Science 24 February 1995: Vol. 267. no. 5201, pp. 1183 - 1185 DOI: 10.1126/science.7855602

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Articles

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair.

E. Bolderson, D. J. Richard, B.-B. S. Zhou, and K. K. Khanna (2009)
Clin. Cancer Res. 15, 6314-6320
 |  Abstract »  |  Full Text »  |  PDF »

Enhancing the Apoptotic Potential of Insulin-Like Growth Factor-Binding Protein-3 in Prostate Cancer by Modulation of CK2 Phosphorylation.

L. J. Cobb, H. Mehta, and P. Cohen (2009)
Mol. Endocrinol. 23, 1624-1633
 |  Abstract »  |  Full Text »  |  PDF »

Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1{alpha}-deficient mouse embryonic fibroblasts.

R. Wirthner, S. Wrann, K. Balamurugan, R. H. Wenger, and D. P. Stiehl (2008)
Carcinogenesis 29, 2306-2316
 |  Abstract »  |  Full Text »  |  PDF »

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells.

B. L. Ruis, K. R. Fattah, and E. A. Hendrickson (2008)
Mol. Cell. Biol. 28, 6182-6195
 |  Abstract »  |  Full Text »  |  PDF »

A Role for DEAD Box 1 at DNA Double-Strand Breaks.

L. Li, E. A. Monckton, and R. Godbout (2008)
Mol. Cell. Biol. 28, 6413-6425
 |  Abstract »  |  Full Text »  |  PDF »

ATM Acts Downstream of ATR in the DNA Damage Response Signaling of Bystander Cells.

S. Burdak-Rothkamm, K. Rothkamm, and K. M. Prise (2008)
Cancer Res. 68, 7059-7065
 |  Abstract »  |  Full Text »  |  PDF »

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.

L. Schulte-Uentrop, R. A. El-Awady, L. Schliecker, H. Willers, and J. Dahm-Daphi (2008)
Nucleic Acids Res. 36, 2561-2569
 |  Abstract »  |  Full Text »  |  PDF »

Sequential and Synergistic Modification of Human RPA Stimulates Chromosomal DNA Repair.

R. W. Anantha, V. M. Vassin, and J. A. Borowiec (2007)
J. Biol. Chem. 282, 35910-35923
 |  Abstract »  |  Full Text »  |  PDF »

DNA repair after irradiation in glioma cells and normal human astrocytes.

S. C. Short, C. Martindale, S. Bourne, G. Brand, M. Woodcock, and P. Johnston (2007)
Neuro-oncol 9, 404-411
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Mammalian Target of Rapamycin Signaling by 2-(Morpholin-1-yl)pyrimido[2,1-{alpha}]isoquinolin-4-one.

L. M. Ballou, E. S. Selinger, J. Y. Choi, D. G. Drueckhammer, and R. Z. Lin (2007)
J. Biol. Chem. 282, 24463-24470
 |  Abstract »  |  Full Text »  |  PDF »

Human Polynucleotide Kinase Participates in Repair of DNA Double-Strand Breaks by Nonhomologous End Joining but not Homologous Recombination.

F. Karimi-Busheri, A. Rasouli-Nia, J. Allalunis-Turner, and M. Weinfeld (2007)
Cancer Res. 67, 6619-6625
 |  Abstract »  |  Full Text »  |  PDF »

Nonhomologous End Joining Is Essential for Cellular Resistance to the Novel Antitumor Agent, {beta}-Lapachone.

M. S. Bentle, K. E. Reinicke, Y. Dong, E. A. Bey, and D. A. Boothman (2007)
Cancer Res. 67, 6936-6945
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts.

L. F. Povirk, R.-Z. Zhou, D. A. Ramsden, S. P. Lees-Miller, and K. Valerie (2007)
Nucleic Acids Res. 35, 3869-3878
 |  Abstract »  |  Full Text »  |  PDF »

The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.

S. Kuhfittig-Kulle, E. Feldmann, A. Odersky, A. Kuliczkowska, W. Goedecke, A. Eggert, and P. Pfeiffer (2007)
Mutagenesis 22, 217-233
 |  Abstract »  |  Full Text »  |  PDF »

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.

M. Wang, W. Wu, W. Wu, B. Rosidi, L. Zhang, H. Wang, and G. Iliakis (2006)
Nucleic Acids Res. 34, 6170-6182
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation by DNA-Dependent Protein Kinase Is Critical for Apoptosis Induction by Insulin-Like Growth Factor Binding Protein-3..

L. J. Cobb, B. Liu, K.-W. Lee, and P. Cohen (2006)
Cancer Res. 66, 10878-10884
 |  Abstract »  |  Full Text »  |  PDF »

ATM mediates oxidative stress-induced dephosphorylation of DNA ligase III{alpha}.

Z. Dong and A. E. Tomkinson (2006)
Nucleic Acids Res. 34, 5721-5279
 |  Abstract »  |  Full Text »  |  PDF »

Homologous recombination is required for AAV-mediated gene targeting.

A. Vasileva, R. M. Linden, and R. Jessberger (2006)
Nucleic Acids Res. 34, 3345-3360
 |  Abstract »  |  Full Text »  |  PDF »

Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441..

Y. Zhao, H. D. Thomas, M. A. Batey, I. G. Cowell, C. J. Richardson, R. J. Griffin, A. H. Calvert, D. R. Newell, G. C.M. Smith, and N. J. Curtin (2006)
Cancer Res. 66, 5354-5362
 |  Abstract »  |  Full Text »  |  PDF »

Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage..

C. M. Sturgeon, Z. A. Knight, K. M. Shokat, and M. Roberge (2006)
Mol. Cancer Ther. 5, 885-892
 |  Abstract »  |  Full Text »  |  PDF »

Induction of CAF-1 Expression in Response to DNA Strand Breaks in Quiescent Human Cells..

A. Nabatiyan, D. Szuts, and T. Krude (2006)
Mol. Cell. Biol. 26, 1839-1849
 |  Abstract »  |  Full Text »  |  PDF »

Radiosensitization by the poly(ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis..

G. Noel, C. Godon, M. Fernet, N. Giocanti, F. Megnin-Chanet, and V. Favaudon (2006)
Mol. Cancer Ther. 5, 564-574
 |  Abstract »  |  Full Text »  |  PDF »

Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.

R. Sakasai, K. Shinohe, Y. Ichijima, N. Okita, A. Shibata, K. Asahina, and H. Teraoka (2006)
Genes Cells 11, 237-246
 |  Abstract »  |  Full Text »  |  PDF »

The Dispersal of Replication Proteins after Etoposide Treatment Requires the Cooperation of Nbs1 with the Ataxia Telangiectasia Rad3-Related/Chk1 Pathway.

R. Rossi, M. R. Lidonnici, S. Soza, G. Biamonti, and A. Montecucco (2006)
Cancer Res. 66, 1675-1683
 |  Abstract »  |  Full Text »  |  PDF »

The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor.

A. Lankoff, J. Bialczyk, D. Dziga, W.W. Carmichael, I. Gradzka, H. Lisowska, T. Kuszewski, S. Gozdz, I. Piorun, and A. Wojcik (2006)
Mutagenesis 21, 83-90
 |  Abstract »  |  Full Text »  |  PDF »

DNA damage-induced phosphorylation of the human telomere-associated protein TRF2.

H. Tanaka, M. S. Mendonca, P. S. Bradshaw, D. J. Hoelz, L. H. Malkas, M. S. Meyn, and D. Gilley (2005)
PNAS 102, 15539-15544
 |  Abstract »  |  Full Text »  |  PDF »

A role for PKC{zeta} in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin.

C. Reis, N. Giocanti, C. Hennequin, F. Megnin-Chanet, M. Fernet, R. Filomenko, A. Bettaieb, E. Solary, and V. Favaudon (2005)
Mol. Cancer Ther. 4, 1457-1464
 |  Abstract »  |  Full Text »  |  PDF »

ATM-dependent DNA Damage-independent Mitotic Phosphorylation of H2AX in Normally Growing Mammalian Cells.

K. J. McManus and M. J. Hendzel (2005)
Mol. Biol. Cell 16, 5013-5025
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-induced Epidermal Growth Factor Receptor Nuclear Import Is Linked to Activation of DNA-dependent Protein Kinase.

K. Dittmann, C. Mayer, B. Fehrenbacher, M. Schaller, U. Raju, L. Milas, D. J. Chen, R. Kehlbach, and H. P. Rodemann (2005)
J. Biol. Chem. 280, 31182-31189
 |  Abstract »  |  Full Text »  |  PDF »

A Cell-permeable, Activity-based Probe for Protein and Lipid Kinases.

M.-c. Yee, S. C. Fas, M. M. Stohlmeyer, T. J. Wandless, and K. A. Cimprich (2005)
J. Biol. Chem. 280, 29053-29059
 |  Abstract »  |  Full Text »  |  PDF »

High Mobility Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damage-Dependent Phosphatidylinositol 3-Kinase-Related Protein Kinase Activation.

L. M. Boo, H. H. Lin, V. Chung, B. Zhou, S. G. Louie, M. A. O'Reilly, Y. Yen, and D. K. Ann (2005)
Cancer Res. 65, 6622-6630
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic H-Ras Up-regulates Expression of Ku80 to Protect Cells from {gamma}-Ray Irradiation in NIH3T3 Cells.

I.-Y. Chang, C.-K. Youn, H.-B. Kim, M.-H. Kim, H.-J. Cho, Y. Yoon, Y.-S. Lee, M.-H. Chung, and H. J. You (2005)
Cancer Res. 65, 6811-6819
 |  Abstract »  |  Full Text »  |  PDF »

Ku86 preserves chromatin integrity in cells adapted to high NaCl.

N. I. Dmitrieva, A. Celeste, A. Nussenzweig, and M. B. Burg (2005)
PNAS 102, 10730-10735
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of DNA Repair by a Herpes Simplex Virus Vector Enhances the Radiosensitivity of Human Glioblastoma Cells.

C. G. Hadjipanayis and N. A. DeLuca (2005)
Cancer Res. 65, 5310-5316
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of the DNA-Dependent Protein Kinase Catalytic Subunit Radiosensitizes Malignant Glioma Cells by Inducing Autophagy.

S. Daido, A. Yamamoto, K. Fujiwara, R. Sawaya, S. Kondo, and Y. Kondo (2005)
Cancer Res. 65, 4368-4375
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria.

Y. Arima, M. Nitta, S. Kuninaka, D. Zhang, T. Fujiwara, Y. Taya, M. Nakao, and H. Saya (2005)
J. Biol. Chem. 280, 19166-19176
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks.

B. P. C. Chen, D. W. Chan, J. Kobayashi, S. Burma, A. Asaithamby, K. Morotomi-Yano, E. Botvinick, J. Qin, and D. J. Chen (2005)
J. Biol. Chem. 280, 14709-14715
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of CHK2 by DNA-dependent Protein Kinase.

J. Li and D. F. Stern (2005)
J. Biol. Chem. 280, 12041-12050
 |  Abstract »  |  Full Text »  |  PDF »

DNA Damage Sensors ATM, ATR, DNA-PKcs, and PARP-1 Are Dispensable for Human Immunodeficiency Virus Type 1 Integration.

Y. Ariumi, P. Turelli, M. Masutani, and D. Trono (2005)
J. Virol. 79, 2973-2978
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency in the Catalytic Subunit of DNA-Dependent Protein Kinase Causes Down-Regulation of ATM.

Y. Peng, R. G. Woods, H. Beamish, R. Ye, S. P. Lees-Miller, M. F. Lavin, and J. S. Bedford (2005)
Cancer Res. 65, 1670-1677
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1).

T. Zhou, J. W. Lee, H. Tatavarthi, J. R. Lupski, K. Valerie, and L. F. Povirk (2005)
Nucleic Acids Res. 33, 289-297
 |  Abstract »  |  Full Text »  |  PDF »

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint Response.

X. Zhang, J. Succi, Z. Feng, S. Prithivirajsingh, M. D. Story, and R. J. Legerski (2004)
Mol. Cell. Biol. 24, 9207-9220
 |  Abstract »  |  Full Text »  |  PDF »

Diverse Roles for E4orf3 at Late Times of Infection Revealed in an E1B 55-Kilodalton Protein Mutant Background.

R. N. Shepard and D. A. Ornelles (2004)
J. Virol. 78, 9924-9935
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage.

M. T. Jack, R. A. Woo, N. Motoyama, H. Takai, and P. W. K. Lee (2004)
J. Biol. Chem. 279, 15269-15273
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.

W. D. Block, Y. Yu, and S. P. Lees-Miller (2004)
Nucleic Acids Res. 32, 997-1005
 |  Abstract »  |  Full Text »  |  PDF »

A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity.

M. Kuhne, E. Riballo, N. Rief, K. Rothkamm, P. A. Jeggo, and M. Lobrich (2004)
Cancer Res. 64, 500-508
 |  Abstract »  |  Full Text »  |  PDF »

Repair of a minimal DNA double-strand break by NHEJ requires DNA-PKcs and is controlled by the ATM/ATR checkpoint.

C. Kuhne, M.-L. Tjornhammar, S. Pongor, L. Banks, and A. Simoncsits (2003)
Nucleic Acids Res. 31, 7227-7237
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer.

A. Kashishian, H. Douangpanya, D. Clark, S. T. Schlachter, C. T. Eary, J. G. Schiro, H. Huang, L. E. Burgess, E. A. Kesicki, and J. Halbrook (2003)
Mol. Cancer Ther. 2, 1257-1264
 |  Abstract »  |  Full Text »  |  PDF »

Down-Regulation of Histone H2B by DNA-Dependent Protein Kinase in Response to DNA Damage through Modulation of Octamer Transcription Factor 1.

C. Schild-Poulter, A. Shih, N. C. Yarymowich, and R. J. G. Hache (2003)
Cancer Res. 63, 7197-7205
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical evidence for Ku-independent backup pathways of NHEJ.

H. Wang, A. R. Perrault, Y. Takeda, W. Qin, H. Wang, and G. Iliakis (2003)
Nucleic Acids Res. 31, 5377-5388
 |  Abstract »  |  Full Text »  |  PDF »

Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair.

Q. Ding, Y. V. R. Reddy, W. Wang, T. Woods, P. Douglas, D. A. Ramsden, S. P. Lees-Miller, and K. Meek (2003)
Mol. Cell. Biol. 23, 5836-5848
 |  Abstract »  |  Full Text »  |  PDF »

Novel Localization of the DNA-PK Complex in Lipid Rafts: A PUTATIVE ROLE IN THE SIGNAL TRANSDUCTION PATHWAY OF THE IONIZING RADIATION RESPONSE.

H. Lucero, D. Gae, and G. E. Taccioli (2003)
J. Biol. Chem. 278, 22136-22143
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes.

T. Furuta, H. Takemura, Z.-Y. Liao, G. J. Aune, C. Redon, O. A. Sedelnikova, D. R. Pilch, E. P. Rogakou, A. Celeste, H. T. Chen, et al. (2003)
J. Biol. Chem. 278, 20303-20312
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Radiation and Chemotherapy-mediated Cell Killing of Human Cancer Cells by Small Inhibitory RNA Silencing of DNA Repair Factors.

S. J. Collis, M. J. Swartz, W. G. Nelson, and T. L. DeWeese (2003)
Cancer Res. 63, 1550-1554
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Phosphatidylinositol 3-Kinase/Akt Pathway for Enhancing Breast Cancer Cells to Radiotherapy.

K. Liang, W. Jin, C. Knuefermann, M. Schmidt, G. B. Mills, K. K. Ang, L. Milas, and Z. Fan (2003)
Mol. Cancer Ther. 2, 353-360
 |  Abstract »  |  Full Text »  |  PDF »

Nonhomologous end joining and V(D)J recombination require an additional factor.

Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger, and P. A. Jeggo (2003)
PNAS 100, 2462-2467
 |  Abstract »  |  Full Text »  |  PDF »

Human Ku70/80 Associates Physically with Telomerase through Interaction with hTERT.

W. Chai, L. P. Ford, L. Lenertz, W. E. Wright, and J. W. Shay (2002)
J. Biol. Chem. 277, 47242-47247
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Ku70 and Ku80 Mediated by NF-kappa B and Cyclooxygenase-2 Is Related to Proliferation of Human Gastric Cancer Cells.

J. W. Lim, H. Kim, and K. H. Kim (2002)
J. Biol. Chem. 277, 46093-46100
 |  Abstract »  |  Full Text »  |  PDF »

Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites.

X. Mo and W. S. Dynan (2002)
Mol. Cell. Biol. 22, 8088-8099
 |  Abstract »  |  Full Text »  |  PDF »

A Targeted Inhibition of DNA-Dependent Protein Kinase Sensitizes Breast Cancer Cells Following Ionizing Radiation.

C.-H. Kim, S.-J. Park, and S.-H. Lee (2002)
J. Pharmacol. Exp. Ther. 303, 753-759
 |  Abstract »  |  Full Text »  |  PDF »

An Antisense Oligonucleotide Targeted to Human Ku86 Messenger RNA Sensitizes M059K Malignant Glioma Cells to Ionizing Radiation, Bleomycin, and Etoposide but not DNA Cross-Linking Agents.

A. I. Belenkov, J.-P. Paiement, L. C. Panasci, B. P. Monia, and T. Y. K. Chow (2002)
Cancer Res. 62, 5888-5896
 |  Abstract »  |  Full Text »  |  PDF »

DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.

S. K. Mauldin, R. C. Getts, W. Liu, and T. D. Stamato (2002)
Nucleic Acids Res. 30, 4075-4087
 |  Abstract »  |  Full Text »  |  PDF »

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

D. W. Chan, B. P.-C. Chen, S. Prithivirajsingh, A. Kurimasa, M. D. Story, J. Qin, and D. J. Chen (2002)
Genes & Dev. 16, 2333-2338
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Responses to the DNA Strand-scission Enediyne C-1027 Can Be Independent of ATM, ATR, and DNA-PK Kinases.

J. Dziegielewski and T. A. Beerman (2002)
J. Biol. Chem. 277, 20549-20554
 |  Abstract »  |  Full Text »  |  PDF »

Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation.

P. Karmakar, J. Piotrowski, R. M. Brosh Jr., J. A. Sommers, S. P. L. Miller, W.-H. Cheng, C. M. Snowden, D. A. Ramsden, and V. A. Bohr (2002)
J. Biol. Chem. 277, 18291-18302
 |  Abstract »  |  Full Text »  |  PDF »

Sensing and repairing DNA double-strand breaks.

S. P. Jackson (2002)
Carcinogenesis 23, 687-696
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.

C. Allen, A. Kurimasa, M. A. Brenneman, D. J. Chen, and J. A. Nickoloff (2002)
PNAS 99, 3758-3763
 |  Abstract »  |  Full Text »  |  PDF »

Replication protein A is sequentially phosphorylated during meiosis.

G. S. Brush, D. M. Clifford, S. M. Marinco, and A. J. Bartrand (2001)
Nucleic Acids Res. 29, 4808-4817
 |  Abstract »  |  Full Text »  |  PDF »

Replication Protein A2 Phosphorylation after DNA Damage by the Coordinated Action of Ataxia Telangiectasia-Mutated and DNA-dependent Protein Kinase.

H. Wang, J. Guan, H. Wang, A. R. Perrault, Y. Wang, and G. Iliakis (2001)
Cancer Res. 61, 8554-8563
 |  Abstract »  |  Full Text »  |  PDF »

In vitro repair of complex unligatable oxidatively induced DNA double-strand breaks by human cell extracts.

E. Pastwa, R. D. Neumann, and T. A. Winters (2001)
Nucleic Acids Res. 29, e78
 |  Abstract »  |  Full Text »  |  PDF »

Reduced DNA-dependent protein kinase activity is associated with lung cancer.

D. H. Auckley, R. E. Crowell, E. R. Heaphy, C. A. Stidley, J. F. Lechner, F. D. Gilliland, and S. A. Belinsky (2001)
Carcinogenesis 22, 723-727
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-induced Genomic Rearrangements Formed by Nonhomologous End-Joining of DNA Double-Strand Breaks.

K. Rothkamm, M. Kühne, P. A. Jeggo, and M. Löbrich (2001)
Cancer Res. 61, 3886-3893
 |  Abstract »  |  Full Text »

UV-induced Hyperphosphorylation of Replication Protein A Depends on DNA Replication and Expression of ATM Protein.

G. G. Oakley, L. I. Loberg, J. Yao, M. A. Risinger, R. L. Yunker, M. Zernik-Kobak, K. K. Khanna, M. F. Lavin, M. P. Carty, and K. Dixon (2001)
Mol. Biol. Cell 12, 1199-1213
 |  Abstract »  |  Full Text »

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage-Signaling Pathways.

I. Rappold, K. Iwabuchi, T. Date, and J. Chen (2001)
J. Cell Biol. 153, 613-620
 |  Abstract »  |  Full Text »  |  PDF »

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

H. Wang, Z.-C. Zeng, A. R. Perrault, X. Cheng, W. Qin, and G. Iliakis (2001)
Nucleic Acids Res. 29, 1653-1660
 |  Abstract »  |  Full Text »  |  PDF »

BCR-ABL down-regulates the DNA repair protein DNA-PKcs.

E. Deutsch, A. Dugray, B. AbdulKarim, E. Marangoni, L. Maggiorella, S. Vaganay, R. M'Kacher, S. D. Rasy, F. Eschwege, W. Vainchenker, et al. (2001)
Blood 97, 2084-2090
 |  Abstract »  |  Full Text »  |  PDF »

Wortmannin Potentiates Integrase-Mediated Killing of Lymphocytes and Reduces the Efficiency of Stable Transduction by Retroviruses.

R. Daniel, R. A. Katz, G. Merkel, J. C. Hittle, T. J. Yen, and A. M. Skalka (2001)
Mol. Cell. Biol. 21, 1164-1172
 |  Abstract »  |  Full Text »

DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration.

V. Baekelandt, A. Claeys, P. Cherepanov, E. De Clercq, B. De Strooper, B. Nuttin, and Z. Debyser (2000)
J. Virol. 74, 11278-11285
 |  Abstract »  |  Full Text »

Signal Joint Formation Is Also Impaired in DNA-Dependent Protein Kinase Catalytic Subunit Knockout Cells.

R. Fukumura, R. Araki, A. Fujimori, Y. Tsutsumi, A. Kurimasa, G. C. Li, D. J. Chen, K. Tatsumi, and M. Abe (2000)
J. Immunol. 165, 3883-3889
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-bending protein, HMG1, is required for correct cleavage of 23 bp recombination signal sequences by recombination activating gene proteins in vitro.

T. Yoshida, A. Tsuboi, K.-i. Ishiguro, F. Nagawa, and H. Sakano (2000)
Int. Immunol. 12, 721-729
 |  Abstract »  |  Full Text »  |  PDF »

Purification and Characterization of ATM from Human Placenta. A MANGANESE-DEPENDENT, WORTMANNIN-SENSITIVE SERINE/THREONINE PROTEIN KINASE.

D. W. Chan, S.-C. Son, W. Block, R. Ye, K. K. Khanna, M. S. Wold, P. Douglas, A. A. Goodarzi, J. Pelley, Y. Taya, et al. (2000)
J. Biol. Chem. 275, 7803-7810
 |  Abstract »  |  Full Text »  |  PDF »

The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication.

J. Guan, S. DiBiase, and G. Iliakis (2000)
Nucleic Acids Res. 28, 1183-1192
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent Protein Kinase Stimulates an Independently Active, Nonhomologous, End-Joining Apparatus.

S. J. DiBiase, Z.-C. Zeng, R. Chen, T. Hyslop, W. J. Curran Jr., and G. Iliakis (2000)
Cancer Res. 60, 1245-1253
 |  Abstract »  |  Full Text »

Double-strand Break Repair in Human Cells.

S.C. WEST, C. CHAPPELL, L.A. HANAKAHI, J.-Y. MASSON, M.J. MCILWRAITH, and E. VAN DYCK (2000)
Cold Spring Harb Symp Quant Biol 65, 315-322
 |  Abstract »  |  PDF »

Involvement of DNA-dependent Protein Kinase in UV-induced Replication Arrest.

J.-S. Park, S.-J. Park, X. Peng, M. Wang, M.-A. Yu, and S.-H. Lee (1999)
J. Biol. Chem. 274, 32520-32527
 |  Abstract »  |  Full Text »  |  PDF »

Ku is associated with the telomere in mammals.

H.-L. Hsu, D. Gilley, E. H. Blackburn, and D. J. Chen (1999)
PNAS 96, 12454-12458
 |  Abstract »  |  Full Text »  |  PDF »

Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action.

M. E. Cardenas, M. C. Cruz, M. Del Poeta, N. Chung, J. R. Perfect, and J. Heitman (1999)
Clin. Microbiol. Rev. 12, 583-611
 |  Abstract »  |  Full Text »  |  PDF »

Ku Autoantigen Affects the Susceptibility to Anticancer Drugs.

S. H. Kim, D. Kim, J. S. Han, C. S. Jeong, B. S. Chung, C. D. Kang, and G. C. Li (1999)
Cancer Res. 59, 4012-4017
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Replication Protein A and DNA-dependent Protein Kinase in the Regulation of DNA Replication following DNA Damage.

Y. Wang, X.-Y. Zhou, H. Wang, M. S. Huq, and G. Iliakis (1999)
J. Biol. Chem. 274, 22060-22064
 |  Abstract »  |  Full Text »  |  PDF »

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage.

Z. Dong, Q. Zhong, and P.-L. Chen (1999)
J. Biol. Chem. 274, 19513-19516
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic Effects of Retinoic Acid and 8-Chloro-Adenosine 3',5'-Cyclic Monophosphate on the Regulation of Retinoic Acid Receptor {beta} and Apoptosis: Involvement of Mitochondria.

R. K. Srivastava, A. R. Srivastava, Y. S. Cho-Chung, and D. L. Longo (1999)
Clin. Cancer Res. 5, 1892-1904
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Expression of the DNA Repair Protein Complex DNA-Dependent Protein Kinase after Ischemia and Reperfusion.

D. A. Shackelford, T. Tobaru, S. Zhang, and J. A. Zivin (1999)
J. Neurosci. 19, 4727-4738
 |  Abstract »  |  Full Text »  |  PDF »

Competitive and Noncompetitive Inhibition of the DNA-dependent Protein Kinase.

R. A. Izzard, S. P. Jackson, and G. C. M. Smith (1999)
Cancer Res. 59, 2581-2586
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining.

A. Kurimasa, S. Kumano, N. V. Boubnov, M. D. Story, C.-S. Tung, S. R. Peterson, and D. J. Chen (1999)
Mol. Cell. Biol. 19, 3877-3884
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-dependent protein kinase.

G. C.M. Smith and S. P. Jackson (1999)
Genes & Dev. 13, 916-934
 |  Full Text »

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