances Myelin Formation: A Novel Role for CNTF and CNTF-Related Molecules.

B. Stankoff, M.-S. Aigrot, F. Noel, A. Wattilliaux, B. Zalc, and C. Lubetzki (2002)
J. Neurosci. 22, 9221-9227
 |  Abstract »  |  Full Text »  |  PDF »

ErbB-2 Activates Stat3alpha in a Src- and JAK2-dependent Manner.

Z. Ren and T. S. Schaefer (2002)
J. Biol. Chem. 277, 38486-38493
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Down-regulates the Expression of Cyclin D during Liver Development.

T. Matsui, T. Kinoshita, T. Hirano, T. Yokota, and A. Miyajima (2002)
J. Biol. Chem. 277, 36167-36173
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Both Positive and Negative Domains within the Epidermal Growth Factor Receptor COOH-terminal Region for Signal Transducer and Activator of Transcription (STAT) Activation.

L. Xia, L. Wang, A. S. Chung, S. S. Ivanov, M. Y. Ling, A. M. Dragoi, A. Platt, T. M. Gilmer, X.-Y. Fu, and Y. E. Chin (2002)
J. Biol. Chem. 277, 30716-30723
 |  Abstract »  |  Full Text »  |  PDF »

SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.

A. M. Kant, P. De, X. Peng, T. Yi, D. J. Rawlings, J. S. Kim, and D. L. Durden (2002)
Blood 100, 1852-1859
 |  Abstract »  |  Full Text »  |  PDF »

Mutational switch of an IL-6 response to an interferon-gamma -like response.

A. P. Costa-Pereira, S. Tininini, B. Strobl, T. Alonzi, J. F. Schlaak, H. Is'harc, I. Gesualdo, S. J. Newman, I. M. Kerr, and V. Poli (2002)
PNAS 99, 8043-8047
 |  Abstract »  |  Full Text »  |  PDF »

Interdomain Interaction of Stat3 Regulates Its Src Homology 2 Domain-mediated Receptor Binding Activity.

T. Zhang, K. T. Seow, C. T. Ong, and X. Cao (2002)
J. Biol. Chem. 277, 17556-17563
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.

K. Kirito, K. Nakajima, T. Watanabe, M. Uchida, M. Tanaka, K. Ozawa, and N. Komatsu (2002)
Blood 99, 102-110
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Activation by STAT6 Requires the Direct Interaction with NCoA-1.

C. M. Litterst and E. Pfitzner (2001)
J. Biol. Chem. 276, 45713-45721
 |  Abstract »  |  Full Text »  |  PDF »

Protein tyrosine phosphatase epsilon C selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling.

N. Tanuma, H. Shima, K. Nakamura, and K. Kikuchi (2001)
Blood 98, 3030-3034
 |  Abstract »  |  Full Text »  |  PDF »

Gas6 Induces Mesangial Cell Proliferation via Latent Transcription Factor STAT3.

M. Yanagita, H. Arai, T. Nakano, K. Ohashi, K. Mizuno, A. Fukatsu, T. Doi, and T. Kita (2001)
J. Biol. Chem. 276, 42364-42369
 |  Abstract »  |  Full Text »  |  PDF »

Stem Cells from the Mammalian Blastocyst.

J. Rossant (2001)
Stem Cells 19, 477-482
 |  Abstract »  |  Full Text »

The Vesicular Stomatitis Virus Matrix Protein Inhibits Glycoprotein 130-Dependent STAT Activation.

L. Terstegen, P. Gatsios, S. Ludwig, S. Pleschka, W. Jahnen-Dechent, P. C. Heinrich, and L. Graeve (2001)
J. Immunol. 167, 5209-5216
 |  Abstract »  |  Full Text »  |  PDF »

Simultaneous Tyrosine and Serine Phosphorylation of STAT3 Transcription Factor Is Involved in Rho A GTPase Oncogenic Transformation.

S. Aznar, P. F. Valeron, S. V. del Rincon, L. F. Perez, R. Perona, and J. C. Lacal (2001)
Mol. Biol. Cell 12, 3282-3294
 |  Abstract »  |  Full Text »  |  PDF »

Defective gp130-mediated Signal Transducer and Activator of Transcription (STAT) Signaling Results in Degenerative Joint Disease, Gastrointestinal Ulceration, and Failure of Uterine Implantation.

M. Ernst, M. Inglese, P. Waring, I. K. Campbell, S. Bao, F. J. Clay, W. S. Alexander, I. P. Wicks, D. M. Tarlinton, U. Novak, et al. (2001)
J. Exp. Med. 194, 189-204
 |  Abstract »  |  Full Text »  |  PDF »

The soluble interleukin 6 receptor: mechanisms of production and implications in disease.

S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER (2001)
FASEB J 15, 43-58
 |  Abstract »  |  Full Text »  |  PDF »

Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma.

C. L. Campbell, Z. Jiang, D. M. F. Savarese, and T. M. Savarese (2001)
Am. J. Pathol. 158, 25-32
 |  Abstract »  |  Full Text »  |  PDF »

Two Different Epitopes of the Signal Transducer gp130 Sequentially Cooperate on IL-6-Induced Receptor Activation.

S. Pflanz, I. Kurth, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (2000)
J. Immunol. 165, 7042-7049
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas.

R. Rawat, G. J. Rainey, C. D. Thompson, M. R. Frazier-Jessen, R. T. Brown, and R. P. Nordan (2000)
Blood 96, 3514-3521
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor {alpha} chain 1: redundancy of requirement of tyrosine residue for STAT3 activation.

R. Umeshita-Suyama, R. Sugimoto, M. Akaiwa, K. Arima, B. Yu, M. Wada, M. Kuwano, K. Nakajima, N. Hamasaki, and K. Izuhara (2000)
Int. Immunol. 12, 1499-1509
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways.

S. T. Ahmed and L. B. Ivashkiv (2000)
J. Immunol. 165, 5227-5237
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of STAT3 by Direct Binding to the Rac1 GTPase.

A. R. Simon, H. G. Vikis, S. Stewart, B. L. Fanburg, B. H. Cochran, and K.-L. Guan (2000)
Science 290, 144-147
 |  Abstract »  |  Full Text »

The Coiled-Coil Domain of Stat3 Is Essential for Its SH2 Domain-Mediated Receptor Binding and Subsequent Activation Induced by Epidermal Growth Factor and Interleukin-6.

T. Zhang, W. H. Kee, K. T. Seow, W. Fung, and X. Cao (2000)
Mol. Cell. Biol. 20, 7132-7139
 |  Abstract »  |  Full Text »

Protein Phosphorylation Cascades Associated with Methamphetamine-induced Glial Activation.

M. A. HEBERT and J. P. O'CALLAGHAN (2000)
Ann. N.Y. Acad. Sci. 914, 238-262
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Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation.

D. Anhuf, M. Weissenbach, J. Schmitz, R. Sobota, H. M. Hermanns, S. Radtke, S. Linnemann, I. Behrmann, P. C. Heinrich, and F. Schaper (2000)
J. Immunol. 165, 2535-2543
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Lentivirus Infection in the Brain Induces Matrix Metalloproteinase Expression: Role of Envelope Diversity.

J. B. Johnston, Y. Jiang, G. van Marle, M. B. Mayne, W. Ni, J. Holden, J. C. McArthur, and C. Power (2000)
J. Virol. 74, 7211-7220
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Leukemia-Inhibitory Factor--Neuroimmune Modulator of Endocrine Function.

C. J. Auernhammer and S. Melmed (2000)
Endocr. Rev. 21, 313-345
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Stat 5B, Activated by Insulin in a Jak-Independent Fashion, Plays a Role in Glucokinase Gene Transcription.

D. Sawka-Verhelle, S. Tartare-Deckert, J.-F. Decaux, J. Girard, and E. Van Obberghen (2000)
Endocrinology 141, 1977-1988
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Ciliary Neurotrophic Factor and Stress Stimuli Activate the Jak-STAT Pathway in Retinal Neurons and Glia.

W. M. Peterson, Q. Wang, R. Tzekova, and S. J. Wiegand (2000)
J. Neurosci. 20, 4081-4090
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SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130.

J. Schmitz, M. Weissenbach, S. Haan, P. C. Heinrich, and F. Schaper (2000)
J. Biol. Chem. 275, 12848-12856
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Activation of the IL-4 STAT Pathway in Rheumatoid Synovium.

U. Muller-Ladner, M. Judex, W. Ballhorn, F. Kullmann, O. Distler, K. Schlottmann, R. E. Gay, J. Scholmerich, and S. Gay (2000)
J. Immunol. 164, 3894-3901
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Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation.

Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen (2000)
Mol. Cell. Biol. 20, 2043-2054
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Synergy of Activin and Ciliary Neurotrophic Factor Signaling Pathways in the Induction of Vasoactive Intestinal Peptide Gene Expression.

A. J. Symes, R. L. Pitts, J. Conover, K. Kos, and J. Coulombe (2000)
Mol. Endocrinol. 14, 429-439
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