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Science 17 February 1995:
Vol. 267. no. 5200, pp. 1031 - 1034
DOI: 10.1126/science.7863331
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Articles

Science, Vol 267, Issue 5200, 1031-1034
Copyright © 1995 by American Association for the Advancement of Science

articles

Molecular cloning and characterization of an inner ear-specific structural protein

JG Davis, JC Oberholtzer, FR Burns, and MI Greene

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.

Molecular biological studies of the mammalian inner ear have been limited by the relatively small size of the sensory endorgans contained within. The saccular otolithic organ in teleostian fish is structurally similar to its mammalian counterpart but can contain an order of magnitude more sensory cells. The prospect of the evolutionary conservation of proteins utilized in the vertebrate inner ear and the relative abundance of teleostian saccular sensory tissue made this an attractive system for molecular biological studies. A complementary DNA obtained by differential screening of a saccular complementary DNA library was identified that encodes an inner ear-specific collagen molecule.


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Chemical composition of saccular endolymph and otolith in fish inner ear: lack of spatial uniformity.
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Otogelin: A glycoprotein specific to the acellular membranes of the inner ear.
M. Cohen-Salmon, A. El-Amraoui, M. Leibovici, and C. Petit (1997)
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Identification of a structural constituent and one possible site of postembryonic formation of a teleost otolithic membrane.
J. G. Davis, F. R. Burns, D. Navaratnam, A. M. Lee, S. Ichimiya, J. C. Oberholtzer, and M. I. Greene (1997)
PNAS 94, 707-712
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From the Cover: Regulation of the stem cell leukemia (SCL) gene: A tale of two fishes.
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