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Science 3 March 1995:
Vol. 267. no. 5202, pp. 1347 - 1349
DOI: 10.1126/science.7871432
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Articles

Science, Vol 267, Issue 5202, 1347-1349
Copyright © 1995 by American Association for the Advancement of Science

articles

Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway

MH Heim, IM Kerr, GR Stark, and JE Darnell Jr

Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.

In response to specific ligands, various STAT proteins (signal transducers and activators of transcription) are phosphorylated on tyrosine by Jak protein kinases and translocated to the nucleus to direct gene transcription. Selection of a STAT at the interferon gamma receptor as well as specific STAT dimer formation depended on the presence of particular SH2 groups (phosphotyrosine-binding domains), whereas the amino acid sequence surrounding the phosphorylated tyrosine on the STAT could vary. Thus, SH2 groups in STAT proteins may play crucial roles in specificity at the receptor kinase complex and in subsequent dimerization, whereas the kinases are relatively nonspecific.


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J. Immunol. 164, 2533-2541
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The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction.
J. Schmitz, H. Dahmen, C. Grimm, C. Gendo, G. Muller-Newen, P. C. Heinrich, and F. Schaper (2000)
J. Immunol. 164, 848-854
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The Jak-Stat pathway in normal and perturbed hematopoiesis.
A. C. Ward, I. Touw, and A. Yoshimura (2000)
Blood 95, 19-29
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Rapid STAT Phosphorylation via the B Cell Receptor. MODULATORY ROLE OF CD19.
L. Su, R. C. Rickert, and M. David (1999)
J. Biol. Chem. 274, 31770-31774
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Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway.
M. H. Heim, D. Moradpour, and H. E. Blum (1999)
J. Virol. 73, 8469-8475
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R.E. Curiel, C.S. Garcia, S. Rottschafer, M.C. Bosco, and I. Espinoza-Delgado (1999)
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N. Jain, T. Zhang, W. H. Kee, W. Li, and X. Cao (1999)
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Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.
K. Friedrich, W. Kammer, I. Erhardt, S. Brandlein, W. Sebald, and R. Moriggl (1999)
Int. Immunol. 11, 1283-1294
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STAT Protein Recruitment and Activation in c-Kit Deletion Mutants.
M. F. Brizzi, P. Dentelli, A. Rosso, Y. Yarden, and L. Pegoraro (1999)
J. Biol. Chem. 274, 16965-16972
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Replication of Toxoplasma gondii, but Not Trypanosoma cruzi, Is Regulated in Human Fibroblasts Activated with Gamma Interferon: Requirement of a Functional JAK/STAT Pathway.
I. P. Ceravolo, A. C. L. Chaves, C. A. Bonjardim, D. Sibley, A. J. Romanha, and R. T. Gazzinelli (1999)
Infect. Immun. 67, 2233-2240
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TGF-{beta} Does Not Inhibit IL-12- and IL-2-Induced Activation of Janus Kinases and STATs.
C. Sudarshan, J. Galon, Y.-j. Zhou, and J. J. O'Shea (1999)
J. Immunol. 162, 2974-2981
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EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells.
L. R. Johnson, S. A. McCormack, C.-H. Yang, S. R. Pfeffer, and L. M. Pfeffer (1999)
Am J Physiol Cell Physiol 276, C419-C425
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Induction of beta -R1/I-TAC by Interferon-beta Requires Catalytically Active TYK2.
M. R. S. Rani, C. Gauzzi, S. Pellegrini, E. N. Fish, T. Wei, and R. M. Ransohoff (1999)
J. Biol. Chem. 274, 1891-1897
   Abstract »    Full Text »    PDF »
Characterization and Binding Specificity of the Monomeric STAT3-SH2 Domain.
S. Haan, U. Hemmann, U. Hassiepen, F. Schaper, J. Schneider-Mergener, A. Wollmer, P. C. Heinrich, and J. Grotzinger (1999)
J. Biol. Chem. 274, 1342-1348
   Abstract »    Full Text »    PDF »
Tyrosine-Dependent and -Independent Mechanisms of STAT3 Activation by the Human Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Differentially Utilized Depending on G-CSF Concentration.
A. C. Ward, M. H.A. Hermans, L. Smith, Y. M. van Aesch, A. M. Schelen, C. Antonissen, and I. P. Touw (1999)
Blood 93, 113-124
   Abstract »    Full Text »    PDF »
A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities.
C. Boucheron, S. Dumon, S. C. R. Santos, R. Moriggl, L. Hennighausen, S. Gisselbrecht, and F. Gouilleux (1998)
J. Biol. Chem. 273, 33936-33941
   Abstract »    Full Text »    PDF »
Role of the STAT1-SH2 Domain and STAT2 in the Activation and Nuclear Translocation of STAT1.
K. Mowen and M. David (1998)
J. Biol. Chem. 273, 30073-30076
   Abstract »    Full Text »    PDF »
Amino-terminal Signal Transducer and Activator of Transcription (STAT) Domains Regulate Nuclear Translocation and STAT Deactivation.
I. Strehlow and C. Schindler (1998)
J. Biol. Chem. 273, 28049-28056
   Abstract »    Full Text »    PDF »
Positive Selection of Apoptosis-resistant Cells Correlates with Activation of Dominant-Negative STAT5.
C. Bovolenta, L. Testolin, L. Benussi, P. M.-J. Lievens, and E. Liboi (1998)
J. Biol. Chem. 273, 20779-20784
   Abstract »    Full Text »    PDF »
Identification of Amino Acid Residues Critical for the Src-homology 2 Domain-dependent Docking of Stat2 to the Interferon alpha  Receptor.
K. Krishnan, B. Singh, and J. J. Krolewski (1998)
J. Biol. Chem. 273, 19495-19501
   Abstract »    Full Text »    PDF »
Mutational Analysis of the STAT6 SH2 Domain.
T. Mikita, C. Daniel, P. Wu, and U. Schindler (1998)
J. Biol. Chem. 273, 17634-17642
   Abstract »    Full Text »    PDF »
Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration.
T. M. LaVallee, I. A. Prudovsky, G. A. McMahon, X. Hu, and T. Maciag (1998)
J. Cell Biol. 141, 1647-1658
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Activation of STAT Proteins and Cytokine Genes in Human Th1 and Th2 Cells Generated in the Absence of IL-12 and IL-4.
R. Moriggl, C. Kristofic, B. Kinzel, S. Volarevic, B. Groner, and V. Brinkmann1 (1998)
J. Immunol. 160, 3385-3392
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Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression.
J. Zamorano, H. Y. Wang, R. Wang, Y. Shi, G. D. Longmore, and A. D. Keegan (1998)
J. Immunol. 160, 3502-3512
   Abstract »    Full Text »    PDF »
Prolactin Receptor Regulates Stat5 Tyrosine Phosphorylation and Nuclear Translocation by Two Separate Pathways.
S. Ali and S. Ali (1998)
J. Biol. Chem. 273, 7709-7716
   Abstract »    Full Text »    PDF »
A Sweat Gland-derived Differentiation Activity Acts through Known Cytokine Signaling Pathways.
B. A. Habecker, A. J. Symes, N. Stahl, N. J. Francis, A. Economides, J. S. Fink, G. D. Yancopoulos, and S. C. Landis (1997)
J. Biol. Chem. 272, 30421-30428
   Abstract »    Full Text »    PDF »
Defective TNF-{alpha}-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases.
A. Kumar, M. Commane, T. W. Flickinger, C. M. Horvath, and G. R. Stark (1997)
Science 278, 1630-1632
   Abstract »    Full Text »    PDF »
Targeted Inhibition of Interferon-gamma -dependent Intercellular Adhesion Molecule-1 (ICAM-1) Expression Using Dominant-Negative Stat1.
M. J. Walter, D. C. Look, R. M. Tidwell, W. T. Roswit, and M. J. Holtzman (1997)
J. Biol. Chem. 272, 28582-28589
   Abstract »    Full Text »    PDF »
Dexamethasone inhibits lung epithelial cell apoptosis induced by IFN-gamma and Fas.
L.-P. Wen, K. Madani, J. A. Fahrni, S. R. Duncan, and G. D. Rosen (1997)
Am J Physiol Lung Cell Mol Physiol 273, L921-L929
   Abstract »    Full Text »    PDF »
Tyrosine-dependent Basolateral Sorting Signals Are Distinct from Tyrosine-dependent Internalization Signals.
S. Lin, H. Y. Naim, and M. G. Roth (1997)
J. Biol. Chem. 272, 26300-26305
   Abstract »    Full Text »    PDF »
Distinct STAT Structure Promotes Interaction of STAT2 with the p48 Subunit of the Interferon-alpha -stimulated Transcription Factor ISGF3.
M. Martinez-Moczygemba, M. J. Gutch, D. L. French, and N. C. Reich (1997)
J. Biol. Chem. 272, 20070-20076
   Abstract »    Full Text »    PDF »
Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.
S. J. Haque, Q. Wu, W. Kammer, K. Friedrich, J. M. Smith, I. M. Kerr, G. R. Stark, and B. R. G. Williams (1997)
PNAS 94, 8563-8568
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The Amino Acid Residues Immediately Carboxyl-terminal to the Tyrosine Phosphorylation Site Contribute to Interleukin 6-specific Activation of Signal Transducer and Activator of Transcription 3.
M. Inoue, M. Minami, M. Matsumoto, T. Kishimoto, and S. Akira (1997)
J. Biol. Chem. 272, 9550-9555
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Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain.
J. G. Drachman and K. Kaushansky (1997)
PNAS 94, 2350-2355
   Abstract »    Full Text »    PDF »
Chimeric Erythropoietin-Interferon gamma Receptors Reveal Differences in Functional Architecture of Intracellular Domains for Signal Transduction.
G. Muthukumaran, S. Kotenko, R. Donnelly, J. N. Ihle, and S. Pestka (1997)
J. Biol. Chem. 272, 4993-4999
   Abstract »    Full Text »    PDF »
A Single STAT Recruitment Module in a Chimeric Cytokine Receptor Complex Is Sufficient for STAT Activation.
I. Behrmann, C. Janzen, C. Gerhartz, H. S.-V. de Leur, H. Hermanns, B. Heesel, L. Graeve, F. Horn, J. Tavernier, and P. C. Heinrich (1997)
J. Biol. Chem. 272, 5269-5274
   Abstract »    Full Text »    PDF »
Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes.
J. G. Drachman, D. F. Sabath, N. E. Fox, and K. Kaushansky (1997)
Blood 89, 483-492
   Abstract »    Full Text »    PDF »
In vitro activation of Stat3 by epidermal growth factor receptor kinase.
O. K. Park, T. S. Schaefer, and D. Nathans (1996)
PNAS 93, 13704-13708
   Abstract »    Full Text »    PDF »
Stat3 Recruitment by Two Distinct Ligand-induced, Tyrosine-phosphorylated Docking Sites in the Interleukin-10 Receptor Intracellular Domain.
R. M. Weber-Nordt, J. K. Riley, A. C. Greenlund, K. W. Moore, J. E. Darnell, and R. D. Schreiber (1996)
J. Biol. Chem. 271, 27954-27961
   Abstract »    Full Text »    PDF »
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-gamma.
S. V. Kotenko, L. S. Izotova, B. P. Pollack, G. Muthukumaran, K. Paukku, O. Silvennoinen, J. N. Ihle, and S. Pestka (1996)
J. Biol. Chem. 271, 17174-17182
   Abstract »    Full Text »    PDF »
Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130. I. DEFINITION OF A NOVEL PHOSPHOTYROSINE MOTIF MEDIATING STAT1 ACTIVATION.
C. Gerhartz, B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. C. Heinrich, and L. Graeve (1996)
J. Biol. Chem. 271, 12991-12998
   Abstract »    Full Text »    PDF »
Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130. II. Src HOMOLOGY SH2 DOMAINS DEFINE THE SPECIFICITY OF STAT FACTOR ACTIVATION.
U. Hemmann, C. Gerhartz, B. Heesel, J. Sasse, G. Kurapkat, J. Grotzinger, A. Wollmer, Z. Zhong, J. E. Darnell Jr., L. Graeve, et al. (1996)
J. Biol. Chem. 271, 12999-13007
   Abstract »    Full Text »    PDF »
Application of Genomic DNA Affinity Chromatography Identifies Multiple Interferon-alpha-regulated Stat2 Complexes.
J. J. Ghislain and E. N. Fish (1996)
J. Biol. Chem. 271, 12408-12413
   Abstract »    Full Text »    PDF »
STAT Activation by Epidermal Growth Factor (EGF) and Amphiregulin.
M. David, L. Wong, R. Flavell, S. A. Thompson, A. Wells, A. C. Larner, and G. R. Johnson (1996)
J. Biol. Chem. 271, 9185-9188
   Abstract »    Full Text »    PDF »
Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction.
A. Kaptein, V.ér. Paillard, and M. Saunders (1996)
J. Biol. Chem. 271, 5961-5964
   Abstract »    Full Text »    PDF »
Purification, Microsequencing, and Immunolocalization of p36, a New Interferon-alpha-induced Protein That Is Associated with Human Lupus Inclusions.
S. A. Rich, M. Bose, P. Tempst, and U. H. Rudofsky (1996)
J. Biol. Chem. 271, 1118-1126
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Reconstitution of a High Affinity Binding Site for Type I Interferons.
D. Russell-Harde, H. Pu, M. Betts, R. N. Harkins, H. D. Perez, and E. Croze (1995)
J. Biol. Chem. 270, 26033-26036
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Roles of Protein-tyrosine Phosphatases in Stat1alpha-mediated Cell Signaling.
S. J. Haque, V. Flati, A. Deb, and B. R. G. Williams (1995)
J. Biol. Chem. 270, 25709-25714
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Interaction of the Transcriptional Activator Stat-2 with the Type I Interferon Receptor.
S. Uddin, A. Chamdin, and L. C. Platanias (1995)
J. Biol. Chem. 270, 24627-24630
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(1995)
J. Biol. Chem. 270, 20952-20961
   Abstract »    Full Text »    PDF »
Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor.
F. W. Quelle, W. Thierfelder, B. A. Witthuhn, B. Tang, S. Cohen, and J. N. Ihle (1995)
J. Biol. Chem. 270, 20775-20780
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Activation of the STAT Pathway by Angiotensin II in T3CHO/AT[IMAGE] Cells.
G. J. Bhat, T. J. Thekkumkara, W. G. Thomas, K. M. Conrad, and K. M. Baker (1995)
J. Biol. Chem. 270, 19059-19065
   Abstract »    Full Text »    PDF »
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors.
N Stahl, T. Farruggella, T. Boulton, Z Zhong, J. Darnell Jr, and G. Yancopoulos (1995)
Science 267, 1349-1353
   Abstract »    PDF »
Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cdelta Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation.
J.-J. Schuringa, L. V. Dekker, E. Vellenga, and W. Kruijer (2001)
J. Biol. Chem. 276, 27709-27715
   Abstract »    Full Text »    PDF »
Transcription Factor STAT5A Is a Substrate of Bruton's Tyrosine Kinase in B Cells.
S. Mahajan, A. Vassilev, N. Sun, Z. Ozer, C. Mao, and F. M. Uckun (2001)
J. Biol. Chem. 276, 31216-31228
   Abstract »    Full Text »    PDF »
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation.
J. Turkson, D. Ryan, J. S. Kim, Y. Zhang, Z. Chen, E. Haura, A. Laudano, S. Sebti, A. D. Hamilton, and R. Jove (2001)
J. Biol. Chem. 276, 45443-45455
   Abstract »    Full Text »    PDF »
Hydrophobic Residues Phe751 and Leu753 Are Essential for STAT5 Transcriptional Activity.
B. A. Callus and B. Mathey-Prevot (2000)
J. Biol. Chem. 275, 16954-16962
   Abstract »    Full Text »    PDF »


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